Sat.Sep 14, 2024 - Fri.Sep 20, 2024

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Metals in the body from pollutants associated with progression of harmful plaque buildup in the arteries

Medical Xpress - Cardiology

Metal exposure from environmental pollution is associated with increased buildup of calcium in the coronary arteries at a level that is comparable to traditional risk factors like smoking and diabetes, according to a study by Columbia University Mailman School of Public Health.

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The molecular landscape of vascular cells in the human brain

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 20 September 2024; doi:10.1038/s41569-024-01079-x A study using advanced single-cell technologies has broadened our understanding of the diversity and complexity of brain endothelial cells by uncovering new endothelial subtypes and transcriptional patterns. These findings offer insights into potential therapeutic targets and emphasize the need for further research on vascular lineages and neurovascular interactions.

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Happy with your life? Research links contentment with fewer heart attacks and strokes

American Heart News - Heart News

Research Highlights: People who are satisfied with their lives or feel contentment or well-being may be less likely to develop heart disease and stroke than their unsatisfied counterparts. The analysis of health records for more than 120,000 adults.

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A patient-led Roundtable on late, missed and misdiagnosis of heart disease in women

Heart Sisters

“These cardiac care recommendations are patient-centred and targeted towards addressing women’s specific needs and concerns.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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A transparent AI approach helps provide a more tailored cardiovascular risk assessment

Medical Xpress - Cardiology

Risk calculators are used to evaluate disease risk for millions of patients, making their accuracy crucial. But when national models are adapted for local populations, they often deteriorate, losing accuracy and interpretability.

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The gut microbiota in thrombosis

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 17 September 2024; doi:10.1038/s41569-024-01070-6 The gut microbiota has emerged as a risk factor that affects thrombotic phenotypes in several cardiovascular diseases. In this Review, Reinhardt and colleagues discuss the link between the gut microbiota, its metabolites and thromboembolic diseases, and summarize potential therapeutic interventions to modulate the gut microbiota.

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Genetic risk-factor overlap between Alzheimer's disease, and all-cause and vascular dementias

Science Daily - Stroke

Medical researchers conducted the largest-ever genome-wide association study of all-cause dementia, finding substantial genetic overlap with vascular dementia.

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Unhealthy behaviors contribute to more coronary artery disease deaths in the poor

Science Daily - Heart Disease

Lower socioeconomic status is associated with higher rates of death from coronary artery disease compared to higher socioeconomic status, and more than half of the disparities can be explained by four unhealthy behaviors, according to a new study.

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Study shows estrogen blocker treatment does not increase risk of coronary heart disease in breast cancer patients

Medical Xpress - Cardiology

New evidence shows that extended estrogen suppression treatment using aromatase inhibitors for hormone receptor-positive postmenopausal breast cancer is safe; it does not increase the risk of coronary artery calcification, a sign of active coronary atherosclerosis, as some prior studies had indicated.

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Metal Exposure Also Linked to More Coronary Artery Calcium

Med Page Today

(MedPage Today) -- Exposure to metals, essential or not, was associated with the progression of subclinical atherosclerosis, according to longitudinal data from a geographically diverse cohort. Study participants with the highest urinary metal.

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Physiology Friday #237: An Evolutionary Perspective on Why Exercise Promotes Longevity

Physiologically Speaking

Greetings! Welcome to the Physiology Friday newsletter. This week, I’m sharing one of my favorite articles I’ve ever written. I published it a few years ago, but since then have gained quite a few new subscribers. If you’re new, I hope you enjoy it for the first time. If you’re a long-time reader, I hope you re-enjoy it! I’ll be back next week with the usual coverage of a brand-new study.

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Stroke rates increasing in individuals living with SCD despite treatment guidelines

Science Daily - Heart Disease

The incidence of stroke continues to increase for adults and children living with sickle cell disease (SCD) despite the Stroke Prevention Trial in Sickle Cell Anemia (STOP) establishing standards of care like transfusions and tests to measure blood flow in the brain for those deemed high-risk, according to a new study.

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Happy with your life? Research links contentment with fewer heart attacks and strokes

Medical Xpress - Cardiology

People who are content with their lives or feel a sense of well-being may be less likely to develop heart disease and/or stroke compared to those with a lower sense of well-being, according to a new analysis published today (Sept. 18) in the Journal of the American Heart Association.

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NKT cells promote Th1 immune bias to dengue virus that governs long-term protective antibody dynamics

Journal of Clinical Investigation - Cardiology

NKT cells are innate-like T cells, recruited to the skin during viral infection, yet their contributions to long-term immune memory to viruses are unclear. We identified granzyme K, a product made by cytotoxic cells including NKT cells, as linked to induction of Th1-associated antibodies during primary dengue virus (DENV) infection in humans. We examined the role of NKT cells in vivo using DENV-infected mice lacking CD1d-dependent (CD1ddep) NKT cells.

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FDA Approves Arimoclomol, First Drug for Niemann-Pick Disease, Type C

HCPLive

Arimoclomol, in combination with miglustat, is approved to treat neurological symptoms associated with NPC in adults and children aged ≥2 years.

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Metal exposure can increase cardiovascular disease risk

Science Daily - Heart Disease

Metal exposure from environmental pollution is associated with increased calcium buildup in the coronary arteries at a level comparable to traditional risk factors, according to a new study. The findings support that metals in the body are associated with the progression of plaque buildup in the arteries and potentially provide a new strategy for managing and preventing atherosclerosis.

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Why Measuring ApoB Is The Key To Preventing Heart Disease.

Dr. Paddy Barrett

Preventing heart disease is possible. You just need to know how. To prevent heart disease, you need to know what causes it, how to measure the relevant factors and what to do about them. When we say heart disease, what we really mean is plaque in the artery wall. This Is Known As Atherosclerosis. The fundamental cause of atherosclerosis is when a cholesterol particle crosses into the artery wall from the bloodstream, gets stuck, and sets off an inflammatory process 1.

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Brain Health Risks: Digital Quality Measures and the Future of Neurological Care

Med Page Today

(MedPage Today) -- As the American Academy of Neurology's (AAN) Brain Health Summit convenes in September, it's an opportune moment to explore the future of neurology and the role that digital quality measures (dQMs) will play in the evolution.

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New Report Estimates Potential Demand of Psilocybin-Assisted Therapy for MDD

HCPLive

A report shows only 24%, 56%, and 62% of patients meet the criteria PSIL-AT for depression according to low-bound, mid-range, and upper-bound estimates, respectively.

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New guidelines urge regular screenings to prevent peripheral arterial disease complications

Science Daily - Heart Disease

An international group of cardiologists, angiologists and vascular surgeons is urging regular screening to help prevent complications in people with Peripheral Arterial Disease (PAD).

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Risk of clots, stroke from incorrect blood thinner dosing reduced using online dashboard

Science Daily - Stroke

Doctors and pharmacists treating people with blood thinners can reduce the rate of inappropriate dosing -- as well as blood clots and strokes that can result from it -- using an electronic patient management system, a study suggests. Direct oral anticoagulants can be incorrectly prescribed up to 20% of the time.

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Study suggests hypertensive people can lower risk of developing dementia by drinking coffee regularly

Medical Xpress - Cardiology

A team of public health researchers at Ningxia Medical University, in China, has found, via analysis of health record data, that some regular coffee drinkers with high blood pressure may have a lower risk of developing dementia than people who do not drink coffee. Their study is published in Scientific Reports.

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3 Cups of Coffee a Day May Reduce the Risk of New-Onset Cardiometabolic Multimorbidity

HCPLive

A new study revealed those who consume a moderate amount of coffee or caffeine had a 48.1% and 40.7% reduced risk for developing cardiometabolic multimorbidity.

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Researchers develop nanoparticle technology for targeted diagnosis and treatment of atherosclerosis

Science Daily - Heart Disease

A team developed a nanoparticle technology that offers an effective solution to diagnose and treat atherosclerosis, in a non-invasive manner. Atherosclerosis is the build-up of plaque in the arteries which causes their narrowing and is a primary cause of ischemic heart disease (IHD) and ischemic stroke (IS), major contributors to deaths caused by cardiovascular diseases globally.

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Reversible cold-induced lens opacity in a hibernator reveals a molecular target for treating cataracts

Journal of Clinical Investigation - Cardiology

Maintaining protein homeostasis (proteostasis) requires precise control of protein folding and degradation. Failure to properly respond to stresses disrupts proteostasis, which is a hallmark of many diseases, including cataracts. Hibernators are natural cold-stress adaptors; however, little is known about how they keep a balanced proteome under conditions of drastic temperature shift.

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FDA Approves Digital Health Solution for Heart Failure Management

DAIC

tim.hodson Thu, 09/19/2024 - 09:42 Sept. 18, 2024 – Astellas Pharma Inc. recently announced that Digitiva, a non-invasive digital health solution for heart failure management, has been listed with the U.S. Food and Drug Administration (FDA). Digitiva is classified as a Class I Software as a Medical Device (SaMD) and is exempt from 510(k) premarket submission*.

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Most Promising New Drugs for Hidradenitis Suppurativa, with Raj Chovatiya, MD, PhD

HCPLive

This interview with Chovatiya highlights promising therapies in the dermatology space for the treatment of patients with the skin condition HS.

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Over Half of Adults With Uncontrolled Hypertension Unaware of Their Condition

Med Page Today

(MedPage Today) -- More than half of U.S. adults with uncontrolled hypertension are unaware they have hypertension in the first place, according to a recent study in JAMA Network Open. Furthermore, more than two-thirds of those on treatment had.

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A correctable immune niche for epithelial stem cell reprogramming and post-viral lung diseases

Journal of Clinical Investigation - Cardiology

Epithelial barriers are programmed for defense and repair but are also the site of long-term structural remodeling and disease. In general, this paradigm features epithelial stem cells (ESCs) that are called on to regenerate damaged tissues but can also be reprogrammed for detrimental remodeling. Here we identified a Wfdc21-dependent monocyte-derived dendritic cell (moDC) population that functioned as an early sentinel niche for basal ESC reprogramming in mouse models of epithelial injury after

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Five ways to rethink what a 'balanced diet' means

Medical Xpress - Cardiology

Most of us probably think we have a pretty good idea of what a "balanced diet" looks like. And a lot of us may be wrong.

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Low Purine Diet Lower Uric Acid in People With Gout

HCPLive

Patients also experienced a substantial decrease in systolic blood pressure and diastolic blood pressure.

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Reconsider When a Prophylactic ICD Is Needed in Nonischemic Dilated Cardiomyopathy

Med Page Today

(MedPage Today) -- Better imaging parameters may exist for risk stratification in nonischemic dilated cardiomyopathy (NIDCM), based on a meta-analysis. The presence and extent of late gadolinium enhancement (LGE) on cardiac MRI was a significant.

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Biotronik Catheter Gets FDA Approval

DAIC

tim.hodson Mon, 09/16/2024 - 15:15 Sept. 16, 2024 — Biotronik has received U.S. Food and Drug Administration (FDA) labeling approval of its Selectra 3D catheter in conjunction with its Solia S lead for use in left bundle branch area pacing (LBBAP). The two products represent the first and only FDA-approved stylet-driven lead and dedicated delivery catheter system approved for LBBAP.

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Mild initial clinical course seen for COVID-19 vaccine-linked myocarditis

Medical Xpress - Cardiology

COVID-19 vaccine-associated myocarditis (C-VAM) has a mild initial clinical course, but myocardial injury is common, according to a study published online in the October issue of eClinicalMedicine.

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Patients With Arthritis, IBD, Experience High Rates of Long Covid Affecting QoL

HCPLive

Notably, people with fewer vaccine doses were more likely to experience post-acute sequelae of COVID-19.

COVID-19 110
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Long-term risk of heart failure in adult cancer survivors: a systematic review and meta-analysis

Heart BMJ

Background Cancer survivors are at increased risk of heart failure (HF). While cardiotoxicity is commonly sought at the time of cancer chemotherapy, HF develops as a result of multiple ‘hits’ over time, and there is limited evidence regarding the frequency and causes of HF during survivorship. Objectives This systematic review sought to investigate the relationship between cardiotoxic cancer therapies and HF during survivorship.

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