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Follow HCPLive's coverage of the full-day FDA committee meeting regarding Lykos Therapeutics' application for MDMA-assisted therapy as a novel treatment for patients with PTSD.
Embargoed until 4 a.m. CT/5 a.m. ET Tuesday, June 4, 2024 DALLAS, June 4, 2024 — Driven by an older, more diverse population, along with a significant increase in risk factors including high blood pressure and obesity, total costs related to.
(MedPage Today) -- The popular low-calorie sweetener xylitol was linked to increased cardiovascular and thrombotic risk, a series of experiments showed. Metabolomic studies linked xylitol intake to higher risk for major adverse cardiovascular.
Driven by an older, more diverse population, along with a significant increase in risk factors including high blood pressure and obesity, total costs related to cardiovascular disease (CVD) conditions are likely to triple by 2050, according to recent projections. At least 6 in 10 U.S. adults (61%), more than 184 million people, are expected to have some type of CVD within the next 30 years, reflecting a disease prevalence that will have a $1.8 trillion price tag in direct and indirect costs.
Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
The ECG in Figure-1 was obtained from a previously healthy older man — who presented to the ED ( E mergency D epartment ) with new but atypical CP ( C hest P ain ) for several hours. QUESTIONS: Given this history — How would YOU interpret this ECG? Which lead is the most concerning? Figure-1: The initial ECG in today's case. ( To improve visualization — I've digitized the original ECG using PMcardio ).
(MedPage Today) -- Vigorous exercise appeared to preserve cognitive function in older adults with hypertension, a post hoc analysis of SPRINT MIND trial data showed. At least one vigorous physical activity session per week reduced the risk of.
(MedPage Today) -- Vigorous exercise appeared to preserve cognitive function in older adults with hypertension, a post hoc analysis of SPRINT MIND trial data showed. At least one vigorous physical activity session per week reduced the risk of.
Research Highlights: Women with excess weight at age 14 or 31 may have increased ischemic (clot caused) stroke risk before age 55. The same ischemic stroke risk was not found in men. Losing excess weight after adolescence may not eliminate the stroke.
A majority of adults in the U.S. — around 61% — are likely to be diagnosed with a form of cardiovascular disease by 2050, according to new American Heart Association data. The increased burden will cost the U.S. health system $1.8 trillion in the time frame.
Written by Magnus Nossen The patient in todays case is a 50 year old male. He has a medical hx notable for hypertension, hyperlipidemia and previous tobacco use disorder. The patient presented due to chest pain that was typical in nature, retrosternal and radiating to the left arm and neck. He denied any exertional chest pain. The below ECG was recorded.
(MedPage Today) -- A quick cognitive assessment tool helped improve dementia-related care in primary care patients, a randomized controlled trial showed. Compared with standard care, the 5-Cog system tripled the odds that a patient would receive.
Adolescents with elevated blood pressure and arterial stiffness may experience poorer cognitive functions, according to a recent study. Young people with higher blood pressure performed worse, especially in tasks that measured attention and learning. In addition, arterial stiffness was reflected in weaker working memory. In view of the findings, the importance of preventing high blood pressure and arterial stiffness in childhood and adolescence is emphasized.
During SLEEP 2024, Judite Blanc, PhD, discussed her team’s ongoing study assessing whether an education VR program improves maternal stress and sleep among women of color.
When we learn something new, our brain cells (neurons) communicate with each other through electrical and chemical signals. If the same group of neurons communicate together often, the connections between them get stronger. This process helps our brains learn and remember things and is known as long-term potentiation or LTP. Another type of LTP occurs when the brain is deprived of oxygen temporarily -- anoxia-induced long-term potentiationor aLTP. aLTP blocks the former process, thereby impairin
Antibodies can initiate lung injury in a variety of disease states such as autoimmunity, in reactions to transfusions, or after organ transplantation, but the key factors determining in vivo pathogenicity of injury-inducing antibodies are unclear. Harmful antibodies often activate the complement cascade. A model for how IgG antibodies trigger complement activation involves interactions between IgG Fc domains driving the assembly of IgG hexamer structures that activate C1 complexes.
Scientists have discovered a way to regenerate damaged heart muscle cells in mice, a development which may provide a new avenue for treating congenital heart defects in children and heart attack damage in adults, according to a new study.
A study presented at SLEEP 2024 found persistent or progressive insomnia symptoms are linked to a greater depression risk than subthreshold cases with gradual improvement.
For survivors of strokes, regaining fine motor skills is critical for recovering independence and quality of life. But getting intensive, frequent rehabilitation therapy can be challenging and expensive. Now, researchers are developing a new technology that could allow stroke patients to undergo rehabilitation exercises at home by tracking their wrist movements through a simple setup: a smartphone strapped to the forearm and a low-cost gaming controller called the Novint Falcon.
DALLAS, date, 2024 — Significant barriers prevent or slow treatment for many patients with stroke, including long travel times to stroke center hospitals and the lack of availability of stroke specialists who can evaluate the patient and determine if.
Blocking a protein known as CDK7 could prevent heart damage associated with a commonly used cancer chemotherapy medication, according to a new study. Importantly, the researchers also found that inhibiting CDK7 could help enhance the medication's cancer-killing capability. Based on an animal model, the study findings could provide a foundation for future treatment strategies to reduce chemotherapy-related heart toxicity and increase treatment effectiveness.
Caristo Diagnostics Limited has announced the results of a landmark clinical study published in The Lancet that support the ability of Caristo's CaRi-Heart AI technology to quantify coronary artery inflammation and accurately predict cardiac events. Image courtesy: Caristo Diagnostics christine.book Tue, 06/04/2024 - 10:00 June 4, 2024 — Caristo Diagnostics Limited , a global provider of cardiovascular disease diagnostics and risk prediction, has announced the results of a landmark clinical stud
(MedPage Today) -- Around the world, cardiovascular deaths associated with cold temperatures vastly outnumbered those from the heat, though high temperature-related deaths gained steam in recent years. From 2000 to 2019, based on daily cardiovascular.
Women with excess weight at age 14 or 31 may have increased ischemic (clot caused) stroke risk before age 55. The same ischemic stroke risk was not found in men. Losing excess weight after adolescence may not eliminate the stroke risk.
Stroke recovery is a challenging process that extends for months after hospital discharge. Issues like cognitive impairment and social determinants of health (SDOH) hurdles often go unrecognized until patients are home. To improve outcomes and be in compliance with new regulations, it's crucial to better identify and address these issues during the recovery period.
(MedPage Today) -- TTHealthWatch is a weekly podcast from Texas Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine in Baltimore, and Rick Lange, MD, president of the Texas Tech University Health Sciences Center.
Written by Jesse McLaren A 45-year-old presented with 24 hours of intermittent chest pain. Below are serial ECGs focusing on the inferior leads and aVL. Can you guess the sequence? First, what’s the interpretation of each ECG on its own? #1 There’s T wave inversion in III/aVF and a taller T wave in aVL and V2. On it’s own this is nonspecific, but in the right context this could be diagonal occlusion (if active chest pain) or infero-posterior reperfusion (if resolved chest pain). #2 Normal ECG #3
Researchers found higher amounts of the sugar alcohol xylitol are associated with increased risk of cardiovascular events like heart attack and stroke. The team confirmed the association in a large-scale patient analysis, preclinical research models and a clinical intervention study.
While dysfunction and death of light-detecting photoreceptor cells underlie most inherited retinal dystrophies, knowledge of the species-specific details of human rod and cone photoreceptor cell development remains limited. Here, we generated retinal organoids carrying retinal disease–causing variants in NR2E3, as well as isogenic and unrelated controls.
(MedPage Today) -- For people with obesity and diabetes, bariatric metabolic surgery was associated with a greater reduction in mortality compared with first-generation GLP-1 receptor agonists if the individuals had their diabetes for a decade.
milla1cf Fri, 06/07/2024 - 14:55 June 7, 2024 — BioCardia, Inc. , a company focused on cellular and cell-derived therapeutics for the treatment of cardiovascular and pulmonary diseases, announced that the Unites States Patent Office has granted Patent No: 11,986,611 titled “Radial and Transendocardial Delivery Catheter,” with a patent term that will expire in 2036.
The DanShock trial (NCT01633502) assessed the efficacy of the Impella CP ventricular assist device in reducing mortality following myocardial infarction (MI). The Impella CP is a catheter-based axial flow pump that directly channels blood from the left ventricle into the circulation, delivering 3.5L/min (approximately 75% of normal cardiac output). Investigators randomized 360 patients to receive either a microaxial flow pump plus standard of care (SOC) (n=179) or SOC alone (n=176).
(MedPage Today) -- The addition of androgen receptor signaling inhibitors (ARSIs) alongside standard androgen deprivation therapy (ADT) in advanced prostate cancer was associated with a significantly increased risk of adverse heart events, a systematic.
New research has linked multiple types of per- and polyfluoroalkyl substances (PFAS, also known as 'forever chemicals') with increased risk of cardiovascular diseases in postmenopausal women. Specifically, the study reveals how PFAS chemicals interact with pro-inflammatory pathways in older women, providing potential explanations for the increased risk.
milla1cf Fri, 06/07/2024 - 14:50 June 7, 2024 — Medtronic today announced new data from the CoreValve Evolut Clinical Program , reinforcing the positive performance of the Evolut transcatheter aortic valve replacement (TAVR) System compared to surgical aortic valve replacement (SAVR) and other TAVR valves. Two analyses were presented as late-breaking data at the New York Valves Structural Heart Summit, including a secondary analysis of the SMall Annuli Randomized To Evolut or SAPIEN (SMART
Alkhouri explains the unmet need in MASH leading up to resmetirom’s historic FDA approval and the impact its availability has had for both patients and clinicians.
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