Ken Grauer, MD
JANUARY 13, 2024
The ECG in Figure-1 was obtained from a middle-aged man with known hypertension — who presented to the ED ( E mergency D epartment ) for CP ( C hest P ain ) over the preceding 2-3 days. QUESTIONS: How would YOU interpret the ECG in Figure-1 ? Should you activate the cath lab? If not — What next? Figure-1: The initial ECG in today's case — obtained from a middle-aged man with CP for the past 2-3 days.
American Heart News - Heart News
JANUARY 17, 2024
Research Highlights: Consistently high scores of perceived stress during adolescence through adulthood may contribute to worse cardiometabolic health including obesity in young adults. Researchers suggest the adoption of healthy coping strategies.
HCPLive
JANUARY 18, 2024
Both the FDA and EU regulators indicated visual acuity may serve as primary endpoint to evaluate MCO-010 in the treatment of low-vision retinitis pigmentosa patients.
Cardiovascular Diabetology
JANUARY 19, 2024
Legume consumption has been linked to a reduced risk of type 2 diabetes (T2D) and cardiovascular disease (CVD), while the potential association between plasma metabolites associated with legume consumption and.
Med Page Today
JANUARY 18, 2024
(MedPage Today) -- The new nomenclature for classifying steatotic liver disease (SLD) can help clinicians determine distinct prognoses, with the integration of alcohol intake as an aid in risk stratification, according to an analysis of a prospective.
Journal of Clinical Investigation - Cardiology
JANUARY 16, 2024
Heterozygous (HET) truncating variant mutations in the TTN gene (TTNtvs), encoding the giant titin protein, are the most common genetic cause of dilated cardiomyopathy (DCM). However, the molecular mechanisms by which TTNtv mutations induce DCM are controversial. Here, we studied 127 clinically identified DCM human cardiac samples with next-generation sequencing (NGS), high-resolution gel electrophoresis, Western blot analysis, and super-resolution microscopy in order to dissect the structural a
American Heart News - Heart News
JANUARY 16, 2024
Highlights: Research teams share findings and progress on projects aimed at harnessing digital solutions — including text messaging, smartphone apps, wearable devices and artificial intelligence — to improve health, reduce health care disparities,
Cardiovascular Update brings together the best content for cardiovascular medicine professionals from the widest variety of industry thought leaders.
Cardiology Update
JANUARY 14, 2024
The perplexing landscape of angina with nonobstructive coronary arteries (ANOCA) encompasses diverse pathophysiological entities, including coronary microvascular disease (CMD), coronary artery spasm, and the enigmatic myocardial bridging (MB). Traditionally deemed benign, MBs, marked by the intramyocardial passage of an epicardial artery, are increasingly implicated in chronic angina and acute ischemic events.
Journal of Clinical Investigation - Cardiology
JANUARY 16, 2024
Vascular aging affects multiple organ systems, including the brain, where it can lead to vascular dementia. However, a concrete understanding of how aging specifically affects the brain vasculature, along with molecular readouts, remains vastly incomplete. Here, we demonstrate that aging is associated with a marked decline in Notch3 signaling in both murine and human brain vessels.
HCPLive
JANUARY 17, 2024
These data indicate that e-cigarettes and nicotine patches were found not to negatively impact pregnant smokers in a significant way, though further study may be valuable.
DAIC
JANUARY 15, 2024
A public-private partnership Think Tank, focused on leveraging remote monitoring for cardiac safety in clinical trials, has been announced by the Cardiac Safety Research Consortium, CSRC, to be held Feb. 29-Mar. 1, 2024 in San Diego, CA, and will include representatives from the FDA, academia and industry. Image courtesy: CSRC christine.book Mon, 01/15/2024 - 13:36 January 15, 2024 — A public-private partnership Think Tank, scheduled for Feb. 29-March 1, will be presented by the Cardiac Safety R
Medical Xpress - Cardiology
JANUARY 17, 2024
A new study has hailed camel milk for its ability to lower heart disease risk among diabetics and help in the treatment of dyslipidemia.
Journal of Clinical Investigation - Cardiology
JANUARY 16, 2024
Recent studies using cell type–specific knockout mouse models have improved our understanding of the pathophysiological relevance of suppressor of lin-12-like–HMG-CoA reductase degradation 1 (SEL1L-HRD1) endoplasmic reticulum–associated (ER-associated) degradation (ERAD); however, its importance in humans remains unclear, as no disease variant has been identified.
Becker's Hospital Review - Cardiology
JANUARY 18, 2024
New York City-based NewYork-Presbyterian Morgan Stanley Children's Hospital performed the first "domino" heart transplant on babies, according to an American Hospital Association report.
DAIC
JANUARY 17, 2024
The application of AI technology in the diagnosis of cardiovascular diseases using coronary CT angiography (CCTA) has gradually deepened, and efficient and intelligent methods are optimizing and reshaping the clinical diagnosis pathways, including optimization of image quality, fully automated calculation of calcification score, coronary stenosis, quantitative and qualitative assessment of plaque components, quantification of perivascular and pericardiac fat, and calculation of non-invasive CT-d
HCPLive
JANUARY 14, 2024
A study compared the efficacy of febuxostat and benzbromarone in treating gout, emphasizing the lack of consensus in previous research and the need for future, well-designed studies.
American Heart News - Heart News
JANUARY 16, 2024
DALLAS, 16 DE ENERO DE 2024 - La salud bucal de un paciente puede ser un indicador de su salud y bienestar general. Las investigaciones demuestran que la inflamación crónica de las encías puede estar asociada con otras enfermedades crónicas, como.
Med Page Today
JANUARY 18, 2024
(MedPage Today) -- Operators reported the initial success of a novel transcatheter technique for treating complex paravalvular leaks (PVLs) after transcatheter aortic valve replacement (TAVR) or transcatheter mitral valve replacement (TMVR) in.
DAIC
JANUARY 18, 2024
The American Heart Association has issued a new Policy Statement focused on the need to address structural racism as a central component to reducing cardiovascular disparities across the United States. Image courtesy: AHA christine.book Thu, 01/18/2024 - 13:33 January 18, 2024 — A new American Heart Association (AHA) policy statement examines the history of structural racism, and offers public policy considerations for several key social drivers of health disparities, including health care, heal
HCPLive
JANUARY 19, 2024
Evidence from the Look AHEAD study suggests achieving remission in type 2 diabetes is associated with risk reductions in chronic kidney disease and cardiovascular disease.
Science Daily - Stroke
JANUARY 16, 2024
This month, a group of stroke survivors in British Columbia will test a new technology designed to aid their recovery, and ultimately restore use of their limbs and hands. Participants will wear a new groundbreaking 'smart glove' capable of tracking their hand and finger movements during rehabilitation exercises.
Dr. Smith's ECG Blog
JANUARY 13, 2024
Written by Willy Frick A man in his 70s with a history of HFrEF and sick sinus syndrome s/p dual chamber pacemaker placement was admitted for overnight observation following outpatient placement of a mitral valve clip. The procedure note indicates uncomplicated clip placement. The next morning, the following ECG was obtained. What do you think? The tracing shows sinus rhythm with PVCs and non-specific ST&T wave abnormality.
DAIC
JANUARY 19, 2024
milla1cf Fri, 01/19/2024 - 10:43 January 19, 2024 — W. L. Gore & Associates, Inc. announced that the first patients have been enrolled in the Gore VBX FORWARD Clinical Study ( NCT05811364 ), a global prospective, multicenter, randomized controlled trial to compare the GORE VIABAHN VBX Balloon Expandable Endoprosthesis (VBX Stent Graft) to bare metal stenting for patients with complex iliac occlusive disease.
HCPLive
JANUARY 17, 2024
The FDA has extended the shelf-life of 4 mg naloxone hydrochloride nasal spray (Narcan) for nonprescription over-the-counter use from 3 years to 4 years.
Journal of Clinical Investigation - Cardiology
JANUARY 16, 2024
Adolescent idiopathic scoliosis (AIS) is the most common form of spinal deformity, affecting millions of adolescents worldwide, but it lacks a defined theory of etiopathogenesis. Because of this, treatment of AIS is limited to bracing and/or invasive surgery after onset. Preonset diagnosis or preventive treatment remains unavailable. Here, we performed a genetic analysis of a large multicenter AIS cohort and identified disease-causing and predisposing variants of SLC6A9 in multigeneration famili
Med Page Today
JANUARY 16, 2024
(MedPage Today) -- Medical marijuana was associated with an elevated risk of new-onset arrhythmia in a Danish population with chronic pain. (European Heart Journal) Severe drug-induced QT prolongation was fairly common in patients taking one of.
DAIC
JANUARY 19, 2024
milla1cf Fri, 01/19/2024 - 10:55 January 19, 2024 — Orchestra BioMed , a biomedical company accelerating high-impact technologies to patients through risk-reward sharing partnerships, today announced the first patient was randomized in the BACKBEAT pivotal study in late December 2023. The BACKBEAT pivotal study will evaluate the efficacy and safety of atrioventricular interval modulation (“AVIM”) therapy (also known as BackBeat CNT), for the treatment of pacemaker-indicated patients with uncont
HCPLive
JANUARY 19, 2024
Patients with IgAN and urine protein levels of 0.75–3.5 g/d treated with corticosteroids exhibited significantly greater overall and complete remission rates compared to those who received supportive care.
Medical Xpress - Cardiology
JANUARY 16, 2024
A 30-minute walk at moderate intensity temporarily reduced blood pressure in women with rheumatoid arthritis, not only at rest but also under stress. This was the conclusion drawn from a study involving physical and cognitive tests conducted at the University of São Paulo (USP) in Brazil.
Becker's Hospital Review - Cardiology
JANUARY 16, 2024
Remembering the life and legacy of pioneering cardiologist Dr. Bruce Wilkoff, who passed away at 69 after a battle with pancreatic cancer.
DAIC
JANUARY 19, 2024
Sumeet Chugh, MD, shown at work in his Cedars-Sinai laboratory, is the recipient of the American College of Cardiology 2024 Distinguished Scientist Award-Clinical Domain. Photo by Cedars-Sinai. milla1cf Fri, 01/19/2024 - 10:38 January 19, 2024 — Heart rhythm expert Sumeet Chugh, MD , associate director of the Smidt Heart Institute at Cedars-Sinai , is the recipient of this year’s American College of Cardiology ( ACC ) Distinguished Scientist Award-Clinical Domain.
HCPLive
JANUARY 14, 2024
In this discussion with E. James Song, MD, several unique clinical pearls for those in dermatology were described and had been drawn from Song’s Winter Clinical presentation.
Journal of Clinical Investigation - Cardiology
JANUARY 16, 2024
Mutations in ATP-binding cassette A3 (ABCA3), a phospholipid transporter critical for surfactant homeostasis in pulmonary alveolar type II epithelial cells (AEC2s), are the most common genetic causes of childhood interstitial lung disease (chILD). Treatments for patients with pathological variants of ABCA3 mutations are limited, in part due to a lack of understanding of disease pathogenesis resulting from an inability to access primary AEC2s from affected children.
Cardiovascular Diabetology
JANUARY 19, 2024
Higher levels of palmitoyl sphingomyelin (PSM, synonymous with sphingomyelin 16:0) are associated with an increased risk of cardiovascular disease (CVD) in people with diabetes. Whether circulating PSM levels.
DAIC
JANUARY 18, 2024
Dr. Rundback (second from left) and team from AIVS in West Orange, NJ. (Photo: Business Wire milla1cf Thu, 01/18/2024 - 14:05 January 18, 2024 — Summa Therapeutics, LLC announced that the first-in-man injectable angioplasty procedures for patients with below-knee peripheral arterial disease (PAD) were performed successfully using its Finesse Injectable balloon catheter platform.
HCPLive
JANUARY 13, 2024
Results confirmed the long-term efficacy of ustekinumab maintenance in patients with ulcerative colitis, demonstrating consistent rates of symptomatic remission and endoscopic improvement with no new safety signals.
Open Heart
JANUARY 19, 2024
Background In patients with distal bifurcation left main stem lesions requiring intervention, the European Bifurcation Club Left Main Coronary Stent Study trial found a non-significant difference in major adverse cardiac events (MACEs, composite of all-cause death, non-fatal myocardial infarction and target lesion revascularisation) favouring the stepwise provisional strategy, compared with the systematic dual stenting.
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