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tim.hodson Fri, 03/14/2025 - 11:42 March 11, 2025 CareDx, Inc. The Transplant Company recently announced that AlloSureis now commercially available for pediatric heart transplant patients of all ages and patients who have received a simultaneous pancreas-kidney (SPK) transplant. Both indications are approved by the New York State Clinical Laboratory Evaluation Program, demonstrating that AlloSure has met the most rigorous validation standards for laboratory developed tests (LDTs).
Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post. You can find more products I’m affiliated with on my website. Physiologically Speaking is a reader-supported publication.
As one of our board certified vascular surgeons, Dr. Nicolas Zea performs a variety of complex procedures, and his dedication to patient care and service is exceptional. What you might not know about him is that he is also an avid adventurer, running ultra marathons and traveling far and wide to embark on trail run excursions and mountain climbing expeditions.
Circulation: Heart Failure, Ahead of Print. The most common form of hereditary transthyretin cardiac amyloidosis (hATTR-CA) in the United States and the United Kingdom is the p.V142I variant. About 3% to 4% of patients with African ancestry carry this genetic predisposition to develop signs and symptoms of hATTR-CA. Nevertheless, clinical manifestations of hATTR-CA appear only late in the fifth and sixth decades of life, despite its clear genetic background.
Circulation: Cardiovascular Interventions, Ahead of Print. Background:Nickel-containing devices, such as the Amplatzer PFO Occluder and Gore Cardioform Septal Occluder (GSO), are used for transcatheter patent foramen ovale (PFO) closure. However, the impact of nickel hypersensitivity on post-procedural outcomes remains poorly understood. This study aimed to evaluate the risk of adverse events, in patients with nickel hypersensitivity undergoing PFO closure.Methods:Our study was a prospective, do
tim.hodson Tue, 03/11/2025 - 11:19 Mar. 10, 2025-- Corcept Therapeutics Inc., a commercial-stage company engaged in the discovery and development of medications to treat severe endocrinologic, oncologic, metabolic and neurologic disorders by modulating the effects of the hormone cortisol, recently announced the initiation of Momentum, a clinical trial examining the prevalence of endogenous hypercortisolism (Cushings syndrome) in patients with resistant hypertension.
BackgroundCommunity-based models of care with the involvement of pharmacists and other nonphysician healthcare professionals can help improve blood pressure (BP) control. We aimed to synthesize the evidence of effectiveness of pharmacist interventions on BP among patients with hypertension.MethodsWe performed systematic searches to identify randomized controlled trials (RCTs) assessing the effect of pharmacist interventions on BP among outpatients (latest search, March 2024).
One of the biggest risk factors for patients who need coronary revascularization is diabetes, and a new study in JAMA suggests CABG could be a better option than FFR-guided PCI when it comes to long term outcomes for these patients. The debate has been heating up over the last few years on PCI vs. CABG for improving heart bloodflow, but few studies have looked at the benefits for patients with T2D.
One of the biggest risk factors for patients who need coronary revascularization is diabetes, and a new study in JAMA suggests CABG could be a better option than FFR-guided PCI when it comes to long term outcomes for these patients. The debate has been heating up over the last few years on PCI vs. CABG for improving heart bloodflow, but few studies have looked at the benefits for patients with T2D.
In developing hearts, cells shuffle around, bumping into each other to find their place, and the stakes are high: pairing with the wrong cell could mean the difference between a beating heart and one that falters. A study demonstrates how heart cells go about this 'matchmaking' process. The researchers model the intricate movements of these cells and predict how genetic variations could disrupt the heart development process in fruit flies.
Stroke, Ahead of Print. Brain arteriovenous malformations (AVMs), cerebral cavernous malformations (CCMs), and intracranial aneurysms are major causes of hemorrhagic stroke, yet noninvasive therapies to prevent growth or rupture are lacking. Understanding the genetic basis of these malformations is critical for uncovering underlying mechanisms, developing targeted prevention strategies, and identifying novel therapeutic targets.
IntroductionNon-contrast CT calcium scoring (CTCS) exams have been widely used to assess coronary artery disease. However, their clinical applications in predicting coronary arterial remodeling remain unknown. This study aimed to develop a novel machine learning model to predict positive remodeling (PR) from CTCS scans and evaluate its clinical value in predicting major adverse cardiovascular events (MACE).MethodsWe analyzed data from 1,324 patients who underwent both CTCS and CT angiography.
Background Observational studies have reported that sleep is associated with the risk of major depressive disorder (MDD) and cardiovascular diseases (CVDs). However, the causal relationships among various sleep traits remain contentious, and whether MDD mediates the impact of specific sleep traits on CVDs is unclear. Methods We performed two-sample Mendelian randomisation analyses to explore whether insomnia, sleep time, daytime napping, daytime sleepiness, chronotype, snoring or obstructive sle
AI is making its mark across healthcare fields, with over 1,000 AI models now cleared by the FDA. A large portion of these advancements directly impact cardiologymore specifically, cardiac sonography. Interpreting cardiac ultrasounds has become more complex and time-consuming for clinicians: With the shift toward a more quantitative analysis, there are more parameters for clinicians to measure.
Objective To investigate the associations between a comprehensive set of retinal vascular parameters and incident stroke to unveil new associations and explore its predictive power for stroke risk. Methods Retinal vascular parameters were extracted from the UK Biobank fundus images using the Retina-based Microvascular Health Assessment System. We used Cox regression analysis, adjusted for traditional risk factors, to examine the associations, with false discovery rate adjustment for multiple com
BackgroundObesity is a global epidemic and a major risk factor for cardiovascular diseases. Laparoscopic sleeve gastrectomy (LSG) is an effective bariatric surgery, but its effect on cardiac functions remains unclear. This study aims to investigate the impact of weight loss after LSG on the left ventricular myocardial work (LVMW) in obese patients and explore the clinical value of the left ventricular pressure - strain loop (LV - PSL).MethodsThirty - eight obese patients (body mass index30kg/m2)
(MedPage Today) -- Healthier diet and lower waist-to-hip ratio throughout midlife were associated with better brain and cognitive health in older age, longitudinal data from the Whitehall II cohort study in England showed. A better midlife diet.
tim.hodson Mon, 03/10/2025 - 11:17 At the Cardiovascular Research Technologies (CRT) 2025 conference in Washington, D.C., Medtronicpresented new data and clinical milestones across its Coronary, Structural Heart and Renal Denervationbusinesses. The conference will showcase key data presentations and advancements across its Coronary, Structural Heart and Renal Denervation businesses in the Medtronic Cardiovascular portfolio.
Background In patients with tricuspid regurgitation (TR), delayed surgical intervention is associated with poor outcomes, particularly in advanced stages. This study aimed to assess whether earlier tricuspid valve (TV) surgery provides a survival benefit in patients with moderate to severe TR who are considered at low to intermediate risk of adverse clinical or surgical outcomes.
BackgroundZhigancao Decoction (ZGCD) is derived from Treatise on Febrile Diseases and is traditionally prescribed for treating a variety of cardiovascular conditions. As of now, there are no data to support its use as a treatment for diabetic cardiomyopathy (DCM) and the mechanism behind the effect is unclear as well. In the present study, clinical evidence for the efficacy of ZGCD in patients with DCM was examined using a meta-analysis and its underlying anti-DCM molecular mechanisms were explo
Research Highlights: Increased physical activity including taking more daily steps was linked to a lower risk of death from cardiovascular disease among postmenopausal women with a history of cancer. The study found that engaging in one hour per day.
tim.hodson Tue, 03/11/2025 - 10:25 March 11, 2025 Caristo Diagnosticshas received U.S. Food and Drug Administration (FDA) 510(k) clearance of its CaRi-Plaquetechnology, an AI-assisted image analysis application to aid the diagnosis of coronary artery disease (CAD). The CaRi-Plaque technology supports non-invasive analysis of coronary anatomy and pathology from routine coronary computed tomography angiography (CCTA) scans to determine the presence, extent and severity of coronary plaques and lum
The tricuspid valve (TV), historically deemed the ’forgotten valve’, is undergoing a renaissance as mounting evidence highlights its critical role in cardiovascular outcomes. The article by Gwak et al provides a pivotal contribution to this field, illustrating that early surgical intervention for tricuspid regurgitation (TR) in patients with low to intermediate risk yields significant survival benefits. 1 This editorial expands on these findings, weaving them into the broader fabric
Females with Fabry disease (FD) often have a milder phenotype, later symptom onset, and slower disease progression than males, causing delayed diagnosis and undertreatment. A survey was conducted at nine Italian FD centers to evaluate routine management of females with FD; results were discussed at a meeting of eleven Italian specialists and recommendations developed.
For 27-year-old Rachael Boyle, heart health was a familiar topic. Her younger brother had experienced heart problems as a teenager, but she had always been healthy. That all changed when she fell ill in April 2024. As Rachael wrapped up her spring semester at the University of Texas, she started experiencing persistent fevers and headaches.
Out-of-hospital cardiac arrest (OHCA) in people experiencing a heart attack is a time-dependent medical emergency requiring immediate cardiopulmonary resuscitation (CPR).
For most patients with chronic, progressive illnesses, maintaining good quality of life (QoL), with preserved functional capacity, is just as crucial as prolonging survival. Patients with heart failure (HF) experience much worse QoL and effort intolerance than both the general population and people with other chronic conditions, since they present a range of physical and psychological symptoms, including shortness of breath, chest discomfort, fatigue, fluid congestion, trouble with sleeping, and
Transcatheter aortic valve replacement (TAVR) has become a leading treatment for aortic stenosis, but managing thromboembolic and bleeding risks post-procedure remains challenging. This review examines current evidence on antithrombotic therapy after TAVR. Subclinical leaflet thrombosis is observed in 10%20% of patients, though its clinical significance remains uncertain.
In this episode, Dr. Koh hosts Drs. Sharmila Dorbala and Victoria Delgado who share their personal experiences in becoming a woman leader in cardiology. Drs. Dorbala and Delgado elaborate on how the landscape of women leadership in cardiology has changed, their paths towards becoming successful leaders in their field, and tips for women who wish to ascend towards leadership positions.
(MedPage Today) -- The FDA has allowed a substantial amount of late reports and undated reports into its Manufacturer and User Facility Device Experience (MAUDE) safety database, researchers confirmed. During a 3.5-year period in 2019-2022, there.
BackgroundThe renin-angiotensin system (RAS) plays a pivotal role in regulating blood volume, systemic vascular resistance, and electrolyte balance, serving as a key component of cardiovascular health. Recent findings highlight the role of angiotensin II (Ang II) in inducing autophagy through angiotensin II receptor type 1 (AT1R). Autophagy, a process of self-degradation and turnover of cellular components, is a homeostatic response that eliminates superfluous materials.
tim.hodson Fri, 03/14/2025 - 16:12 SCAI Scientific Sessions 2025 will take place May 1 to 3, attheWalter E. Washington Convention Center in Washington, DC. Some of the late-breaking topics that will be covered include transcatheter aortic valve replacement (TAVR), peripheral artery disease (PAD), and pulmonary embolism (PE): Impact of Age on Procedural Timing for Asymptomatic Severe Aortic Stenosis: Results from the Early TAVR Trial The PERFORMANCE II Trial: A Prospective Multicenter Single Arm
Struggling to afford food today could mean heart problems tomorrow. Young adults experiencing food insecurity have a 41% greater risk of developing heart disease in midlife, even after accounting for demographic and socioeconomic factors, according to a new study. Food insecurity -- struggling to get enough nutritious food to stay healthy -- affects one in eight households in the U.S. each year.
IntroductionIcosapent ethyl (IPE) is indicated for the treatment of severe hypertriglyceridemia (triglycerides 500mg/dl) and for reducing the risk of cardiovascular (CV) events in statin-treated adults with moderately elevated triglycerides (150499mg/dl) and established CV disease [secondary prevention (SP)] or diabetes with CV risk factors [primary prevention (PP)].
tim.hodson Wed, 03/12/2025 - 15:36 Broward Health recently announced it is now offering the Farapulse Pulsed Field Ablation System to treat atrial fibrillation (A-Fib). This innovative treatment represents a significant advancement over traditional thermal ablation methods and provides a more effective solution for patients. Farapulse Field Ablation System from Boston Scientific Pulsed Field Ablation is a game-changer in cardiovascular care," said Jose Baez, M.D., Broward Healths chief of cardio
Association of clonal haematopoiesis with heart failure incidence and outcomes: A systematic review and meta-analysis. Clonal haematopoiesis and heart failure: a meta-analysis. CH, clonal haematopoiesis; CI, confidence interval; HF, heart failure. Abstract Aims Clonal haematopoiesis (CH) is recognized as a significant risk factor for various non-haematologic conditions, including cardiovascular diseases.
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