Sat.Aug 17, 2024 - Fri.Aug 23, 2024

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Gut microbial pathway identified as target for improved heart disease treatment

Medical Xpress - Cardiology

Cleveland Clinic researchers have made a significant discovery about how the gut microbiome interacts with cells to cause cardiovascular disease. The study published in Nature Communications found that phenylacetylglutamine (PAG), produced by gut bacteria as a waste product, then absorbed and formed in the liver, interacts with previously undiscovered locations on beta-2 adrenergic receptors on heart cells once it enters the circulation.

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Pentoxifylline ameliorates subclinical atherosclerosis progression in patients with type 2 diabetes and chronic kidney disease: a randomized pilot trial

Cardiovascular Diabetology

Diabetic kidney disease (DKD) is associated with a higher risk of cardiovascular disease (CVD). Pentoxifylline (PTF), a nonselective phosphodiesterase inhibitor with anti-inflammatory, antiproliferative, and a.

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Lifesaving But Not Perfect: Addressing Sleep Health in Patients on Dialysis

HCPLive

Care for dialysis patients often focuses on kidney health, but experts and a patient stress the need for interdisciplinary care that also addresses sleep health.

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Semaglutide Has Disproportionate Suicidality Signal, Analysis Finds

Med Page Today

(MedPage Today) -- A disproportionality analysis based on reports in a World Health Organization (WHO) database suggested a suicidal ideation signal with the GLP-1 receptor agonist semaglutide (Ozempic, Rybelsus, Wegovy). Between 2000 and 2023.

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Physiology Friday #232: Higher Aerobic Fitness Protects Against Declines in Brain Myelination

Physiologically Speaking

Greetings! Welcome to the Physiology Friday newsletter. A quick plug (and discount code!) for an electrolyte supplement I’ve been loving. FSTFUEL combines electrolytes with amino acids to help your body maintain hydration and optimal functioning during exercise or intermittent fasting, so you don't have to choose between fasting and fitness. It’s a zero-sugar electrolyte drink that tastes awesome.

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Weight loss drug's heart benefits extend to people with heart failure

Science Daily - Heart Disease

The researchers looked at data from 4,286 people -- out of a total of 17,605 from the landmark Semaglutide and Cardiovascular Outcomes (SELECT) trial who were randomly assigned either semaglutide or a placebo -- who were followed up over an average of more than three years.

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ECG Blog #444 — CP and Aberrant SVT?

Ken Grauer, MD

The ECG shown in Figure-1 — was obtained from an older man with “CP” ( C hest P ain ) for the past 2 days. BP = 80/50 mm/Hg. Adenosine 6 mg IV was tried without response. QUESTIONS: How would YOU interpret this ECG? Your thoughts regarding optimal management? Figure-1: The initial ECG in today's case. ( To improve visualization — I've digitized the original ECG using PMcardio ).

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Heart Defects in Kids Linked to Dads' Hepatitis B History Too

Med Page Today

(MedPage Today) -- A child's risk of congenital heart disease (CHD) may be related to a past hepatitis B virus (HBV) infection in either parent, according to a retrospective cohort study. Paternal preconception HBV infection was linked to significantly.

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Benzodiazepine linked to increased cardiovascular disease risk: Study

Becker's Hospital Review - Cardiology

Benzodiazepine class insomnia drugs were associated with an increased risk of cardiovascular disease, according to a study published Aug. 7 in the European Journal of Preventive Cardiology.

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Why Exercise Is The Key To A Longer Life

Dr. Paddy Barrett

High levels of fitness are arguably the best predictors of longevity. If you want to extend your lifespan, prioritising fitness is essential. If you are not prioritising fitness, then you are leaving huge potential gains on the table. Here’s why. The evidence that high levels of exercise and subsequent fitness are linked with increased lifespan and health span is clear.

Exercise 111
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AI tools help uncover connections between radiotherapy for lung cancer and heart complications

Medical Xpress - Cardiology

Researchers from Brigham and Women's Hospital have used artificial intelligence tools to accelerate the understanding of the risk of specific cardiac arrhythmias when various parts of the heart are exposed to different thresholds of radiation as part of a treatment plan for lung cancer.

Cancer 105
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Here's How Compounders Make Popular Weight-Loss Drugs

Med Page Today

(MedPage Today) -- This story is part of a series called "Ozempic: Weighing the Risks and Benefits." It was produced in part through a grant from the NIHCM Foundation. Shortages of popular new weight-loss drugs have driven a compounding boom that.

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Qazi Corner, Edition 7: ERCP Timing, GLP-1 RA Considerations, Seronegative Villous Atrophy

HCPLive

The third quarterly issue of 2024 reviews early versus late ERCP outcomes post-transplant, the impact of GLP-1RA use on endoscopic management, and the differential diagnosis of seronegative villous atrophy.

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Expanding a child's heart implant with light

Science Daily - Heart Disease

Children born with certain heart defects undergo a series of invasive surgeries early in life. The first surgery includes implantation of a shunt to improve blood flow. However, as children grow, the shunt must be replaced to accommodate their changing bodies. Now, researchers report designing a shunt that expands when activated by light. This device could reduce the number of open-chest surgeries these children receive.

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Improving access to heart-failure screening with a low-cost saliva test

Medical Xpress - Cardiology

Heart failure is a leading cause of death worldwide and is especially fatal for people who don't have access to medical facilities. So, a team of researchers aims to bring heart failure screening from the lab to the home. Their point-of-care electrochemical biosensor prototype, which resembles a see-through lateral flow test for COVID-19, can measure levels of two biomarkers for heart failure in as little as 15 minutes from just a drop of saliva.

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Outsized Death Risk for Women With Afib After Heart Surgery

Med Page Today

(MedPage Today) -- After cardiac surgery, women were particularly vulnerable to poor outcomes in the long run if the most common procedural complication had occurred, according to a large retrospective study from two tertiary care centers. Although.

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Sonal Kumar, MD, MPH: PPAR Agonists in PBC, Advances in Second-Line Therapy

HCPLive

Kumar explains what is known about the use of PPAR agonists in primary biliary cholangitis and the significance of the recent FDA accelerated approvals of elafibranor and seladelpar.

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Nurses play key role in addressing mental well-being for people after a stroke

American Heart News - Stroke News

Statement Highlights: The latest research indicates that 16% to 85% of people recovering from a stroke experience at least one psychosocial symptom, including depression, anxiety, stress, fatigue and/or decreased quality of life. Critical nursing.

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ECG Cases 51 – Artifact and Lead Misplacement

ECG Cases

ECG artifact and lead reversal can mimic tachy-arrhythmia, infarct or Brugada. Learn how to identify these errors to prevent misdiagnosis on this month's ECG Cases with Dr. Jesse McLaren. The post ECG Cases 51 – Artifact and Lead Misplacement appeared first on Emergency Medicine Cases.

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Tiny killers: How autoantibodies attack the heart in lupus patients

Medical Xpress - Cardiology

Cardiovascular disease is the leading cause of death in patients suffering from lupus, an autoimmune disease in which our immune system attacks our own tissues and organs, the heart, blood, lung, joints, brain, and skin. Lupus myocarditis—inflammation of the heart muscle—can be very serious because the inflammation alters the regularity of the rhythm and strength of the heartbeat.

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Direct Oral Penicillin Challenge Effective Among Those with Penicillin Allergies

HCPLive

This analysis evaluated the long-term follow-up and risks linked to the self-reported penicillin allergy persistence after a successful oral penicillin challenge and allergy label removal.

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Nurses play key role in addressing mental well-being for people after a stroke

Science Daily - Heart Disease

The latest research indicates that 16% to 85% of people recovering from a stroke experience at least one psychosocial symptom, including depression, anxiety, stress, fatigue and/or decreased quality of life. Critical nursing interventions, such as regular mental health screenings, education, symptom management and follow-up care, are key to reducing the negative effects on a patient's mental well-being after a stroke, yet only a small proportion of patients receive treatment.

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Researchers Hit the Road to Learn Why CVD and COPD Are Rampant in the Rural South

Med Page Today

(MedPage Today) -- Darrell Dixon's father was just 25 when he had a major heart attack in the rural Mississippi Delta. By his early 40s, a series of additional attacks had left his heart muscle too weak to pump enough blood to his body. He died.

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Study finds constipation is a significant risk factor for major cardiac events

Medical Xpress - Cardiology

An international study led by Monash University researchers has found a surprising connection between constipation and an increased risk of major adverse cardiac events (MACE), including heart attacks, strokes and heart failure.

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Cardiovascular Event Risk Increases in Year After Statin Discontinuation

HCPLive

A systematic review identified a notable link between the first year of statin discontinuation and the risk of adverse cardiovascular outcomes.

Outcomes 111
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Study of pythons could lead to new therapies for heart disease, other illnesses

Science Daily - Heart Disease

In the first 24 hours after a python devours its massive prey, its heart grows bigger, softer and stronger and its metabolism speeds up forty-fold. The extraordinary process could inspire novel treatments for heart disease and metabolic disorders.

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Counseling for PAD Walking Issues Might Hold Cardiovascular Benefit

Med Page Today

(MedPage Today) -- While counseling about walking did not increase step counts for people with peripheral artery disease (PAD), it still was linked to cardiovascular prevention in a post hoc analysis of a small randomized trial. After a few sessions.

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Blood platelet score detects previously unmeasured risk of heart attack and stroke

Medical Xpress - Cardiology

Platelets are circulating cell fragments known to clump up and form blood clots that stop bleeding in injured vessels. Cardiologists have long known that platelets can become "hyperreactive" to cause abnormal clotting that blocks arteries and contributes to heart attack, stroke, and poor blood flow (peripheral artery disease) in the legs of millions of Americans.

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Study Highlights Happiness Differences in European Countries Among Dermatology Patients

HCPLive

These data highlight the necessity of equality in access to treatment and to the future development of psychological intervention measures using country-specific differences.

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High or low oxygen levels are safe during heart surgery, study finds

Science Daily - Heart Disease

A recent study explored one possible cause -- hyperoxia or high concentrations of oxygen given to such patients during surgery -- as opposed to doses more similar to air. The study concluded that hyperoxia increased oxidative stress during surgery, but this effect did not persist after surgery and did not lead to more acute kidney injury.

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Back to basics: what's going on here?

Dr. Smith's ECG Blog

Written by Pendell Meyers A man in his 70s presented with history of pacemaker presented with shortness of breath with exertion and presyncope. Here is his triage ECG with minimal symptoms: What do you think? The ECG shows pacemaker failure with inability to capture or sense, with either underlying atrial fibrillation or junctional escape rhythm. The QRS shows LVH and there are diffuse ST-T abnormalities likely in part appropriate for the LVH, though memory T waves are also a consideration.

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Positive effects of rhythm and music in brain disorder

Science Daily - Stroke

Music-based movement therapy, known as the Ronnie Gardiner Method, has the potential to contribute to rehabilitation after a stroke and in other brain disorders.

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Intensive Lipid-Lowering Therapy May Reduce MACE Risk in ACS

HCPLive

Intensive lipid-lowering treatment regimens were linked to a notable reduction in three-point MACE risk and ACS recurrence versus background statin therapy.

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Epicardial and liver fat implications in albuminuria: a retrospective study

Cardiovascular Diabetology

Albuminuria is considered an early and sensitive marker of kidney dysfunction, but also an independent cardiovascular risk factor. Considering the possible relationship among metabolic liver disease, cardiovas.

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New insights and potential treatments for pulmonary hypertension

Science Daily - Heart Disease

A new study has found that asporin, a protein encoded by the ASPN gene, plays a protective role in pulmonary arterial hypertension (PAH).

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Redefining Cardiac Involvement in Systemic Immunoglobulin AL Amyloidosis

JAMA Cardiology

This cohort study analyzes data for 560 patients newly diagnosed with systemic AL amyloidosis to assess the differences between biomarkers, echocardiography, and cardiovascular magnetic resonance with extracellular volume mapping in characterizing cardiac amyloid infiltration.

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Metabolic Risk Factors Contribute to Diabetic Macular Edema Development

HCPLive

Modifiable risk factors, including elevated HbA1C and blood pressure, were linked to a higher risk of DME development in a large multicenter database.