Ken Grauer, MD

JULY 4, 2024

I was sent the ECG in Figure-1 — but without the benefit of any history. QUESTIONS: How would YOU interpret this tracing? WHY do I say there is, "A 2-Part Answer?" Figure-1: The initial ECG in today's case. ( To improve visualization — I've digitized the original ECG using PMcardio ). MY Thoughts on Today's CASE: As important as providing a brief, relevant history is for optimal clinical ECG interpretation — Cases like the one today often prove even more educational, because we are not given any

Blog 143

Blog STEMI Education Arrhythmia 143

Cardiovascular Diabetology

JUNE 30, 2024

The available evidence on the impact of specific non-pharmacological interventions on glycaemic control is currently limited. Consequently, there is a need to determine which interventions could provide the mo.

Pharmacology 144

Pharmacology Diabetes 144

Journal of Clinical Investigation - Cardiology

JULY 1, 2024

Healthy adipose tissue is essential for normal physiology. There are 2 broad types of adipose tissue depots: brown adipose tissue (BAT), which contains adipocytes poised to burn energy through thermogenesis, and white adipose tissue (WAT), which contains adipocytes that store lipids. However, within those types of adipose, adipocytes possess depot and cell-specific properties that have important implications.

Obesity 139

Obesity Physiology 139

Med Page Today

JULY 3, 2024

(MedPage Today) -- Use of the GLP-1 receptor agonist semaglutide (Ozempic, Wegovy) may be linked with an increased risk of the second most common form of optic neuropathy, a retrospective study suggested. Over a mean follow-up of nearly 3 years.

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Medical Xpress - Cardiology

JULY 2, 2024

A new study sheds light on a medical question scientists have long wondered: why do 40% of children with the rare neurodevelopmental disorder KBG syndrome have heart defects? The research now points to a critical link between the heart and the brain. The research is published in the journal Nature Communications.

Research 132

Research 132

American Heart News - Stroke News

JULY 2, 2024

DALLAS and MINNEAPOLIS, July 2, 2024 — The American Academy of Neurology and the American Heart Association have awarded the first-ever Ralph L. Sacco Scholarships for Brain Health to two researchers, Patrick Devlin, Ph.D., of Houston, Texas, and Cyprien.

Research 116

Research 116

American Heart News - Heart News

JULY 1, 2024

Statement Highlights: Palliative medication management focuses on providing relief from symptoms and enhancing quality of life for people with cardiovascular disease throughout the various stages of the disease. Decisions about initiating, adjusting.

Quality of Life 114

Quality of Life Cardiovascular Disease 114

Medical Xpress - Cardiology

JULY 2, 2024

The Mediterranean diet is a powerful ally for health even after a cancer diagnosis. This is the key result of an Italian study carried out as part of the UMBERTO Project, conducted by the Joint Research Platform Umberto Veronesi Foundation—Department of Epidemiology and Prevention of the I.R.C.C.S. Neuromed of Pozzilli, in collaboration with the LUM "Giuseppe Degennaro" University of Casamassima (BA).

Diet 116

Diet Cancer Cardiovascular Disease Research 116

Science Daily - Heart Disease

JULY 3, 2024

Drosophila -- known as fruit flies -- are a valuable model for human heart pathophysiology, including cardiac aging and cardiomyopathy. However, a choke point in evaluating fruit fly hearts is the need for human intervention to measure the heart at moments of its largest expansion or its greatest contraction to calculate cardiac dynamics. Researchers now show a way to significantly cut the time needed for that analysis while utilizing more of the heart region, using deep learning and high-speed

Cardiomyopathy 108

Cardiomyopathy Research 108

Nature Reviews - Cardiology

JULY 4, 2024

Nature Reviews Cardiology, Published online: 05 July 2024; doi:10.1038/s41569-024-01039-5 In this Review, Catapano and colleagues discuss the evidence supporting the LDL cumulative exposure hypothesis and how measuring cumulative LDL exposure can be used to estimate risk and contribute to the prevention of atherosclerotic cardiovascular disease.

Cardiovascular Disease 105

Cardiovascular Disease 105

Med Page Today

JULY 3, 2024

(MedPage Today) -- Inflammation in young adulthood was associated with midlife cognitive outcomes, data from the CARDIA study showed. Compared with lower stable levels of C-reactive protein (CRP), consistently higher CRP levels over 18 years led.

Outcomes 124

Outcomes 124

Journal of Clinical Investigation - Cardiology

JULY 1, 2024

Diffuse midline glioma (DMG) H3K27-altered is one of the most malignant childhood cancers. Radiation therapy remains the only effective treatment yet provides a 5-year survival rate of only 1%. Several clinical trials have attempted to enhance radiation antitumor activity using radiosensitizing agents, although none have been successful. Given this, there is a critical need for identifying effective therapeutics to enhance radiation sensitivity for the treatment of DMG.

Pharmacology 106

Pharmacology Cancer 106

Science Daily - Heart Disease

JULY 3, 2024

Researchers have created a questionnaire test for home use that quickly identifies high risk of heart attack. A study shows that it has the same level of accuracy as blood tests and blood pressure measurements.

Heart Attack 106

Heart Attack Heart attacks Blood Pressure Research 106

DAIC

JULY 3, 2024

Jon Kobashigawa, MD, of the Smidt Heart Institute at Cedars-Sinai, is an expert in heart transplantation, heart failure, and other complex cardiac conditions. Photo by Cedars-Sinai. mtaschetta-millane Wed, 07/03/2024 - 10:25 July 3, 2024 — Jon Kobashigawa, MD , director of the Heart Transplant Program in the Department of Cardiology in the Smidt Heart Institute at Cedars-Sinai, has assumed the top volunteer leadership position of the American Society of Transplantation.

Transplant 105

Transplant Heart Transplant Heart Failure Education 105

Med Page Today

JULY 5, 2024

(MedPage Today) -- GLP-1 receptor agonists lowered the risk of several obesity-associated cancers, a retrospective analysis of electronic health records suggested. Compared with insulin, GLP-1s were associated with a lower risk for developing.

Obesity 116

Obesity Cancer Diabetes 116

HCPLive

JUNE 30, 2024

Carol Levy, MD, discusses INHALE-3 trial and how to incorporate individual patient-level factors into the management of patients with type 1 diabetes who could benefit from inhaled insulin.

Diabetes 105

Diabetes 105

Open Heart

JULY 4, 2024

Background and aims The independent role of body fat distribution and fat-free mass in heart failure (HF) risk is unclear. We investigated the role of different body composition compartments in risk of HF. Methods Present analyses include 428 087 participants (mean age 55.9 years, 44% male) from the UK Biobank. Associations of long-term average levels of body composition measures with incident HF were determined using adjusted Cox proportional hazards regression models.

Heart Failure 98

Heart Failure Preserved Ejection Fraction BMI 98

DAIC

JULY 2, 2024

mtaschetta-millane Tue, 07/02/2024 - 09:45 July 2, 2024 — Biotronik announced the availability of an expanded Maximum Allowed Diameters (MAD) range for the Orsiro Mission Drug Eluting Stent (DES). Diameters 2.25 mm to 3.00 mm of the Orsiro Mission DES can now be extended up to 4.0mm, while diameters 3.5 mm and 4.0 mm can reach up to 5.0 mm. This new MAD expansion follows the approvals from CE, FDA, and Health Canada obtained in the past months.

Stents 105

Stents Stent Anatomy Technology 105

Med Page Today

JULY 2, 2024

(MedPage Today) -- Over 100 batches of potassium chloride are being recalled because they are not dissolving correctly, which may lead to hyperkalemia that can ultimately cause cardiac arrhythmias and death in some cases, per an FDA alert. And.

Exercise 105

Exercise Arrhythmia 105

HCPLive

JULY 5, 2024

Patients with chronic tonsillitis had greater IgAN event rates than those without, and further analysis revealed chronic tonsillitis was linked to a greater risk of developing IgAN.

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98

Journal of Clinical Investigation - Cardiology

JULY 1, 2024

Endothelial cells (ECs) in the descending aorta are exposed to high laminar shear stress, and this supports an antiinflammatory phenotype. High laminar shear stress also induces flow-aligned cell elongation and front-rear polarity, but whether these are required for the antiinflammatory phenotype is unclear. Here, we showed that caveolin-1–rich microdomains polarize to the downstream end of ECs that are exposed to continuous high laminar flow.

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DAIC

JULY 2, 2024

From FDA approvals to new clinical trials, here is a look at DAIC's top-read content during the month of June: 1. Medtronic Launches the Avalus Ultra Valve Engineered for Ease of Use at Implant and Lifetime Patient Management 2. Landmark Clinical Study in The Lancet Finds New AI Technology Can Predict Cardiac Events Due to Coronary Inflammation at Least 10 Years in Advance 3.

Blood Pressure 105

Blood Pressure TAVR Aortic Technology 105

Med Page Today

JULY 1, 2024

(MedPage Today) -- Routine ECGs for the general population had clinical utility in a study of Japan's unique health screening program, with screening results tied to subsequent health outcomes. Out of more than 3.5 million generally healthy working.

Outcomes 98

Outcomes 98

HCPLive

JULY 3, 2024

Our June 2024 month-in-review includes the latest pipeline news, the impact of vision issues on public health, and expert-led insight on the latest in ophthalmology.

Public Health 98

Public Health 98

Journal of Clinical Investigation - Cardiology

JULY 1, 2024

Ubiquitination plays an essential role in protein stability, subcellular localization, and interactions. Crosstalk between different types of ubiquitination results in distinct biological outcomes for proteins. However, the role of ubiquitination-related crosstalk in lymph node (LN) metastasis and the key regulatory factors controlling this process have not been determined.

Cancer 96

Cancer Outcomes 96

DAIC

JULY 1, 2024

Philip B. Adamson, MD, MSc, FACC, FESC, FRCP (Ed) milla1cf Mon, 07/01/2024 - 12:24 July 1, 2024 — CVRx, Inc. , a commercial-stage medical device company, announced three additions to its senior leadership team. Philip B. Adamson, MD, MSc, FACC, FESC, FRCP (Ed ) has been appointed as Chief Medical Officer, Bonnie Handke, RN, MBA will assume the role of Senior Vice President of Patient Access, Reimbursement, and Healthcare Economics, and Jennifer E.

Reimbursement 105

Reimbursement RN Heart Failure Laboratory 105

Heart Sisters

JUNE 30, 2024

My daughter's moving day reminded me of what I was once able to accomplish both physically and mentally when I was "in my prime". But where did my prime go? And did I notice it leaving?

Heart Disease 95

Heart Disease 95

Cardiovascular Diabetology

JULY 3, 2024

Artificial sweeteners are widely popular worldwide as substitutes for sugar or caloric sweeteners, but there are still several important unknowns and controversies regarding their associations with cardiovascu.

Cardiovascular Disease 100

Cardiovascular Disease Research 100

Medical Xpress - Cardiology

JULY 3, 2024

Results from a large stud show that protein analyses taken during the first trimester of pregnancy did not improve predictions for identifying people at risk for experiencing conditions related to having high blood pressure during pregnancy.

Blood Pressure 99

Blood Pressure Hypertension 99

HCPLive

JULY 1, 2024

Across the Phase 2 ReCLAIM-2 trial, elamipretide demonstrated photoreceptor protection and the potential for visual function improvement in eyes with dry AMD.

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Dr. Paddy Barrett

JULY 5, 2024

We do a terrible job of identifying and managing high blood pressure. We can send spacecraft across the solar system. We have managed to harness the power of the atom. And we still do an awful job of identifying and managing high blood pressure. Here’s why. And what to do about it. The Scale Of The Problem. As a risk factor for death, high blood pressure is responsible for more deaths than any other risk factor, including smoking.

Blood Pressure 89

Blood Pressure Heart Attack Heart attacks Risk Factors 89

Science Daily - Stroke

JULY 1, 2024

Scientists found the choroid plexus and cerebrospinal fluid play a key role in maintaining a pool of newly born neurons to repair the adult brain after injury.

Stroke 79

Stroke Strokes 79

Medical Xpress - Cardiology

JULY 3, 2024

Drosophila—commonly known as fruit flies—are a valuable model for human heart pathophysiology, including cardiac aging and cardiomyopathy. However, a choke point in evaluating fruit fly hearts is the need for human intervention to measure the heart at moments of its largest expansion or its greatest contraction, measurements that allow calculations of cardiac dynamics.

Cardiomyopathy 98

Cardiomyopathy 98

HCPLive

JULY 1, 2024

A panel of ophthalmologists discuss strategies for managing AMD and DME patients who exhibit suboptimal responses to their current anti-VEGF therapy.

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95

American College of Cardiology

JULY 2, 2024

The following are key points to remember from a state-of-the-art review on practical guidance for hemodynamic assessment by right heart catheterization (RHC) in the management of heart failure (HF):

Heart Failure 75

Heart Failure Article 75

HeartRhythm

JUNE 30, 2024

ADAS-3D software elaborates Cardiac Magnetic Resonance (CMR) images to obtain a quantitative evaluation of dense scar and border zone (BZ), including BZ channels, which can be useful for ventricular tachycardia ablation and for risk-stratification. However, most prior reports with ADAS-3D used flexible thresholds (60%±5% and 40%±5% of maximum pixel signal intensity -PSI) to define dense scar and BZ.

Tachycardia 75

Tachycardia Ablation 75

Medical Xpress - Cardiology

JULY 2, 2024

In 2012, Neil Armstrong, the first man to walk on the moon, died of post-surgery complications at the age of 82 following what should have been a routine heart surgery. Armstrong had undergone bypass surgery, the most common open-heart operation in the United States, and a surgery where the overall chance of death has dropped to almost zero.

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