Sat.Jan 13, 2024 - Fri.Jan 19, 2024

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Subclasses of Steatotic Liver Disease Can Help Determine Prognosis

Med Page Today

(MedPage Today) -- The new nomenclature for classifying steatotic liver disease (SLD) can help clinicians determine distinct prognoses, with the integration of alcohol intake as an aid in risk stratification, according to an analysis of a prospective.

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MCO-010 Gene Therapy for Retinitis Pigmentosa Receives Regulatory Feedback

HCPLive

Both the FDA and EU regulators indicated visual acuity may serve as primary endpoint to evaluate MCO-010 in the treatment of low-vision retinitis pigmentosa patients.

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Plasma metabolite profile of legume consumption and future risk of type 2 diabetes and cardiovascular disease

Cardiovascular Diabetology

Legume consumption has been linked to a reduced risk of type 2 diabetes (T2D) and cardiovascular disease (CVD), while the potential association between plasma metabolites associated with legume consumption and.

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Childhood stress linked to higher risk of high blood pressure, obesity, diabetes in adults

American Heart News - Heart News

Research Highlights: Consistently high scores of perceived stress during adolescence through adulthood may contribute to worse cardiometabolic health including obesity in young adults. Researchers suggest the adoption of healthy coping strategies.

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Ultromics Announces Partnership to Expedite Development of Echo AI Algorithm for Early Detection of Cardiac Amyloidosis

DAIC

Image courtesy of Ultromics milla1cf Mon, 01/15/2024 - 12:54 January 15, 2024 — Ultromics , a patient outcomes-focused AI-driven health technology company with roots at the University of Oxford, UK, has entered into an agreement with Pfizer to support the validation and FDA clearance of its AI-based technology for the detection of cardiac amyloidosis.

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Decoding the Menace Within: Unraveling Myocardial Bridges and Exercise-Induced Ischemia

Cardiology Update

The perplexing landscape of angina with nonobstructive coronary arteries (ANOCA) encompasses diverse pathophysiological entities, including coronary microvascular disease (CMD), coronary artery spasm, and the enigmatic myocardial bridging (MB). Traditionally deemed benign, MBs, marked by the intramyocardial passage of an epicardial artery, are increasingly implicated in chronic angina and acute ischemic events.

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Truncated titin is structurally integrated into the human dilated cardiomyopathic sarcomere

Journal of Clinical Investigation - Cardiology

Heterozygous (HET) truncating variant mutations in the TTN gene (TTNtvs), encoding the giant titin protein, are the most common genetic cause of dilated cardiomyopathy (DCM). However, the molecular mechanisms by which TTNtv mutations induce DCM are controversial. Here, we studied 127 clinically identified DCM human cardiac samples with next-generation sequencing (NGS), high-resolution gel electrophoresis, Western blot analysis, and super-resolution microscopy in order to dissect the structural a

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Cardiac Safety Research Consortium Announces Think Tank Program with FDA Regulators, Industry and Academia Focused on Cardiac Remote Monitoring Trials and AI

DAIC

A public-private partnership Think Tank, focused on leveraging remote monitoring for cardiac safety in clinical trials, has been announced by the Cardiac Safety Research Consortium, CSRC, to be held Feb. 29-Mar. 1, 2024 in San Diego, CA, and will include representatives from the FDA, academia and industry. Image courtesy: CSRC christine.book Mon, 01/15/2024 - 13:36 January 15, 2024 — A public-private partnership Think Tank, scheduled for Feb. 29-March 1, will be presented by the Cardiac Safety R

Research 116
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Drinking camel milk can lead to significant reduction in cholesterol levels among diabetics

Medical Xpress - Cardiology

A new study has hailed camel milk for its ability to lower heart disease risk among diabetics and help in the treatment of dyslipidemia.

Diabetes 132
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'Tootsie Roll' Introduced for Leaky Transcatheter Heart Valves

Med Page Today

(MedPage Today) -- Operators reported the initial success of a novel transcatheter technique for treating complex paravalvular leaks (PVLs) after transcatheter aortic valve replacement (TAVR) or transcatheter mitral valve replacement (TMVR) in.

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New York hospital performs 1st 'domino' heart transplant on babies

Becker's Hospital Review - Cardiology

New York City-based NewYork-Presbyterian Morgan Stanley Children's Hospital performed the first "domino" heart transplant on babies, according to an American Hospital Association report.

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Artificial Intelligence Helps Coronary CT Angiography and Accelerates the Development of Precision Medicine

DAIC

The application of AI technology in the diagnosis of cardiovascular diseases using coronary CT angiography (CCTA) has gradually deepened, and efficient and intelligent methods are optimizing and reshaping the clinical diagnosis pathways, including optimization of image quality, fully automated calculation of calcification score, coronary stenosis, quantitative and qualitative assessment of plaque components, quantification of perivascular and pericardiac fat, and calculation of non-invasive CT-d

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Study Compares Clinical Efficacy of Febuxostat, Benzbromarone in Gout Treatment

HCPLive

A study compared the efficacy of febuxostat and benzbromarone in treating gout, emphasizing the lack of consensus in previous research and the need for future, well-designed studies.

Research 111
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Medical Cannabis-Arrhythmia Link; Watch Out for Lipoprotein(a); New SAVR Alternative

Med Page Today

(MedPage Today) -- Medical marijuana was associated with an elevated risk of new-onset arrhythmia in a Danish population with chronic pain. (European Heart Journal) Severe drug-induced QT prolongation was fairly common in patients taking one of.

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Hypomorphic variants of SEL1L-HRD1 ER-associated degradation are associated with neurodevelopmental disorders

Journal of Clinical Investigation - Cardiology

Recent studies using cell type–specific knockout mouse models have improved our understanding of the pathophysiological relevance of suppressor of lin-12-like–HMG-CoA reductase degradation 1 (SEL1L-HRD1) endoplasmic reticulum–associated (ER-associated) degradation (ERAD); however, its importance in humans remains unclear, as no disease variant has been identified.

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American Heart Association New Policy Statement: Addressing Structural Racism Central to Reducing U.S. Cardiovascular Disease Disparities

DAIC

The American Heart Association has issued a new Policy Statement focused on the need to address structural racism as a central component to reducing cardiovascular disparities across the United States. Image courtesy: AHA christine.book Thu, 01/18/2024 - 13:33 January 18, 2024 — A new American Heart Association (AHA) policy statement examines the history of structural racism, and offers public policy considerations for several key social drivers of health disparities, including health care, heal

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Achieving Diabetes Remission, For No Matter How Long, Can Lower Kidney, Cardiovascular Risk

HCPLive

Evidence from the Look AHEAD study suggests achieving remission in type 2 diabetes is associated with risk reductions in chronic kidney disease and cardiovascular disease.

Diabetes 111
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Childhood stress linked to higher risk of high blood pressure, obesity, diabetes in adults

Science Daily - Heart Disease

Young adults who reported higher stress as adolescents were more likely to have high blood pressure, obesity and other cardiometabolic risk factors as adults, finds new study.

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Erectile Dysfunction Drugs Plus Nitrates Still a Losing Combination, Study Shows

Med Page Today

(MedPage Today) -- As expected, men taking nitrates for stable coronary artery disease (CAD) fared poorly if they added certain erectile dysfunction (ED) drugs to their medicine cabinet, a Swedish population-based study found. Compared with nitrate.

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First Patients Enrolled in the Gore VBX Forward Clinical Study

DAIC

milla1cf Fri, 01/19/2024 - 10:43 January 19, 2024 — W. L. Gore & Associates, Inc. announced that the first patients have been enrolled in the Gore VBX FORWARD Clinical Study ( NCT05811364 ), a global prospective, multicenter, randomized controlled trial to compare the GORE VIABAHN VBX Balloon Expandable Endoprosthesis (VBX Stent Graft) to bare metal stenting for patients with complex iliac occlusive disease.

Stents 107
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FDA Extends Shelf-Life for Naloxone Nasal Spray

HCPLive

The FDA has extended the shelf-life of 4 mg naloxone hydrochloride nasal spray (Narcan) for nonprescription over-the-counter use from 3 years to 4 years.

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Vigilant monitoring is needed to manage cardiac risks in patients using antipsychotics, doctors say

Science Daily - Heart Disease

The use of the antipsychotic drugs quetiapine and haloperidol is associated with an increased risk of ventricular arrhythmias and sudden cardiac death (SCD) caused by drug-induced QT prolongation, reports a new study. Caution is advised to manage cardiac risks in patients prescribed these medications, the authors of the study and an accompanying editorial say.

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Experiences of racism may contribute to the disproportionately high incidence of cardiovascular disease in Black women

Medical Xpress - Cardiology

Cardiovascular disease (CVD) is the leading cause of death in the United States. Black women have a disproportionally higher burden of coronary heart disease (CHD) and CHD-related mortality and earlier onset than women of other racial and ethnic groups.

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Orchestra BioMed Announces Initiation of BACKBEAT Pivotal Study of AVIM Therapy in Hypertensive Pacemaker Patients

DAIC

milla1cf Fri, 01/19/2024 - 10:55 January 19, 2024 — Orchestra BioMed , a biomedical company accelerating high-impact technologies to patients through risk-reward sharing partnerships, today announced the first patient was randomized in the BACKBEAT pivotal study in late December 2023. The BACKBEAT pivotal study will evaluate the efficacy and safety of atrioventricular interval modulation (“AVIM”) therapy (also known as BackBeat CNT), for the treatment of pacemaker-indicated patients with uncont

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Corticosteroids Induce Remission in Patients With IgA Nephropathy, Moderate Proteinuria

HCPLive

Patients with IgAN and urine protein levels of 0.75–3.5 g/d treated with corticosteroids exhibited significantly greater overall and complete remission rates compared to those who received supportive care.

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Lives Prolonged for Longtime CRT-D Users With Heart Failure

Med Page Today

(MedPage Today) -- Eligible heart failure patients with a wide QRS complex spent more time alive after use of a cardiac resynchronization therapy defibrillator (CRT-D) compared with an implantable cardioverter-defibrillator (ICD), according to.

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Cleveland Clinic cardiology pioneer dies at 69

Becker's Hospital Review - Cardiology

Remembering the life and legacy of pioneering cardiologist Dr. Bruce Wilkoff, who passed away at 69 after a battle with pancreatic cancer.

Cancer 116
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Smidt Heart Institute Sudden Cardiac Arrest Expert Receives 2024 Distinguished Scientist Award

DAIC

Sumeet Chugh, MD, shown at work in his Cedars-Sinai laboratory, is the recipient of the American College of Cardiology 2024 Distinguished Scientist Award-Clinical Domain. Photo by Cedars-Sinai. milla1cf Fri, 01/19/2024 - 10:38 January 19, 2024 — Heart rhythm expert Sumeet Chugh, MD , associate director of the Smidt Heart Institute at Cedars-Sinai , is the recipient of this year’s American College of Cardiology ( ACC ) Distinguished Scientist Award-Clinical Domain.

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Eingun James Song, MD: Tips, Tricks for Dermatologists Treating Palmoplantar Psoriasis

HCPLive

In this discussion with E. James Song, MD, several unique clinical pearls for those in dermatology were described and had been drawn from Song’s Winter Clinical presentation.

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Impaired glycine neurotransmission causes adolescent idiopathic scoliosis

Journal of Clinical Investigation - Cardiology

Adolescent idiopathic scoliosis (AIS) is the most common form of spinal deformity, affecting millions of adolescents worldwide, but it lacks a defined theory of etiopathogenesis. Because of this, treatment of AIS is limited to bracing and/or invasive surgery after onset. Preonset diagnosis or preventive treatment remains unavailable. Here, we performed a genetic analysis of a large multicenter AIS cohort and identified disease-causing and predisposing variants of SLC6A9 in multigeneration famili

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Circulating palmitoyl sphingomyelin levels predict the 10-year increased risk of cardiovascular disease death in Chinese adults: findings from the Da Qing Diabetes Study

Cardiovascular Diabetology

Higher levels of palmitoyl sphingomyelin (PSM, synonymous with sphingomyelin 16:0) are associated with an increased risk of cardiovascular disease (CVD) in people with diabetes. Whether circulating PSM levels.

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Injectable Angioplasty Balloon Catheter Transforms Peripheral Procedures, Users Report Reduced Equipment and Contrast Needs

DAIC

Dr. Rundback (second from left) and team from AIVS in West Orange, NJ. (Photo: Business Wire milla1cf Thu, 01/18/2024 - 14:05 January 18, 2024 — Summa Therapeutics, LLC announced that the first-in-man injectable angioplasty procedures for patients with below-knee peripheral arterial disease (PAD) were performed successfully using its Finesse Injectable balloon catheter platform.

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UNIFI Long-Term Extension Shows Safety, Efficacy of Ustekinumab for Ulcerative Colitis Through 4 Years

HCPLive

Results confirmed the long-term efficacy of ustekinumab maintenance in patients with ulcerative colitis, demonstrating consistent rates of symptomatic remission and endoscopic improvement with no new safety signals.

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'Smart glove' can boost hand mobility of stroke patients

Science Daily - Stroke

This month, a group of stroke survivors in British Columbia will test a new technology designed to aid their recovery, and ultimately restore use of their limbs and hands. Participants will wear a new groundbreaking 'smart glove' capable of tracking their hand and finger movements during rehabilitation exercises.

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Cost-effectiveness of stepwise provisional versus systematic dual stenting strategies in patients with distal bifurcation left main stem lesions: economic analysis of the EBC MAIN trial

Open Heart

Background In patients with distal bifurcation left main stem lesions requiring intervention, the European Bifurcation Club Left Main Coronary Stent Study trial found a non-significant difference in major adverse cardiac events (MACEs, composite of all-cause death, non-fatal myocardial infarction and target lesion revascularisation) favouring the stepwise provisional strategy, compared with the systematic dual stenting.

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Abbott Announces First Global Procedures in a Clinical Trial of its Volt Pulsed Field Ablation System to Treat Patients with Abnormal Heart Rhythms

DAIC

milla1cf Thu, 01/18/2024 - 14:21 January 18, 2024 — Abbott announced the first global procedures have been conducted using the company's new Volt Pulsed Field Ablation (PFA) System to treat patients battling common abnormal heart rhythms such as atrial fibrillation (AFib). Over 30 patients were recently treated in Australia as part of Abbott's Volt CE Mark study, a pre-market, multi-center clinical study designed to evaluate the safety and effectiveness of Abbott's Volt PFA System.

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Drinking Caffeine, Raising Stereo Volume to Stay Alert Could be Warning Sign for Sleep Apnea

HCPLive

In a new study, nearly a third of participants with OSA reported using > 3 coping strategies, but participants without OSA reported never using > 3 coping strategies.

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