Sat.Jul 27, 2024 - Fri.Aug 02, 2024

article thumbnail

Study identifies 18 proteins linked to heart failure, frailty

Medical Xpress - Cardiology

An analysis of blood samples from thousands of study participants, led by researchers at UT Southwestern Medical Center, revealed 18 proteins associated with both heart failure and frailty, conditions that commonly develop in late life. Their findings, published in JAMA Cardiology, could lead to new strategies to jointly predict risk, administer preventive approaches, or treat these conditions, which often occur together.

article thumbnail

Meningeal lymphatic CGRP signaling governs pain via cerebrospinal fluid efflux and neuroinflammation in migraine models

Journal of Clinical Investigation - Cardiology

Recently developed antimigraine therapeutics targeting calcitonin gene–related peptide (CGRP) signaling are effective, though their sites of activity remain elusive. Notably, the lymphatic vasculature is responsive to CGRP signaling, but whether meningeal lymphatic vessels (MLVs) contribute to migraine pathophysiology is unknown. Mice with lymphatic vasculature deficient in the CGRP receptor (CalcrliLEC mice) treated with nitroglycerin-mediated (NTG-mediated) chronic migraine exhibit reduced pai

137
137
article thumbnail

How Good Is Wegovy's Heart Benefit?

Med Page Today

(MedPage Today) -- This story is the first in a series called "Ozempic: Weighing the Risks and Benefits." It was produced in part through a grant from the NIHCM Foundation. When the final results of the SELECT trial were reported last fall, investigators.

130
130
article thumbnail

Survey Details General Public's Eroding Trust Level with Healthcare After COVID-19

HCPLive

Trust in physicians and hospitals dropped from over 70% in 2020 to under 50% in 2024, with declines seen across all demographics, a new survey shows.

COVID-19 140
article thumbnail

Rapid and Accurate Prediction Model for Cardiac Arrest Treatment

DAIC

R-EDByUS score features variables using only prehospital resuscitation data. Image courtesy of Takenobu Shimada, Osaka Metropolitan University (CC BY 4.0, [link] mtaschetta-millane Mon, 07/29/2024 - 09:09 July 29, 2024 — When it comes to treating cardiac arrest, acting quickly can mean the difference between life and death. Researchers from Osaka Metropolitan University have developed a new scoring model, using only prehospital resuscitation data, that accurately predicts neurological outcomes o

article thumbnail

Why skipping breakfast can be bad for your heart

Medical Xpress - Cardiology

Some say that breakfast is the most important meal of the day. Is it really? That's up for debate. However, skipping the first meal is not the healthiest choice and can even put someone at risk for health issues. In this Mayo Clinic Minute, Dr. Francisco Lopez-Jimenez, a Mayo Clinic cardiologist, explains why.

112
112
article thumbnail

Dementia Risk Linked With Processed Red Meat

Med Page Today

(MedPage Today) -- PHILADELPHIA -- Eating two servings of processed red meat a week over decades raised the odds of subsequent dementia, a prospective study of 130,000 healthcare professionals showed. Over up to 43 years of follow-up, participants.

Dementia 130

More Trending

article thumbnail

Risks of anxiety, suicide attempt may rise significantly after cardiovascular hospitalization

American Heart News - Heart News

Research Highlights: In this study, people hospitalized with heart disease, stroke or other cardiovascular diseases were 83% more likely to be diagnosed with a psychiatric disorder, such as anxiety and depression, and had a higher risk of suicide.

Hospital 116
article thumbnail

Anterior OMI. What does the angiogram show?

Dr. Smith's ECG Blog

Written by Willy Frick A 50 year old man with no medical history presented with acute onset substernal chest pain. His ECG is shown below. Pretty obvious anterior current of injury. This was a machine read STEMI positive OMI. Readers of this blog can easily appreciate the hyperacute T waves in the precordium, clearest in V1-V4. What would you guess is the culprit artery?

STEMI 112
article thumbnail

Expert Panel: Target These 14 Factors to Cut Dementia Incidence by Nearly Half

Med Page Today

(MedPage Today) -- PHILADELPHIA -- The Lancet Commission on dementia prevention, intervention, and care has raised the number of modifiable risk factors definitively linked to cognitive loss to 14, based on research conducted since its last update.

Dementia 126
article thumbnail

Connections between obesity and heart failure

Science Daily - Heart Disease

A new small study has revealed the impact of obesity on muscle structure in patients having a form of heart failure called heart failure with a preserved ejection fraction (HFpEF).

article thumbnail

Vaping Low Nicotine (<5%) Linked to Acute Compensatory Puffing

HCPLive

A new study found using e-cigarettes with partial nicotine reduction was linked to greater puffing time, puff duration, and total inhaled volume than 5% nicotine concentration.

111
111
article thumbnail

University Hospitals Researcher Develops New Score System to Better Screen and Treat HFpEF Heart Failure Patients

DAIC

mtaschetta-millane Wed, 07/31/2024 - 06:00 July 31, 2024 — A novel study co-authored by a heart failure cardiologist at University Hospitals Harrington Heart & Vascular Institute, demonstrates the effectiveness of a newly developed scoring system in identifying patients with Heart Failure with Preserved Ejection Fraction (HFpEF). The study, “ An Evidence-Based Screening Tool for Heart Failure with Preserved Ejection Fraction: The HFpEF-ABA Score ," was published in the July 12 issue of Natur

article thumbnail

These Metals in Urine Predict Heart Disease and Death

Med Page Today

(MedPage Today) -- Traces of non-essential and essential metals in urine were associated with increased risk of cardiovascular disease (CVD) and all-cause mortality, according to the largest epidemiological study on the topic to date. Based on.

article thumbnail

Researcher develops new score system to better screen and treat HFpEF heart failure patients

Medical Xpress - Cardiology

A novel study co-authored by a heart failure cardiologist at University Hospitals Harrington Heart & Vascular Institute demonstrates the effectiveness of a newly developed scoring system in identifying patients with Heart Failure with Preserved Ejection Fraction (HFpEF). The study, titled "An Evidence-Based Screening Tool for Heart Failure with Preserved Ejection Fraction: The HFpEF-ABA Score," was published in Nature Medicine.

article thumbnail

Androgen aggravates aortic aneurysms via suppression of PD-1 in mice

Journal of Clinical Investigation - Cardiology

Androgen has long been recognized for its pivotal role in the sexual dimorphism of cardiovascular diseases, including aortic aneurysms (AAs), a devastating vascular disease with a higher prevalence and fatality rate in men than in women. However, the mechanism by which androgen mediates AAs is largely unknown. Here, we found that male, not female, mice developed AAs when exposed to aldosterone and high salt (Aldo-salt).

Aneurysm 109
article thumbnail

Kidney Dysfunction May Predict Sudden Cardiac Death in Patients with Heart Failure

DAIC

This study by Fujita Health University researchers revealed that kidney function, considered in terms of estimated glomerular filtration rate (eGFR), can be used as a predictor for SCD in patients with congestive heart failure. Image courtesy of Yoshihiro Sobue from Fujita Health University mtaschetta-millane Tue, 07/30/2024 - 09:18 July 30, 2024 — Patients with congestive heart failure (CHF) having a compromised blood supply, are at greater risk of sudden cardiac death (SCD).

article thumbnail

Statin Use Linked to Higher Risk of Glaucoma

Med Page Today

(MedPage Today) -- Statin use was associated with a higher likelihood of glaucoma in adults with hyperlipidemia, even those whose "bad" cholesterol was at optimal levels, according to a cross-sectional, population-based study. Among over 79,000.

article thumbnail

Boston Children's performs elective partial heart transplant

Becker's Hospital Review - Cardiology

Discover the groundbreaking work of Boston Children's cardiac surgeons as they perform the first elective partial heart transplant on a 4-year-old boy

article thumbnail

People Aged > 30 Years Report Inadequate Knowledge Towards Gouty Arthritis

HCPLive

Although half of participants strongly agreed that gouty arthritis is painful and can cause anxiety, only 15.28% agreed on the importance of dietary intake as a means for prevention.

109
109
article thumbnail

CorVascular’s VasoGuard Earns FDA 510(k) Clearance

DAIC

mtaschetta-millane Mon, 07/29/2024 - 09:16 July 29, 2024 — CorVascular , a leading producer of peripheral arterial disease (PAD) / peripheral vascular disease (PVD) testing devices, today announced the U.S. Food and Drug Administration (FDA) has cleared its VasoGuard V-Series as Class II medical devices. The clearance allows CorVascular to immediately begin marketing and selling the devices to clinics, hospitals, and teaching institutions across the country, expanding access to diagnostic testi

article thumbnail

Hint of Alzheimer's Benefit Seen With GLP-1 Drug

Med Page Today

(MedPage Today) -- PHILADELPHIA -- A GLP-1 receptor agonist may have the ability to protect cognition in people with mild Alzheimer's dementia, data from the phase IIb ELAD trial suggested. Liraglutide (Saxenda, Victoza) showed benefit on one.

Dementia 112
article thumbnail

Are cardiovascular risk factors linked to migraine?

Science Daily - Heart Disease

Having high blood pressure, specifically high diastolic blood pressure, was linked to a slightly higher odds of ever having migraine in female participants, according to a new study. Diastolic pressure is when the heart is resting between beats. However, the study did not find an increased risk between other cardiovascular risk factors and migraine.

article thumbnail

Fathers with Type 1 Diabetes May Be More Likely to Pass on Disease than Mothers

HCPLive

An analysis of more than 11,000 people with T1D found people were more likely to report an affected father than an affected mother.

Diabetes 124
article thumbnail

Heart Rhythm Society’s HRX 2024 to Draw Cardiovascular Innovators to Atlanta

DAIC

The Heart Rhythm Society (HRS) is preparing for HRX 2024, the third annual event of its kind, which will be held from September 5-7, 2024, in Atlanta, GA, gathering cardiovascular health innovators together to explore discoveries and advance partnerships between medicine and technology. christine.book Tue, 07/30/2024 - 14:20 July 30, 2024 — The Heart Rhythm Society ( HRS ) is preparing for HRX 2024 , bringing cardiovascular health innovators to Georgia's capital.

article thumbnail

Midlife Blood Biomarkers Predict Late-Life Dementia

Med Page Today

(MedPage Today) -- PHILADELPHIA -- Blood biomarkers specific to Alzheimer's disease -- specifically, amyloid-beta 42/40 ratios and measures of phosphorylated tau 181 (p-tau181) -- had a relationship with subsequent dementia that started in.

Dementia 109
article thumbnail

Everyday activities aren't enough to protect against stroke

Science Daily - Stroke

Research shows that the physical activities we do as we go about our lives, at work or in the home, aren't enough to protect us from having a stroke. However, exercising in our free time and using active modes of transport are associated with a decreased risk of stroke.

Stroke 103
article thumbnail

FDA Approves Paliperidone Palmitate for Schizophrenia, Schizoaffective Disorder

HCPLive

This extended-release injectable suspension for schizophrenia and schizoaffective disorder is approved as a monotherapy and as an adjunct to mood stabilizers or antidepressants.

103
103
article thumbnail

Magenta Medical, Developer of World’s Smallest Heart Pump, Closes $105M Financing Round

DAIC

Magenta Medical, developer of Elevate, the world's smallest heart pump, has closed a $105M financing round led by global healthcare investment firm Novo Holdings. Funding will support Magenta's clinical programs in support of FDA approval for Elevate, described as the world's smallest heart pump, according to a statement issued by the company, led by CEO Dr.

article thumbnail

Alzheimer's Biomarkers Show Tantalizing Hint at Utility for Tracking Prevention

Med Page Today

(MedPage Today) -- PHILADELPHIA -- Blood tests for Alzheimer's disease biomarkers may not only be useful for clinical diagnosis but could also make it possible to test preventive therapies in people not yet showing any signs of the condition.

article thumbnail

Top medication spend for cardiopulmonary drugs

Becker's Hospital Review - Cardiology

Cardiopulmonary medications made up 5.08% of pharmacy program participants' drug spend from April 2023 to March 2024, according to Vizient's "Summer 2024 Pharmacy Market Outlook" report.

99
article thumbnail

FDA Grants Cytisinicline Breakthrough Therapy Designation for Vaping Dependence

HCPLive

This designation was based on the ORCA-V1 trial’s phase 2 findings indicating that cytisinicline more than doubled patients’ odds of e-cigarette cessation versus placebo.

105
105
article thumbnail

BioCardia Submits for FDA Approval of Morph DNA Steerable Introducer Product Family

DAIC

mtaschetta-millane Wed, 07/31/2024 - 07:00 July 31, 2024 — BioCardia, Inc. , a developer of cellular and cell-derived therapeutics for the treatment of cardiovascular and pulmonary diseases, reported it has submitted a 510(k) for approval of its patented Morph DNA Steerable Introducer Sheath. This product family is intended to provide a pathway through which medical instruments, such as balloon dilatation catheters, guidewires, or other therapeutic devices, may be introduced into the peripheral

article thumbnail

FDA Warns of Overdoses With Compounded Semaglutide

Med Page Today

(MedPage Today) -- Overdoses, some even requiring hospitalization, have occurred due to patient and physician confusion around compounded semaglutide, the FDA detailed in an alert. Adverse events reported to the agency have ranged from gastrointestinal.

Hospital 108
article thumbnail

CHIP: a clonal odyssey of the bone marrow niche

Journal of Clinical Investigation - Cardiology

Clonal hematopoiesis of indeterminate potential (CHIP) is characterized by the selective expansion of hematopoietic stem and progenitor cells (HSPCs) carrying somatic mutations. While CHIP is typically asymptomatic, it has garnered substantial attention due to its association with the pathogenesis of multiple disease conditions, including cardiovascular disease (CVD) and hematological malignancies.

Diet 133
article thumbnail

Body Dysmorphia More Common Among Women with Dermatologic Conditions

HCPLive

These data highlight gender differences related to dysmorphic concern and the prevalence of body dysmorphic disorder among those with various dermatologic disorders.

105
105
article thumbnail

American College of Cardiology, ACC, Releases Guide to Remote Patient Management

DAIC

The American College of Cardiology has released a workbook on remote patient management (RPM), which aims to guide CV care professionals on definitions, clinical uses, benefits and limitations. Image courtesy: ACC christine.book Wed, 07/31/2024 - 13:18 July 31, 2024 — The American College of Cardiology ( ACC ) has announced its release of the ACC Remote Patient Management (RPM) Workbook , available at ACC.org/RPM , which provides guidance to the cardiovascular care team on definitions, types, cl