Sat.Oct 05, 2024 - Fri.Oct 11, 2024

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ECG Blog #451 — Premature Closure.

Ken Grauer, MD

I was sent the ECG shown in Figure-1 — told only that the patient was a middle-aged man with septicemia. QUESTIONS: Is this rhythm too fast to be sinus tachycardia? Are flutter waves hidden within the QRS and T waves? Are we seeing the retrograde P waves of AVNRT? Is this ATach ( A trial T achycardia )? Figure-1: The initial ECG in today's case. MY Thoughts on Today’s CASE: In my opinion — none of the above answers are optimal to describe the rhythm in Figure-1.

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COVID-19 infection appeared to increase risk of heart attack & stroke up to 3 years later

American Heart News - Heart News

Research Highlights: An analysis of UK Biobank health data that included adults who had mild to severe COVID-19 before vaccines were available found an increased risk of heart attack, stroke and death among those adults during the nearly three-year.

COVID-19 145
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History of COVID-19 found to double long-term risk of heart attack, stroke and death

Medical Xpress - Cardiology

A history of COVID-19 can double the risk of heart attack, stroke or death according to new research led by Cleveland Clinic and the University of Southern California.

COVID-19 145
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Certain Arm Positions Can Lead to Inaccurate Blood Pressure Readings

Med Page Today

(MedPage Today) -- Certain arm positions -- supported on a lap or hanging by the side of the body -- led to significant overestimation of blood pressure readings compared with standardized positioning, a randomized trial in JAMA Internal Medicine.

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Nanoscope Signals BLA Submission for MCO-010 for Retinitis Pigmentosa

HCPLive

Based on the regulatory feedback provided by the FDA, Nanoscope announced plans to initiate Biologics License Application submission in Q1 2025.

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Heart failure, atrial fibrillation & coronary heart disease linked to cognitive impairment

American Heart News - Heart News

Statement Highlights: Previous studies have found that 14-81% of patients with heart failure experience some degree of cognitive impairment affecting language, memory or executive function. Evidence also indicates that people with atrial fibrillation.

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Caffeine intake linked to better vascular health in study

Medical Xpress - Cardiology

Consuming more caffeine may improve heart health, according to a study published in the Rheumatology journal.

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Having a sweet tooth is linked to higher risk of depression, diabetes, and stroke, study finds

Science Daily - Heart Disease

People with a preference for sweets are at a higher risk of developing depression, diabetes, and suffering a stroke, according to new research.

Diabetes 119
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How terrible can it be to fail to recognize OMI? To whom is OMI Obvious or Not Obvious?

Dr. Smith's ECG Blog

This was sent to me by a reader who wishes to remain anonymous. A lady in her 60s came to the ER with chest discomfort and shortness of breath. She had a history of previous anterior MI treated by primary PCI to the proximal LAD. The first EKG is from 2:30 PM on the day of presentation to the ER. Smith : To me this is a blatantly obvious acute anterior OMI.

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Relapse Common 6-Month Post Electroconvulsive Therapy for Schizophrenia

HCPLive

These data suggest that relapse among those with schizophrenia may be common 6 months after ECT, with more than half of patients likely to experience relapse within 2 years.

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One Way to Spot Early Cognitive Decline? Medicare Wellness Visits

Med Page Today

(MedPage Today) -- A Medicare annual wellness visit (AWV) was associated with greater recognition of mild cognitive impairment in older adults, a population-based cohort study in Texas showed. Compared with those who didn't have an annual visit.

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Arm position effect on blood pressure readings: 5 things to know

Becker's Hospital Review - Cardiology

Insufficient arm support can lead to an overestimated blood pressure reading of almost 7mmHG and a potential misdiagnosis of hypertension, according to a study published Oct. 7 in JAMA Internal Medicine.

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AstraZeneca Adds Lp(a) Candidate with CSPC Licensing Move

CardiacWire

AstraZeneca expanded its cardiovascular pipeline this week, signing an exclusive license agreement for CSPC Pharmaceutical Group’s Lp(a) disruptor candidate, YS2302018. The deal comes with a $100M upfront investment that could reach $1.92B depending on further milestones. YS2302018 is a small molecule Lipoprotein (a) disruptor intended to treat dyslipidemia patients by preventing the formation of excess blood lipids.

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Stronger Safety Considerations Needed for Lumateprone Use, Especially for Women

HCPLive

Being female and having bipolar II disorder were independent risk factors for serious AEs in a new study.

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Checkpoint Inhibitors for Lung Cancer Linked to Pulmonary Embolism

Med Page Today

(MedPage Today) -- BOSTON -- Patients with metastatic lung cancer who were treated with immune checkpoint inhibitors (ICIs) had higher odds of developing a pulmonary embolism, according to a retrospective cohort study. Among propensity-matched.

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Commonly used arm positions can substantially overestimate blood pressure readings

Science Daily - Heart Disease

Researchers conclude that commonly used ways of positioning the patient's arm during blood pressure (BP) screenings can substantially overestimate test results and may lead to a misdiagnosis of hypertension.

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If you were this patient, would you prefer to be managed with the Queen of Hearts?

Dr. Smith's ECG Blog

Written by Pendell Meyers A man in his early sixties with no significant medical history (including a "negative cardiac workup a few years ago" for unclear indication) called 911 for acute chest pain constantly for the past 5 hours. EMS arrived and recorded vital signs within normal limits and the following ECG during active pain: EMS1 @ 0157: What do you think?

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Anemia May Worsen Prognosis of Primary Care Patients with Heart Failure

HCPLive

Anemia is frequently observed in primary care patients with HF and is linked to worse prognosis and comorbidities, including cancer.

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SGLT2 Inhibitors Tied to Better Outcomes in Pulmonary Arterial Hypertension

Med Page Today

(MedPage Today) -- BOSTON -- Sodium-glucose cotransporter-2 (SGLT2) inhibitors were linked to long-term reductions in mortality risk among patients with pulmonary arterial hypertension (PAH), according to an observational cohort study. At 1.

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Dual-Antiplatelet Therapy After Drug-Eluting Stenting in ACS

JAMA Cardiology

This systematic review and network meta-analysis investigates the optimal duration of dual antiplatelet therapy in patients with acute coronary syndromes (ACS) undergoing percutaneous coronary intervention with drug-eluting stents.

Stents 108
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Researchers succeed in creating two interconnected vascular networks

Medical Xpress - Cardiology

Researchers from the Faculty of Medicine and Health Technology (MET) at Tampere University have successfully created a cell culture platform that allows two cultivated vascular networks to interconnect. The blood vessels in these networks are equivalent to human capillaries in size and structure, facilitating the study of human capillary networks in a laboratory setting.

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FDA Approves Marstacimab-hncq (Hympavzi) for Hemophilia A or B Without Inhibitors

HCPLive

The anti-TFPI significantly reduced ABR compared to routine prophylaxis treatment in the phase 3 BASIS trial.

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Safety Data Favor Diuretic Strategy Triggered by Cardiac Monitoring Alerts in HF

Med Page Today

(MedPage Today) -- For a range of hospitalized patients at risk of worsening heart failure (HF), tying medical interventions to cardiac monitoring seemed safe thus far according to the small ALLEVIATE-HF trial. There were no serious adverse events.

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COVID-19 infection appeared to increase risk of heart attack and stroke up to 3 years later

Science Daily - Heart Disease

An analysis of data in the UK Biobank has found that COVID-19 infection may increase the risk of heart attack, stroke and death from any cause for up to three years for people with and without cardiovascular disease, according to new research.

COVID-19 106
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Cancer drug could be used to save the limbs of peripheral artery disease patients, pre-clinical study suggests

Medical Xpress - Cardiology

Researchers at the Heart Research Institute (HRI) have made a new discovery, finding an existing drug used to kill tumor cells in cancer patients could also be used to save the limbs of patients with blocked arteries in their legs.

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Jonathan Meyer, MD: Cognitive Gains, Dopamine-Free Schizophrenia Treatment with Xanomeline Trospium Chloride

HCPLive

Xanomeline trospium chloride offers a new pathway in schizophrenia treatment, improving cognitive symptoms without D2 receptor-related side effects like tardive dyskinesia.

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The most frightening cardiac symptom

Heart Sisters

“The most prominent symptom I had – which kept getting stronger and would NOT go away – is the one I now warn all my friends about…”

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La insuficiencia cardíaca, la fibrilación auricular y la enfermedad coronaria están relacionadas con el deterioro cognitivo

American Heart News - Heart News

Aspectos destacados de la declaración: En estudios anteriores se ha descubierto que entre el 14 y el 81% de los pacientes con insuficiencia cardíaca presentan algún grado de deterioro cognitivo que afecta el lenguaje, la memoria o la función.

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Potential therapy target for cardiac arrhythmias found in SK2 channels

Medical Xpress - Cardiology

A new study by researchers at the University of Arizona College of Medicine–Phoenix and the University of California Davis Health identified a new target for developing a therapy to treat atrial fibrillation, the most common type of abnormal heart rhythm.

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Short-Term Surge in Air Pollution May Trigger Schizophrenia Episodes

HCPLive

A short-term rise in air pollution levels between neighboring days was significantly linked to an increased risk of schizophrenia hospitalizations in China.

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Common consumer product chemicals now tied to cardiac electrical changes

Science Daily - Heart Disease

Some environmental phenols are known to have cardiac toxicities. Now, a new study is revealing their adverse impact on the heart's electrical properties.

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Highest Paid Medical Specialties in 2024

Med Page Today

(MedPage Today) -- While it's true that becoming a doctor means a guaranteed six-figure salary, these salaries vary dramatically between specialties. The good news is in 2024, the Physician Compensation Report from Doximity listed 12 medical.

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Heart failure, atrial fibrillation and coronary heart disease linked to cognitive impairment

Medical Xpress - Cardiology

Three common cardiovascular diseases in adults—heart failure, atrial fibrillation and coronary heart disease—are linked to cognitive impairment and increased risk of dementia, according to "Cardiac Contributions to Brain Health," a new scientific statement from the American Heart Association published today in the journal, Stroke.

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FDA Grants Breakthrough Therapy Designation to Volixibat for Cholestatic Pruritus in PBC

HCPLive

The designation was granted to Mirum Pharmaceuticals based on a positive interim analysis of the phase 2b VANTAGE study of volixibat.

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Are We Too Obsessed with Protein?

Physiologically Speaking

Protein is everywhere. High-protein cereal. Protein-packed frozen meals. There’s even protein water. The deluge of protein-centric products is the result of one thing: we’re convinced that we don’t get enough of it. Or at least that’s what everyone wants you to think. Has the fixation on protein come at a cost? Maybe. One thing I’ve noticed is that the term “protein” is now equated with “healthy.” This couldn’t be further from the truth

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Cardiac Surgery-Associated AKI Lower With Extracorporeal Blood Purification

Med Page Today

(MedPage Today) -- A nonselective extracorporeal blood purification (EBP) device connected to the cardiopulmonary bypass circuit during surgery reduced the risk of cardiac surgery-associated acute kidney injury (CSA-AKI), a randomized trial found.

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Mavacamten linked to cardiac biomarker improvements in HFpEF patients

Medical Xpress - Cardiology

Mavacamten, a drug initially developed to treat hypertrophic cardiomyopathy, has shown signs of reducing heart stress in patients with heart failure with preserved ejection fraction.