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Metal exposure from environmental pollution is associated with increased buildup of calcium in the coronary arteries at a level that is comparable to traditional risk factors like smoking and diabetes, according to a study by Columbia University Mailman School of Public Health.
Nature Reviews Cardiology, Published online: 20 September 2024; doi:10.1038/s41569-024-01079-x A study using advanced single-cell technologies has broadened our understanding of the diversity and complexity of brain endothelial cells by uncovering new endothelial subtypes and transcriptional patterns. These findings offer insights into potential therapeutic targets and emphasize the need for further research on vascular lineages and neurovascular interactions.
Research Highlights: People who are satisfied with their lives or feel contentment or well-being may be less likely to develop heart disease and stroke than their unsatisfied counterparts. The analysis of health records for more than 120,000 adults.
Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Risk calculators are used to evaluate disease risk for millions of patients, making their accuracy crucial. But when national models are adapted for local populations, they often deteriorate, losing accuracy and interpretability.
Nature Reviews Cardiology, Published online: 17 September 2024; doi:10.1038/s41569-024-01070-6 The gut microbiota has emerged as a risk factor that affects thrombotic phenotypes in several cardiovascular diseases. In this Review, Reinhardt and colleagues discuss the link between the gut microbiota, its metabolites and thromboembolic diseases, and summarize potential therapeutic interventions to modulate the gut microbiota.
By Smith, peer-reviewed by Interventional Cardiologist Emre Aslanger Submitted by anonymous A 53 y.o. male presents to the ED at 6:45 AM with left sided chest dull pressure that woke him up from sleep at 3am. The pain radiated to both shoulders. He arrived to the ED at around 6:45am, and stated the pain has persisted. He has had similar pain in recent weeks that has occurred at rest, but it typically goes away after about an hour.
By Smith, peer-reviewed by Interventional Cardiologist Emre Aslanger Submitted by anonymous A 53 y.o. male presents to the ED at 6:45 AM with left sided chest dull pressure that woke him up from sleep at 3am. The pain radiated to both shoulders. He arrived to the ED at around 6:45am, and stated the pain has persisted. He has had similar pain in recent weeks that has occurred at rest, but it typically goes away after about an hour.
Medical researchers conducted the largest-ever genome-wide association study of all-cause dementia, finding substantial genetic overlap with vascular dementia.
Lower socioeconomic status is associated with higher rates of death from coronary artery disease compared to higher socioeconomic status, and more than half of the disparities can be explained by four unhealthy behaviors, according to a new study.
New evidence shows that extended estrogen suppression treatment using aromatase inhibitors for hormone receptor-positive postmenopausal breast cancer is safe; it does not increase the risk of coronary artery calcification, a sign of active coronary atherosclerosis, as some prior studies had indicated.
(MedPage Today) -- Exposure to metals, essential or not, was associated with the progression of subclinical atherosclerosis, according to longitudinal data from a geographically diverse cohort. Study participants with the highest urinary metal.
Greetings! Welcome to the Physiology Friday newsletter. This week, I’m sharing one of my favorite articles I’ve ever written. I published it a few years ago, but since then have gained quite a few new subscribers. If you’re new, I hope you enjoy it for the first time. If you’re a long-time reader, I hope you re-enjoy it! I’ll be back next week with the usual coverage of a brand-new study.
The incidence of stroke continues to increase for adults and children living with sickle cell disease (SCD) despite the Stroke Prevention Trial in Sickle Cell Anemia (STOP) establishing standards of care like transfusions and tests to measure blood flow in the brain for those deemed high-risk, according to a new study.
People who are content with their lives or feel a sense of well-being may be less likely to develop heart disease and/or stroke compared to those with a lower sense of well-being, according to a new analysis published today (Sept. 18) in the Journal of the American Heart Association.
NKT cells are innate-like T cells, recruited to the skin during viral infection, yet their contributions to long-term immune memory to viruses are unclear. We identified granzyme K, a product made by cytotoxic cells including NKT cells, as linked to induction of Th1-associated antibodies during primary dengue virus (DENV) infection in humans. We examined the role of NKT cells in vivo using DENV-infected mice lacking CD1d-dependent (CD1ddep) NKT cells.
Metal exposure from environmental pollution is associated with increased calcium buildup in the coronary arteries at a level comparable to traditional risk factors, according to a new study. The findings support that metals in the body are associated with the progression of plaque buildup in the arteries and potentially provide a new strategy for managing and preventing atherosclerosis.
Preventing heart disease is possible. You just need to know how. To prevent heart disease, you need to know what causes it, how to measure the relevant factors and what to do about them. When we say heart disease, what we really mean is plaque in the artery wall. This Is Known As Atherosclerosis. The fundamental cause of atherosclerosis is when a cholesterol particle crosses into the artery wall from the bloodstream, gets stuck, and sets off an inflammatory process 1.
(MedPage Today) -- As the American Academy of Neurology's (AAN) Brain Health Summit convenes in September, it's an opportune moment to explore the future of neurology and the role that digital quality measures (dQMs) will play in the evolution.
A report shows only 24%, 56%, and 62% of patients meet the criteria PSIL-AT for depression according to low-bound, mid-range, and upper-bound estimates, respectively.
An international group of cardiologists, angiologists and vascular surgeons is urging regular screening to help prevent complications in people with Peripheral Arterial Disease (PAD).
Doctors and pharmacists treating people with blood thinners can reduce the rate of inappropriate dosing -- as well as blood clots and strokes that can result from it -- using an electronic patient management system, a study suggests. Direct oral anticoagulants can be incorrectly prescribed up to 20% of the time.
A team of public health researchers at Ningxia Medical University, in China, has found, via analysis of health record data, that some regular coffee drinkers with high blood pressure may have a lower risk of developing dementia than people who do not drink coffee. Their study is published in Scientific Reports.
A new study revealed those who consume a moderate amount of coffee or caffeine had a 48.1% and 40.7% reduced risk for developing cardiometabolic multimorbidity.
A team developed a nanoparticle technology that offers an effective solution to diagnose and treat atherosclerosis, in a non-invasive manner. Atherosclerosis is the build-up of plaque in the arteries which causes their narrowing and is a primary cause of ischemic heart disease (IHD) and ischemic stroke (IS), major contributors to deaths caused by cardiovascular diseases globally.
Maintaining protein homeostasis (proteostasis) requires precise control of protein folding and degradation. Failure to properly respond to stresses disrupts proteostasis, which is a hallmark of many diseases, including cataracts. Hibernators are natural cold-stress adaptors; however, little is known about how they keep a balanced proteome under conditions of drastic temperature shift.
tim.hodson Thu, 09/19/2024 - 09:42 Sept. 18, 2024 – Astellas Pharma Inc. recently announced that Digitiva, a non-invasive digital health solution for heart failure management, has been listed with the U.S. Food and Drug Administration (FDA). Digitiva is classified as a Class I Software as a Medical Device (SaMD) and is exempt from 510(k) premarket submission*.
(MedPage Today) -- More than half of U.S. adults with uncontrolled hypertension are unaware they have hypertension in the first place, according to a recent study in JAMA Network Open. Furthermore, more than two-thirds of those on treatment had.
Epithelial barriers are programmed for defense and repair but are also the site of long-term structural remodeling and disease. In general, this paradigm features epithelial stem cells (ESCs) that are called on to regenerate damaged tissues but can also be reprogrammed for detrimental remodeling. Here we identified a Wfdc21-dependent monocyte-derived dendritic cell (moDC) population that functioned as an early sentinel niche for basal ESC reprogramming in mouse models of epithelial injury after
(MedPage Today) -- Better imaging parameters may exist for risk stratification in nonischemic dilated cardiomyopathy (NIDCM), based on a meta-analysis. The presence and extent of late gadolinium enhancement (LGE) on cardiac MRI was a significant.
tim.hodson Mon, 09/16/2024 - 15:15 Sept. 16, 2024 — Biotronik has received U.S. Food and Drug Administration (FDA) labeling approval of its Selectra 3D catheter in conjunction with its Solia S lead for use in left bundle branch area pacing (LBBAP). The two products represent the first and only FDA-approved stylet-driven lead and dedicated delivery catheter system approved for LBBAP.
COVID-19 vaccine-associated myocarditis (C-VAM) has a mild initial clinical course, but myocardial injury is common, according to a study published online in the October issue of eClinicalMedicine.
Background Cancer survivors are at increased risk of heart failure (HF). While cardiotoxicity is commonly sought at the time of cancer chemotherapy, HF develops as a result of multiple ‘hits’ over time, and there is limited evidence regarding the frequency and causes of HF during survivorship. Objectives This systematic review sought to investigate the relationship between cardiotoxic cancer therapies and HF during survivorship.
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