Sat.Jun 01, 2024 - Fri.Jun 07, 2024

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Live Updates from the FDA Psychopharmacologic Advisory Committee Meeting on MDMA for PTSD

HCPLive

Follow HCPLive's coverage of the full-day FDA committee meeting regarding Lykos Therapeutics' application for MDMA-assisted therapy as a novel treatment for patients with PTSD.

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Population shifts, risk factors may triple U.S. cardiovascular disease costs by 2050

American Heart News - Heart News

Embargoed until 4 a.m. CT/5 a.m. ET Tuesday, June 4, 2024 DALLAS, June 4, 2024 — Driven by an older, more diverse population, along with a significant increase in risk factors including high blood pressure and obesity, total costs related to.

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ECG #433 — Which Lead Convinced Me?

Ken Grauer, MD

The ECG in Figure-1 was obtained from a previously healthy older man — who presented to the ED ( E mergency D epartment ) with new but atypical CP ( C hest P ain ) for several hours. QUESTIONS: Given this history — How would YOU interpret this ECG? Which lead is the most concerning? Figure-1: The initial ECG in today's case. ( To improve visualization — I've digitized the original ECG using PMcardio ).

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Sugar Substitute Linked to Heart, Thrombotic Risk

Med Page Today

(MedPage Today) -- The popular low-calorie sweetener xylitol was linked to increased cardiovascular and thrombotic risk, a series of experiments showed. Metabolomic studies linked xylitol intake to higher risk for major adverse cardiovascular.

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61% of US adults will have cardiovascular disease by 2050, American Heart Association says

Becker's Hospital Review - Cardiology

A majority of adults in the U.S. — around 61% — are likely to be diagnosed with a form of cardiovascular disease by 2050, according to new American Heart Association data. The increased burden will cost the U.S. health system $1.8 trillion in the time frame.

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Women with excess weight as a teen or young adult may have higher stroke risk by age 55

American Heart News - Stroke News

Research Highlights: Women with excess weight at age 14 or 31 may have increased ischemic (clot caused) stroke risk before age 55. The same ischemic stroke risk was not found in men. Losing excess weight after adolescence may not eliminate the stroke.

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Judite Blanc, PhD: VR on Maternal Stress, Sleep Reduction in Women of Color

HCPLive

During SLEEP 2024, Judite Blanc, PhD, discussed her team’s ongoing study assessing whether an education VR program improves maternal stress and sleep among women of color.

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Normal angiogram one week prior. Must be myocarditis then?

Dr. Smith's ECG Blog

Written by Magnus Nossen The patient in todays case is a 50 year old male. He has a medical hx notable for hypertension, hyperlipidemia and previous tobacco use disorder. The patient presented due to chest pain that was typical in nature, retrosternal and radiating to the left arm and neck. He denied any exertional chest pain. The below ECG was recorded.

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Population shifts, risk factors may triple U.S. cardiovascular disease costs by 2050

Science Daily - Heart Disease

Driven by an older, more diverse population, along with a significant increase in risk factors including high blood pressure and obesity, total costs related to cardiovascular disease (CVD) conditions are likely to triple by 2050, according to recent projections. At least 6 in 10 U.S. adults (61%), more than 184 million people, are expected to have some type of CVD within the next 30 years, reflecting a disease prevalence that will have a $1.8 trillion price tag in direct and indirect costs.

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Moral injury in cardiac misdiagnosis

Heart Sisters

Moral injury is “the distressing psychological, behavioral, social, and sometimes spiritual aftermath of our exposure to serious stress and trauma”

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Quick Test Helps Detect Dementia

Med Page Today

(MedPage Today) -- A quick cognitive assessment tool helped improve dementia-related care in primary care patients, a randomized controlled trial showed. Compared with standard care, the 5-Cog system tripled the odds that a patient would receive.

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Persistent Insomnia Symptoms Linked to a Greater Depression Risk

HCPLive

A study presented at SLEEP 2024 found persistent or progressive insomnia symptoms are linked to a greater depression risk than subthreshold cases with gradual improvement.

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IgG hexamers initiate complement-dependent acute lung injury

Journal of Clinical Investigation - Cardiology

Antibodies can initiate lung injury in a variety of disease states such as autoimmunity, in reactions to transfusions, or after organ transplantation, but the key factors determining in vivo pathogenicity of injury-inducing antibodies are unclear. Harmful antibodies often activate the complement cascade. A model for how IgG antibodies trigger complement activation involves interactions between IgG Fc domains driving the assembly of IgG hexamer structures that activate C1 complexes.

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Landmark Clinical Study in The Lancet Finds New AI Technology Can Predict Cardiac Events Due to Coronary Inflammation at Least 10 Years in Advance

DAIC

Caristo Diagnostics Limited has announced the results of a landmark clinical study published in The Lancet that support the ability of Caristo's CaRi-Heart AI technology to quantify coronary artery inflammation and accurately predict cardiac events. Image courtesy: Caristo Diagnostics christine.book Tue, 06/04/2024 - 10:00 June 4, 2024 — Caristo Diagnostics Limited , a global provider of cardiovascular disease diagnostics and risk prediction, has announced the results of a landmark clinical stud

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Most Heart Disease Deaths Still Occur in Cold Weather, but Heat Is a Growing Problem

Med Page Today

(MedPage Today) -- Around the world, cardiovascular deaths associated with cold temperatures vastly outnumbered those from the heat, though high temperature-related deaths gained steam in recent years. From 2000 to 2019, based on daily cardiovascular.

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Bruce Sands, MD: Phase 3 Treat-Through Data for Mirikizumab in Crohn’s Disease

HCPLive

Sands reviews key findings from the phase 3 VIVID-1 study of mirikizumab in Crohn’s disease presented at DDW.

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Regenerating damaged heart cells in mice

Science Daily - Heart Disease

Scientists have discovered a way to regenerate damaged heart muscle cells in mice, a development which may provide a new avenue for treating congenital heart defects in children and heart attack damage in adults, according to a new study.

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Bridging the Gap: Enhancing Stroke Recovery Through Digital Health Solutions

DAIC

Stroke recovery is a challenging process that extends for months after hospital discharge. Issues like cognitive impairment and social determinants of health (SDOH) hurdles often go unrecognized until patients are home. To improve outcomes and be in compliance with new regulations, it's crucial to better identify and address these issues during the recovery period.

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NR2E3 loss disrupts photoreceptor cell maturation and fate in human organoid models of retinal development

Journal of Clinical Investigation - Cardiology

While dysfunction and death of light-detecting photoreceptor cells underlie most inherited retinal dystrophies, knowledge of the species-specific details of human rod and cone photoreceptor cell development remains limited. Here, we generated retinal organoids carrying retinal disease–causing variants in NR2E3, as well as isogenic and unrelated controls.

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High-Impact Chronic Pain in Sickle Cell Linked to Poor Health Outcomes

HCPLive

High-impact chronic pain is a severely affected subgroup in SCD and is associated with greater pain burden and worse health outcomes.

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Bariatric Surgery Linked With Lower Mortality vs GLP-1 Drugs in Study, but.

Med Page Today

(MedPage Today) -- For people with obesity and diabetes, bariatric metabolic surgery was associated with a greater reduction in mortality compared with first-generation GLP-1 receptor agonists if the individuals had their diabetes for a decade.

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BioCardia Announces United States Patent Issuance on Intramyocardial Delivery of Cell Aggregates to the Heart Including Minimally Invasive Radial Artery Approach

DAIC

milla1cf Fri, 06/07/2024 - 14:55 June 7, 2024 — BioCardia, Inc. , a company focused on cellular and cell-derived therapeutics for the treatment of cardiovascular and pulmonary diseases, announced that the Unites States Patent Office has granted Patent No: 11,986,611 titled “Radial and Transendocardial Delivery Catheter,” with a patent term that will expire in 2036.

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Sugar substitute linked to increased risk of heart attack and stroke, study finds

Science Daily - Heart Disease

Researchers found higher amounts of the sugar alcohol xylitol are associated with increased risk of cardiovascular events like heart attack and stroke. The team confirmed the association in a large-scale patient analysis, preclinical research models and a clinical intervention study.

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Chest pain with serial ECGs – can you guess the sequence?

Dr. Smith's ECG Blog

Written by Jesse McLaren A 45-year-old presented with 24 hours of intermittent chest pain. Below are serial ECGs focusing on the inferior leads and aVL. Can you guess the sequence? First, what’s the interpretation of each ECG on its own? #1 There’s T wave inversion in III/aVF and a taller T wave in aVL and V2. On it’s own this is nonspecific, but in the right context this could be diagonal occlusion (if active chest pain) or infero-posterior reperfusion (if resolved chest pain). #2 Normal ECG #3

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Hypertension After Kidney Donation; Statins in Old and Very Old People

Med Page Today

(MedPage Today) -- TTHealthWatch is a weekly podcast from Texas Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine in Baltimore, and Rick Lange, MD, president of the Texas Tech University Health Sciences Center.

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New Data for Medtronic CoreValve/Evolut TAVR Systems Reinforces Excellent Valve Performance

DAIC

milla1cf Fri, 06/07/2024 - 14:50 June 7, 2024 — Medtronic today announced new data from the CoreValve Evolut Clinical Program , reinforcing the positive performance of the Evolut transcatheter aortic valve replacement (TAVR) System compared to surgical aortic valve replacement (SAVR) and other TAVR valves. Two analyses were presented as late-breaking data at the New York Valves Structural Heart Summit, including a secondary analysis of the SMall Annuli Randomized To Evolut or SAPIEN (SMART

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How does oxygen depletion disrupt memory formation in the brain?

Science Daily - Stroke

When we learn something new, our brain cells (neurons) communicate with each other through electrical and chemical signals. If the same group of neurons communicate together often, the connections between them get stronger. This process helps our brains learn and remember things and is known as long-term potentiation or LTP. Another type of LTP occurs when the brain is deprived of oxygen temporarily -- anoxia-induced long-term potentiationor aLTP. aLTP blocks the former process, thereby impairin

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DanGer Shock: Microaxial Flow Pump versus Standard Care in Infarct-Related Cardiogenic Shock

Cardiology Update

The DanShock trial (NCT01633502) assessed the efficacy of the Impella CP ventricular assist device in reducing mortality following myocardial infarction (MI). The Impella CP is a catheter-based axial flow pump that directly channels blood from the left ventricle into the circulation, delivering 3.5L/min (approximately 75% of normal cardiac output). Investigators randomized 360 patients to receive either a microaxial flow pump plus standard of care (SOC) (n=179) or SOC alone (n=176).

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Naim Alkhouri, MD: Resmetirom Has Been a “Game Changer” in MASH Since FDA Approval

HCPLive

Alkhouri explains the unmet need in MASH leading up to resmetirom’s historic FDA approval and the impact its availability has had for both patients and clinicians.

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American Society of Echocardiography Scientific Sessions ASE 2024 Program Highlights

DAIC

June 4, 2024 — The countdown has begun ahead of the American Society of Echocardiography 35th Annual ASE Scientific Sessions, June 14-26, at the Oregon Convention Center in Portland, OR. This year’s program, “Global Echocardiography: Innovations in Diagnosis and Beyond,” is described as an educational experience gathering global experts and enthusiasts in echocardiography, hosted by the largest global organization for cardiovascular ultrasound imaging serving physicians, sonographers, nurses, a

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Increased Heart Risks With Newer Prostate Cancer Drugs, Meta-Analysis Shows

Med Page Today

(MedPage Today) -- The addition of androgen receptor signaling inhibitors (ARSIs) alongside standard androgen deprivation therapy (ADT) in advanced prostate cancer was associated with a significantly increased risk of adverse heart events, a systematic.

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Higher blood pressure is associated with poorer cognition in adolescence

Science Daily - Heart Disease

Adolescents with elevated blood pressure and arterial stiffness may experience poorer cognitive functions, according to a recent study. Young people with higher blood pressure performed worse, especially in tasks that measured attention and learning. In addition, arterial stiffness was reflected in weaker working memory. In view of the findings, the importance of preventing high blood pressure and arterial stiffness in childhood and adolescence is emphasized.

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Lourdes DelRosso, MD, PhD: Goals, Insights from the “Count on Sleep” OSA Project

HCPLive

In an interview with HCPLive, DelRosso spoke about the 1-year plans of the "Count on Sleep" OSA project.

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HonorHealth Research Institute First in Southwest to Implant New Stroke Prevention Stent

DAIC

milla1cf Tue, 06/04/2024 - 20:51 June 4, 2024 — A patient at HonorHealth Research Institute is one of the nation’s first — and the first in Arizona and the Southwest — to undergo a non-surgical, catheter-based procedure with a new type of stroke-prevention stent that eliminates blockages in neck arteries that could potentially cause a deadly stoke by depriving the brain of oxygen.

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New telehealth stroke certification available to health care professionals

American Heart News - Stroke News

DALLAS, date, 2024 — Significant barriers prevent or slow treatment for many patients with stroke, including long travel times to stroke center hospitals and the lack of availability of stroke specialists who can evaluate the patient and determine if.

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Protein discovery could help prevent cancer treatment-related heart damage

Science Daily - Heart Disease

Blocking a protein known as CDK7 could prevent heart damage associated with a commonly used cancer chemotherapy medication, according to a new study. Importantly, the researchers also found that inhibiting CDK7 could help enhance the medication's cancer-killing capability. Based on an animal model, the study findings could provide a foundation for future treatment strategies to reduce chemotherapy-related heart toxicity and increase treatment effectiveness.

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Study Suggests COPD Preventative Measures Needed During Seasonal Virus Circulations

HCPLive

These data indicate the benefits of implementing individual protective measures in winter by patients with COPD.