Ken Grauer, MD
MARCH 1, 2024
I was sent the 2 ECGs shown in Figure-1 — which were recorded from an elderly man whose heart beat "has been irregular for years". No clear history for recent chest pain — but the patient "has not been well" for the previous week. Regarding the 2 ECGs in Figure-1 : ECG #1 is the initial tracing obtained at the scene by the EMS ( E mergency M edical S ystems ) team — in association with an alert but markedly hypotensive patient.
American Heart News - Heart News
FEBRUARY 28, 2024
Research Highlights: An analysis of survey data for 430,000 adults in the U.S. found that using cannabis has a significant association with an increased risk of heart attack and stroke, independent of tobacco use, with higher odds among the adults.
Med Page Today
FEBRUARY 28, 2024
(MedPage Today) -- Cannabis use was independently linked to adverse cardiovascular outcomes in the general population even after accounting for tobacco cigarette and e-cigarette use, a large national study found. Using data from the CDC's Behavioral.
Journal of Clinical Investigation - Cardiology
MARCH 1, 2024
Long-term organ transplant survival remains suboptimal, and life-long immunosuppression predisposes transplant recipients to an increased risk of infection, malignancy, and kidney toxicity. Promoting the regulatory arm of the immune system by expanding Tregs may allow immunosuppression minimization and improve long-term graft outcomes. While low-dose IL-2 treatment can expand Tregs, it has a short half-life and off-target expansion of NK and effector T cells, limiting its clinical applicability.
HCPLive
FEBRUARY 29, 2024
Cancer patients with behavioral health disorders, such as substance abuse, eating disorders, and sleep disorders have a 7.76% increase in health care costs, a new study found.
American Heart News - Heart News
FEBRUARY 27, 2024
Research Highlights Closer proximity to and a higher number of ready-to-eat food outlets — particularly pubs, bars and fast-food restaurants — may be associated with a greater risk of developing heart failure, according to a study of half a million.
Med Page Today
FEBRUARY 26, 2024
(MedPage Today) -- Lipoprotein(a), or Lp(a), at levels well below currently accepted risk thresholds correlated with increased cardiovascular risk in a large registry study, suggesting a wider patient pool that could benefit from future preventive.
Cardiovascular Update brings together the best content for cardiovascular medicine professionals from the widest variety of industry thought leaders.
DAIC
FEBRUARY 26, 2024
milla1cf Mon, 02/26/2024 - 12:40 February 26, 2024 — More than 6 million Americans live with heart failure , and about half have an enlarged left ventricle, which causes stress on the heart and less blood pumped with each heartbeat. The Ohio State University Wexner Medical Center is the first in central Ohio to take part in a global clinical trial to use a novel therapy to reduce the size of the left ventricle without open-heart surgery.
American Heart News - Heart News
MARCH 1, 2024
DALLAS, March 1, 2024 – Losing an extra hour of sleep may not be the worst thing that could happen when you “spring forward” at the start of daylight saving time. According to the American Heart Association, celebrating one hundred years of lifesaving.
Journal of Clinical Investigation - Cardiology
MARCH 1, 2024
Patients with chronic inflammatory disorders such as psoriasis have an increased risk of cardiovascular disease and elevated levels of LL37, a cathelicidin host defense peptide that has both antimicrobial and proinflammatory properties. To explore whether LL37 could contribute to the risk of heart disease, we examined its effects on lipoprotein metabolism and show that LL37 enhanced LDL uptake in macrophages through the LDL receptor (LDLR), scavenger receptor class B member 1 (SR-B1), and CD36.
HCPLive
FEBRUARY 27, 2024
Minerva Neurosciences announced the receipt of a Complete Response Letter for roluperidone in treatment of negative symptoms in patients with schizophrenia on February 27, 2024 despite clinical trial data indicating improved Negative Symptom Factor Scores and Personal and Social Performance scale scores.
Becker's Hospital Review - Cardiology
FEBRUARY 28, 2024
Discover the top 10 cardiology hospitals in the world, with seven based in the U.S. according to Newsweek's 2024 "World's Best Hospitals" list.
American Heart News - Heart News
MARCH 1, 2024
DALLAS, 1 de marzo de 2024 – Es posible que perder una hora extra de sueño no sea lo peor que podría pasar cuando se “adelanten los relojes” al comienzo del horario de verano. Según la American Heart Association (la Asociación Americana del Corazón), que.
Journal of Clinical Investigation - Cardiology
MARCH 1, 2024
Metastasized colorectal cancer (CRC) is associated with a poor prognosis and rapid disease progression. Besides hepatic metastasis, peritoneal carcinomatosis is the major cause of death in Union for International Cancer Control (UICC) stage IV CRC patients. Insights into differential site-specific reconstitution of tumor cells and the corresponding tumor microenvironment are still missing.
Cardiovascular Diabetology
MARCH 1, 2024
Platelets play an important role in the development of cardiovascular disease (CVD). Mean platelet volume (MPV) is considered as biological marker of platelets activity and function. The aim of the present stu.
DAIC
MARCH 1, 2024
Sumeet Chugh, MD. Photo by Cedars-Sinai milla1cf Fri, 03/01/2024 - 08:25 March 1, 2024 — Two new studies by Cedars-Sinai investigators support using artificial intelligence (AI) to predict sudden cardiac arrest-a health emergency that in 90% of cases leads to death within minutes. “Sudden cardiac arrest is a mostly lethal condition, and prevention will make the biggest impact, but we need to find novel clinical tools to make that possible,” said Sumeet Chugh, MD , director of the Division of A
Nature Reviews - Cardiology
FEBRUARY 27, 2024
Nature Reviews Cardiology, Published online: 28 February 2024; doi:10.1038/s41569-024-01004-2 Atrial fibrillation is the most common sustained arrhythmia and imposes a substantial burden on patients and health-care providers. Clinical evidence suggests that antiarrhythmic therapy to restore and maintain sinus rhythm (rhythm control) can reduce adverse cardiovascular outcomes in patients with new-onset atrial fibrillation.
HCPLive
MARCH 1, 2024
In the February edition of Dermatology Month in Review, new acne guidelines released by AAD, an FDA decision on nemolizumab, and an interview on potentially the first oral IL-23 inhibitor for psoriasis were among the major stories.
Cardiovascular Diabetology
FEBRUARY 27, 2024
Non-alcoholic fatty liver disease (NAFLD), identified by the Fatty Liver Index (FLI), is associated with increased mortality and cardiovascular (CV) outcomes. Whether this also applies to type 1 diabetes (T1D).
DAIC
FEBRUARY 28, 2024
Getty Images milla1cf Wed, 02/28/2024 - 19:13 February 28, 2024 — Artificial intelligence ( AI ) may transform cardiovascular medicine. For now, though, many challenges remain, and few AI tools have been proven to improve care, according to a new American Heart Association scientific statement published today in Circulation , the Association’s flagship, peer-reviewed journal.
Journal of Clinical Investigation - Cardiology
MARCH 1, 2024
Neutrophil extracellular traps (NETs), a web-like structure of cytosolic and granule proteins assembled on decondensed chromatin, kill pathogens and cause tissue damage in diseases. Whether NETs can kill cancer cells is unexplored. Here, we report that a combination of glutaminase inhibitor CB-839 and 5-FU inhibited the growth of PIK3CA-mutant colorectal cancers (CRCs) in xenograft, syngeneic, and genetically engineered mouse models in part through NETs.
Med Page Today
FEBRUARY 28, 2024
(MedPage Today) -- Note that some links may require registration or subscription. In middle-age men with high Alzheimer's dementia risk, higher pancreatic fat was linked with lower cognition and brain volumes. (Obesity) The Department of Justice.
Dr. Paddy Barrett
FEBRUARY 27, 2024
Most people only start to worry about cardiovascular risk later in life. This is a bad idea. Here’s why. When you look at the risk of having a heart attack, it is true that the older you are, the greater the odds of having a heart attack 1. So far, so good. But this graph is very misleading. While only 1-2% of those having a heart attack are less than 65 years of age, 1-2% of this very large number means a LOT of heart attacks.
DAIC
FEBRUARY 27, 2024
milla1cf Tue, 02/27/2024 - 17:29 February 27, 2024 — Aria CV, Inc , a developer of medical devices treating pulmonary hypertension, today announced the first patient was implanted with the Gen 2 Aria CV Pulmonary Hypertension System as part of the ASPIRE PH clinical trial at Ascension St. Vincent Cardiovascular Research Institute in Indianapolis, Indiana.
Becker's Hospital Review - Cardiology
MARCH 1, 2024
Findley, Ohio-based Blanchard Valley Health System is cutting its open-heart surgery program and will instead transfer patients to other systems as needed.
Med Page Today
FEBRUARY 27, 2024
(MedPage Today) -- Patients with type 2 diabetes had better glycemic control and higher rates of diabetes remission over the long term with bariatric surgery compared with lifestyle and medical management in the pre-GLP-1 receptor agonist era.
Journal of Clinical Investigation - Cardiology
MARCH 1, 2024
Nuclear factor of activated T-cells 5 (NFAT5), an osmo-sensitive transcription factor, can be activated by isotonic stimuli, such as infection. It remains unclear, however, whether NFAT5 is required for damage-associated molecular pattern–triggered (DAMP-triggered) inflammation and immunity. Here, we found that several DAMPs increased NFAT5 expression in macrophages.
DAIC
MARCH 1, 2024
milla1cf Fri, 03/01/2024 - 08:50 March 1, 2024 — Boston Scientific Corporation today announced it has received U.S. Food and Drug Administration ( FDA ) approval for the AGENT Drug-Coated Balloon (DCB), which is indicated to treat coronary in-stent restenosis (ISR) in patients with coronary artery disease. ISR is the obstruction or narrowing of a stented vessel by plaque or scar tissue.
ECG Cases
FEBRUARY 27, 2024
Anand Swaminathan on an update on the appropriate selection of induction agents. Hans Rosenberg on when to use gabapentinoids for pain control in the ED. Katie Lin on pearls for neuroprotective intubation. Nour Khatib and Hamza Jalal on an approach to paresthesias in the ED. Eric Wortmann on preventing burnout in emergency medicine. Please support EM Cases with a donation [link] The post EM Quick Hits 55 – Induction Agents, Gabapentinoids, Neuroprotective Intubation, Approach to Paresthesi
Med Page Today
FEBRUARY 27, 2024
(MedPage Today) -- A novel class of antithrombotic medication, the factor XIa inhibitors, has had a rocky start but is powering through phase III trials, which are now underway. MedPage Today sat down to discuss the novel agents with Graeme Hankey.
Journal of Clinical Investigation - Cardiology
MARCH 1, 2024
Converging studies demonstrate the dysfunction of the dopaminergic neurons following chronic opioid administration. However, the therapeutic strategies targeting opioid-responsive dopaminergic ensembles that contribute to the development of opioid withdrawal remain to be elucidated. Here, we used the neuronal activity-dependent Tet-Off system to label dopaminergic ensembles in response to initial morphine exposure (Mor-Ens) in the ventral tegmental area (VTA).
DAIC
FEBRUARY 28, 2024
Wendy Bottinor, MD. Image courtesy of VCU Massey Comprehensive Cancer Center milla1cf Wed, 02/28/2024 - 19:24 February 28, 2024 — New research out of VCU Massey Comprehensive Cancer Center and VCU Health Pauley Heart Center indicates that survivors of childhood cancer are at a significantly higher risk of death following a major cardiovascular event — including heart failure , heart attack or stroke — than the general public.
HCPLive
FEBRUARY 28, 2024
MoodCapture, an app with AI that can detect depression onset from facial cues, accurately diagnosed 75% of participants in a study with early symptoms of depression.
Open Heart
FEBRUARY 27, 2024
Objectives The clinical outcomes of transcatheter aortic valve replacement (TAVR) in patients with aortic stenosis (AS) and concomitant active cancer remain insufficiently explored. This study aimed to assess the midterm outcomes of TAVR in patients diagnosed with AS and active cancer. Methods Data from the OCEAN-TAVI, a prospective Japanese registry of TAVR procedures, was analysed to compare prognoses and clinical outcomes in patients with and without active cancer at the time of TAVR.
Journal of Clinical Investigation - Cardiology
MARCH 1, 2024
Two coding variants of apolipoprotein L1 (APOL1), called G1 and G2, explain much of the excess risk of kidney disease in African Americans. While various cytotoxic phenotypes have been reported in experimental models, the proximal mechanism by which G1 and G2 cause kidney disease is poorly understood. Here, we leveraged 3 experimental models and a recently reported small molecule blocker of APOL1 protein, VX-147, to identify the upstream mechanism of G1-induced cytotoxicity.
DAIC
MARCH 1, 2024
Getty Images milla1cf Fri, 03/01/2024 - 08:32 March 1, 2024 — Prenatal stress is a potential risk factor for cardiovascular disease in offspring later in life. In a new study published in JACC: Heart Failure , maternal loss of a partner or child shortly before or during pregnancy was found to be associated with increased risk of heart failure up to middle-age in the child.
HCPLive
FEBRUARY 28, 2024
This analysis emphasizes the necessity of prevention of melanoma as well as the public health and economic consequences of patients’ delaying of skin cancer diagnoses.
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