Sat.Dec 07, 2024 - Fri.Dec 13, 2024

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FDA Finds Obeticholic Acid (Ocaliva) Linked to Serious Liver Injury in Noncirrhotic PBC

HCPLive

An FDA review of postmarket clinical trial data revealed an increased risk of liver injury with obeticholic acid in patients with PBC without cirrhosis.

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Heart-related side effects of cancer treatment must be addressed as early as possible, experts say

Medical Xpress - Cardiology

The devastating news of a cancer diagnosis understandably makes doctors and patients focus on the cancer itself. However, experts in cardio-oncology from the European Society of Cardiology (ESC) emphasize that heart and cardiovascular health must be included as early as possible in the patient's cancer treatment plan to ensure the best possible outcomes.

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ICD Therapy for Primary Prevention in HFrEF: Key Points

American College of Cardiology

The following are key points to remember from a state-of-the-art review on revisiting implantable cardioverter-defibrillator (ICD) therapy for primary prevention in patients with heart failure and reduced ejection fraction (HFrEF).

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Sudden Palpitations in a Young Adult

Dr. Smith's ECG Blog

Written by Magnus Nossen and Ken Grauer ( with Comment by Smith ) The ECG in Figure-1 was electronically transmitted by the ambulance service for evaluation. The patient is a young adult male with acute onset of palpitations. He was hemodynamically stable at the time ECG #1 was recorded. QUESTIONS: How would you interpret this ECG? What entities to consider in your differential diagnosis?

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The Long COVID Patient Journey: A Complex and Uncertain Road

HCPLive

Navigating the long road of Long COVID requires more than just recovery from an infection, it demands specialized, multifaceted care to address persistent and often invisible neurological symptoms.

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Analysis offers new explanation for dangerous atherosclerotic plaques in type 2 diabetes

Medical Xpress - Cardiology

People with type 2 diabetes have a higher risk of suffering a stroke, a heart attack and premature death due to atherosclerosis, but it has been unclear what the underlying mechanisms are. Andreas Edsfeldt and Isabel Gonalves, researchers at Lund University Diabetes Centre, have led a study that has mapped out differences in the atherosclerotic process in people who have type 2 diabetes and in people who do not have the disease.

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ACC ECDP for Diagnosis and Management of Myocarditis: Key Points

American College of Cardiology

The following are key points to remember from a 2024 American College of Cardiology (ACC) expert consensus decision pathway (ECDP) on strategies and criteria for the diagnosis and management of myocarditis.

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Micro-Factors May Explain the Connection Between COVID-19, Schizophrenia

HCPLive

Patients with schizophrenia and COVID-19 both present dysregulated energy metabolism, explaining the high COVID-19 rates among those with schizophrenia.

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Mediterranean plants show promise in heart disease prevention

Medical Xpress - Cardiology

Cardiovascular problems are the leading cause of disease and mortality worldwide. Plant extracts, rich in bioactive compounds, have contributed significantly to the development of drugs, as they offer therapeutic potential for several of these diseases. However, their use is limited by possible side effects, drugdrug interactions and the lack of scientific evidence from quality preclinical and clinical studies.

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Physical Activity and CVD Risk in Cancer Survivors

American College of Cardiology

How do changes in physical activity levels before and after a cancer diagnosis affect the risk of developing cardiovascular diseases (CVDs) in cancer survivors?

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Artificial intelligence-assisted echocardiographic monitoring in pediatric patients on extracorporeal membrane oxygenation

Frontiers in Cardiovascular Medicine

BackgroundPercutaneous extracorporeal membrane oxygenation (ECMO) is administered to pediatric patients with cardiogenic shock or cardiac arrest. The traditional method uses focal echocardiography to complete the left ventricular measurement. However, echocardiographic determination of the ejection fraction (EF) by manual tracing of the endocardial borders is time consuming and operator dependent.

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Steven W. Pipe, MD: Fitusiran With Anti-Thrombin Modulation Yields Effective Bleed Control, Reduces Infusions for Hemophilia

HCPLive

Pipe discussed findings from the open-label extension of the ATLAS studies at ASH 2024.

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Scientists create first-ever blood-generating heart organoid

Medical Xpress - Cardiology

How do human organs develop and what happens to them when they become diseased? To answer these questions, researchers are increasingly focusing on so-called organoids. These mini-organs, just a few millimeters in size, consist of groups of cells cultivated in the laboratory that can form organ-like structures.

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Sudden Cardiac Arrest and Death in Athletes: Key Points

American College of Cardiology

The following are key points to remember from a contemporary review of sudden cardiac arrest and death in competitive and recreational athletes.

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Vandalia Health launches telecardiology service for rural patients

Becker's Hospital Review - Cardiology

Charleston, W.Va.-based Vandalia Healths Mon Health Heart & Vascular Center has launched a new telecardiology service in partnership with the system's Webster Springs, W.Va.-based Webster Memorial Hospital.

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Integration of Cardiovascular Care Into CKD Management

HCPLive

Panelists discuss the role of cardiovascular risk management for patients with chronic kidney disease (CKD) and how cardiovascular care can be effectively integrated into CKD management strategies.

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Sugary drinks significantly raise cardiovascular disease risk, but occasional sweet treats don't, scientists find

Medical Xpress - Cardiology

A little of what you fancy does you good unless it's a fizzy drink. Scientists studying the impact of sugar on the risk of cardiovascular disease have found that eating too much added sugar increases your risk of stroke or aneurysm, but eating a few treats is associated with a lower risk of cardiovascular diseases. Meanwhile, drinking sweetened beverages raises your risk of stroke, heart failure, and atrial fibrillation.

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State-of-the-Art Review Provides Strategies to Address Post-TAVR CDs and PPI

American College of Cardiology

A State-of-the-Art review published in JACC: Cardiovascular Interventions covers the epidemiology, clinical implications, risk factors and preventive strategies for new-onset conduction disturbances (CDs) and the need for permanent pacemaker implantation (PPI) after TAVR, which the authors note are a limitation of this therapy.

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The relationship between inflammatory factors and heart failure: evidence based on bidirectional Mendelian randomization analysis

Frontiers in Cardiovascular Medicine

ObjectiveInflammatory factors play a crucial role in the onset and progression of heart failure. To further explore the causal relationship between inflammatory factors and heart failure, we employed bidirectional Mendelian randomization analysis to investigate the causal links between 91 inflammatory cytokines and heart failure.MethodsWe conducted our study using the bidirectional Mendelian randomization approach.

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Innovative Hemophilia Treatments Offer Hope Amid Lingering Clinical Challenges

HCPLive

At ASH 2024, Annette von Drygalski, MD, PharmD, described the paradigm shift that has taken place in hemophilia over the past decade.

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Endothelial cells lining veins in lungs contribute to repair of blood vessels after injury, researchers discover

Medical Xpress - Cardiology

Veins in the lungs, or pulmonary veins, play a critical role not only in lung functioning but also in maintaining sufficient oxygen in tissues throughout the body. When a person sustains a pulmonary injury from an illness such as influenza or COVID, repair of blood vessels and the creation of new ones is vital to meet oxygen demands; however, research in these areas remains underexplored.

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Smoking From Childhood Associated With Greater Risk of Cardiac Damage

American College of Cardiology

Tobacco smoking from ages 10 to 24 years was associated with a 33% to 52% odds of premature structural and functional cardiac injury, according to a new study published in JACC. Furthermore, smoking from childhood through early adulthood was also associated with cardiac mass increase, with one-third of the effect estimate retained after controlling for risk factors.

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The causal relationship between 233 metabolites and coronary atherosclerosis: a Mendelian randomization study

Frontiers in Cardiovascular Medicine

ObjectiveTo investigate the causal relationship between 233 newly reported metabolites and coronary atherosclerosis through Mendelian randomization analysis.MethodsFive different methods were used to perform Mendelian randomization analysis on the 233 metabolites and coronary atherosclerosis, with inverse variance weighting as the primary result, supplemented by other methods.ResultsThe analysis identified that certain metabolites increase the susceptibility risk of coronary atherosclerosis, inc

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Ben Samelson-Jones, MD, PhD: Validating Long-Term Safety of Hemophilia AAV Gene Therapy

HCPLive

Samelson-Jones discussed follow-up data of up to 6 years with investigations of fidanacogene elaparvovec.

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Study likely to change standard of care for deadly strokes

Medical Xpress - Cardiology

Endovascular therapy, or EVT, a minimally invasive surgery performed inside the blood vesselsis 2 times more likely than standard medical management to achieve a positive outcome after vertebrobasilar stroke that affects the back of the brain, including the brain stem.

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ACC Issues Guidance For Diagnosing and Managing Myocarditis

American College of Cardiology

The ACC has issued guidance for the diagnosis and management of acute myocarditis in adult patients, delivering a streamlined decision-making framework that reflects recent advancements in clinical practice. The 2024 ACC Expert Consensus Decision Pathway (ECDP) on Strategies and Criteria for the Diagnosis and Management of Myocarditis, published in JACC, includes a 5-step care pathway, as well as recommendations for returning to strenuous physical activity and opportunities to close knowledge ga

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Association between waist-to-hip ratio and risk of myocardial infarction: a systematic evaluation and meta-analysis

Frontiers in Cardiovascular Medicine

BackgroundMyocardial infarction(MI) is one of the most serious health threats. Despite the increasing number of clinical methods used to predict the onset of MI, the prediction of MI is still unsatisfactory and necessitates new methods.ObjectiveTo systematically review observational studies from the past two decades on the association between waist-to-hip ratio (WHR) and MI risk.MethodsOriginal literature on the correlation between WHR and MI was searched in PubMed, Embase, Web of Science, Cochr

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Adults aged 50 – 80 years Often Experience Loneliness, Social isolation

HCPLive

A recent study found that loneliness among adults aged 50 80 increased from 2018 to 2022 and dropped in 2023 and 2024.

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Research reveals new insights about how 'bad' cholesterol works in the body

Medical Xpress - Cardiology

National Institute of Health (NIH) scientists have made a significant breakthrough in understanding how "bad" cholesterol, known as low-density lipoprotein-cholesterol or LDL-C, builds up in the body. The researchers were able to show for the first time how the main structural protein of LDL binds to its receptora process that starts the clearing of LDL from the bloodand what happens when that process gets impaired.

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NT-proBNP and Troponin I in Cardiac Function

American College of Cardiology

How do N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hs-cTnT) and I (hs-CTnI) predict long-term changes in cardiac structure and function in older adults?

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Aortic valve replacement in a bicuspid aortic valve patient followed by reoperation for ascending aorta rupture: a case report

Frontiers in Cardiovascular Medicine

Bicuspid aortic valve (BAV), the most common congenital cardiac anomaly, predisposes individuals to aortic stenosis and regurgitation due to valve degeneration. Abnormal hemodynamics, arterial wall characteristics, and genetic factors contribute to ascending aorta dilatation, potentially leading to severe complications like aortic dissection. Presently, the most recent guidelines propose that individuals with BAV requiring valve replacement due to valve dysfunction should undergo simultaneous re

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Autonomic Modulation May Benefit Patients with Constipation-Predominant IBS

HCPLive

Study findings highlight systemic and local autonomic imbalance in patients with IBS-C, pointing to the value of autonomic modulation in this population.

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New gene therapy reverses heart failure in large animal model

Medical Xpress - Cardiology

A new gene therapy can reverse the effects of heart failure and restore heart function in a large animal model. The therapy increases the amount of blood the heart can pump and dramatically improves survival, in what a paper describing the results calls "an unprecedented recovery of cardiac function.

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Capstan’s Robotic MR/TR Frontier Funding

CardiacWire

Capstan Medical took a key step towards its vision of launching the first robotic cardiac valve surgery system, landing $110M in Series C funding. The new funding eclipses the $31M Series B round that Capstan raised in August 2023, bringing its total funding to over $150M. Capstan earmarked the funds for expanding its team to meet its upcoming development goals and execute its future pivotal trials.

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Associations between self-reported sleep duration and incident cardiovascular diseases in a nationwide prospective cohort study of Chinese middle-aged and older adults

Frontiers in Cardiovascular Medicine

PurposeThis study explores the correlation between sleep duration and cardiovascular disease (CVD) among middle-aged and older adults in China. Furthermore, we aim to investigate the association between sleep duration and incident CVD in this population, while assessing potential variations across different age and gender subgroups.MethodsUtilizing data from the nationwide prospective survey of the China Health and Retirement Longitudinal Study (CHARLS) conducted in 2011, 2013, 2015, and 2018, i

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Significance of Proteinuria for Potential IgAN

HCPLive

Panelists discuss how clinicians determine the significance of proteinuria in assessing patients for potential IgA nephropathy (IgAN), including the levels and patterns that prompt further investigation and the specific diagnostic red flags that may suggest IgAN over other kidney disorders.

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Scientists identify a probable contributor to weakness of the aorta in people with genetic disorder

Medical Xpress - Cardiology

Studying the cells of people and genetically engineered mice, Johns Hopkins Medicine scientists say they have uncovered a potential reason why patients with Loeys-Dietz syndrome, an inherited connective tissue disorder, are especially prone to developing aneurysms at the root of the aorta, the major artery that carries blood away from the heart and to the rest of the body.