Sat.Feb 03, 2024 - Fri.Feb 09, 2024

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Immune genes are altered in Alzheimer's patients' blood

Science Daily - Stroke

A new study has found the immune system in the blood of Alzheimer's patients is epigenetically altered. That means the patients' behavior or environment has caused changes that affect the way their genes work. Many of these altered immune genes are the same ones that increase an individual's risk for Alzheimer's. Scientists now theorize the cause could be a previous viral infection, environmental pollutants or other lifestyle factors and behaviors.

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Even With Alzheimer's Pathology, Healthy Lifestyles May Preserve Cognition

Med Page Today

(MedPage Today) -- Cognitive function was better for older adults with healthy lifestyles even if they had Alzheimer's or other dementia-related pathologies, autopsy data showed. A 1-point increase in a healthy lifestyle score was associated with.

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Scientist shows focused ultrasound can reach deep into the brain to relieve pain

Science Daily - Heart Disease

Scientists have found soundwaves from low-intensity focused ultrasound aimed at a place deep in the brain called the insula can reduce both the perception of pain and other effects of pain, such as heart rate changes.

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11 leading stroke scientists to receive American Stroke Association honors

American Heart News - Stroke News

Embargoed until 8 a.m. MT/10 a.m. ET, Tuesday, Feb. 6, 2024 PHOENIX, Feb. 6, 2024 – Eleven scientists leading the way in stroke research will be recognized during the American Stroke Association’s International Stroke Conference 2024 for their.

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Double diabetes—when type 1 diabetes meets type 2 diabetes: definition, pathogenesis and recognition

Cardiovascular Diabetology

Currently, the differentiation between type 1 diabetes (T1D) and type 2 diabetes (T2D) is not straightforward, and the features of both types of diabetes coexist in one subject. This situation triggered the ne.

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Deepak Bhatt, MD, MPH: Need for In-Hospital Initiation, Uptitration of GDMT in Acute Heart Failure

HCPLive

Deepak Bhatt, MD, MPH, discusses the need to improve in-hospital initiation and uptitration of guideline-directed medical therapy in heart failure.

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Senators Thrash Pharma CEOs for Pricing Drugs Higher in the U.S.

Med Page Today

(MedPage Today) -- Senators pummeled the CEOs of three of the largest pharmaceutical companies with demands that they explain why one in four Americans can't afford their prescription drugs, prices of which are higher in the U.S. compared with.

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New weight loss medication may help lower blood pressure in adults with obesity

American Heart News - Heart News

Research Highlights: The weight loss medication tirzepatide significantly lowered the systolic blood pressure of nearly 500 adults who had obesity and took the medication for 36 weeks, or about eight months, in a subset of an international clinical.

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New weight loss medication may help lower blood pressure in adults with obesity

Science Daily - Heart Disease

Weight loss medication reduced both day and nighttime blood pressure levels, finds new study.

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Lawrence Eichenfield, MD: Discussing New Findings on Topical Roflumilast for Atopic Dermatitis

HCPLive

In this interview, Eichenfield discussed the recent pooled analysis from two phase 3 studies looking at once-daily, topical roflumilast for patients 6 and older with eczema.

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Blood thinners added to clot-busting medication did not improve stroke outcomes

American Heart News - Stroke News

Research Highlights: Although giving blood thinners along with clot-busting medication may help in treating heart attacks, it did not improve 90-day outcomes in people with clot-caused strokes. Enrollment in a large clinical trial, which had been.

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High-Risk HPV in Women Heightens Risk of Heart Disease Death

Med Page Today

(MedPage Today) -- Women with high-risk strains of human papillomavirus (HPV) had a far higher risk of death from certain types of cardiovascular disease (CVD), a prospective cohort study from Korea found. Compared to women without high-risk strains.

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Study finds new treatment to reverse inflammation and arterial blockages in rheumatoid arthritis

Science Daily - Heart Disease

Researchers have found that the molecule RvT4 enhances the body's natural defenses against atherosclerosis (hardening of the arteries) in patients with rheumatoid arthritis.

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Nipocalimab Demonstrates Clinical Efficacy in Generalized Myasthenia Gravis, Sjögren's Syndrome Treatment

HCPLive

Promising results of the phase 2 and 3 trials offer hope for patients with chronic and debilitating autoantibody-driven diseases.

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Blocking artery supplying the brain covering after subdural hematoma reduced repeat surgery

American Heart News - Stroke News

Research Highlights: In the EMBOLISE clinical trial, obstructing (or blocking) an artery that supplies blood to the dura, the protective covering of the brain, along with surgery to remove pooled blood reduced the chances by nearly 3-fold that blood.

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Triptans Warrant Their Current Contraindication, Analysis Suggests

Med Page Today

(MedPage Today) -- An initial triptan prescription was linked with ischemic stroke and myocardial infarction for people with a high-risk cardiovascular profile, a case-crossover study in Denmark found. Among more than 400,000 people who redeemed.

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CTA and ACC Collaborate to Tackle Cardiovascular Disease with Technology

DAIC

milla1cf Wed, 02/07/2024 - 18:05 February 7, 2024 — The Consumer Technology Association ( CTA ) and the American College of Cardiology ( ACC ) are announcing the release of their second industry framework for the use of consumer cardiovascular technology solutions in the screening and diagnosis for cardiovascular conditions. This new document builds off of the previously published Best Practices for Consumer Cardiovascular Technology Solutions in January 2022.

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Stephen Harrison, MD: Resmetirom Could Address 'Monumental' Unmet Need in NASH

HCPLive

Stephen Harrison, MD, provides insight into the use of resmetirom for NASH with fibrosis ahead of the thyroid hormone receptor-β selective agonist’s March 14 PDUFA date.

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Heart organoids simulate pregestational diabetes-induced congenital heart disease

Science Daily - Heart Disease

An advanced human heart organoid system can be used to model embryonic heart development under pregestational diabetes-like conditions, researchers report. The organoids recapitulate hallmarks of pregestational diabetes-induced congenital heart disease found in mice and humans. The findings also showed that endoplasmic reticulum (ER) stress and lipid imbalance are critical factors contributing to these disorders, which could be ameliorated with exposure to omega-3s.

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Can a Common Diabetes Drug Turn Patients' Urine Into Alcohol?

Med Page Today

(MedPage Today) -- One patient had multiple false positive toxicology tests after taking a popular diabetes drug. Despite not ingesting alcohol for over 10 months, a man in his early 60s tested positive for ethanol in his urine on the last four.

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ISC 2024 News: Late-Breaking Science Findings from EMBOLISE Clinical Trial Reveals Blocking Artery Supplying the Brain Covering After Subdural Hematoma Reduced Repeat Surgery

DAIC

Preliminary late-breaking science presented today, the final day of the American Stroke Association’s International Stroke Conference 2024, ISC 2024, focused on findings from the EMBOLISE clinical trial, presented by Jason Davies, M.D., Ph.D., an associate professor in the departments of neurosurgery and biomedical informatics at the State University of New York, Buffalo.

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Psychologically Distressed Patients Faced Challenges During COVID-19

HCPLive

According to a new study, overall outpatient mental health care increased from 11.2% to 12.4% between 2018 and 2018. However, for individuals with serious psychological distress, the rate of care decreased from 46.5% to 40.4%.

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Weight loss surgery most effective for long-term blood pressure control

Science Daily - Heart Disease

Bariatric surgery is more effective in controlling hypertension rates, or high blood pressure, in people with obesity and uncontrolled high blood pressure compared to blood pressure medication alone, according to a new study. People who underwent bariatric surgery had lower BMI and were on fewer medications after five years while maintaining normal blood pressure levels than those who only used antihypertensive medications.

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Before Stroke Thrombectomy, Keep the Bed Flat, Trial Says

Med Page Today

(MedPage Today) -- PHOENIX -- For large vessel occlusion (LVO) acute ischemic stroke patients planned for mechanical thrombectomy, bed positioning made a big difference in clinical worsening, the ZODIAC trial showed. Keeping the head of the.

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Una nueva investigación científica probará la calculadora de riesgo PREVENT entre diversos grupos

American Heart News - Heart News

DALLAS, 7 de febrero de 2024 — Equipos de investigación de Northwestern University Feinberg School of Medicine, New York University y Duke University trabajarán juntos para evaluar la precisión de la nueva calculadora de riesgo PREVENTTM de la American.

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‘Vision Loss in Later Life is not Normal’: Vision Loss Projected to Rise in Older Adults

HCPLive

Since the Baby Boomers are transitioning into older age by 2040 and 2050, the dramatic rise in the global aging population will increase demands for ophthalmic care.

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New research uncovers biological drivers of heart disease risk

Science Daily - Heart Disease

Over the past 15 years, researchers have identified hundreds of regions in the human genome associated with heart attack risk. However, researchers lack efficient ways to explore how these genetic variants are molecularly connected to cardiovascular disease, limiting efforts to develop therapeutics. To streamline analysis of hundreds of genetic variants associated with coronary artery disease (CAD), a team of researchers combined multiple sequencing and experimental techniques to map the relatio

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Anticoagulant Falls Short for Secondary Stroke Prevention in Atrial Cardiopathy

Med Page Today

(MedPage Today) -- Oral anticoagulation (OAC) was no better than low-dose aspirin for secondary stroke prevention in people with left atrial cardiopathy absent evidence of atrial fibrillation (Afib or AF), the ARCADIA trial showed. Recurrent strokes.

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Machine Learning Informs a New Tool to Guide Treatment for Acute Decompensated Heart Failure

DAIC

The Texas Heart Institute at Baylor St. Luke's Medical Center Cardiovascular Disease Fellow Dr. Matthew Segar co-authored a study in JACC Heart Failure led by his research and residency mentor, University of Texas Southwestern Medical Center's Dr. Ambarish Pandey , that utilized a machine learning-based-approach to identify, understand, and predict diuretic responsiveness in patients with acute decompensated heart failure (ADHF).

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Tirzepatide Significantly Reduces HbA1c, Body Weight in Type 1 Diabetes

HCPLive

A new proof-of-concept observation study reports the dual GLP-1/GIP agonist's positive efficacy and safety for adults with T1D.

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The association between triglyceride glucose-body mass index and all-cause mortality in critically ill patients with atrial fibrillation: a retrospective study from MIMIC-IV database

Cardiovascular Diabetology

The TyG-BMI index, which is a reliable indicator of insulin resistance (IR), has been found to have a significant correlation with the occurrence of cardiovascular events. However, there still lacks study on t.

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Durable Weight Loss Follows Just a Few Injections of Novel Drug

Med Page Today

(MedPage Today) -- A once-monthly injectable weight management agent safely induced durable weight loss in a phase I human trial. At the highest dose tested, patients with overweight or obesity lost 14.5% of their body weight by day 85, Murielle.

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Smidt Heart Institute Physicians Advance Transcatheter Tricuspid Valve Replacement

DAIC

Physicians in the Smidt Heart Institute at Cedars-Sinai have pioneered using a catheter-based approach to treat patients with tricuspid valve disease. Image by Getty. milla1cf Fri, 02/09/2024 - 08:45 February 9, 2024 — Physicians in the Smidt Heart Institute at Cedars-Sinai have achieved two significant firsts: completing the institute’s 100 th minimally invasive tricuspid valve replacement and performing the first-ever implantation of a new bioprosthetic tricuspid valve following its approva

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New Study Finds Tirzepatide Use Lowered Blood Pressure in Patients with Obesity

HCPLive

Tirzepatide, a dual GLP-1/GIP agonist approved for diabetes and obesity, was associated with significant blood pressure reductions in an analysis of the SURMOUNT-1 trial.

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?-Blocker Withdrawal and Functional Capacity Improvement in Patients With HFpEF

JAMA Cardiology

This study attempts assess to the association of β-blocker treatment withdrawal on changes in the percentage of predicted peak oxygen consumption across indexed left ventricular diastolic and systolic volumes, and left ventricular ejection fraction in patients with heart failure with preserved ejection fraction and chronotropic incompetence.

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Health Affects of Diabetes Remission; High-Deductible Plans for Cancer Patients

Med Page Today

(MedPage Today) -- TTHealthWatch is a weekly podcast from Texas Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine in Baltimore, and Rick Lange, MD, president of the Texas Tech University Health Sciences Center.

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MIVI Neuroscience Presents Primary Endpoint Results from the EvaQ Trial — at the 2024 International Stroke Conference

DAIC

milla1cf Fri, 02/09/2024 - 09:28 February 9, 2024 — MIVI Neuroscience, Inc. announced the primary endpoint results of its EvaQ Trial , a prospective, multi-center, global, single arm, FDA-regulated IDE trial study to evaluate the safety and effectiveness of the MIVI Q Revascularization System for treating acute ischemic stroke. The data were presented yesterday at the 2024 International Stroke Conference (AZ), a premier event featuring global thought leaders and dedicated to the latest in the s

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