Sat.Jun 01, 2024 - Fri.Jun 07, 2024

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Live Updates from the FDA Psychopharmacologic Advisory Committee Meeting on MDMA for PTSD

HCPLive

Follow HCPLive's coverage of the full-day FDA committee meeting regarding Lykos Therapeutics' application for MDMA-assisted therapy as a novel treatment for patients with PTSD.

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Population shifts, risk factors may triple U.S. cardiovascular disease costs by 2050

American Heart News - Heart News

Embargoed until 4 a.m. CT/5 a.m. ET Tuesday, June 4, 2024 DALLAS, June 4, 2024 — Driven by an older, more diverse population, along with a significant increase in risk factors including high blood pressure and obesity, total costs related to.

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Sugar Substitute Linked to Heart, Thrombotic Risk

Med Page Today

(MedPage Today) -- The popular low-calorie sweetener xylitol was linked to increased cardiovascular and thrombotic risk, a series of experiments showed. Metabolomic studies linked xylitol intake to higher risk for major adverse cardiovascular.

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ECG #433 — Which Lead Convinced Me?

Ken Grauer, MD

The ECG in Figure-1 was obtained from a previously healthy older man — who presented to the ED ( E mergency D epartment ) with new but atypical CP ( C hest P ain ) for several hours. QUESTIONS: Given this history — How would YOU interpret this ECG? Which lead is the most concerning? Figure-1: The initial ECG in today's case. ( To improve visualization — I've digitized the original ECG using PMcardio ).

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61% of US adults will have cardiovascular disease by 2050, American Heart Association says

Becker's Hospital Review - Cardiology

A majority of adults in the U.S. — around 61% — are likely to be diagnosed with a form of cardiovascular disease by 2050, according to new American Heart Association data. The increased burden will cost the U.S. health system $1.8 trillion in the time frame.

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Population shifts, risk factors may triple U.S. cardiovascular disease costs by 2050

Science Daily - Heart Disease

Driven by an older, more diverse population, along with a significant increase in risk factors including high blood pressure and obesity, total costs related to cardiovascular disease (CVD) conditions are likely to triple by 2050, according to recent projections. At least 6 in 10 U.S. adults (61%), more than 184 million people, are expected to have some type of CVD within the next 30 years, reflecting a disease prevalence that will have a $1.8 trillion price tag in direct and indirect costs.

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Better Cognitive Outcomes Tied to Vigorous Exercise in Hypertensive Adults

Med Page Today

(MedPage Today) -- Vigorous exercise appeared to preserve cognitive function in older adults with hypertension, a post hoc analysis of SPRINT MIND trial data showed. At least one vigorous physical activity session per week reduced the risk of.

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Judite Blanc, PhD: VR on Maternal Stress, Sleep Reduction in Women of Color

HCPLive

During SLEEP 2024, Judite Blanc, PhD, discussed her team’s ongoing study assessing whether an education VR program improves maternal stress and sleep among women of color.

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Regenerating damaged heart cells in mice

Science Daily - Heart Disease

Scientists have discovered a way to regenerate damaged heart muscle cells in mice, a development which may provide a new avenue for treating congenital heart defects in children and heart attack damage in adults, according to a new study.

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Quick Test Helps Detect Dementia

Med Page Today

(MedPage Today) -- A quick cognitive assessment tool helped improve dementia-related care in primary care patients, a randomized controlled trial showed. Compared with standard care, the 5-Cog system tripled the odds that a patient would receive.

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Women with excess weight as a teen or young adult may have higher stroke risk by age 55

American Heart News - Stroke News

Research Highlights: Women with excess weight at age 14 or 31 may have increased ischemic (clot caused) stroke risk before age 55. The same ischemic stroke risk was not found in men. Losing excess weight after adolescence may not eliminate the stroke.

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Persistent Insomnia Symptoms Linked to a Greater Depression Risk

HCPLive

A study presented at SLEEP 2024 found persistent or progressive insomnia symptoms are linked to a greater depression risk than subthreshold cases with gradual improvement.

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Landmark Clinical Study in The Lancet Finds New AI Technology Can Predict Cardiac Events Due to Coronary Inflammation at Least 10 Years in Advance

DAIC

Caristo Diagnostics Limited has announced the results of a landmark clinical study published in The Lancet that support the ability of Caristo's CaRi-Heart AI technology to quantify coronary artery inflammation and accurately predict cardiac events. Image courtesy: Caristo Diagnostics christine.book Tue, 06/04/2024 - 10:00 June 4, 2024 — Caristo Diagnostics Limited , a global provider of cardiovascular disease diagnostics and risk prediction, has announced the results of a landmark clinical stud

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Most Heart Disease Deaths Still Occur in Cold Weather, but Heat Is a Growing Problem

Med Page Today

(MedPage Today) -- Around the world, cardiovascular deaths associated with cold temperatures vastly outnumbered those from the heat, though high temperature-related deaths gained steam in recent years. From 2000 to 2019, based on daily cardiovascular.

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Sugar substitute linked to increased risk of heart attack and stroke, study finds

Science Daily - Heart Disease

Researchers found higher amounts of the sugar alcohol xylitol are associated with increased risk of cardiovascular events like heart attack and stroke. The team confirmed the association in a large-scale patient analysis, preclinical research models and a clinical intervention study.

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DanGer Shock: Microaxial Flow Pump versus Standard Care in Infarct-Related Cardiogenic Shock

Cardiology Update

The DanShock trial (NCT01633502) assessed the efficacy of the Impella CP ventricular assist device in reducing mortality following myocardial infarction (MI). The Impella CP is a catheter-based axial flow pump that directly channels blood from the left ventricle into the circulation, delivering 3.5L/min (approximately 75% of normal cardiac output). Investigators randomized 360 patients to receive either a microaxial flow pump plus standard of care (SOC) (n=179) or SOC alone (n=176).

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Bridging the Gap: Enhancing Stroke Recovery Through Digital Health Solutions

DAIC

Stroke recovery is a challenging process that extends for months after hospital discharge. Issues like cognitive impairment and social determinants of health (SDOH) hurdles often go unrecognized until patients are home. To improve outcomes and be in compliance with new regulations, it's crucial to better identify and address these issues during the recovery period.

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Hypertension After Kidney Donation; Statins in Old and Very Old People

Med Page Today

(MedPage Today) -- TTHealthWatch is a weekly podcast from Texas Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine in Baltimore, and Rick Lange, MD, president of the Texas Tech University Health Sciences Center.

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Higher blood pressure is associated with poorer cognition in adolescence

Science Daily - Heart Disease

Adolescents with elevated blood pressure and arterial stiffness may experience poorer cognitive functions, according to a recent study. Young people with higher blood pressure performed worse, especially in tasks that measured attention and learning. In addition, arterial stiffness was reflected in weaker working memory. In view of the findings, the importance of preventing high blood pressure and arterial stiffness in childhood and adolescence is emphasized.

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How does oxygen depletion disrupt memory formation in the brain?

Science Daily - Stroke

When we learn something new, our brain cells (neurons) communicate with each other through electrical and chemical signals. If the same group of neurons communicate together often, the connections between them get stronger. This process helps our brains learn and remember things and is known as long-term potentiation or LTP. Another type of LTP occurs when the brain is deprived of oxygen temporarily -- anoxia-induced long-term potentiationor aLTP. aLTP blocks the former process, thereby impairin

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New Data for Medtronic CoreValve/Evolut TAVR Systems Reinforces Excellent Valve Performance

DAIC

milla1cf Fri, 06/07/2024 - 14:50 June 7, 2024 — Medtronic today announced new data from the CoreValve Evolut Clinical Program , reinforcing the positive performance of the Evolut transcatheter aortic valve replacement (TAVR) System compared to surgical aortic valve replacement (SAVR) and other TAVR valves. Two analyses were presented as late-breaking data at the New York Valves Structural Heart Summit, including a secondary analysis of the SMall Annuli Randomized To Evolut or SAPIEN (SMART

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Bariatric Surgery Linked With Lower Mortality vs GLP-1 Drugs in Study, but.

Med Page Today

(MedPage Today) -- For people with obesity and diabetes, bariatric metabolic surgery was associated with a greater reduction in mortality compared with first-generation GLP-1 receptor agonists if the individuals had their diabetes for a decade.

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Protein discovery could help prevent cancer treatment-related heart damage

Science Daily - Heart Disease

Blocking a protein known as CDK7 could prevent heart damage associated with a commonly used cancer chemotherapy medication, according to a new study. Importantly, the researchers also found that inhibiting CDK7 could help enhance the medication's cancer-killing capability. Based on an animal model, the study findings could provide a foundation for future treatment strategies to reduce chemotherapy-related heart toxicity and increase treatment effectiveness.

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Normal angiogram one week prior. Must be myocarditis then?

Dr. Smith's ECG Blog

Written by Magnus Nossen The patient in todays case is a 50 year old male. He has a medical hx notable for hypertension, hyperlipidemia and previous tobacco use disorder. The patient presented due to chest pain that was typical in nature, retrosternal and radiating to the left arm and neck. He denied any exertional chest pain. The below ECG was recorded.

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HonorHealth Research Institute First in Southwest to Implant New Stroke Prevention Stent

DAIC

milla1cf Tue, 06/04/2024 - 20:51 June 4, 2024 — A patient at HonorHealth Research Institute is one of the nation’s first — and the first in Arizona and the Southwest — to undergo a non-surgical, catheter-based procedure with a new type of stroke-prevention stent that eliminates blockages in neck arteries that could potentially cause a deadly stoke by depriving the brain of oxygen.

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Increased Heart Risks With Newer Prostate Cancer Drugs, Meta-Analysis Shows

Med Page Today

(MedPage Today) -- The addition of androgen receptor signaling inhibitors (ARSIs) alongside standard androgen deprivation therapy (ADT) in advanced prostate cancer was associated with a significantly increased risk of adverse heart events, a systematic.

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Women with excess weight as a teen or young adult may have higher stroke risk by age 55

Science Daily - Heart Disease

Women with excess weight at age 14 or 31 may have increased ischemic (clot caused) stroke risk before age 55. The same ischemic stroke risk was not found in men. Losing excess weight after adolescence may not eliminate the stroke risk.

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Naim Alkhouri, MD: Resmetirom Has Been a “Game Changer” in MASH Since FDA Approval

HCPLive

Alkhouri explains the unmet need in MASH leading up to resmetirom’s historic FDA approval and the impact its availability has had for both patients and clinicians.

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American Society of Echocardiography Scientific Sessions ASE 2024 Program Highlights

DAIC

June 4, 2024 — The countdown has begun ahead of the American Society of Echocardiography 35th Annual ASE Scientific Sessions, June 14-26, at the Oregon Convention Center in Portland, OR. This year’s program, “Global Echocardiography: Innovations in Diagnosis and Beyond,” is described as an educational experience gathering global experts and enthusiasts in echocardiography, hosted by the largest global organization for cardiovascular ultrasound imaging serving physicians, sonographers, nurses, a

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Brain-Protected TAVR Results in Fewer Real-World Disabling Strokes

Med Page Today

(MedPage Today) -- NEW YORK CITY -- Researchers eked out evidence of a small clinical benefit with the Sentinel cerebral embolic protection (CEP) device in transcatheter aortic valve replacement (TAVR) -- and pointed to the patients more likely.

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Moral injury in cardiac misdiagnosis

Heart Sisters

Moral injury is “the distressing psychological, behavioral, social, and sometimes spiritual aftermath of our exposure to serious stress and trauma”

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Study reveals how 'forever chemicals' may impact heart health in older women

Science Daily - Heart Disease

New research has linked multiple types of per- and polyfluoroalkyl substances (PFAS, also known as 'forever chemicals') with increased risk of cardiovascular diseases in postmenopausal women. Specifically, the study reveals how PFAS chemicals interact with pro-inflammatory pathways in older women, providing potential explanations for the increased risk.

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In Memoriam: Stuart J. Connolly, MD

DAIC

June 7, 2024 — It is with great sadness that the Diagnostic and Interventional Cardiology (DAIC) team has learned of the passing of arrhythmia medicine pioneer Stuart J. Connolly, MD, on June 2. According to his obituary published in the Hamilton Spectator, he completed a Bachelor of Philosophy at McGill University, then a Master of Philosophy at Fordham University, then returned to McGill where he graduated from medical school in 1977.

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Search for Missing Doctor; Energy Drinks and Sudden Death; Unusual Pandemic Cancers

Med Page Today

(MedPage Today) -- Note that some links may require registration or subscription. Concern is growing as Greek authorities continue to search for Michael Mosley, MD, a British weight-loss doctor and television personality who went missing Wednesday.

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Italy’s Pioneering Push for Telemedicine. Supported by AI

Cardiomatics

Italy is pioneering a push for telemedicine and home care in cardiology with the application of groundbreaking new regulation that took effect in January 2024. This is radically simplifying the patient pathway for Electrocardiogram (ECG) tests. As a result, innovative service providers are growing rapidly by leveraging integrated remote monitoring solutions to provide ECGs via extensive pharmacy networks.

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Type 2 cannabinoid receptor expression on microglial cells regulates neuroinflammation during graft-versus-host disease

Journal of Clinical Investigation - Cardiology

Neuroinflammation is a recognized complication of immunotherapeutic approaches such as immune checkpoint inhibitor treatment, chimeric antigen receptor therapy, and graft versus host disease (GVHD) occurring after allogeneic hematopoietic stem cell transplantation. While T cells and inflammatory cytokines play a role in this process, the precise interplay between the adaptive and innate arms of the immune system that propagates inflammation in the central nervous system remains incompletely unde

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Edwards Lifesciences to Sell Critical Care to BD

DAIC

Getty Images milla1cf Wed, 06/05/2024 - 20:33 June 5, 2024 — Edwards Lifesciences announced it has entered into a definitive agreement to sell its Critical Care product group to BD (Becton, Dickinson and Company), in an all-cash transaction valued at $4.2 billion. With this agreement, Edwards is no longer pursuing the previously announced spin-off of Critical Care.