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Background Individual cardiometabolic diseases (CMDs) increase atrial fibrillation (AF) risk; however, whether multiple CMDs exert a cumulative effect on AF risk remains unclear. Our objective was to examine the link between coexisting CMDs and AF, as well as their cumulative impact. Methods This UK Biobank-based prospective cohort study included data from participants with information related to CMDs and AF.
Nature Reviews Cardiology, Published online: 28 February 2025; doi:10.1038/s41569-025-01143-0 Epigenetic editing holds great promise for the treatment of many diseases, including cardiovascular disease. However, realizing this potential requires more than developing robust technology and demands a steadfast focus on patient needs and inclusion, to ensure that access to epigenetic medicine will be equitable and will benefit diverse populations worldwide.
Background Menopause is a timely opportunity to screen for cardiovascular disease (CVD) and intervene with healthier lifestyles. We investigated the association between premature/early menopause and the likelihood of CVD and whether a healthy lifestyle is associated with a lower likelihood of CVD in menopausal woman. Methods The Sax Institute’s 45 and Up Study prospectively recruited participants aged ≥45 years (n=267 357) between 2005 and 2009 (New South Wales, Australia).
Journal of the American Heart Association, Ahead of Print. Perinatal psychological health conditions (eg, perinatal depression, anxiety) are some of the leading causes of maternal mortality in the United States and are associated with adverse pregnancy outcomes, longterm cardiovascular outcomes, and intergenerational effects on offspring neurodevelopment.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Coronary artery disease (CAD), or the narrowing of the coronary arteries, is the leading cause of morbidity and mortality throughout the world. Atherosclerosis, or the buildup of plaque in the arteries, develops when low-density lipoprotein cholesterol (LDL-C) enters the blood vessel walls through dysfunctional endothelial cells (EC), leading to the formation of plaques.
Background Understanding pandemic-related reductions and subsequent recovery of cardiovascular testing in Asia is important for guiding regional public health efforts. Objectives This study sought to evaluate the recovery of cardiovascular testing in Asia 1 year into the COVID-19 pandemic. Methods In this subanalysis of a worldwide survey on the impact of COVID-19 on cardiovascular diagnostic care in April 2020 and April 2021, recovery of testing volume in Asia was compared among subregions, Wor
One in five women suffer from hypertension worldwide, and almost half of the mortality in women is caused by cardiovascular disease (CVD) (WHO). The timely launch of the Women’s Health Strategy for England in 2022 focuses attention on the changing health and needs of women across their life. It is ambitious—aiming to identify the critical stages where there are opportunities to promote good health during the woman’s life course.
One in five women suffer from hypertension worldwide, and almost half of the mortality in women is caused by cardiovascular disease (CVD) (WHO). The timely launch of the Women’s Health Strategy for England in 2022 focuses attention on the changing health and needs of women across their life. It is ambitious—aiming to identify the critical stages where there are opportunities to promote good health during the woman’s life course.
BackgroundPrevious studies have shown that exercise can improve arterial stiffness (AS). However, it remains unclear which type of exercise is most effective for managing AS, particularly in individuals at high risk for cardiovascular diseases (CVD). This review aims to evaluate the effects of various exercises on AS and related variables in individuals at high risk for CVD.MethodsA comprehensive search strategy was employed to systematically explore MEDLINE (PubMed), Embase, Cochrane Library, E
Hospital-based researchers from Denmark have reported a substantial increase in cardiovascular disease risk among male users of anabolic androgenic steroids (AAS). Long-term health outcomes for AAS users show extreme increases in heart-related health risks.
Background Iron deficiency (ID) is a highly prevalent comorbidity in patients with chronic and acute heart failure and is associated with worse clinical outcomes. We aimed to evaluate the prevalence and clinical characteristics of ID and its association with in-hospital congestion and postdischarge outcomes. Methods FiER deficit in Insuficienta Cardiaca in Romania was a prospective, multicentric study, enrolling 163 patients hospitalised for worsening chronic heart failure (WCHF) irrespective of
A significant proportion of patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI) have concomitant coronary artery disease (CAD). The best way to treat these patients is contentious. Conventional assessments of ischaemia such as fractional flow reserve (FFR) and instantaneous wave-free ratio are not validated in the context of severe AS despite having a Class I European Society of Cardiology indication in patients with isolated coronary disease.
ObjectiveDespite advancements in surgical techniques, many patients born with congenital heart defects (CHD) require repeated reinterventions due to the limitations of materials used in congenital cardiac surgery (CCS). Traditional biogenic polymers, such as bovine or equine pericardium, are prone to calcification, have limited durability, and fail to adapt to the growth of infants.
A machine learning algorithm running on a smartwatch demonstrated the ability to detect sudden loss of pulse with high specificity (99.99%) and moderate sensitivity (67.23%), according to a study led by Google Research. Designed to identify cardiac arrest events, the system can automatically place an emergency call when it senses an event has occurred, even if the user is unresponsive.
(MedPage Today) -- Antidepressant medications were associated with faster rates of cognitive decline in patients with dementia, a national cohort study in Sweden showed. Among nearly 19,000 people with dementia, people prescribed antidepressants.
Background Health inequalities in cardiovascular care have been identified in the UK. The sociodemographic characteristics of patients undergoing intervention for aortic stenosis (AS) in England, and the impact of COVID-19, is unknown. Methods National linked data sets identified all surgical aortic valve replacement (SAVR) and transcatheter aortic valve implantation (TAVI) for AS, and post-intervention cardiovascular mortality, between 2000 and 2023.
BackgroundCoronary heart disease seriously jeopardizes human health and has become a principal public health problem of global concern. While percutaneous coronary intervention (PCI) repairs narrowed arteries and extends patients' lives, cardiac rehabilitation offers additional benefits post-PCI. Numerous previous studies have shown that cardiac rehabilitation can inhibit the progression of atherosclerotic plaques in patients after coronary intervention, effectively controlling patients' clinica
Cardiologists have a wide selection of TAVR valves to choose from, and a new study pitting the top three second generation devices against each other suggests theres not much difference in the long run. Second generation TAVR valves improve on first gen valves by featuring better deliverability, reduced paravalvular leakage, and easier repositioning or retrieval.
(MedPage Today) -- Despite concerns, there was no significant increase in sudden cardiac arrest (SCA) among young athletes during the COVID-19 pandemic, according to national surveillance data. Comparing prepandemic and pandemic periods, the numbers.
Background Little evidence is available about heart rate (HR) response to exercise as well as its relationship with functional capacity in amyloid cardiomyopathy. Then, in a multicentre cohort of patients with amyloid cardiomyopathy, we investigated the prevalence of chronotropic incompetence (CI) and its relationships with cardiopulmonary exercise testing (CPET) variables.
Research objectiveThis study is based on bioinformatics analysis to explore the co-expressed differentially expressed genes (DEGs) between atrial fibrillation (AF) and chronic kidney disease (CKD), identify the biomarkers for the occurrence and development of the two diseases, investigate the potential connections between AF and CKD, and explore the associations with immune cells.MethodsWe downloaded Two AF gene chip datasets (GSE79768, GSE14975) and two CKD gene chip datasets (GSE37171, GSE1206
Todays patients expect more than quality care. They also want convenience and efficient access to necessary services. Yet, for many, completing the diagnostic-to-treatment process often presents significant challenges. Advanced diagnostic imaging, particularly dedicated cardiac CT, can play an important role in easing this process and enable healthcare systems to provide faster and more reliable care.
This secondary analysis of the Finerenone Trial to Investigate Efficacy and Safety Superior to Placebo in Patients With Heart Failure (FINEARTS-HF) randomized clinical trial evaluates the effect of finerenone on outpatient worsening heart failure events requiring oral diuretic intensification among patients with heart failure with mildly reduced or preserved ejection fraction.
Over the last century, cardiology training in the UK has evolved from an unstructured apprenticeship to an increasingly formalised and assessment-driven programme. 1 Since its inception in 1995, the UK national cardiology curriculum has sought to define uniform expectations of the knowledge and skills that should be acquired prior to the completion of training. 2 3 Over time, updates to the curriculum have been made to reflect changes in evidence-based cardiology practice and to accordingly revi
BackgroundCongenital heart disease (CHD) is a major contributor to morbidity and infant mortality and imposes the highest burden on global healthcare costs. Early diagnosis and prompt treatment of CHD contribute to enhanced neonatal outcomes and survival rates; however, there is a shortage of proficient examiners in remote regions. Artificial intelligence (AI)-powered ultrasound provides a potential solution to improve the diagnostic accuracy of fetal CHD screening.MethodsA literature search was
Researchers at the TechMed Center of the University of Twente and Radboud University Medical Center have removed blood clots with wireless magnetic robots. This innovation promises to transform treatment for life-threatening vascular conditions like thrombosis.
High blood pressure is known as the silent killer. It doesn’t have to be. About 50% of all adults have high blood pressure and most people find it confusing and hard to manage. How do you know what is ‘Too High’? How do you even properly check for high blood pressure? What are the lifestyle factors that cause high blood pressure? What are the things that YOU can do to lower high blood pressure?
BackgroundMyocardial intramural course (MIC), a benign anatomical lesion, is an abnormal anatomical structure formed due to abnormal blood vessel routing. An increasing number of studies indicate that MIC is associated with coronary heart disease (CHD). However, it remains unclear whether MIC contributes to cardiac function impairment in patients with CHD.
Statement Highlights: It is essential for health care professionals to routinely screen pregnant and postpartum women for depression and anxiety, address modifiable risk factors and consider behavioral and pharmacological interventions to improve.
Background Unlike other suggested therapies, myosin inhibitors have been shown to change the course of hypertrophic cardiomyopathy by altering the contractile mechanics of cardiomyocytes. This meta-analysis sought to determine the efficacy of mavacamten and aficamten in hypertrophic cardiomyopathy. Methods The online databases were searched from inception to July 2024, including the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, ClinicalTrials.gov.
BackgroundRecent studies demonstrated satisfactory results of del Nido cardioplegia in minimally invasive cardiac surgery (MICS). We aimed to evaluate the efficacy of our modified bloodless del Nido cardioplegia in MICS compared to the histidine-tryptophan-ketoglutarate (HTK) solution.MethodsWe retrospectively reviewed 471 patients who underwent minimally invasive cardiac surgery (MICS) in our institution between January 2015 and September 2022.
Bone marrow transplantation (BMT) can potentially cure sickle cell disease, an inherited and painful blood disorder, but because of its potential drawbacks and costs, patients and caregivers often face the difficult decision of whether to undergo the procedure. However, new research suggests that earlier BMT may provide protection from stroke later in life.
Cardiac defibrillation ranks among the most important scientific developments and serves well as an iconic example of a procedure that changed medicine. In discussing this topic with the journals editor, I suggested we highlight 2 momentous observations, one by Paul Zoll and the other by Michel Mirowski. Because neither is alive to tell their story, I was asked to write the article, adding information on the early days of the implantable transvenous cardioverter.
(MedPage Today) -- Diabetes prevalence among U.S. adults remained stable over the past decade but glycemic control worsened, National Health and Nutrition Examination Survey (NHANES) data indicated. In a sample of 24,263 adults, the prevalence.
The increasing prevalence of heart failure (HF) has led to advancements in therapeutic strategies, including the development of new pharmacological treatments and the expansion of guideline recommendations across the spectrum of left ventricular ejection fractions. Despite these advancements, the full benefits of guideline-directed medical therapy (GDMT) are often limited by various barriers that result in incomplete implementation or suboptimal responses.
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