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Researchers have successfully repaired damaged mouse hearts using a protein from zebrafish. They discovered that the protein Hmga1 plays a key role in heart regeneration in zebrafish. In mice, this protein was able to restore the heart by activating dormant repair genes without causing side effects, such as heart enlargement. This study marks an important step toward regenerative therapies to prevent heart failure.
By Smith with comments from our electrophysiologist, Rehan Karim. (And of course Ken's comments at the bottom) An elderly obese woman with cardiomyopathy, Left bundle branch block, and chronic hypercapnea presented hypoxic with altered mental status. She was intubated. Bedside cardiac ultrasound showed moderately decreased LV function. CT of the chest showed no pulmonary embolism but bibasilar infiltrates.
Walking in a winter wonderland may sound serene and peaceful, but shoveling your sidewalks to take that walk could quickly change delightful to deadly. According to the American Heart Association, the world's leading nonprofit organization focused on heart and brain health for all, research shows that the exertion of shoveling snow may lead to an increased risk of a heart attack or sudden cardiac arrest.
What is inside the Heart Health Formula? A step-step guide to: - Understanding Heart Disease. - Defining Heart Disease Risk. - Reducing Heart Disease Risk. When I set out on my journey over a decade ago to put together a system to do this comprehensively, it did not exist in a way that I found useful. So, I created a system myself. The Heart Health Formula is made up of 3 main modules.
Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post. You can find more products I’m affiliated with on my website. Physiologically Speaking is a reader-supported publication.
Curtain etal1 performed an analysis of the VALIANT (Valsartan in Acute Myocardial Infarction) and PARADISE-MI (Prospective ARNi vs ACE Inhibitor Trial to Determine Superiority in Reducing Heart Failure Events After MI) trials to evaluate whether risk of sudden cardiac arrest (SCA) following acute myocardial infarction (MI) has changed over time. Patients recruited to these trials had left ventricular ejection fraction (LVEF) <40% following acute MI.
Nature Reviews Cardiology, Published online: 02 January 2025; doi:10.1038/s41569-024-01109-8 In this Review, Lavine and colleagues describe the known subsets of cardiac macrophages, highlighting newly identified macrophage states and associated cellular neighbourhoods, and discuss the roles of cardiac macrophages in homeostasis and disease, including in inflammation, fibrosis, age-associated pathologies, mechanosensing, efferocytosis, angiogenesis, arrhythmias and transplant allograft survival.
Nature Reviews Cardiology, Published online: 02 January 2025; doi:10.1038/s41569-024-01109-8 In this Review, Lavine and colleagues describe the known subsets of cardiac macrophages, highlighting newly identified macrophage states and associated cellular neighbourhoods, and discuss the roles of cardiac macrophages in homeostasis and disease, including in inflammation, fibrosis, age-associated pathologies, mechanosensing, efferocytosis, angiogenesis, arrhythmias and transplant allograft survival.
"Frustrated, lost and confused." That was the main feedback I got from thousands of readers when I asked them about their experience working with existing healthcare systems to implement a plan to prevent heart disease. This is not good. Heart disease is the leading cause of death worldwide, and with the right approaches, 80% or more can be prevented at an early age.
Adding to a relentless trend of Medicare schemes, 16 cardiology practices agreed to pay more than $17.7M to resolve allegations that they overbilled for diagnostic radiopharmaceuticals and violated the False Claims Act. In 13 states and D.C., Medicare Part B reimburses providers for radiopharmaceuticals based on self-reported acquisition costs, leaving billing up to the honor system.
Interactions with friends and family may keep us healthy because they boost our immune system and reduce our risk of diseases such as heart disease, stroke and type 2 diabetes, new research suggests. Researchers drew this conclusion after studying proteins from blood samples taken from over 42,000 adults recruited to the UK Biobank.
Nature Reviews Cardiology, Published online: 02 January 2025; doi:10.1038/s41569-024-01103-0 Vascular cells are finely regulated by complex microenvironments, including biomechanical signals from the extracellular matrix. In this Review, Kong and colleagues describe the role of the extracellular matrix in vascular development, ageing and disease, and highlight the potential of novel therapies targeting this fine-tuned network.
The Heart Health Formula is everything you need to address your risk of heart disease. If you are looking to: Lower high cholesterol. Lower high blood pressure. Lose visceral fat. Assess for genetic risks of heart disease. Understand what tests best define risk. And much more. The Heart Health Formula has these covered and so much more. In addition to the 9 hours of content covering these topics, the Heart Health Formula comes with two free bonuses.
COVID-19 is a respiratory disease primarily affecting the lungs. However, the SARS-CoV-2 virus that causes COVID-19 surprised doctors and scientists by causing an unusually large percentage of patients to experience vascular complicationsissues related to blood flow, such as blood clots, heart attacks, and strokes.
(MedPage Today) -- A three-step process underscores new clinical practice guidelines for primary and specialty care clinicians to evaluate patients who may have cognitive impairment or dementia due to Alzheimer's or a related disease. In broad.
Although the oral navacaprant 80 mg failed to bring statistically significant improvements in depression symptoms, the study showed females respond better than males.
Journal of the American Heart Association, Ahead of Print. BackgroundInfective endocarditis (IE) is still a fatal disease, and given its rarity, ongoing updates to patient characteristics and outcomes of IE are essential for providing precision diagnoses and effective treatments. This study sought to examine temporal trends in the clinical characteristics and inhospital occurrence of adverse outcomes of IE.Methods and ResultsUsing the Japan nationwide administrative database, we identified patie
Interactions with friends and family may keep us healthy because they boost our immune system and reduce our risk of diseases such as heart disease, stroke and type 2 diabetes, new research suggests.
(MedPage Today) -- In January, we reported on the FDA clearing GLP-1 receptor agonists of suicidality risk following a preliminary evaluation. In this report, we follow up on what has happened since. Not long after the FDA wrapped its preliminary.
Glucagon-like peptide-1 receptor agonist (GLP-1RA) treatment reduces cardiovascular events in type 2 diabetes. Yet, the impact of GLP-1RA treatment before ST-segment elevation myocardial infarction (STEMI) on.
A systematic review and meta-analysis of observational real-world data finds nearly half of patients who begin a GLP-1 RA will discontinue within a year.
The U.S. government's premier research body has made an important discovery that could help create new drugs to lower "bad" cholesterol, and hopefully prevent heart attacks and stroke.
(MedPage Today) -- Despite guidelines recommending other anticoagulants for people hospitalized with acute pulmonary embolism (PE), old habits and misconceptions have kept unfractionated heparin (UFH) the initial choice for many physicians in the.
This prognostic study evaluates the ability of an electrocardiography-based artificial intelligence risk estimator to predict incident hypertension and stratify risk for hypertension-associated adverse events.
There's no question that exercise is good for the heart. Regular exercise lowers blood pressure and cholesterol and reduces the chances of having a heart attack or stroke.
(MedPage Today) -- MedPage Today's enterprise and investigative team covers a lot of ground. We jump in when there's breaking news in healthcare. We write second-day stories on the implications of that news. We craft compelling feature stories.
Notwithstanding many insightful observations, the electrocardiogram (ECG) arguably ignited the big bang in our understanding of cardiac arrhythmias. Using ECG recording and deductive reasoning, our teachers and predecessors classified the bradycardias and tachycardias and proposed many mechanisms, subsequently proven to be correct. The development of electrophysiology (EP) studies through intravascular catheters provided the leap to verifying mechanisms, setting the stage for interventions.
Researchers from the Bakkers group at the Hubrecht Institute have successfully repaired damaged mouse hearts using a protein from zebrafish. They discovered that the protein Hmga1 plays a key role in heart regeneration in zebrafish. In mice, this protein was able to restore the heart by activating dormant repair genes without causing side effects, such as heart enlargement.
(MedPage Today) -- Atherosclerosis progression was more than twice as common in younger people with systemic lupus erythematosus (SLE) than in healthy controls in a prospective study from Greece, but the rate difference narrowed substantially with.
Was this particular article the most popular of 2024 because my HEART SISTERS readers aren't getting clear jargon-free, patient-friendly answers from their doctors?
Cardiovascular disease (CVD) and cancer are the two leading causes of death in the U.S. According to researchers from The University of Texas MD Anderson Cancer Center, patients diagnosed with late-stage or metastatic breast cancer have a statistically significant increased risk of pre-diagnosis CVD compared to those with early-stage cancer at diagnosis.
Despite the promising results of both MitraClip and PASCAL systems for the treatment of mitral regurgitation (MR), there is limited data on the comparison of both systems regarding their safety and efficacy. W.
(MedPage Today) -- TTHealthWatch is a weekly podcast from Texas Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine in Baltimore, and Rick Lange, MD, president of the Texas Tech University Health Sciences Center.
Abstract The participatory co-design method has received significant attention recently. Experience-based co-design is an approach that enables patients (service users) and healthcare providers (service delivers) to co-design services and care pathways in partnership to improve health outcomes based on their experience. Traditionally, it was used as a quality improvement technique.
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