Ken Grauer, MD
DECEMBER 15, 2023
== CLICK HERE — for a V ideo presentation of this case! ( 18:00 min. ) Below are slides used in my video presentation. For full discussion of this case — See ECG Blog #392 — == The ECG in Figure-1 was obtained from a man in his 60s — who described the sudden onset of "chest tightness" that began 20 minutes earlier, but who now ( at the time this ECG was recorded ) — was no longer having symptoms.
Cardiovascular Ultrasound
DECEMBER 13, 2023
Physical activity contributes to changes in cardiac morphology, which are known as “athlete’s heart”. Therefore, these modifications can be characterized using different imaging modalities such as echocardiogr.
Dr. Malcolm Kendrick
DECEMBER 10, 2023
10th December 2023 A very important study – please watch Very high low density lipoprotein levels with no impact on plaque progression I interrupt my series on what is wrong with the health service to bring you breaking news. I was sent the e-mail below, directing me to a short YouTube presentation by Dr Shawn Baker. It highlights a study which provides very strong evidence that a very high LDL (as seen in some people who go on a keto diet), has no impact on coronary artery plaque progression.
Journal of Clinical Investigation - Cardiology
DECEMBER 15, 2023
Ghrelin exerts key effects on islet hormone secretion to regulate blood glucose levels. Here, we sought to determine whether ghrelin’s effects on islets extend to the alteration of islet size and β cell mass. We demonstrate that reducing ghrelin — by ghrelin gene knockout (GKO), conditional ghrelin cell ablation, or high-fat diet (HFD) feeding — was associated with increased mean islet size (up to 62%), percentage of large islets (up to 854%), and β cell cross-sectional area (up to 51%).
Medical Xpress - Cardiology
DECEMBER 14, 2023
Cardiovascular diseases are the leading cause of death in the world according to the Global Burden of Disease study, with 18.6 million annual deaths in 2019, of which around 7.9 are attributable to diet. This means that diet plays a major role in the development and progression of these diseases.
Med Page Today
DECEMBER 14, 2023
(MedPage Today) -- Sleep regularity in midlife and at older ages may be a novel dementia risk factor, data from 88,000 people in Great Britain suggested. Day-to-day consistency in sleep-wake patterns showed a U-shaped association with incident.
Science Daily - Heart Disease
DECEMBER 13, 2023
Individuals infected with COVID-19 are also at an increased risk of suffering from heart rhythm disturbances, such as atrial fibrillation, according to a new study.
Cardiovascular Update brings together the best content for cardiovascular medicine professionals from the widest variety of industry thought leaders.
Medical Xpress - Cardiology
DECEMBER 12, 2023
A new artificial intelligence (AI) model designed by Scripps Research scientists could help clinicians better screen patients for atrial fibrillation (or AFib)—an irregular, fast heartbeat that is associated with stroke and heart failure. The model picks up on tiny variations in a person's normal heartbeat that signify AFib risk, which standard screening tests cannot detect.
HCPLive
DECEMBER 15, 2023
Laura Donlin, PhD, highlights the significance of identifying new subtypes of rheumatoid arthritis, emphasizing the potential for a paradigm shift in RA treatment toward personalized care and early interventions.
Dr. Smith's ECG Blog
DECEMBER 11, 2023
Occlusion myocardial infarction is a clinical diagnosis Written by Willy Frick (@Willyhfrick). Willy is a cardiology fellow with a keen interest in the ECG in OMI. A woman in her late 70s presented with left arm pain. The arm pain started the day prior when she was at the dentist's office for a root canal. Her systolic blood pressure at the dentist was over 200 mm Hg.
Journal of Clinical Investigation - Cardiology
DECEMBER 15, 2023
Cell therapies such as tumor-infiltrating lymphocyte (TIL) therapy have shown promise in the treatment of patients with refractory solid tumors, with improvement in response rates and durability of responses nevertheless sought. To identify targets capable of enhancing the antitumor activity of T cell therapies, large-scale in vitro and in vivo clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 screens were performed, with the SOCS1 gene identified as a top T cell–enhancing
Medical Xpress - Cardiology
DECEMBER 14, 2023
A large international research collaboration, led by an academic from Royal Holloway, University of London, found that blood groups could help predict the risk of venous strokes associated with the Oxford-AstraZeneca COVID-19 vaccine.
Med Page Today
DECEMBER 12, 2023
(MedPage Today) -- The U.S. Preventive Services Task Force (USPSTF) plans to recommend intensive behavioral interventions -- but not pharmacologic therapies -- for kids with a high body mass index (BMI). In its draft recommendation statement.
HCPLive
DECEMBER 13, 2023
Patients with gout who did not experience recurrent flares had a shorter mean time between diagnosis and the start of urate-lowering therapy compared with those who had ≥1 flare.
Journal of Clinical Investigation - Cardiology
DECEMBER 13, 2023
Increased extracellular matrix (ECM) stiffness has been implicated in esophageal adenocarcinoma (EAC) progression, metastasis, and resistance to therapy. However, the underlying protumorigenic pathways are yet to be defined. Additional work is needed to develop physiologically relevant in vitro 3D culture models that better recapitulate the human tumor microenvironment and can be used to dissect the contributions of matrix stiffness to EAC pathogenesis.
American Heart News - Heart News
DECEMBER 13, 2023
Research Highlights: An analysis of death certificate data from 1999 to 2020 showed a decline in deaths related to infective endocarditis throughout most of the United States yet found an alarming increase of 2%-5% among adults ages 25-44. There was.
Med Page Today
DECEMBER 14, 2023
(MedPage Today) -- Potential unintended consequences of Medicare's drug-price negotiation program were examined during a panel discussion hosted by The Hill and sponsored by the Alliance for Aging Research, an industry-funded nonprofit. Wednesday.
HCPLive
DECEMBER 11, 2023
It is common for patients with rheumatoid arthritis to have mental health conditions. Test your knowledge of the impact of anxiety and depression in rheumatoid arthritis with this quiz.
Journal of Clinical Investigation - Cardiology
DECEMBER 15, 2023
Cell lineage plasticity is one of the major causes for the failure of targeted therapies in various cancers. However, the driver and actionable drug targets in promoting cancer cell lineage plasticity are scarcely identified. Here, we found that a G protein-coupled receptor, ADORA2A, is specifically upregulated during neuroendocrine differentiation, a common form of lineage plasticity in prostate cancer and lung cancer following targeted therapies.
Dr. Smith's ECG Blog
DECEMBER 13, 2023
This middle aged patient presented with chest pain: What do you think? There is VERY low voltage. There is some ST Elevation, but it is MINIMAL. But look how small the QRS is!! Let's stretch out the QRS vertically so it is not so tiny: On upper left is the original. On the right are the precordial leads stretched vertically, so that the QRS is not tiny.
DAIC
DECEMBER 12, 2023
milla1cf Tue, 12/12/2023 - 07:00 December 12, 2023 — Patients who received the anticoagulant drug warfarin after bioprosthetic aortic valve replacement had lower incidence of mortality and a decreased risk of blood clots, according to a retrospective study published in Mayo Clinic Proceedings. The use of bioprosthetic aortic valve replacement has increased significantly during the past decade.
HCPLive
DECEMBER 15, 2023
The past year has seen a multitude of FDA approvals, ranging from IL-23 and JAK inhibitors to biologics and subcutaneous treatment administrations, that have helped redefine what it means to treat IBD.
Med Page Today
DECEMBER 13, 2023
(MedPage Today) -- After discontinuing the weight-management injectable tirzepatide (Zepbound), most patients had a hard time keeping the weight off during the phase III SURMOUNT-4 trial. People on a maximum tolerated dose of tirzepatide (10 or.
Journal of Clinical Investigation - Cardiology
DECEMBER 15, 2023
A20 is a ubiquitin-modifying protein that negatively regulates NF-κB signaling. Mutations in A20/TNFAIP3 are associated with a variety of autoimmune diseases, including multiple sclerosis (MS). We found that deletion of A20 in central nervous system (CNS) endothelial cells (ECs) enhances experimental autoimmune encephalomyelitis (EAE), a mouse model of MS.
DAIC
DECEMBER 14, 2023
Ioannis Katsoularis, image courtesy of Klas Sjöberg milla1cf Thu, 12/14/2023 - 09:23 December 14, 2023 — Individuals infected with COVID-19 are also at an increased risk of suffering from heart rhythm disturbances, such as atrial fibrillation. This is shown in a new study at Umeå University, Sweden , which is one of the largest studies of its kind in the world.
HCPLive
DECEMBER 10, 2023
Study results presented at the 2023 American Society of Hematology Annual Meeting and Exposition found equal immune tolerance induction success rates regardless of race/ethnicity.
Cardiovascular Diabetology
DECEMBER 14, 2023
Previous studies have found that the triglyceride glucose index (TyG index) trajectories are associated with cardiovascular diseases. However, the association between the patterns of TyG index trajectories and.
Journal of Clinical Investigation - Cardiology
DECEMBER 13, 2023
Many cancers harbor homologous recombination defects (HRDs). A HRD is a therapeutic target that is being successfully utilized in treatment of breast/ovarian cancer via synthetic lethality. However, canonical HRD caused by BRCAness mutations do not prevail in liver cancer. Here we report a subtype of HRD caused by the perturbation of a proteasome variant (CDW19S) in hepatitis B virus–bearing (HBV-bearing) cells.
NOVARAD
DECEMBER 11, 2023
In today’s healthcare world, sharing medical images securely and in compliance with regulations is nothing short of a tightrope walk. As we move further into the digital age, the task of keeping sensitive patient data under lock and key while still at the ready for healthcare professionals has become a priority. That’s where PACS image sharing steps into the limelight.
HCPLive
DECEMBER 14, 2023
Patients who reported almost daily fresh vegetable consumption had higher eGFR compared to those with occasional consumption and those who consumed salt-preserved vegetables.
DAIC
DECEMBER 13, 2023
milla1cf Wed, 12/13/2023 - 10:24 December 13, 2023 — A new artificial intelligence (AI) model designed by Scripps Research scientists could help clinicians better screen patients for atrial fibrillation (or AFib)—an irregular, fast heartbeat that is associated with stroke and heart failure. The model picks up on tiny variations in a person’s normal heartbeat that signify AFib risk, which standard screening tests cannot detect.
Journal of Clinical Investigation - Cardiology
DECEMBER 13, 2023
Intranasal vaccines are anticipated to be powerful tools for combating many infectious diseases, including SARS-CoV-2, because they induce not only systemic immunity but also mucosal immunity at the site of initial infection. However, they are generally inefficient in inducing an antigen-specific immune response without adjuvants. Here, we developed an adjuvant-free intranasal vaccine platform that utilizes the preexisting immunity induced by previous infection or vaccination to enhance vaccine
Dr. Smith's ECG Blog
DECEMBER 9, 2023
A 50-something had syncope while driving. He was belted and it was low speed. He had a prehospital ECG. He was ambulatory at the scene. He has a history of STEMI and heart failure. The medics stated he had been nauseated and diaphoretic, but he did not have any chest pain or SOB. They recorded a prehospital ECG: What do you think? I read this blinded, with no clinical information, and read it as inferior OMI.
HCPLive
DECEMBER 13, 2023
Patients with gout achieving target serum uric acid levels showed good adherence to urate-lowering therapy, used antihypertensive agents, and lacked a family history of gout.
Med Page Today
DECEMBER 15, 2023
(MedPage Today) -- Patients living in more disadvantaged neighborhoods were more likely to leave their prescriptions for standard heart failure medications unfilled, retrospective data from a large health system showed. Among patients with heart.
Journal of Clinical Investigation - Cardiology
DECEMBER 15, 2023
Metabolic syndrome, today affecting more than 20% of the US population, is a group of 5 conditions that often coexist and that strongly predispose to cardiovascular disease. How these conditions are linked mechanistically remains unclear, especially two of these: obesity and elevated blood pressure. Here, we show that high fat consumption in mice leads to the accumulation of lipid droplets in endothelial cells throughout the organism and that lipid droplet accumulation in endothelium suppresses
DAIC
DECEMBER 14, 2023
Medtronic PulseSelect PFA System milla1cf Thu, 12/14/2023 - 13:29 December 14, 2023 — Medtronic plc , a global leader in healthcare technology, today announced that the United States Food and Drug Administration (FDA) has approved the PulseSelect Pulsed Field Ablation (PFA) System for the treatment of both paroxysmal and persistent atrial fibrillation (AF).
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