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Circulation, Ahead of Print. The Physical Activity Guidelines for Americans supports sitting less and moving more. Growing evidence suggests that a waking behavior profile with less sedentary behavior and more light-intensity physical activity is associated with more favorable cardiovascular health. Remarkably, little is known about how these behaviors relate to cardiovascular health during pregnancy.
Nature Reviews Cardiology, Published online: 07 April 2025; doi:10.1038/s41569-025-01145-y To regenerate the injured heart, cardiomyocytes must proliferate to replace lost myocardial tissue, but this capacity is largely absent in adult mammals. In this Review, Koopmans and van Rooij explore the key pathways that drive cardiomyocyte maturation after birth and how targeted manipulation might reactivate the cell cycle in adult cardiomyocytes.
New research has uncovered a surprising culprit underlying cardiovascular diseases in obesity and diabetes -- not the presence of certain fats, but their suppression. The study challenges the conventional belief that a type of fat called ceramides accumulates in blood vessels causing inflammation and health risks. Instead, their findings reveal that when ceramides decrease in endothelial cells lining blood vessels, it can be damaging and cause chronic illnesses.
More than heart disease or cancer, dementia is the primary concern for many of the patients I see. Heart disease and cancer attack your body, but dementia attacks your mind and identity. It strips away the fabric of who a person is. That is why I believe people fear dementia so much. Thankfully, 45% of all dementia is preventable 1. Many factors make up that 45%, but one factor seems to impact the risk of dementia the most.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Circulation, Ahead of Print. Populations most affected by cardiovascular health disparities, including underrepresented populations with lower socioeconomic status, people with disabilities, and those living in underserved rural communities, are disproportionately exposed to adverse social determinants of health. Specifically, economic instability and suboptimal living conditions within the neighborhood and built environment directly determine access to resources and opportunities for healthful
Background Kuwait, one of the world’s hottest countries, faces increasing temperatures due to climate change. With a large migrant population predominantly employed in physically demanding jobs, the exact effects and burdens of temperature exposure on cardiovascular risk among this population remain unknown. This study aimed to investigate the relationship between temperature and myocardial infarction (MI) risk among migrants in Kuwait.
Casting doubt on value based cardiac care, a JAMA study found that outpatient cardiology practices enrolled in an accountable care organization (ACO) through the Medicare Shared Savings Program (MSSP) dont offer better care than non-ACO practices. MSSP was introduced in 2012 to improve care quality and lower Medicare costs by having ACOs assume responsibility for Medicare beneficiaries costs and care quality.
Casting doubt on value based cardiac care, a JAMA study found that outpatient cardiology practices enrolled in an accountable care organization (ACO) through the Medicare Shared Savings Program (MSSP) dont offer better care than non-ACO practices. MSSP was introduced in 2012 to improve care quality and lower Medicare costs by having ACOs assume responsibility for Medicare beneficiaries costs and care quality.
ObjectiveTo compare the image quality, radiation dose, and examination time between non-electrocardiogram (ECG)-gated coronary CT angiography (ECG-less CCTA) and conventional ECG-gated CCTA using wide-detector CT, and validate its clinical applicability.MethodsIn this prospective study, 109 patients with suspected coronary artery disease were divided into ECG-less (Group A, n=59) and ECG-gated (Group B, n=50) groups.
tim.hodson Mon, 04/07/2025 - 16:15 April 4, 2025 Viz.ai has been named an Award Winner in the 2025 Edison Awards, for the third year in a row. Viz HCM, the companys AI software solution designed to detect and triage patients with signs of hypertrophic cardiomyopathy (HCM), was recognized in the Health Medical & Biotech category and Cardiovascular Health Diagnostics and Monitoring subcategory.
Background Heart failure (HF) guidelines recommend routine testing for iron deficiency (ID) and, for those with ID, intravenous iron if the left ventricular ejection fraction is <50%. Guideline adherence to these recommendations by cardiologists in China is unknown. Methods and results An independent academic web-based survey was designed and distributed via social networks to cardiologists across China.
Expanding the potential patient population for pulsed field ablation, results from the SINGLE SHOT CHAMPION study suggest PFA might be just as good as cryoballoon ablation for patients with paroxysmal AFib. Paroxysmal atrial fibrillation is a type of AFib that causes short, intermittent episodes of irregular and rapid heartbeats originating in the atria.
Unlike mammals, zebrafish can regenerate their heart after cardiac insult. There are several ways to perform cardiac injury in zebrafish, but cryoinjury most closely resembles human myocardial infarction (MI). Studies demonstrated that macrophages are essential cells from the beginning to later stages of cardiac injury throughout the regenerative process in zebrafish.
(MedPage Today) -- SAN DIEGO -- New data explored the potential beneficial impact that glucagon-like peptide-1 (GLP-1) receptor agonists may have on neurodegenerative diseases. In a plenary session at the annual American Academy of Neurology.
Since the first implementation in 2002 by Alain Cribier, transcatheter aortic valve replacement (TAVR) has become a standard procedure for high-risk and elderly patients with severe aortic valve stenosis. Recently, the use of TAVR has expanded to relatively younger patients with low to moderate surgical risk. Infective endocarditis (IE) after TAVR, first reported in medical literature in 2010, is a relatively new and extremely concerning complication. 1 Its incidence, reported as 1.1% per person
Objective Pulsed-field ablation (PFA) is a new technology of catheter ablation for atrial fibrillation (AF). This research is to investigate the feasibility of a new strategy (transoesophageal echocardiography-guided pulsed field ablation, TEEP) to guide PFA for AF with no contrast and zero fluoroscopy. Methods Patients with AF underwent TEEP under general anaesthesia with the guidance of three-dimensional (3D) transoesophageal echocardiography (TEE) throughout the procedure.
With the global impact of cardiovascular disease, there is a dire need to understand the mechanisms in the heart during injury and stress. It has been shown that the regulation of the extracellular matrix via cardiac fibroblasts plays a major role in the progression of heart failure and worsening function of the heart. Importantly, it has been suggested that crosstalk between other cardiac cells like cardiomyocytes, immune cells, and endothelial cells are influenced by the pathological function
(MedPage Today) -- As measles continues to spread through vulnerable communities in the U.S., HHS Secretary Robert F. Kennedy Jr. has suggested that there are long-term health benefits to contracting the virus, despite decades of data that suggest.
‘Real knowledge is to know the extent of one’s ignorance ’ Confucius This editorial refers to ‘Gaps in knowledge and management of iron deficiency in heart failure: a nationwide survey of cardiologists in China’, by Su et al. 1 Over the last 25 years, an accumulation of data has highlighted the prevalence of iron deficiency and the value of its correction in patients with heart failure and reduced (HFrEF) or mildly reduced ejection fraction (HFmrEF).
tim.hodson Wed, 04/09/2025 - 14:38 April 9, 2025 Idorsia Ltd recently announced that the US Food & Drug Administration (FDA), after having released Tryvio from its REMS (Risk Evaluation and Mitigation Strategy) requirement ( announced March 17, 2025 ), has now approved the updated label for Tryvio(aprocitentan). Tryvio is Idorsias dual endothelin receptor antagonist (ERA) indicated for the treatment of systemic hypertension in combination with other antihypertensives to lower blood pressure in
ObjectiveAdvanced glycation end-products (AGEs) may contribute to the pathogenesis of atherosclerotic cardiovascular disease (ASCVD), potentially influencing its development and progression differently at various life stages. This study aimed to elucidate the associations between AGEs and the risk of ASCVD across different age groups.MethodsIn this cross-sectional study, 1,240 subjects were enrolled and divided into three groups (Group , 2039 years old, n=468; Group , 4059 years old, n=471; Grou
(MedPage Today) -- Comorbidities in midlife were associated with a modestly higher risk of cancer overall and more strongly associated with a risk for multiple individual cancer types, according to a secondary analysis of the prospective Prostate.
Objective To validate the prognostic utility of peak creatine kinase-myocardial band isoenzyme (CK-MB) level, left ventricular posterior wall diameter (LVPWD), and a score model for successful weaning from mechanical circulatory support (MCS) in fulminant myocarditis (FM). Furthermore, the severity of the histological data was stratified, and its relationship with the clinical findings was investigated.
Cardio-kidney metabolic (CKM) syndrome represents a complex and circular interplay of cardiovascular, renal, and metabolic dysfunctions, significantly contributing to global morbidity and mortality. This expert opinion synthesizes insights from a panel of Italian specialists in cardiology, nephrology, and diabetology, advocating for a holistic and integrated framework for CKM management.
Prof. David Luria (left), Director of Electrophysiology at Hadassah Medical Center, and Ziv Menshes (right), CEO of CardioVia tim.hodson Tue, 04/08/2025 - 14:38 April 7, 2025 CardioVia, a medical device company specializing in advanced cardiac care solutions, has received U.S. Food and Drug Administration (FDA) clearance for its ViaOne system. This device is designed to enable safe and precise access to the hearts surface (pericardial space) for both diagnostic and therapeutic interventions wi
"Our medical language is filled with negativity and dehumanization." Dr. Colleen Christmas, Johns Hopkins University School of Medicine. Why doctors need to stop using words that hurt patients.
The International Journal of Cardiovascular Sciences (IJCS) is seeking a volunteer Assistant Editor to support the Editor-in-Chief in the journal’s editorial activities. This is an excellent opportunity for early-career individuals in the cardiovascular health field who wish to develop editorial skills and contribute to the advancement of science in this area, as well as engage in the journals outreach activities.
Arteria lusoria (AL), an anomaly of the right subclavian artery, occurs in 2% of individuals and can cause symptoms such as dysphagia due to its retroesophageal course. Often associated with Kommerell's diverticulum (KD), a dilation at the artery's origin, this condition poses risks of rupture or dissection. Symptomatic cases and aneurysms necessitate surgical intervention, while asymptomatic cases may warrant observation.
(MedPage Today) -- People taking medications for attention deficit-hyperactivity disorder (ADHD) showed small changes to their cardiovascular metrics -- and it wasn't just the stimulants to watch out for, a systematic review suggested. Based.
Most people have right-dominant heartswhich to a doctor or a researcher means they have an artery that extends from the right side of their hearts to supply oxygenated blood to the back side. For some people, this artery, called the posterior descending artery, comes from the left side or from both directions. A study has found that the gene CXCL12 is connected to this artery's formation and that its directional pattern is set very early in human development.
Hypertension, Ahead of Print. BACKGROUND:Aberrant BMPR2 (bone morphogenetic protein receptor 2) signaling is associated with the pathogenesis of pulmonary hypertension. SMAD4 is an essential downstream effector of BMPR2 signaling, but whether and how it participates in pulmonary hypertension are unclear.METHODS:Globally and vascular cell-specifically inducible knockout mouse models were used to examine the role of SMAD4 deficiency in differential cell compartments in the development of pulmonary
Stroke, Ahead of Print. BACKGROUND:The National Institutes of Health Stroke Scale is used globally to rate neurological deficits in patients with acute stroke. Originally designed for research use, the scale uses idiosyncratic scoring rules and requires thorough training for proper use. Currently available training and certification systems are timeworn and limited in the range of demonstrated neurological findings.
Researchers have developed an AI tool that creates synthetic yet medically accurate models of fibrotic heart tissue (heart scarring), aiding treatment planning for atrial fibrillation (AF) patients. The study could lead to more personalized care for patients affected by this common heart rhythm disorder.
(MedPage Today) -- The link between narcolepsy and cardiovascular disease (CVD) was strengthened by new evidence that the relationship applied to subclinical disease and was apparent early in life, based on a retrospective cohort study. Across.
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