Sat.Oct 05, 2024 - Fri.Oct 11, 2024

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ECG Blog #451 — Premature Closure.

Ken Grauer, MD

I was sent the ECG shown in Figure-1 — told only that the patient was a middle-aged man with septicemia. QUESTIONS: Is this rhythm too fast to be sinus tachycardia? Are flutter waves hidden within the QRS and T waves? Are we seeing the retrograde P waves of AVNRT? Is this ATach ( A trial T achycardia )? Figure-1: The initial ECG in today's case. MY Thoughts on Today’s CASE: In my opinion — none of the above answers are optimal to describe the rhythm in Figure-1.

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COVID-19 infection appeared to increase risk of heart attack & stroke up to 3 years later

American Heart News - Heart News

Research Highlights: An analysis of UK Biobank health data that included adults who had mild to severe COVID-19 before vaccines were available found an increased risk of heart attack, stroke and death among those adults during the nearly three-year.

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History of COVID-19 found to double long-term risk of heart attack, stroke and death

Medical Xpress - Cardiology

A history of COVID-19 can double the risk of heart attack, stroke or death according to new research led by Cleveland Clinic and the University of Southern California.

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Certain Arm Positions Can Lead to Inaccurate Blood Pressure Readings

Med Page Today

(MedPage Today) -- Certain arm positions -- supported on a lap or hanging by the side of the body -- led to significant overestimation of blood pressure readings compared with standardized positioning, a randomized trial in JAMA Internal Medicine.

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Relapse Common 6-Month Post Electroconvulsive Therapy for Schizophrenia

HCPLive

These data suggest that relapse among those with schizophrenia may be common 6 months after ECT, with more than half of patients likely to experience relapse within 2 years.

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Heart failure, atrial fibrillation & coronary heart disease linked to cognitive impairment

American Heart News - Heart News

Statement Highlights: Previous studies have found that 14-81% of patients with heart failure experience some degree of cognitive impairment affecting language, memory or executive function. Evidence also indicates that people with atrial fibrillation.

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Arm position effect on blood pressure readings: 5 things to know

Becker's Hospital Review - Cardiology

Insufficient arm support can lead to an overestimated blood pressure reading of almost 7mmHG and a potential misdiagnosis of hypertension, according to a study published Oct. 7 in JAMA Internal Medicine.

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AstraZeneca Adds Lp(a) Candidate with CSPC Licensing Move

CardiacWire

AstraZeneca expanded its cardiovascular pipeline this week, signing an exclusive license agreement for CSPC Pharmaceutical Group’s Lp(a) disruptor candidate, YS2302018. The deal comes with a $100M upfront investment that could reach $1.92B depending on further milestones. YS2302018 is a small molecule Lipoprotein (a) disruptor intended to treat dyslipidemia patients by preventing the formation of excess blood lipids.

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Jonathan Meyer, MD: Cognitive Gains, Dopamine-Free Schizophrenia Treatment with Xanomeline Trospium Chloride

HCPLive

Xanomeline trospium chloride offers a new pathway in schizophrenia treatment, improving cognitive symptoms without D2 receptor-related side effects like tardive dyskinesia.

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Caffeine intake linked to better vascular health in study

Medical Xpress - Cardiology

Consuming more caffeine may improve heart health, according to a study published in the Rheumatology journal.

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One Way to Spot Early Cognitive Decline? Medicare Wellness Visits

Med Page Today

(MedPage Today) -- A Medicare annual wellness visit (AWV) was associated with greater recognition of mild cognitive impairment in older adults, a population-based cohort study in Texas showed. Compared with those who didn't have an annual visit.

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La insuficiencia cardíaca, la fibrilación auricular y la enfermedad coronaria están relacionadas con el deterioro cognitivo

American Heart News - Heart News

Aspectos destacados de la declaración: En estudios anteriores se ha descubierto que entre el 14 y el 81% de los pacientes con insuficiencia cardíaca presentan algún grado de deterioro cognitivo que afecta el lenguaje, la memoria o la función.

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Nanoscope Signals BLA Submission for MCO-010 for Retinitis Pigmentosa

HCPLive

Based on the regulatory feedback provided by the FDA, Nanoscope announced plans to initiate Biologics License Application submission in Q1 2025.

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Commonly used arm positions can substantially overestimate blood pressure readings

Science Daily - Heart Disease

Researchers conclude that commonly used ways of positioning the patient's arm during blood pressure (BP) screenings can substantially overestimate test results and may lead to a misdiagnosis of hypertension.

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Checkpoint Inhibitors for Lung Cancer Linked to Pulmonary Embolism

Med Page Today

(MedPage Today) -- BOSTON -- Patients with metastatic lung cancer who were treated with immune checkpoint inhibitors (ICIs) had higher odds of developing a pulmonary embolism, according to a retrospective cohort study. Among propensity-matched.

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How terrible can it be to fail to recognize OMI? To whom is OMI Obvious or Not Obvious?

Dr. Smith's ECG Blog

This was sent to me by a reader who wishes to remain anonymous. A lady in her 60s came to the ER with chest discomfort and shortness of breath. She had a history of previous anterior MI treated by primary PCI to the proximal LAD. The first EKG is from 2:30 PM on the day of presentation to the ER. Smith : To me this is a blatantly obvious acute anterior OMI.

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Researchers succeed in creating two interconnected vascular networks

Medical Xpress - Cardiology

Researchers from the Faculty of Medicine and Health Technology (MET) at Tampere University have successfully created a cell culture platform that allows two cultivated vascular networks to interconnect. The blood vessels in these networks are equivalent to human capillaries in size and structure, facilitating the study of human capillary networks in a laboratory setting.

Research 101
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COVID-19 infection appeared to increase risk of heart attack and stroke up to 3 years later

Science Daily - Heart Disease

An analysis of data in the UK Biobank has found that COVID-19 infection may increase the risk of heart attack, stroke and death from any cause for up to three years for people with and without cardiovascular disease, according to new research.

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Short-Term Surge in Air Pollution May Trigger Schizophrenia Episodes

HCPLive

A short-term rise in air pollution levels between neighboring days was significantly linked to an increased risk of schizophrenia hospitalizations in China.

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Dual-Antiplatelet Therapy After Drug-Eluting Stenting in ACS

JAMA Cardiology

This systematic review and network meta-analysis investigates the optimal duration of dual antiplatelet therapy in patients with acute coronary syndromes (ACS) undergoing percutaneous coronary intervention with drug-eluting stents.

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If you were this patient, would you prefer to be managed with the Queen of Hearts?

Dr. Smith's ECG Blog

Written by Pendell Meyers A man in his early sixties with no significant medical history (including a "negative cardiac workup a few years ago" for unclear indication) called 911 for acute chest pain constantly for the past 5 hours. EMS arrived and recorded vital signs within normal limits and the following ECG during active pain: EMS1 @ 0157: What do you think?

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The titanium heart keeping transplant patients alive

Becker's Hospital Review - Cardiology

Banner-University Medical Center Phoenix has become the third U.S. hospital to perform a BiVACOR Total Artificial Heart implantation as part of the FDA's early feasibility study.

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Comorbid Migraine, Insomnia Linked to Aberrant Locus Coeruleus Functional Connectivity

HCPLive

Comorbid migraine and insomnia are linked to altered locus coeruleus connectivity, suggesting it is a biomarker for sleep disturbances and a potential therapeutic target.

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Potential therapy target for cardiac arrhythmias found in SK2 channels

Medical Xpress - Cardiology

A new study by researchers at the University of Arizona College of Medicine–Phoenix and the University of California Davis Health identified a new target for developing a therapy to treat atrial fibrillation, the most common type of abnormal heart rhythm.

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Highest Paid Medical Specialties in 2024

Med Page Today

(MedPage Today) -- While it's true that becoming a doctor means a guaranteed six-figure salary, these salaries vary dramatically between specialties. The good news is in 2024, the Physician Compensation Report from Doximity listed 12 medical.

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Are We Too Obsessed with Protein?

Physiologically Speaking

Protein is everywhere. High-protein cereal. Protein-packed frozen meals. There’s even protein water. The deluge of protein-centric products is the result of one thing: we’re convinced that we don’t get enough of it. Or at least that’s what everyone wants you to think. Has the fixation on protein come at a cost? Maybe. One thing I’ve noticed is that the term “protein” is now equated with “healthy.” This couldn’t be further from the truth

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Study Supports News of Benzene in Benzoyl Peroxide Acne Products

HCPLive

These new data provide additional evidence for a range of benzene concentrations detected by in over-the-counter drug products with BPO maintained at room temperature.

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Heart failure, atrial fibrillation and coronary heart disease linked to cognitive impairment

Medical Xpress - Cardiology

Three common cardiovascular diseases in adults—heart failure, atrial fibrillation and coronary heart disease—are linked to cognitive impairment and increased risk of dementia, according to "Cardiac Contributions to Brain Health," a new scientific statement from the American Heart Association published today in the journal, Stroke.

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SGLT2 Inhibitors Tied to Better Outcomes in Pulmonary Arterial Hypertension

Med Page Today

(MedPage Today) -- BOSTON -- Sodium-glucose cotransporter-2 (SGLT2) inhibitors were linked to long-term reductions in mortality risk among patients with pulmonary arterial hypertension (PAH), according to an observational cohort study. At 1.

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Lifetime effects and cost-effectiveness of statin therapy for older people in the United Kingdom: a modelling study

Heart BMJ

Background Cardiovascular disease (CVD) risk increases with age. Statins reduce cardiovascular risk but their effects are less certain at older ages. We assessed the long-term effects and cost-effectiveness of statin therapy for older people in the contemporary UK population using a recent meta-analysis of randomised evidence of statin effects in older people and a new validated CVD model.

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Time-Restricted Eating Shows Promise for Metabolic Syndrome in 3-Month Trial

HCPLive

Time-restricted eating, even without calorie restriction, improved glycemic control and cardiometabolic health in patients with metabolic syndrome.

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The most frightening cardiac symptom

Heart Sisters

“The most prominent symptom I had – which kept getting stronger and would NOT go away – is the one I now warn all my friends about…”

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Cancer drug could be used to save the limbs of peripheral artery disease patients, pre-clinical study suggests

Medical Xpress - Cardiology

Researchers at the Heart Research Institute (HRI) have made a new discovery, finding an existing drug used to kill tumor cells in cancer patients could also be used to save the limbs of patients with blocked arteries in their legs.

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Common consumer product chemicals now tied to cardiac electrical changes

Science Daily - Heart Disease

Some environmental phenols are known to have cardiac toxicities. Now, a new study is revealing their adverse impact on the heart's electrical properties.

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FASCINATE-2: Denifanstat Improves Disease Activity, MASH Resolution, Fibrosis

HCPLive

New phase 2b data highlight denifanstat’s impact on histological features of MASH, meeting both fibrosis improvement and MASH resolution primary endpoints.

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Body Roundness to Predict Cardiovascular Disease; Myopia on the Rise

Med Page Today

(MedPage Today) -- TTHealthWatch is a weekly podcast from Texas Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine in Baltimore, and Rick Lange, MD, president of the Texas Tech University Health Sciences Center.

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The heart health, dementia link: 7 things to know

Becker's Hospital Review - Cardiology

Addressing heart health earlier in life may affect and even deter dementia risk later in life, according to research published by The American Heart Association Oct. 10 in Stroke.