Sat.Feb 12, 2022 - Fri.Feb 18, 2022

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Dos and Don’ts of the Mobile ECMO Team

Society of Thoracic Surgeons - Critical Care

Webinar Dos and Don’ts of the Mobile ECMO Team kchalko Thu, 02/17/2022 - 12:54 March 3, 2022 In this episode of the STS Webinar Series, a multidisciplinary panel shares their expertise in establishing and maintaining an effective mobile ECMO unit. In addition to optimal staffing, logistical details, and contingency plans for transport, the panel discusses findings from research on ECMO-facilitated resuscitation and contraindications for deploying the mobile ECMO unit.

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Impact of prior oral anticoagulant use and outcomes on patients from secondary analysis in the AUGUSTUS trial

Open Heart

Objective Managing antithrombotic therapy in patients with atrial fibrillation (AF) and an acute coronary syndrome (ACS) and/or percutaneous coronary intervention (PCI) is challenging and can be affected by prior oral anticoagulant (OAC) treatment. We examined the relationship between prior OAC use and outcomes in the AUGUSTUS trial. Methods This prespecified secondary analysis is from AUGUSTUS, an open-label, 2-by-2 factorial, RCT to evaluate the safety of apixaban versus vitamin K antagonist (

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JJ 20 Outpatient Medications for COVID-19

ECG Cases

In this Journal Jam podcast we dig deep into the science of FDA-approved outpatient medications for COVID with 3 critical appraisal masters: Dr. Andrew Morris, Dr. Rohit Mohindra and Dr. Justin Morgenstern. What is the evidence for the neutralizing monoclonal antibody medications like Sotrovimab? The nucleoside analogs like Remdesivir and Paxlovid? The inhaled corticosteroids like Budesonide and Ciclesonide?

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Looking Back And Looking Ahead: The Future For Heartbeat Health

The Beat Blog

Back in 2017, nearly a decade into my clinical training, I had just finished a difficult overnight cardiology shift managing critically ill patients with advanced cardiovascular disease. As I rode the New York City subway back to my upper west side apartment recounting the patients I had managed, and the decisions I had made that night, a lingering thought began growing.

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Disrupting circ-GNB4 mitigates high glucose-induced human mesangial cells injury by regulating the proliferation, ECM accumulation, inflammation and oxidative stress through circ-GNB4/miR-23c/EGR1 pathway

Journal of Cardiovascular Pharmacology

Diabetic nephropathy (DN) is the most common complication of diabetes mellitus. Although G protein subunit beta 4 (GNB4)-derived circular RNA (circ-GNB4; hsa_circ_0068087) is a promising candidate biomarker in diabetes mellitus, whether circ-GNB4 participates in DN occurrence and development remains unknown. Herein, we focused on DN-associated human renal mesangial cells (HRMCs) injury, and HRMCs were exposed in high glucose (HG) condition.

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Copper chelation in patients with hypertrophic cardiomyopathy

Open Heart

Background Disturbances of copper (Cu) homeostasis can lead to hypertrophic cardiac phenotypes (eg, Wilson’s disease). We previously identified abnormal Cu homeostasis in patients with hypertrophic cardiomyopathy (HCM) and, therefore, hypothesised that Cu 2+ –selective chelation with trientine dihydrochloride may slow or reverse disease progression in HCM.

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Can There Ever Be a "Kinder and Gentler" MOC?

Dr. Wes

It has been a long time since I have written anything concerning the American Board of Medical Specialties' (ABMS) Maintenance of Certification (MOC) board re-certification program. But when I read pieces in the media, like the one recently published in Medscape that spin the soothing narrative that MOC can become "kinder and gentler," I feel the need to speak out.