Sat.Apr 13, 2024 - Fri.Apr 19, 2024

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Only One Harm From mRNA COVID Vaccines, Report Determines

Med Page Today

(MedPage Today) -- Independent reviewers confirmed a causal relationship between the first mRNA COVID-19 vaccines and myocarditis, and also determined that, more broadly, intramuscular shots can cause a series of shoulder injuries. At the same.

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Physical activity lowers cardiovascular disease risk by reducing stress-related brain activity, study finds

Medical Xpress - Cardiology

New research indicates that physical activity lowers cardiovascular disease risk in part by reducing stress-related signaling in the brain.

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Talking about women’s heart disease to medical students

Heart Sisters

Can we do a better job teaching medical and nursing students about women’s unique cardiac issues? The answer might be in these nine teaching modules!

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FDA Approves Ustekinumab-aekn for PsO, PsA

HCPLive

The FDA approved ustekinumab-aekn for the treatment of moderate to severe plaque psoriasis and active psoriatic arthritis.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Cardiac Events Common in Older, Hospitalized RSV Patients

Med Page Today

(MedPage Today) -- More than one in five older adults hospitalized for respiratory syncytial virus (RSV) infection experienced an acute cardiac event, an observational study found. Among 6,248 hospitalized patients 50 or older with laboratory.

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Is OMI an ECG Diagnosis?

Dr. Smith's ECG Blog

Written by Jesse McLaren A 70 year old with prior MIs and stents to LAD and RCA presented to the emergency department with 2 weeks of increasing exertional chest pain radiating to the left arm, associated with nausea. The pain recurred at rest 90 minutes prior to presentation, felt like the patient’s prior MIs, and was not relieved by 6 sprays of nitro.

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More Trending

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Melanie Jay, MD: Advancing Equitable Approaches to Improve Obesity Care

HCPLive

This interview segment featured a discussion on Jay’s ACP Internal Medicine Meeting presentation ‘Advancing Equitable Approaches to Improve Obesity Care.

Obesity 119
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Antipsychotics in Dementia Tied to Wider Range of 'Serious Harms'

Med Page Today

(MedPage Today) -- Use of antipsychotics in dementia patients was associated with an increased risk for a wider range of adverse outcomes than previously acknowledged, a population-based matched cohort study from the U.K. showed. In the analysis.

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56 year old male had 5/10 chest pain for several hours, then presented to the ED in the middle of the night with 1/10 pain.

Dr. Smith's ECG Blog

A 56 year old male with PMHx significant for hypertension had chest pain for several hours, then presented to the ED in the middle of the night. He reported chest pain that developed several hours prior to arrival and was 5/10 in intensity. The pain was located in the mid to left chest and developed after riding his bike. There was associated fatigue when symptoms developed and mild shortness of breath at onset of chest pain however that has since resolved.

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Why can zebrafish regenerate damaged heart tissue, while other fish species cannot?

Science Daily - Heart Disease

A heart attack will leave a permanent scar on a human heart, yet other animals, including zebrafish, can clear cardiac scar tissue and regrow damaged muscle as adults. Biologists sheds new light on how zebrafish heal heart tissue by comparing how this species responds to heart injury with medaka, a fish species that cannot regenerate cardiac tissue.

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Study Investigates Optimal COVID-19 Vaccination Timing in Inflammatory Disease

HCPLive

Most (94%) anti-nucleocapsid positivity was linked to a self-reported COVID-19 infection within the prior 3 months.

COVID-19 119
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Tirzepatide Improves Sleep Apnea in Patients With Obesity, Drugmaker Says

Med Page Today

(MedPage Today) -- Tirzepatide (Zepbound) injections reduced sleep apnea severity among patients with obesity, regardless of positive airway pressure (PAP) use, according to topline data from two phase III trials. In the SURMOUNT-OSA 1 study.

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Small molecules that disrupt RAD54-BLM interaction hamper tumor proliferation in colon cancer chemoresistance models

Journal of Clinical Investigation - Cardiology

RAD54 and BLM helicase play pivotal roles during homologous recombination repair (HRR) to ensure genome maintenance. BLM amino acids (aa 181–212) interact with RAD54 and enhance its chromatin remodeling activity. Functionally, this interaction heightens HRR, leading to a decrease in residual DNA damage in colon cancer cells. This contributes to chemoresistance in colon cancer cells against cisplatin, camptothecin, and oxaliplatin, eventually promoting tumorigenesis in preclinical colon cancer mo

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Adults with congenital heart disease faced higher risk of abnormal heart rhythms

Science Daily - Heart Disease

Adults with congenital heart defects were more likely to experience an abnormal, irregular heartbeat, finds a new study.

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ECG Blog #425 — Are there P Waves?

Ken Grauer, MD

I was sent the ECG in Figure-1 — told only that the patient was 70 years old, and had a history of an ASD ( A trial S eptal D efect ). Serum K+ was normal. The patient was hemodynamically stable with ECG #1. QUESTIONS: How would YOU interpret the rhythm in Figure-1 ? Are there P waves? Figure-1: The initial ECG in today's case. MY Initial Thoughts on Today's CASE: Knowing that today's patient has a history of an ASD ( A trial S eptal D efect ) — is relevant to the interpretation of today's inter

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After Adverse Pregnancy Outcomes, Mortality Risk Lingers for Decades

Med Page Today

(MedPage Today) -- Women who experienced major adverse pregnancy outcomes still had increased mortality risks decades later, a population-based cohort study of Swedish data found. Adverse pregnancy outcomes independently associated with increased.

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Plant-Based Diet Intervention Improves Disease Activity, Symptoms in RA, Osteoarthritis

HCPLive

Participants described the intervention as complete and coherent and would recommend this intervention to other patients.

Diet 115
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Researchers find that accelerated aging biology in the placenta contributes to a rare form of pregnancy-related heart failure

Science Daily - Heart Disease

In a new study, researchers show that elevated levels of proteins related to cellular senescence, or aging, in the blood and the placenta are linked to this form of heart failure.

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Shorten the Blanking Period After Atrial Fibrillation Ablation, Experts Say

DAIC

Based on continuous monitoring of early recurrence of atrial tachyarrhythmia immediately after patients have undergone atrial fibrillation ablation, Musat et al. recommend shortening the blanking period from three months to one. Graphic courtesy of Dan Musat milla1cf Thu, 04/18/2024 - 13:32 April 18, 2024 — New evidence-based research calls into question the conventional three-month blanking period immediately after atrial fibrillation (AF) ablation, when early occurrences of AF are thought not

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Time-Restricted Eating Tied to Modest Weight Loss

Med Page Today

(MedPage Today) -- Restricting daily eating to a 10-hour window was no silver bullet for boosting weight loss in people with obesity and prediabetes, a small study found. In the 12-week trial, both time-restricted eating (TRE) and a usual pattern.

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GPT-4 Nears "Expert-Level" Performance in Ophthalmology Examination

HCPLive

Modern large language models perform strongly on ophthalmic knowledge assessments and approach or exceed the scores of fully qualified and trainee ophthalmologists.

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Circulating biomolecules identify patients with atrial fibrillation at high risk of cardiovascular events

Medical Xpress - Cardiology

An analysis of the biomolecule substudy of the EAST–AFNET 4 trial has revealed that biomolecule concentrations in the blood of patients with atrial fibrillation can be used to identify patients at high and low cardiovascular risk. The findings were published in Cardiovascular Research.

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Around 10% of Deaths from Coronary Stenting, Balloon Angioplasty are Preventable

DAIC

Getty Images milla1cf Tue, 04/16/2024 - 12:43 April 16, 2024 — Each year more than 500,000 Americans undergo percutaneous coronary intervention , or PCI, a minimally invasive procedure to unclog the arteries that feed the heart. While PCI, which includes both angioplasty and stenting, is one of the most common operations in the world, it does carry a small (about 1-2%) but significant risk of death.

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17% of cardiologists may leave medicine due to burnout

Becker's Hospital Review - Cardiology

Seventeen percent of cardiologists said their burnout was so severe that they may leave medicine, according to a Medscape report.

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ACP's New Type 2 Diabetes Guidance Recommends SGLT2is, GLP-1 RAs as Second-Line to Metformin

HCPLive

The American College of Physicians released new recommendations for the management of type 2 diabetes with inadequate glycemic control using metformin or other first-line therapies.

Diabetes 106
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ACC: Ticagrelor monotherapy cuts bleeding risk in acute coronary syndrome

Medical Xpress - Cardiology

Treatment with ticagrelor alone results in a lower rate of clinically relevant bleeding compared with ticagrelor and aspirin among patients with an acute coronary syndrome who had percutaneous coronary intervention and remained event-free for one month on dual antiplatelet therapy, according to a study published online April 7 in The Lancet to coincide with the annual meeting of the American College of Cardiology, held from April 6 to 8 in Atlanta.

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AskBio Receives FDA Fast Track Designation for AB-1002 Investigational Gene Therapy Program in Congestive Heart Failure

DAIC

Getty Images milla1cf Thu, 04/18/2024 - 13:20 April 18, 2024 — Bayer AG and Asklepios BioPharmaceutical , Inc., a gene therapy company wholly owned and independently operated as a subsidiary of Bayer AG, today announced that the U.S. Food and Drug Administration ( FDA ) has granted Fast Track Designation for the AB-1002 program. AB-1002 is an investigational one-time gene therapy that is administered to the heart with the intention of helping to promote the production of a constitutively active

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Evolution of nasal and olfactory infection characteristics of SARS-CoV-2 variants

Journal of Clinical Investigation - Cardiology

SARS-CoV-2 infection of the upper airway and the subsequent immune response are early, critical factors in COVID-19 pathogenesis. By studying infection of human biopsies in vitro and in a hamster model in vivo, we demonstrated a transition in nasal tropism from olfactory to respiratory epithelium as the virus evolved. Analyzing each variant revealed that SARS-CoV-2 WA1 or Delta infect a proportion of olfactory neurons in addition to the primary target sustentacular cells.

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Budesonide Maintains IgA Nephropathy Kidney Failure Reduction, Quality of Life at 2 Years

HCPLive

New phase 3 findings show daily oral budesonide reduces eGFR decline while maintaining patient quality of life over 2 years.

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The role of COVID-19 vaccines in preventing post-COVID-19 thromboembolic and cardiovascular complications

Heart BMJ

Objective To study the association between COVID-19 vaccination and the risk of post-COVID-19 cardiac and thromboembolic complications. Methods We conducted a staggered cohort study based on national vaccination campaigns using electronic health records from the UK, Spain and Estonia. Vaccine rollout was grouped into four stages with predefined enrolment periods.

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Karoo Health Launches Proprietary Technology Platform Kohere.ai to Supercharge Its Cardiac Value-based Care Model

DAIC

milla1cf Thu, 04/18/2024 - 13:23 April 18, 2024 — Karoo Health , the only operational provider of cardiac value-based care (VBC) enablement with published results, today launched Kohere.ai, its proprietary cloud-based platform that augments the company's proven model of care (MoC) for cardiovascular healthcare providers, payers, and patients. The Kohere.ai platform launch and 2024 roadmap are composed of the following modules: FLOW is uniquely designed and A/B tested to drive Karoo Health's MoC

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Ectopic expression of the transcription factor ONECUT3 drives a complex karyotype in myelodysplastic syndromes

Journal of Clinical Investigation - Cardiology

Chromosomal instability is a prominent biological feature of myelodysplastic syndromes (MDS), with over 50% of patients with MDS harboring chromosomal abnormalities or a complex karyotype (CK). Despite this observation, the mechanisms underlying mitotic and chromosomal defects in MDS remain elusive. In this study, we identified ectopic expression of the transcription factor ONECUT3, which is associated with CKs and poorer survival outcomes in MDS.

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NSAIDs Decreased the Odds of Adverse Cardiovascular Events in Gout

HCPLive

NSAID use decreased the odds of a cardiovascular event by 12% in patients with gouts

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ACC 2024 Highlights

Cardiology Update

Dr. Chadi Alraies discusses the top impactful trials presented at the 2024 American College of Cardiology conference. Learn more about the highlights from ACC 2024. For more cardiology research news join our newsletter or follow us on Twitter , Facebook , LinkedIn or Instagram. The post ACC 2024 Highlights appeared first on Cardiology Update.

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Vivasure Medical Announces First Large Hole Venous Patient Treated with PerQseal Elite Vascular Closure System

DAIC

milla1cf Tue, 04/16/2024 - 12:40 April 16, 2024 — Vivasure Medical , a company pioneering novel fully absorbable technology for percutaneous vessel closure, today announced it has treated the first large bore venous patient with the PerQseal Elite vascular closure system, a sutureless and fully bioresorbable large-bore vessel closure device. The first successful implant was completed by Prof.

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A BMP-controlled metabolic/epigenetic signaling cascade directs midfacial morphogenesis

Journal of Clinical Investigation - Cardiology

Craniofacial anomalies, especially midline facial defects, are among the most common birth defects in patients and are associated with increased mortality or require lifelong treatment. During mammalian embryogenesis, specific instructions arising at genetic, signaling, and metabolic levels are important for stem cell behaviors and fate determination, but how these functionally relevant mechanisms are coordinated to regulate craniofacial morphogenesis remain unknown.