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This talk dives into the science of cardiovascular fitness, its profound impact on longevity, and how to train smarter without overcomplicating it. I delivered it at the Golden Age Health Summit on March 15, 2025, in Austin, TX. Key Takeaways: Why VO2 max is your longevity superpower How aerobic fitness declines with age—and what to do about it A simplified 3-zone training model: Easy (50-70% HR max), Moderate (70-85% HR max), and Hard (85-100% HR max) Practical tips to train effectively w
Chimeric antigen receptor (CAR) T cell therapy shows promise for various diseases. Our studies in humanized mice and nonhuman primates demonstrate that hematopoietic stem cells (HSCs) modified with anti-HIV CAR achieve lifelong engraftment, providing functional antiviral CAR-T cells that reduce viral rebound after antiretroviral therapy (ART) withdrawal.
The average consultation time with a doctor is only about 15 minutes. This is not enough. If you want to get a proper heart health assessment, you will need to work smarter. Ideally, we should live in a world where doctors and healthcare professionals have infinite time to: Explain key concepts. Lay out all the pros and cons of each decision. Answer all your questions.
Implantation of an intra-aortic balloon pump (IABP) did not improve 60-day survival or bridge to heart replacement (HRT) therapies in patients with heart failure-cardiogenic shock (HF-CS) compared to standard care, according to a study presented during a Featured Clinical Research session at ACC.25 in Chicago and simultaneously published in JACC. The trial was stopped by the Data Safety and Monitoring Board at the prespecified interim analysis due to futility.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
A panelist discusses how alopecia areata is clinically characterized by sudden, patchy hair loss with exclamation point hairs at the periphery and is typically diagnosed through clinical examination, dermoscopy, and sometimes scalp biopsy, noting that patients with a personal or family history of autoimmune disorders, certain genetic markers, or significant stress exposure may be at higher risk for developing this condition.
When we move, it's harder for existing wearable devices to accurately track our heart activity. But researchers found that a starfish's five-arm shape helps solve this problem. Inspired by how a starfish flips itself over -- shrinking one of its arms and using the others in a coordinated motion to right itself -- scientists have created a starfish-shaped wearable device that tracks heart health in real time.
Nature Reviews Cardiology, Published online: 04 April 2025; doi:10.1038/s41569-025-01146-x Heart transplantation remains the optimal long-term treatment for appropriate patients with advanced heart failure. However, the donor heart shortage is a limiting factor, and the risk profile of transplant candidates is worsening. In this landscape, the utility of conventional cold static storage for donor hearts is increasingly limited.
Nature Reviews Cardiology, Published online: 04 April 2025; doi:10.1038/s41569-025-01146-x Heart transplantation remains the optimal long-term treatment for appropriate patients with advanced heart failure. However, the donor heart shortage is a limiting factor, and the risk profile of transplant candidates is worsening. In this landscape, the utility of conventional cold static storage for donor hearts is increasingly limited.
The SGLT2 inhibitor dapagliflozin was superior to standard care alone in decreasing rates of all-cause mortality or worsening heart failure (HF) in older adults with aortic stenosis undergoing TAVI, resulting in a 28% relative risk reduction, according to results from the DAPA-TAVI study presented during a Late-Breaking Clinical Trial session during ACC.25 in Chicago and simultaneously published in the NEJM.
Lysyl hydroxylase 2 (LH2) is highly expressed in multiple tumor types and accelerates disease progression by hydroxylating lysine residues on fibrillar collagen telopeptides to generate stable collagen cross links in tumor stroma. Here, we show that a galactosylhydroxylysyl glucosyltransferase (GGT) domain on LH2-modified type-VI collagen (Col6) to promote lung adenocarcinoma (LUAD) growth and metastasis.
The ACC 2025 meeting is all wrapped up after matching the attendance and excitement of last years expo, with a clear trend toward better diagnostics and even better pharmaceuticals. Among dozens of highlights, here are Cardiac Wires seven biggest trends from ACC.25. Diverse Pharma ACC.25 saw a deluge of pharmaceutical solutions across the spectrum of heart disease, from HCM all the way to LDL (detection and treatment just have to catch up).
Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post. You can find more products I’m affiliated with on my website. Physiologically Speaking is a reader-supported publication.
After stent implantation, a three-month regimen of dual antiplatelet therapy (DAPT) was more effective than a one-month regimen at reducing adverse events without increasing bleeding risk in patients with a high bleeding risk (HBR), according to a Late-Breaking Clinical Trial presented at ACC.25 in Chicago. Furthermore, in patients with a low bleeding risk (LBR), a three-month regimen was found to be superior to 12 months for reducing bleeding risk and comparable in reducing adverse events.
Metabolic dysfunctionassociated steatotic liver disease (MASLD) is a major cause of liver disease worldwide, and our understanding of its pathogenesis continues to evolve. MASLD progresses from steatosis to steatohepatitis, fibrosis, and cirrhosis, and this Review explores how the gut microbiome and their metabolites contribute to MASLD pathogenesis.
BackgroundPostoperative blood glucose levels significantly impact outcomes in cardiac surgery patients undergoing extracorporeal circulation (ECC) auxiliary to open heart surgery. While hypoglycemia and hyperglycemia are known risk factors for adverse outcomes, the optimal glycemic range for patients undergoing ECC remains unclear. This research examined the relationship between blood glucose levels and 90-day mortality in this high-risk group.MethodsThe data for this research were obtained from
Clopidogrel monotherapy was found to be more effective than aspirin monotherapy in lowering risk of major adverse cardiac and cerebrovascular events among patients at high risk of recurrent ischemic events who completed a standard duration of dual antiplatelet therapy (DAPT) following PCI, according to new research presented during a Late-Breaking Clinical Trial session at ACC.25 in Chicago and simultaneously published in The Lancet.
Sleep disturbance is bidirectionally associated with an increased risk of Alzheimers disease and other tauopathies. While the sleep-wake cycle regulates interstitial and cerebrospinal fluid (CSF) tau levels, the underlying mechanisms remain unknown. Understanding these mechanisms is crucial, given the evidence that tau pathology spreads through neuron-to-neuron transfer, involving the secretion and internalization of pathological tau forms.
Intravascular lithotripsy (IVL) may have once been synonymous with Shockwave Medical, but its now rapidly becoming one of the hottest segments in interventional cardiology, spurred on by Abbotts new IVL Investigational Device Exemption (IDE) from the FDA. IVL is a minimally invasive medical catheter-based procedure that treats calcified plaque in blood vessels.
BackgroundPediatric cardiomyopathies are rare but life-threatening conditions with high mortality. Limited data exists on their clinical features and risk factors, especially in Asian populations, highlighting the need for further research in this area.MethodsThis retrospective cohort study analyzed data from 212 pediatric patients diagnosed with hypertrophic cardiomyopathy (HCM), restrictive cardiomyopathy (RCM), or restrictive phenotype hypertrophic cardiomyopathy (RP-HCM) at a single center i
PCI guided by a novel, artificial-intelligence-powered (AI) method of angiographic fractional flow reserve (FFR) assessment known as AngioFFR, which calculates FFR from a single-view angiogram of the coronary arteries, was noninferior to IVUS for outcomes in patients with significant stenosis, according to new research presented during a Late-Breaking Clinical Trial session at ACC.25 in Chicago and simultaneously published in the The Lancet.
Mitochondrial dysfunction fuels vascular inflammation and atherosclerosis. Mitochondrial calcium uptake 1 (MICU1) maintains mitochondrial Ca2+ homeostasis. However, the role of MICU1 in vascular inflammation and atherosclerosis remains unknown. Here, we report that endothelial MICU1 prevents vascular inflammation and atherosclerosis by maintaining mitochondrial homeostasis.
This is an interesting case for your students who want to delve into dysrhythmias with an eye on detail. It is also a good teaching case for discussing treatment options when the diagnosis may be uncertain or controversial. I will start the discussion by admitting that I am not an expert of electrophysiology or complex dysrhythmias. My approach has always been more clinical - how is this rhythm affecting the patient and what are the chances it will deteriorate?
Telocytes (TCs), a newly identified type of mesenchymal cell since 2010, possess substantial potential in maintaining tissue homeostasis, orchestrating organ development, and facilitating tissue regeneration. Their distribution in blood, the adventitia of blood vessels, and the intima implies a close association with vascular function. Ischemic heart disease (IHD), a significant challenge in cardiovascular disease, is characterized by the occlusion of major vessels, obstruction of collateral cir
AZD0780, a novel, once-daily oral molecule inhibitor, had a robust, dose-dependent effect in lowering LDL-C and a favorable safety profile in patients with hypercholesterolemia already on background moderate- or high-intensity statin treatment, according to research presented during a Featured Clinical Research session at ACC.25 in Chicago and simultaneously published in JACC.
Neuroretinal degenerations including retinitis pigmentosa (RP) comprise a heterogeneous collection of pathogenic mutations that ultimately result in blindness. Despite recent advances in precision medicine, therapies for rarer mutations are hindered by burdensome developmental costs. To this end, Von Hippel-Lindau (VHL) is an attractive therapeutic target to treat RP.
This is an interesting case for your students who want to delve into dysrhythmias with an eye on detail. It is also a good teaching case for discussing treatment options when the diagnosis may be uncertain or controversial. I will start the discussion by admitting that I am not an expert of electrophysiology or complex dysrhythmias. My approach has always been more clinical - how is this rhythm affecting the patient and what are the chances it will deteriorate?
IntroductionDepression is a significant comorbidity linked to poor subjective and objective health outcomes in cardiac patients. The paucity of data necessitates further research to elucidate the pathophysiological connection between depression and cardiac diseases in the presence of N-terminal pro-brain natriuretic peptide (NT-proBNP). Therefore, the current systematic review investigated the clinical significance of NT-proBNP as a predictive biomarker in cardiac patients with depressive sympto
Coronary atherosclerotic phenotypes, including total plaque volume (TPV), noncalcified plaque (NCP), calcified plaque (CP) and percentage atheroma volume (PAV), assessed by artificial intelligence-based quantitative coronary computed tomography (AI-QCT) conferred a higher relative risk of major adverse cardiovascular events (MACE) in women, based on findings from the CONFIRM II trial presented at ACC.25 in Chicago and simultaneously published in Circulation: Cardiovascular Imaging.
In the continuously evolving world of healthcare, keeping up with the latest findings, technologies, and best practices is vital for medical professionals. One of the most effective ways to do this is through conferences that focus on medical education. These events are not just a way to earn continuing education credits; they are foundational to shaping how healthcare providers learn and apply knowledge in their practices.
(MedPage Today) -- This story was originally published by ProPublica. ProPublica is a Pulitzer Prize-winning investigative newsroom. Sign up for The Big Story newsletter to receive stories like this one in your inbox. Although it was too late.
This narrative review aims to evaluate strategies for reducing door-to-balloon (D2B) time in ST-elevation myocardial infarction (STEMI) patients, focusing on pre-hospital, in-hospital, and technological innovations, as well as addressing challenges to ensure sustainability. We reviewed recent literature from 2004 onward, examining various approaches to streamline STEMI care and improve D2B time.
From a quiet beginning as an introvert in Brooklyn, NY, Jeffrey A. Towbin, MD, FACC, has evolved to be a renowned leader, researcher and clinician in pediatric cardiology. For his groundbreaking work in gene discovery and identification, growing three different programs as a pediatric cardiology chief and his development of three separate high-level cardiomyopathy, heart failure (HF) and transplant programs, Towbin received the ACC Lifetime Achievement Award during ACC.25 on Saturday during the
Objective In this randomised two-period crossover trial, the objective was to compare acute changes in arterial distensibility between high-intensity interval physical exercise (HIIPE) and moderate-intensity continuous physical exercise (MICPE) sessions in subjects with elevated blood pressure (BP). Methods and analysis Participants underwent either MICPE-HIIPE or HIIPE-MICPE sequences with intensity based on cardiopulmonary exercise testing.
Nonsmall cell lung cancer (NSCLC), the most common type of lung cancer, remains a leading cause of cancer-related mortality worldwide. Immune checkpoint inhibitors (ICIs) have emerged as a promising therapy for NSCLC but only benefit a subset of patients. In this issue of the JCI, Jiao et al. revealed that acetyl-CoA acetyltransferase 1 (ACAT1) limited the efficacy of ICIs in NSCLC by impeding tertiary lymphoid structures (TLS) in the tumor microenvironment (TME).
IntroductionManaging acute coronary syndrome (ACS) remains a major global healthcare concern. Identifying novel biomarkers is crucial to improving early detection and patient classification. Traditional markers such as cardiac troponins have limitations, including delayed detectability in blood samples, necessitating the search for better alternatives.
Among patients with obesity-related heart failure with preserved ejection fraction (HFpEF) and chronic kidney disease (CKD), the baseline estimated glomerular filtration rate (eGFR) did not impact the effect of tirzepatide on reducing major adverse HF events or to enhance health status, according to a post-hoc analysis of the SUMMIT trial presented during a Featured Clinical Research session at ACC.25 in Chicago and simultaneously published in JACC.
Background Patients with light chain (AL) amyloidosis, a rare life-threatening disease, often go through a lengthy diagnostic journey. We qualitatively and quantitatively characterised the diagnostic pathway and the impact of delayed diagnosis on health outcomes among patients with AL amyloidosis. Methods We conducted a retrospective cohort analysis of adults (age ≥18 years) with ≥2 AL amyloidosis diagnoses (index date: first diagnosis date) using the IQVIA PharMetrics Plus US claims
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