Ken Grauer, MD

MARCH 15, 2024

What if you were asked to interpret the ECG in Figure-1 ? How would YOU interpret the rhythm? Even without the benefit of any history — Has there been a recent MI? Figure-1: The initial ECG in today's case. ( To improve visualization — I've digitized the original ECG using PMcardio ). MY Approach to Today’s Tracing: As always — I favor beginning assessment with a quick look at the long lead rhythm strips at the bottom of the tracing.

Blog 161

Blog Arrhythmia STEMI Ischemia 161

Frontiers in Cardiovascular Medicine

MARCH 12, 2024

Cardiogenic shock (CS) is a time-sensitive and hemodynamically complex syndrome with a broad spectrum of etiologies and clinical presentations. Despite contemporary therapies, CS continues to maintain high morbidity and mortality ranging from 35 to 50%. More recently, burgeoning observational research in this field aimed at enhancing the early recognition and characterization of the shock state through standardized team-based protocols, comprehensive hemodynamic profiling, and tailored and selec

Cardiogenic Shock 145

Cardiogenic Shock Pharmacology Outcomes Research 145

American Heart News - Heart News

MARCH 14, 2024

Research Highlights: In a review of data for more than 90,000 veterans hospitalized with stroke, African American veterans who had been previously diagnosed with post-traumatic stress disorder (PTSD) were significantly more likely to be.

Hospital 130

Hospital Stroke Strokes Research 130

Med Page Today

MARCH 14, 2024

(MedPage Today) -- The American West has seen the biggest surge of cardiomyopathy-associated hospital admissions among methamphetamine users, based on 13 years of the latest available hospital admission data. The National Inpatient Sample (NIS.

Cardiomyopathy 131

Cardiomyopathy Inpatient Hospital 131

Ken Grauer, MD

MARCH 11, 2024

I was asked to interpret the 2-lead rhythm strip shown in Figure-1 — without the benefit of any history. What are YOUR thoughts? Is there AV block? If so — Is it complete AV block? Figure-1: You are asked to interpret this 2-lead rhythm strip without the benefit of any history. = NOTE: Today's rhythm is challenging — especially if you have not seen this type of rhythm before.

Blog 155

Blog Arrhythmia Tachycardia 155

Science Daily - Heart Disease

MARCH 14, 2024

It is known that large amounts of licorice cause high blood pressure. A new study now shows that even small amounts of licorice raise blood pressure. The individuals who react most strongly also show signs of strain on the heart.

Blood Pressure 127

Blood Pressure 127

HCPLive

MARCH 14, 2024

To acknowledge World Kidney Day, our latest episode of Crisis Point focuses on the stigma surrounding the use of HCV-positive donor kidneys amid the ongoing organ shortage crisis, with the perspective of a pair of experts and an HCV donor kidney recipient.

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Journal of Clinical Investigation - Cardiology

MARCH 15, 2024

Aneuploidy, a deviation from the normal chromosome copy number, is common in human embryos and is considered a primary cause of implantation failure and early pregnancy loss. Meiotic errors lead to uniformly abnormal karyotypes, while mitotic errors lead to chromosomal mosaicism: the presence of cells with at least 2 different karyotypes within an embryo.

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DAIC

MARCH 13, 2024

milla1cf Wed, 03/13/2024 - 16:52 March 13, 2024 — In the largest randomized clinical trial and first of its kind to date in the United States, a team led by investigators at Beth Israel Deaconess Medical Center (BIDMC) assessed the efficacy and safety of using a drug-coated balloon in patients undergoing coronary angioplasty. In an original investigation presented at the Cardiology Research Technology conference in Washington, D.C. and published simultaneously in JAMA , the team reports that pa

Stent 116

Stent Angioplasty Stents Myocardial Infarction 116

HCPLive

MARCH 15, 2024

On March 15, 2024, the FDA approval of fluticasone propionate nasal spray marks the first approval in agency history for treatment of chronic rhinosinusitis without nasal polyps.

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NOVARAD

MARCH 11, 2024

There's no denying it: burnout is a serious problem among physicians. Over 50% of radiologists say that they've experienced “long-term, unresolved, job-related stress leading to exhaustion, cynicism, detachment from job responsibilities, and lacking a sense of personal accomplishment.” The numbers are startling and point to the need for immediate action to address the high level of burnout among physicians.

Patient Care 111

Patient Care 111

Journal of Clinical Investigation - Cardiology

MARCH 15, 2024

As the leading cause of disability worldwide, low back pain (LBP) is recognized as a pivotal socioeconomic challenge to the aging population and is largely attributed to intervertebral disc degeneration (IVDD). Elastic nucleus pulposus (NP) tissue is essential for the maintenance of IVD structural and functional integrity. The accumulation of senescent NP cells with an inflammatory hypersecretory phenotype due to aging and other damaging factors is a distinctive hallmark of IVDD initiation and p

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DAIC

MARCH 13, 2024

Getty Images milla1cf Wed, 03/13/2024 - 16:49 March 13, 2024 — BioCardia, Inc. , a developer of cellular and cell-derived therapeutics for the treatment of cardiovascular and pulmonary diseases, today announced Centers for Medicare & Medicaid Services (CMS) approval for reimbursement coverage of the confirmatory Phase III clinical trial of CardiAMP autologous cell therapy for the treatment of patients with ischemic heart failure.

CMS 111

CMS Heart Failure Reimbursement Quality of Life 111

HCPLive

MARCH 13, 2024

In a registry-based analysis, more hospitalized children with SCD and COVID-19 had severe infection requiring supplemental oxygen, compared with the general population.

COVID-19 115

COVID-19 Sickle Cell Disease Hospital 115

Dr. Smith's ECG Blog

MARCH 9, 2024

Written by Willy Frick A 67 year old man with a history of hypertension presented with three days of chest pain radiating to his back. He had associated nausea, vomiting, and dyspnea. What do you think? This ECG together with these symptoms is certainly concerning for OMI, but the ECG is not fully diagnostic, and another consideration could be acute pericarditis.

Chest Pain 110

Chest Pain Pericarditis Aortic Echocardiogram 110

Journal of Clinical Investigation - Cardiology

MARCH 15, 2024

Radiotherapy (RT) is considered immunogenic, but clinical data demonstrating RT-induced T cell priming are scarce. Here, we show in a mouse tumor model representative of human lymphocyte–depleted cancer that RT enhanced spontaneous priming of thymus-derived (FOXP3+Helios+) Tregs by the tumor. These Tregs acquired an effector phenotype, populated the tumor, and impeded tumor control by a simultaneous, RT-induced CD8+ cytotoxic T cell (CTL) response.

Cancer 115

Cancer 115

Med Page Today

MARCH 15, 2024

(MedPage Today) -- A computerized clinical decision support (CDS) tool for primary care helped lower blood pressure (BP) in patients with chronic kidney disease (CKD) and uncontrolled hypertension, a cluster-randomized trial found. When primary.

Hypertension 116

Hypertension Kidney Disease Blood Pressure 116

HCPLive

MARCH 15, 2024

A post-hoc analysis of the Ocular Hypertension Treatment Study shows the inclusion of a PRS improved the prediction of POAG onset in patients with ocular hypertension.

Hypertension 111

Hypertension 111

Dr. Smith's ECG Blog

MARCH 14, 2024

Written by Jesse McLaren Three patients presented with acute chest pain and ECGs that were labeled by the computer as completely normal, and which was confirmed by the final cardiology interpretation (which is blinded to patient outcome) also as completely normal. What do you think? Case 1: Case 2: Case 3: Triage ECGs labeled ‘normal’ There have been a number of small studies suggesting that triage ECGs labeled ‘normal’ are unlikely to have clinical significance, and therefore that emergency phy

Chest Pain 107

Chest Pain STEMI Outcomes Academic 107

DAIC

MARCH 15, 2024

milla1cf Fri, 03/15/2024 - 08:56 March 15, 2024 — BioCardia, Inc. , a biotechnology company focused on advancing late-stage cell therapy interventions for cardiovascular disorders, and StemCardia, Inc. , a biotechnology company focused on cell and gene therapy to re-muscularize the failing heart, today announced a long-term partnership to advance StemCardia’s investigational pluripotent stem cell product candidate for the treatment of heart failure.

Heart Failure 105

Heart Failure 105

Med Page Today

MARCH 13, 2024

(MedPage Today) -- Note that some links may require registration or subscription. These types of medications don't mix well with driving, the FDA warned. About 11% of high school seniors reported using delta-8-tetrahydrocannabinol (delta-8-THC.

Heart attacks 111

Heart attacks Heart Attack 111

Frontiers in Cardiovascular Medicine

MARCH 12, 2024

Cardiovascular mortality is still excessively high, despite the considerable progress made in the prevention and treatment of cardiovascular diseases. Although many cardiovascular risk factors (such as arterial hypertension, hypercholesterolemia, diabetes, etc.), identified in the general population, are being promptly treated, to date little consideration is given to a cardiovascular risk factor which we believe has largely demonstrated in the scientific literature of the last three decades tha

Risk Factors 105

Risk Factors Article Cardiovascular Disease Hypertension 105

Cardiovascular Diabetology

MARCH 13, 2024

The association of the triglyceride-glucose (TyG) index with intracranial atherosclerotic stenosis (ICAS) and extracranial atherosclerotic stenosis (ECAS) is unclear. This study aimed to investigate the relati.

Stenosis 105

Stenosis Research 105

DAIC

MARCH 14, 2024

The UCLA Department of Medicine has announced that Priscilla Hsue, MD will be joining as the chief of the Division of Cardiology at UCLA, effective July 1, 2024. Hsue will come to UCLA from UC San Francisco (UCSF), where she leads a portfolio of clinical and translational studies on HIV-related cardiovascular disease and Long COVID. She is currently serving as co-director of the UCSF Center for Excellence in Vascular Research, and is a member of ImmunoX and the Cardiovascular Research Institute.

COVID-19 105

COVID-19 Cardiovascular Disease Research Atherosclerosis 105

HCPLive

MARCH 11, 2024

Patients in France with hemophilia A who switched their FVIII replacement treatment trended towards fewer bleeding events and articular non-bleeding events requiring hospitalization.

Hospital 105

Hospital 105

Journal of Clinical Investigation - Cardiology

MARCH 15, 2024

Breast cancer stem cells (BCSCs) mitigate oxidative stress to maintain their viability and plasticity. However, the regulatory mechanism of oxidative stress in BCSCs remains unclear. We recently found that the histone reader ZMYND8 was upregulated in BCSCs. Here, we showed that ZMYND8 reduced ROS and iron to inhibit ferroptosis in aldehyde dehydrogenase–high (ALDHhi) BCSCs, leading to BCSC expansion and tumor initiation in mice.

Cancer 105

Cancer 105

Med Page Today

MARCH 13, 2024

(MedPage Today) -- Liraglutide (Victoza), a type 2 diabetes drug, may help prevent peripheral artery disease (PAD) progression, the small, open-label STARDUST trial suggested. Over 6 months, adults with type 2 diabetes on subcutaneous liraglutide.

Peripheral Arterial Disease 111

Peripheral Arterial Disease Diabetes 111

Cardiomatics

MARCH 15, 2024

The quality of the ECG signal is an important factor affecting the accuracy of analysis and proper interpretation, particularly for long-term ECG monitoring such as with Holter monitors or ECG patch devices. Misinterpretation can lead to a wrong diagnosis and consequently the selection of inappropriate treatment. The purpose of this article is to discuss possible ways of improving the quality of ECG signals in order to obtain more reliable results.

Technology 98

Technology Best Practices Electrocardiogram Heart Rhythm 98

HCPLive

MARCH 11, 2024

Baseline kidney function, AKD severity, and post-AKD kidney function were identified as important factors for predicting outcomes in patients with acute kidney injury requiring dialysis.

Outcomes 105

Outcomes 105

Journal of Clinical Investigation - Cardiology

MARCH 15, 2024

Virus-induced memory T cells often express functional cross-reactivity, or heterologous immunity, to other viruses and to allogeneic MHC molecules that is an important component of pathogenic responses to allogeneic transplants. During immune responses, antigen-reactive naive and central memory T cells proliferate in secondary lymphoid organs to achieve sufficient cell numbers to effectively respond, whereas effector memory T cell proliferation occurs directly within the peripheral inflammatory

Transplant 98

Transplant 98

DAIC

MARCH 13, 2024

Silence Therapeutics has announces positive topline 36-week data from its ongoing Phase 2 Study of Zerlasiran in patients with high Lipoprotein(a), reporting that the study met the primary endpoint and demonstrated highly significant reductions in Lp(a) to week 36. Image courtesy: Silence Therapeutics christine.book Wed, 03/13/2024 - 13:00 March 13, 2024 — Silence Therapeutics has announced positive topline 36-week data from the ongoing ALPACAR-360 phase 2 study of zerlasiran ( SLN360 ) in 178 s

Cardiovascular Disease 98

Cardiovascular Disease Risk Factors Cholesterol Heart attacks 98

Open Heart

MARCH 15, 2024

Aim Anakinra, an anti IL-1 agent targeting IL-1 alfa and beta, is available for the treatment of recurrent pericarditis in cases with corticosteroid dependence and colchicine resistance after failure of conventional therapies. However, it is unclear if the combination with colchicine, a non-specific inhibitor of the inflammasome targeting the same inflammatory pathway of IL-1, could provide additional benefit to prevent further recurrences.

Pericarditis 96

Pericarditis 96

HCPLive

MARCH 14, 2024

In a landmark decision, the FDA has granted accelerated approval to resmetirom (Rezdiffra) for noncirrhotic NASH with moderate to advanced fibrosis.

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116

Journal of Clinical Investigation - Cardiology

MARCH 15, 2024

Uncontrolled accumulation of extracellular matrix leads to tissue fibrosis and loss of organ function. We previously demonstrated in vitro that the DNA/RNA-binding protein fused in sarcoma (FUS) promotes fibrotic responses by translocating to the nucleus, where it initiates collagen gene transcription. However, it is still not known whether FUS is profibrotic in vivo and whether preventing its nuclear translocation might inhibit development of fibrosis following injury.

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98

Science Daily - Heart Disease

MARCH 14, 2024

Managing circadian rhythms through intense light and chronologically timed therapy can help prevent or treat a variety of circulatory system conditions including heart disease, according to a new study.

Heart Disease 99

Heart Disease 99

Med Page Today

MARCH 9, 2024

(MedPage Today) -- TTHealthWatch is a weekly podcast from Texas Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine in Baltimore, and Rick Lange, MD, president of the Texas Tech University Health Sciences Center.

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105

HCPLive

MARCH 10, 2024

In a phase 3 trial that featured approximately half of participants with skin of color, tapinarof cream 1.0% provided consistent benefit for patients identified as White, Black, or Asian.

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