Cardiovascular Ultrasound
DECEMBER 13, 2023
Physical activity contributes to changes in cardiac morphology, which are known as “athlete’s heart”. Therefore, these modifications can be characterized using different imaging modalities such as echocardiogr.
Dr. Malcolm Kendrick
DECEMBER 10, 2023
10th December 2023 A very important study – please watch Very high low density lipoprotein levels with no impact on plaque progression I interrupt my series on what is wrong with the health service to bring you breaking news. I was sent the e-mail below, directing me to a short YouTube presentation by Dr Shawn Baker. It highlights a study which provides very strong evidence that a very high LDL (as seen in some people who go on a keto diet), has no impact on coronary artery plaque progression.
Ken Grauer, MD
DECEMBER 15, 2023
== CLICK HERE — for a V ideo presentation of this case! ( 18:00 min. ) Below are slides used in my video presentation. For full discussion of this case — See ECG Blog #392 — == The ECG in Figure-1 was obtained from a man in his 60s — who described the sudden onset of "chest tightness" that began 20 minutes earlier, but who now ( at the time this ECG was recorded ) — was no longer having symptoms.
Medical Xpress - Cardiology
DECEMBER 12, 2023
A new artificial intelligence (AI) model designed by Scripps Research scientists could help clinicians better screen patients for atrial fibrillation (or AFib)—an irregular, fast heartbeat that is associated with stroke and heart failure. The model picks up on tiny variations in a person's normal heartbeat that signify AFib risk, which standard screening tests cannot detect.
Science Daily - Heart Disease
DECEMBER 13, 2023
Individuals infected with COVID-19 are also at an increased risk of suffering from heart rhythm disturbances, such as atrial fibrillation, according to a new study.
Journal of Clinical Investigation - Cardiology
DECEMBER 15, 2023
A paucity of chemotherapeutic options for metastatic brain cancer limits patient survival and portends poor clinical outcomes. Using a CNS small-molecule inhibitor library of 320 agents known to be blood-brain barrier permeable and approved by the FDA, we interrogated breast cancer brain metastasis vulnerabilities to identify an effective agent. Metixene, an antiparkinsonian drug, was identified as a top therapeutic agent that was capable of decreasing cellular viability and inducing cell death
Med Page Today
DECEMBER 14, 2023
(MedPage Today) -- Sleep regularity in midlife and at older ages may be a novel dementia risk factor, data from 88,000 people in Great Britain suggested. Day-to-day consistency in sleep-wake patterns showed a U-shaped association with incident.
Cardiovascular Update brings together the best content for cardiovascular medicine professionals from the widest variety of industry thought leaders.
HCPLive
DECEMBER 15, 2023
Laura Donlin, PhD, highlights the significance of identifying new subtypes of rheumatoid arthritis, emphasizing the potential for a paradigm shift in RA treatment toward personalized care and early interventions.
Journal of Clinical Investigation - Cardiology
DECEMBER 15, 2023
Cell therapies such as tumor-infiltrating lymphocyte (TIL) therapy have shown promise in the treatment of patients with refractory solid tumors, with improvement in response rates and durability of responses nevertheless sought. To identify targets capable of enhancing the antitumor activity of T cell therapies, large-scale in vitro and in vivo clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 screens were performed, with the SOCS1 gene identified as a top T cell–enhancing
Med Page Today
DECEMBER 12, 2023
(MedPage Today) -- The U.S. Preventive Services Task Force (USPSTF) plans to recommend intensive behavioral interventions -- but not pharmacologic therapies -- for kids with a high body mass index (BMI). In its draft recommendation statement.
Medical Xpress - Cardiology
DECEMBER 14, 2023
A large international research collaboration, led by an academic from Royal Holloway, University of London, found that blood groups could help predict the risk of venous strokes associated with the Oxford-AstraZeneca COVID-19 vaccine.
HCPLive
DECEMBER 13, 2023
Patients with gout who did not experience recurrent flares had a shorter mean time between diagnosis and the start of urate-lowering therapy compared with those who had ≥1 flare.
Dr. Smith's ECG Blog
DECEMBER 11, 2023
Occlusion myocardial infarction is a clinical diagnosis Written by Willy Frick (@Willyhfrick). Willy is a cardiology fellow with a keen interest in the ECG in OMI. A woman in her late 70s presented with left arm pain. The arm pain started the day prior when she was at the dentist's office for a root canal. Her systolic blood pressure at the dentist was over 200 mm Hg.
Med Page Today
DECEMBER 14, 2023
(MedPage Today) -- Potential unintended consequences of Medicare's drug-price negotiation program were examined during a panel discussion hosted by The Hill and sponsored by the Alliance for Aging Research, an industry-funded nonprofit. Wednesday.
Journal of Clinical Investigation - Cardiology
DECEMBER 15, 2023
The progression of proteinuric kidney diseases is associated with podocyte loss, but the mechanisms underlying this process remain unclear. Podocytes reenter the cell cycle to repair double-stranded DNA breaks. However, unsuccessful repair can result in podocytes crossing the G1/S checkpoint and undergoing abortive cytokinesis. In this study, we identified Pfn1 as indispensable in maintaining glomerular integrity — its tissue-specific loss in mouse podocytes resulted in severe proteinuria and ki
HCPLive
DECEMBER 11, 2023
It is common for patients with rheumatoid arthritis to have mental health conditions. Test your knowledge of the impact of anxiety and depression in rheumatoid arthritis with this quiz.
DAIC
DECEMBER 12, 2023
milla1cf Tue, 12/12/2023 - 07:00 December 12, 2023 — Patients who received the anticoagulant drug warfarin after bioprosthetic aortic valve replacement had lower incidence of mortality and a decreased risk of blood clots, according to a retrospective study published in Mayo Clinic Proceedings. The use of bioprosthetic aortic valve replacement has increased significantly during the past decade.
Med Page Today
DECEMBER 13, 2023
(MedPage Today) -- After discontinuing the weight-management injectable tirzepatide (Zepbound), most patients had a hard time keeping the weight off during the phase III SURMOUNT-4 trial. People on a maximum tolerated dose of tirzepatide (10 or.
Journal of Clinical Investigation - Cardiology
DECEMBER 13, 2023
Increased extracellular matrix (ECM) stiffness has been implicated in esophageal adenocarcinoma (EAC) progression, metastasis, and resistance to therapy. However, the underlying protumorigenic pathways are yet to be defined. Additional work is needed to develop physiologically relevant in vitro 3D culture models that better recapitulate the human tumor microenvironment and can be used to dissect the contributions of matrix stiffness to EAC pathogenesis.
HCPLive
DECEMBER 15, 2023
The past year has seen a multitude of FDA approvals, ranging from IL-23 and JAK inhibitors to biologics and subcutaneous treatment administrations, that have helped redefine what it means to treat IBD.
DAIC
DECEMBER 14, 2023
Ioannis Katsoularis, image courtesy of Klas Sjöberg milla1cf Thu, 12/14/2023 - 09:23 December 14, 2023 — Individuals infected with COVID-19 are also at an increased risk of suffering from heart rhythm disturbances, such as atrial fibrillation. This is shown in a new study at Umeå University, Sweden , which is one of the largest studies of its kind in the world.
Med Page Today
DECEMBER 15, 2023
(MedPage Today) -- Patients living in more disadvantaged neighborhoods were more likely to leave their prescriptions for standard heart failure medications unfilled, retrospective data from a large health system showed. Among patients with heart.
Journal of Clinical Investigation - Cardiology
DECEMBER 15, 2023
Cell lineage plasticity is one of the major causes for the failure of targeted therapies in various cancers. However, the driver and actionable drug targets in promoting cancer cell lineage plasticity are scarcely identified. Here, we found that a G protein-coupled receptor, ADORA2A, is specifically upregulated during neuroendocrine differentiation, a common form of lineage plasticity in prostate cancer and lung cancer following targeted therapies.
HCPLive
DECEMBER 10, 2023
Study results presented at the 2023 American Society of Hematology Annual Meeting and Exposition found equal immune tolerance induction success rates regardless of race/ethnicity.
Cardiovascular Diabetology
DECEMBER 14, 2023
Previous studies have found that the triglyceride glucose index (TyG index) trajectories are associated with cardiovascular diseases. However, the association between the patterns of TyG index trajectories and.
NOVARAD
DECEMBER 11, 2023
In today’s healthcare world, sharing medical images securely and in compliance with regulations is nothing short of a tightrope walk. As we move further into the digital age, the task of keeping sensitive patient data under lock and key while still at the ready for healthcare professionals has become a priority. That’s where PACS image sharing steps into the limelight.
Dr. Smith's ECG Blog
DECEMBER 13, 2023
This middle aged patient presented with chest pain: What do you think? There is VERY low voltage. There is some ST Elevation, but it is MINIMAL. But look how small the QRS is!! Let's stretch out the QRS vertically so it is not so tiny: On upper left is the original. On the right are the precordial leads stretched vertically, so that the QRS is not tiny.
HCPLive
DECEMBER 14, 2023
Patients who reported almost daily fresh vegetable consumption had higher eGFR compared to those with occasional consumption and those who consumed salt-preserved vegetables.
Journal of Clinical Investigation - Cardiology
DECEMBER 15, 2023
A20 is a ubiquitin-modifying protein that negatively regulates NF-κB signaling. Mutations in A20/TNFAIP3 are associated with a variety of autoimmune diseases, including multiple sclerosis (MS). We found that deletion of A20 in central nervous system (CNS) endothelial cells (ECs) enhances experimental autoimmune encephalomyelitis (EAE), a mouse model of MS.
DAIC
DECEMBER 14, 2023
Medtronic PulseSelect PFA System milla1cf Thu, 12/14/2023 - 13:29 December 14, 2023 — Medtronic plc , a global leader in healthcare technology, today announced that the United States Food and Drug Administration (FDA) has approved the PulseSelect Pulsed Field Ablation (PFA) System for the treatment of both paroxysmal and persistent atrial fibrillation (AF).
Med Page Today
DECEMBER 12, 2023
(MedPage Today) -- Adding metformin to insulin treatment for pregnant women with preexisting type 2 or gestational diabetes did not reduce composite neonatal adverse outcomes, according to the randomized MOMPOD trial. The composite outcome -.
HCPLive
DECEMBER 13, 2023
Patients with gout achieving target serum uric acid levels showed good adherence to urate-lowering therapy, used antihypertensive agents, and lacked a family history of gout.
Journal of Clinical Investigation - Cardiology
DECEMBER 13, 2023
Many cancers harbor homologous recombination defects (HRDs). A HRD is a therapeutic target that is being successfully utilized in treatment of breast/ovarian cancer via synthetic lethality. However, canonical HRD caused by BRCAness mutations do not prevail in liver cancer. Here we report a subtype of HRD caused by the perturbation of a proteasome variant (CDW19S) in hepatitis B virus–bearing (HBV-bearing) cells.
DAIC
DECEMBER 14, 2023
Henry Ford Health's National Cardiogenic Shock Initiative research team. Image courtesy of Dr. Basir Babar, Henry Ford Health milla1cf Thu, 12/14/2023 - 09:30 December 14, 2023 — Published results of a large, national heart attack study show that patients with a life-threatening complication known as cardiogenic shock survived at a significantly higher rate when treated with a protocol developed by cardiologists at Henry Ford Health , in collaboration with 80 hospitals nationwide.
Med Page Today
DECEMBER 12, 2023
(MedPage Today) -- Stable patients with pulmonary vascular disease (PVD) tolerated travel to high altitudes fairly well with frequent monitoring and supplemental oxygen therapy provided as necessary, a field study found. Despite the perceived.
HCPLive
DECEMBER 12, 2023
Peter Lio, MD, reviews the contraindications of JAK inhibitors in AD and approaches for monitoring patients who are prescribed a JAK inhibitor.
Journal of Clinical Investigation - Cardiology
DECEMBER 13, 2023
Intranasal vaccines are anticipated to be powerful tools for combating many infectious diseases, including SARS-CoV-2, because they induce not only systemic immunity but also mucosal immunity at the site of initial infection. However, they are generally inefficient in inducing an antigen-specific immune response without adjuvants. Here, we developed an adjuvant-free intranasal vaccine platform that utilizes the preexisting immunity induced by previous infection or vaccination to enhance vaccine
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