Ken Grauer, MD

JULY 4, 2024

I was sent the ECG in Figure-1 — but without the benefit of any history. QUESTIONS: How would YOU interpret this tracing? WHY do I say there is, "A 2-Part Answer?" Figure-1: The initial ECG in today's case. ( To improve visualization — I've digitized the original ECG using PMcardio ). MY Thoughts on Today's CASE: As important as providing a brief, relevant history is for optimal clinical ECG interpretation — Cases like the one today often prove even more educational, because we are not given any

Blog 155

Blog STEMI Education Arrhythmia 155

Cardiovascular Diabetology

JUNE 30, 2024

The available evidence on the impact of specific non-pharmacological interventions on glycaemic control is currently limited. Consequently, there is a need to determine which interventions could provide the mo.

Pharmacology 144

Pharmacology Diabetes 144

Journal of Clinical Investigation - Cardiology

JULY 1, 2024

Healthy adipose tissue is essential for normal physiology. There are 2 broad types of adipose tissue depots: brown adipose tissue (BAT), which contains adipocytes poised to burn energy through thermogenesis, and white adipose tissue (WAT), which contains adipocytes that store lipids. However, within those types of adipose, adipocytes possess depot and cell-specific properties that have important implications.

Physiology 139

Physiology Obesity 139

Med Page Today

JULY 3, 2024

(MedPage Today) -- Use of the GLP-1 receptor agonist semaglutide (Ozempic, Wegovy) may be linked with an increased risk of the second most common form of optic neuropathy, a retrospective study suggested. Over a mean follow-up of nearly 3 years.

134

134

Medical Xpress - Cardiology

JULY 2, 2024

A new study sheds light on a medical question scientists have long wondered: why do 40% of children with the rare neurodevelopmental disorder KBG syndrome have heart defects? The research now points to a critical link between the heart and the brain. The research is published in the journal Nature Communications.

Research 127

Research 127

American Heart News - Heart News

JULY 1, 2024

Statement Highlights: Palliative medication management focuses on providing relief from symptoms and enhancing quality of life for people with cardiovascular disease throughout the various stages of the disease. Decisions about initiating, adjusting.

Quality of Life 131

Quality of Life Cardiovascular Disease 131

Journal of Clinical Investigation - Cardiology

JULY 1, 2024

Cardiomyocyte sarcomeres contain localized ribosomes, but the factors responsible for their localization and the significance of localized translation are unknown. Using proximity labeling, we identified ribosomal protein SA (RPSA) as a Z-line protein. In cultured cardiomyocytes, the loss of RPSA led to impaired local protein translation and reduced sarcomere integrity.

Cardiomyopathy 126

Cardiomyopathy 126

DAIC

JULY 3, 2024

Getty Images mtaschetta-millane Wed, 07/03/2024 - 10:33 July 3, 2024 — Over the past decade, 342 cardiology clinics have been acquired by private equity firms, with over 94% of those occurring between 2021 and 2023, according to a study published in JACC , the flagship journal of the American College of Cardiology , and presented at the AcademyHealth 2024 Annual Research Meeting in Baltimore.

Outpatient 116

Outpatient Innovation Research Cardiovascular Disease 116

Medical Xpress - Cardiology

JULY 2, 2024

The Mediterranean diet is a powerful ally for health even after a cancer diagnosis. This is the key result of an Italian study carried out as part of the UMBERTO Project, conducted by the Joint Research Platform Umberto Veronesi Foundation—Department of Epidemiology and Prevention of the I.R.C.C.S. Neuromed of Pozzilli, in collaboration with the LUM "Giuseppe Degennaro" University of Casamassima (BA).

Diet 108

Diet Cancer Cardiovascular Disease Research 108

American Heart News - Stroke News

JULY 2, 2024

DALLAS and MINNEAPOLIS, July 2, 2024 — The American Academy of Neurology and the American Heart Association have awarded the first-ever Ralph L. Sacco Scholarships for Brain Health to two researchers, Patrick Devlin, Ph.D., of Houston, Texas, and Cyprien.

Research 113

Research 113

Med Page Today

JULY 3, 2024

(MedPage Today) -- Inflammation in young adulthood was associated with midlife cognitive outcomes, data from the CARDIA study showed. Compared with lower stable levels of C-reactive protein (CRP), consistently higher CRP levels over 18 years led.

Outcomes 124

Outcomes 124

Nature Reviews - Cardiology

JULY 4, 2024

Nature Reviews Cardiology, Published online: 05 July 2024; doi:10.1038/s41569-024-01039-5 In this Review, Catapano and colleagues discuss the evidence supporting the LDL cumulative exposure hypothesis and how measuring cumulative LDL exposure can be used to estimate risk and contribute to the prevention of atherosclerotic cardiovascular disease.

Cardiovascular Disease 105

Cardiovascular Disease 105

Journal of Clinical Investigation - Cardiology

JULY 1, 2024

Diffuse midline glioma (DMG) H3K27-altered is one of the most malignant childhood cancers. Radiation therapy remains the only effective treatment yet provides a 5-year survival rate of only 1%. Several clinical trials have attempted to enhance radiation antitumor activity using radiosensitizing agents, although none have been successful. Given this, there is a critical need for identifying effective therapeutics to enhance radiation sensitivity for the treatment of DMG.

Pharmacology 110

Pharmacology Cancer 110

DAIC

JULY 2, 2024

From FDA approvals to new clinical trials, here is a look at DAIC's top-read content during the month of June: 1. Medtronic Launches the Avalus Ultra Valve Engineered for Ease of Use at Implant and Lifetime Patient Management 2. Landmark Clinical Study in The Lancet Finds New AI Technology Can Predict Cardiac Events Due to Coronary Inflammation at Least 10 Years in Advance 3.

Blood Pressure 105

Blood Pressure TAVR Technology Aortic 105

Med Page Today

JULY 5, 2024

(MedPage Today) -- GLP-1 receptor agonists lowered the risk of several obesity-associated cancers, a retrospective analysis of electronic health records suggested. Compared with insulin, GLP-1s were associated with a lower risk for developing.

Obesity 116

Obesity Cancer Diabetes 116

HCPLive

JUNE 30, 2024

Carol Levy, MD, discusses INHALE-3 trial and how to incorporate individual patient-level factors into the management of patients with type 1 diabetes who could benefit from inhaled insulin.

Diabetes 105

Diabetes 105

Science Daily - Heart Disease

JULY 3, 2024

Drosophila -- known as fruit flies -- are a valuable model for human heart pathophysiology, including cardiac aging and cardiomyopathy. However, a choke point in evaluating fruit fly hearts is the need for human intervention to measure the heart at moments of its largest expansion or its greatest contraction to calculate cardiac dynamics. Researchers now show a way to significantly cut the time needed for that analysis while utilizing more of the heart region, using deep learning and high-speed

Cardiomyopathy 106

Cardiomyopathy Research 106

DAIC

JULY 3, 2024

Jon Kobashigawa, MD, of the Smidt Heart Institute at Cedars-Sinai, is an expert in heart transplantation, heart failure, and other complex cardiac conditions. Photo by Cedars-Sinai. mtaschetta-millane Wed, 07/03/2024 - 10:25 July 3, 2024 — Jon Kobashigawa, MD , director of the Heart Transplant Program in the Department of Cardiology in the Smidt Heart Institute at Cedars-Sinai, has assumed the top volunteer leadership position of the American Society of Transplantation.

Transplant 105

Transplant Heart Transplant Heart Failure Education 105

Med Page Today

JULY 2, 2024

(MedPage Today) -- Over 100 batches of potassium chloride are being recalled because they are not dissolving correctly, which may lead to hyperkalemia that can ultimately cause cardiac arrhythmias and death in some cases, per an FDA alert. And.

Exercise 105

Exercise Arrhythmia 105

Heart Sisters

JUNE 30, 2024

My daughter's moving day reminded me of what I was once able to accomplish both physically and mentally when I was "in my prime". But where did my prime go? And did I notice it leaving?

Heart Disease 100

Heart Disease 100

Science Daily - Heart Disease

JULY 3, 2024

Researchers have created a questionnaire test for home use that quickly identifies high risk of heart attack. A study shows that it has the same level of accuracy as blood tests and blood pressure measurements.

Heart attacks 104

Heart attacks Heart Attack Blood Pressure Research 104

DAIC

JULY 1, 2024

Philip B. Adamson, MD, MSc, FACC, FESC, FRCP (Ed) milla1cf Mon, 07/01/2024 - 12:24 July 1, 2024 — CVRx, Inc. , a commercial-stage medical device company, announced three additions to its senior leadership team. Philip B. Adamson, MD, MSc, FACC, FESC, FRCP (Ed ) has been appointed as Chief Medical Officer, Bonnie Handke, RN, MBA will assume the role of Senior Vice President of Patient Access, Reimbursement, and Healthcare Economics, and Jennifer E.

Reimbursement 105

Reimbursement RN Heart Failure Laboratory 105

HCPLive

JULY 5, 2024

Patients with chronic tonsillitis had greater IgAN event rates than those without, and further analysis revealed chronic tonsillitis was linked to a greater risk of developing IgAN.

98

98

Open Heart

JULY 4, 2024

Background and aims The independent role of body fat distribution and fat-free mass in heart failure (HF) risk is unclear. We investigated the role of different body composition compartments in risk of HF. Methods Present analyses include 428 087 participants (mean age 55.9 years, 44% male) from the UK Biobank. Associations of long-term average levels of body composition measures with incident HF were determined using adjusted Cox proportional hazards regression models.

Heart Failure 98

Heart Failure Preserved Ejection Fraction BMI 98

Journal of Clinical Investigation - Cardiology

JULY 1, 2024

Endothelial cells (ECs) in the descending aorta are exposed to high laminar shear stress, and this supports an antiinflammatory phenotype. High laminar shear stress also induces flow-aligned cell elongation and front-rear polarity, but whether these are required for the antiinflammatory phenotype is unclear. Here, we showed that caveolin-1–rich microdomains polarize to the downstream end of ECs that are exposed to continuous high laminar flow.

98

98

Journal of Cardiothoracic Surgery

JUNE 30, 2024

In this study, we compared the analgesic effects of intercostal nerve block (ICNB), ultrasound-guided paravertebral nerve block (PVB), and epidural block (EB) following single-port thoracoscopic lung surgery.

Ultrasound 98

Ultrasound Research 98

Dr. Smith's ECG Blog

JULY 5, 2024

An older patient with no previous medical history arrived at triage complaining of SOB. Her heart rate was very fast, so we obtained an ECG immediately: ECG: What do you think? There is a regular wide complex tachycardia. The QRS morphology is RBBB with LAFB (tiny r-waves in inferior leads followed by deep S-waves; tiny q-wave in aVL followed by large R-wave; Left axis deviation).

Atrial Flutter 96

Atrial Flutter Tachycardia Atrial Fibrillation AFIB 96

HCPLive

JULY 3, 2024

Our June 2024 month-in-review includes the latest pipeline news, the impact of vision issues on public health, and expert-led insight on the latest in ophthalmology.

Public Health 98

Public Health 98

Journal of Clinical Investigation - Cardiology

JULY 1, 2024

Ubiquitination plays an essential role in protein stability, subcellular localization, and interactions. Crosstalk between different types of ubiquitination results in distinct biological outcomes for proteins. However, the role of ubiquitination-related crosstalk in lymph node (LN) metastasis and the key regulatory factors controlling this process have not been determined.

Cancer 96

Cancer Outcomes 96

Dr. Paddy Barrett

JULY 5, 2024

We do a terrible job of identifying and managing high blood pressure. We can send spacecraft across the solar system. We have managed to harness the power of the atom. And we still do an awful job of identifying and managing high blood pressure. Here’s why. And what to do about it. The Scale Of The Problem. As a risk factor for death, high blood pressure is responsible for more deaths than any other risk factor, including smoking.

Blood Pressure 94

Blood Pressure Heart attacks Heart Attack Risk Factors 94

Cardiovascular Diabetology

JULY 3, 2024

Artificial sweeteners are widely popular worldwide as substitutes for sugar or caloric sweeteners, but there are still several important unknowns and controversies regarding their associations with cardiovascu.

Cardiovascular Disease 100

Cardiovascular Disease Research 100

HCPLive

JULY 1, 2024

Across the Phase 2 ReCLAIM-2 trial, elamipretide demonstrated photoreceptor protection and the potential for visual function improvement in eyes with dry AMD.

98

98

Medical Xpress - Cardiology

JULY 2, 2024

In 2012, Neil Armstrong, the first man to walk on the moon, died of post-surgery complications at the age of 82 following what should have been a routine heart surgery. Armstrong had undergone bypass surgery, the most common open-heart operation in the United States, and a surgery where the overall chance of death has dropped to almost zero.

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96

Med Page Today

JULY 1, 2024

(MedPage Today) -- Routine ECGs for the general population had clinical utility in a study of Japan's unique health screening program, with screening results tied to subsequent health outcomes. Out of more than 3.5 million generally healthy working.

Outcomes 98

Outcomes 98

Journal of Clinical Investigation - Cardiology

JULY 1, 2024

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis (CF), a multiorgan disease that is characterized by diverse metabolic defects. However, other than specific CFTR mutations, the factors that influence disease progression and severity remain poorly understood. Aberrant metabolite levels have been reported, but whether CFTR loss itself or secondary abnormalities (infection, inflammation, malnutrition, and various treatments) drive metabolic defe

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92

HCPLive

JULY 1, 2024

A panel of ophthalmologists discuss strategies for managing AMD and DME patients who exhibit suboptimal responses to their current anti-VEGF therapy.

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95

Medical Xpress - Cardiology

JULY 1, 2024

Researchers have developed a "blood vessel-on-a-chip" for heart disease with the potential to change the future of drug testing and development. The technology could also reduce our reliance on animal testing.

Technology 96

Technology Heart Disease Research 96