Sat.Dec 09, 2023 - Fri.Dec 15, 2023

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Increased risk of heart rhythm disruption after COVID-19

Science Daily - Heart Disease

Individuals infected with COVID-19 are also at an increased risk of suffering from heart rhythm disturbances, such as atrial fibrillation, according to a new study.

COVID-19 145
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Cardiac imaging in athlete’s heart: current status and future prospects

Cardiovascular Ultrasound

Physical activity contributes to changes in cardiac morphology, which are known as “athlete’s heart”. Therefore, these modifications can be characterized using different imaging modalities such as echocardiogr.

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Very high LDL no impact on plaque progression

Dr. Malcolm Kendrick

10th December 2023 A very important study – please watch Very high low density lipoprotein levels with no impact on plaque progression I interrupt my series on what is wrong with the health service to bring you breaking news. I was sent the e-mail below, directing me to a short YouTube presentation by Dr Shawn Baker. It highlights a study which provides very strong evidence that a very high LDL (as seen in some people who go on a keto diet), has no impact on coronary artery plaque progression.

Plaque 144
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ECG Video Blog #408 (392) — 20 Minutes Later.

Ken Grauer, MD

== CLICK HERE — for a V ideo presentation of this case! ( 18:00 min. ) Below are slides used in my video presentation. For full discussion of this case — See ECG Blog #392 — == The ECG in Figure-1 was obtained from a man in his 60s — who described the sudden onset of "chest tightness" that began 20 minutes earlier, but who now ( at the time this ECG was recorded ) — was no longer having symptoms.

Blog 140
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Ghrelin deletion and conditional ghrelin cell ablation increase pancreatic islet size in mice

Journal of Clinical Investigation - Cardiology

Ghrelin exerts key effects on islet hormone secretion to regulate blood glucose levels. Here, we sought to determine whether ghrelin’s effects on islets extend to the alteration of islet size and β cell mass. We demonstrate that reducing ghrelin — by ghrelin gene knockout (GKO), conditional ghrelin cell ablation, or high-fat diet (HFD) feeding — was associated with increased mean islet size (up to 62%), percentage of large islets (up to 854%), and β cell cross-sectional area (up to 51%).

Ablation 138
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New AI-powered algorithm could better assess people's risk of common heart condition

Medical Xpress - Cardiology

A new artificial intelligence (AI) model designed by Scripps Research scientists could help clinicians better screen patients for atrial fibrillation (or AFib)—an irregular, fast heartbeat that is associated with stroke and heart failure. The model picks up on tiny variations in a person's normal heartbeat that signify AFib risk, which standard screening tests cannot detect.

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Contraindications for Use of JAK Inhibitors in AD

HCPLive

Peter Lio, MD, reviews the contraindications of JAK inhibitors in AD and approaches for monitoring patients who are prescribed a JAK inhibitor.

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Metixene is an incomplete autophagy inducer in preclinical models of metastatic cancer and brain metastases

Journal of Clinical Investigation - Cardiology

A paucity of chemotherapeutic options for metastatic brain cancer limits patient survival and portends poor clinical outcomes. Using a CNS small-molecule inhibitor library of 320 agents known to be blood-brain barrier permeable and approved by the FDA, we interrogated breast cancer brain metastasis vulnerabilities to identify an effective agent. Metixene, an antiparkinsonian drug, was identified as a top therapeutic agent that was capable of decreasing cellular viability and inducing cell death

Cancer 129
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Eating meals early could reduce cardiovascular risk

Medical Xpress - Cardiology

Cardiovascular diseases are the leading cause of death in the world according to the Global Burden of Disease study, with 18.6 million annual deaths in 2019, of which around 7.9 are attributable to diet. This means that diet plays a major role in the development and progression of these diseases.

Diet 133
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USPSTF Draft Calls for Lifestyle Shift -- Not Meds -- for Kids With Obesity

Med Page Today

(MedPage Today) -- The U.S. Preventive Services Task Force (USPSTF) plans to recommend intensive behavioral interventions -- but not pharmacologic therapies -- for kids with a high body mass index (BMI). In its draft recommendation statement.

BMI 124
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Proportionality is a major element in the ECG Diagnosis of OMI.

Dr. Smith's ECG Blog

This middle aged patient presented with chest pain: What do you think? There is VERY low voltage. There is some ST Elevation, but it is MINIMAL. But look how small the QRS is!! Let's stretch out the QRS vertically so it is not so tiny: On upper left is the original. On the right are the precordial leads stretched vertically, so that the QRS is not tiny.

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Rational design of a SOCS1-edited tumor-infiltrating lymphocyte therapy using CRISPR/Cas9 screens

Journal of Clinical Investigation - Cardiology

Cell therapies such as tumor-infiltrating lymphocyte (TIL) therapy have shown promise in the treatment of patients with refractory solid tumors, with improvement in response rates and durability of responses nevertheless sought. To identify targets capable of enhancing the antitumor activity of T cell therapies, large-scale in vitro and in vivo clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 screens were performed, with the SOCS1 gene identified as a top T cell–enhancing

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Laura Donlin, PhD: Study Discovers New Subtypes of Rheumatoid Arthritis

HCPLive

Laura Donlin, PhD, highlights the significance of identifying new subtypes of rheumatoid arthritis, emphasizing the potential for a paradigm shift in RA treatment toward personalized care and early interventions.

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Blood group may predict risk of stroke when receiving COVID-19 Oxford-AstraZeneca vaccine

Medical Xpress - Cardiology

A large international research collaboration, led by an academic from Royal Holloway, University of London, found that blood groups could help predict the risk of venous strokes associated with the Oxford-AstraZeneca COVID-19 vaccine.

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Occlusion myocardial infarction is a clinical diagnosis

Dr. Smith's ECG Blog

Occlusion myocardial infarction is a clinical diagnosis Written by Willy Frick (@Willyhfrick). Willy is a cardiology fellow with a keen interest in the ECG in OMI. A woman in her late 70s presented with left arm pain. The arm pain started the day prior when she was at the dentist's office for a root canal. Her systolic blood pressure at the dentist was over 200 mm Hg.

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Experts, Lawmakers Explore Downside of Drug-Price Negotiation

Med Page Today

(MedPage Today) -- Potential unintended consequences of Medicare's drug-price negotiation program were examined during a panel discussion hosted by The Hill and sponsored by the Alliance for Aging Research, an industry-funded nonprofit. Wednesday.

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1 in 6 Patients with Gout Experience Second Flare within 1 Year

HCPLive

Patients with gout who did not experience recurrent flares had a shorter mean time between diagnosis and the start of urate-lowering therapy compared with those who had ≥1 flare.

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Use of Anticoagulant Drug after Aortic Valve Replacement Lowers Mortality Risk, Mayo Clinic Study Finds

DAIC

milla1cf Tue, 12/12/2023 - 07:00 December 12, 2023 — Patients who received the anticoagulant drug warfarin after bioprosthetic aortic valve replacement had lower incidence of mortality and a decreased risk of blood clots, according to a retrospective study published in Mayo Clinic Proceedings. The use of bioprosthetic aortic valve replacement has increased significantly during the past decade.

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Syncope While Driving. Activate the Cath Lab?

Dr. Smith's ECG Blog

A 50-something had syncope while driving. He was belted and it was low speed. He had a prehospital ECG. He was ambulatory at the scene. He has a history of STEMI and heart failure. The medics stated he had been nauseated and diaphoretic, but he did not have any chest pain or SOB. They recorded a prehospital ECG: What do you think? I read this blinded, with no clinical information, and read it as inferior OMI.

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Stopping Tirzepatide Led to Weight Gain, Trial Shows

Med Page Today

(MedPage Today) -- After discontinuing the weight-management injectable tirzepatide (Zepbound), most patients had a hard time keeping the weight off during the phase III SURMOUNT-4 trial. People on a maximum tolerated dose of tirzepatide (10 or.

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Anti-Inflammatory Diet May Prevent, Improve Gout

HCPLive

Patients with the highest Dietary Inflammatory Index have an increased risk of gout.

Diet 119
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Researchers discover first ever link between hemoglobin-like protein and normal heart development

Science Daily - Heart Disease

Researchers have discovered that a certain kind of protein similar to hemoglobin, called cytoglobin, plays an important role in the development of the heart. Specifically, it affects the correct left-right pattern of the heart and other asymmetric organs. The findings could eventually lead to the development of new therapeutic interventions to alter the processes that lead to these defects.

Research 113
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Engineered hydrogel reveals contribution of matrix mechanics to esophageal adenocarcinoma and identifies matrix-activated therapeutic targets

Journal of Clinical Investigation - Cardiology

Increased extracellular matrix (ECM) stiffness has been implicated in esophageal adenocarcinoma (EAC) progression, metastasis, and resistance to therapy. However, the underlying protumorigenic pathways are yet to be defined. Additional work is needed to develop physiologically relevant in vitro 3D culture models that better recapitulate the human tumor microenvironment and can be used to dissect the contributions of matrix stiffness to EAC pathogenesis.

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HF Patient's Zip Code Telling of Potential Adherence Issues to Meds

Med Page Today

(MedPage Today) -- Patients living in more disadvantaged neighborhoods were more likely to leave their prescriptions for standard heart failure medications unfilled, retrospective data from a large health system showed. Among patients with heart.

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Rheumatoid Arthritis Quiz: Anxiety and Depression in RA

HCPLive

It is common for patients with rheumatoid arthritis to have mental health conditions. Test your knowledge of the impact of anxiety and depression in rheumatoid arthritis with this quiz.

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Unique cell-based approach for pulmonary arterial hypertension shown to be safe

Science Daily - Heart Disease

Infusions of potentially therapeutic cells derived from the heart are safe for people with pulmonary arterial hypertension, a form of high blood pressure that occurs in the blood vessels of the lungs and typically affects middle-aged women, according to a new study.

Pulmonary 112
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Increased Risk of Heart Rhythm Disruption After COVID-19

DAIC

Ioannis Katsoularis, image courtesy of Klas Sjöberg milla1cf Thu, 12/14/2023 - 09:23 December 14, 2023 — Individuals infected with COVID-19 are also at an increased risk of suffering from heart rhythm disturbances, such as atrial fibrillation. This is shown in a new study at Umeå University, Sweden , which is one of the largest studies of its kind in the world.

COVID-19 111
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How PACS Image Sharing Can Be Simple, Secure & HIPAA Compliant

NOVARAD

In today’s healthcare world, sharing medical images securely and in compliance with regulations is nothing short of a tightrope walk. As we move further into the digital age, the task of keeping sensitive patient data under lock and key while still at the ready for healthcare professionals has become a priority. That’s where PACS image sharing steps into the limelight.

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Fit For All Patients: Advances in IBD Therapy Expand Treatment Landscape

HCPLive

The past year has seen a multitude of FDA approvals, ranging from IL-23 and JAK inhibitors to biologics and subcutaneous treatment administrations, that have helped redefine what it means to treat IBD.

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New AI-powered algorithm could better assess people's risk of common heart condition

Science Daily - Heart Disease

Early detection of atrial fibrillation can reduce the risk of stroke and heart failure, but screening people for the condition has been historically challenging.

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The triglyceride glucose index trajectory is associated with hypertension: a retrospective longitudinal cohort study

Cardiovascular Diabetology

Previous studies have found that the triglyceride glucose index (TyG index) trajectories are associated with cardiovascular diseases. However, the association between the patterns of TyG index trajectories and.

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New AI-powered Algorithm Could Better Assess People’s Risk of Common Heart Condition

DAIC

milla1cf Wed, 12/13/2023 - 10:24 December 13, 2023 — A new artificial intelligence (AI) model designed by Scripps Research scientists could help clinicians better screen patients for atrial fibrillation (or AFib)—an irregular, fast heartbeat that is associated with stroke and heart failure. The model picks up on tiny variations in a person’s normal heartbeat that signify AFib risk, which standard screening tests cannot detect.

AFIB 111
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Phase 3 APPLY-PNH Extension Data Show Sustained Benefit of Iptacopan (Fabhalta) for PNH

HCPLive

Results showed treatment with iptacopan through 48 weeks caused hemoglobin-level increases, blood transfusion avoidance, and reductions in patient-reported fatigue.

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Deaths from heart valve infections drop across U.S. overall, but surged among young adults

American Heart News - Heart News

Research Highlights: An analysis of death certificate data from 1999 to 2020 showed a decline in deaths related to infective endocarditis throughout most of the United States yet found an alarming increase of 2%-5% among adults ages 25-44. There was.

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New Mexico researchers develop cholesterol vaccine

Becker's Hospital Review - Cardiology

Researchers at UNM School of Medicine have developed a new LDL cholesterol vaccine that is tested on mice and monkeys with positive results.

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ADORA2A-driven proline synthesis triggers epigenetic reprogramming in neuroendocrine prostate and lung cancers

Journal of Clinical Investigation - Cardiology

Cell lineage plasticity is one of the major causes for the failure of targeted therapies in various cancers. However, the driver and actionable drug targets in promoting cancer cell lineage plasticity are scarcely identified. Here, we found that a G protein-coupled receptor, ADORA2A, is specifically upregulated during neuroendocrine differentiation, a common form of lineage plasticity in prostate cancer and lung cancer following targeted therapies.

Cancer 109