Sat.Jan 13, 2024 - Fri.Jan 19, 2024

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ECG Blog #412 — Is Cardiac Cath Indicated?

Ken Grauer, MD

The ECG in Figure-1 was obtained from a middle-aged man with known hypertension — who presented to the ED ( E mergency D epartment ) for CP ( C hest P ain ) over the preceding 2-3 days. QUESTIONS: How would YOU interpret the ECG in Figure-1 ? Should you activate the cath lab? If not — What next? Figure-1: The initial ECG in today's case — obtained from a middle-aged man with CP for the past 2-3 days.

Blog 156
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Childhood stress linked to higher risk of high blood pressure, obesity, diabetes in adults

American Heart News - Heart News

Research Highlights: Consistently high scores of perceived stress during adolescence through adulthood may contribute to worse cardiometabolic health including obesity in young adults. Researchers suggest the adoption of healthy coping strategies.

Obesity 133
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Drinking camel milk can lead to significant reduction in cholesterol levels among diabetics

Medical Xpress - Cardiology

A new study has hailed camel milk for its ability to lower heart disease risk among diabetics and help in the treatment of dyslipidemia.

Diabetes 132
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'Smart glove' can boost hand mobility of stroke patients

Science Daily - Stroke

This month, a group of stroke survivors in British Columbia will test a new technology designed to aid their recovery, and ultimately restore use of their limbs and hands. Participants will wear a new groundbreaking 'smart glove' capable of tracking their hand and finger movements during rehabilitation exercises.

Stroke 130
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Artificial Intelligence Closes Care Gaps in Diabetic Eye Exams

HCPLive

Autonomous AI increases diabetic eye exam completion rates in a diverse population of youth with diabetes.

Diabetes 130
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Subclasses of Steatotic Liver Disease Can Help Determine Prognosis

Med Page Today

(MedPage Today) -- The new nomenclature for classifying steatotic liver disease (SLD) can help clinicians determine distinct prognoses, with the integration of alcohol intake as an aid in risk stratification, according to an analysis of a prospective.

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Childhood stress linked to higher risk of high blood pressure, obesity, diabetes in adults

Science Daily - Heart Disease

Young adults who reported higher stress as adolescents were more likely to have high blood pressure, obesity and other cardiometabolic risk factors as adults, finds new study.

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Ultromics Announces Partnership to Expedite Development of Echo AI Algorithm for Early Detection of Cardiac Amyloidosis

DAIC

Image courtesy of Ultromics milla1cf Mon, 01/15/2024 - 12:54 January 15, 2024 — Ultromics , a patient outcomes-focused AI-driven health technology company with roots at the University of Oxford, UK, has entered into an agreement with Pfizer to support the validation and FDA clearance of its AI-based technology for the detection of cardiac amyloidosis.

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Decoding the Menace Within: Unraveling Myocardial Bridges and Exercise-Induced Ischemia

Cardiology Update

The perplexing landscape of angina with nonobstructive coronary arteries (ANOCA) encompasses diverse pathophysiological entities, including coronary microvascular disease (CMD), coronary artery spasm, and the enigmatic myocardial bridging (MB). Traditionally deemed benign, MBs, marked by the intramyocardial passage of an epicardial artery, are increasingly implicated in chronic angina and acute ischemic events.

Exercise 119
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E-Cigarette Use Not Associated with Adverse Pregnancy Outcomes

HCPLive

These data indicate that e-cigarettes and nicotine patches were found not to negatively impact pregnant smokers in a significant way, though further study may be valuable.

Outcomes 118
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Research aims to harness technology for improved heart and brain health

American Heart News - Heart News

Highlights: Research teams share findings and progress on projects aimed at harnessing digital solutions — including text messaging, smartphone apps, wearable devices and artificial intelligence — to improve health, reduce health care disparities,

Research 116
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How health journalists help “to make people who feel invisible feel seen”

Heart Sisters

Having severe symptoms dismissed by the doctors we turn to for help can feel as crushing as the physical suffering itself, says science writer Ed Yong - who believes that journalists can "clarify the unfathomable for people too sick to do it themselves.

COVID-19 116
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Cleveland Clinic cardiology pioneer dies at 69

Becker's Hospital Review - Cardiology

Remembering the life and legacy of pioneering cardiologist Dr. Bruce Wilkoff, who passed away at 69 after a battle with pancreatic cancer.

Cancer 116
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FDA Extends Shelf-Life for Naloxone Nasal Spray

HCPLive

The FDA has extended the shelf-life of 4 mg naloxone hydrochloride nasal spray (Narcan) for nonprescription over-the-counter use from 3 years to 4 years.

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Cardiac Safety Research Consortium Announces Think Tank Program with FDA Regulators, Industry and Academia Focused on Cardiac Remote Monitoring Trials and AI

DAIC

A public-private partnership Think Tank, focused on leveraging remote monitoring for cardiac safety in clinical trials, has been announced by the Cardiac Safety Research Consortium, CSRC, to be held Feb. 29-Mar. 1, 2024 in San Diego, CA, and will include representatives from the FDA, academia and industry. Image courtesy: CSRC christine.book Mon, 01/15/2024 - 13:36 January 15, 2024 — A public-private partnership Think Tank, scheduled for Feb. 29-March 1, will be presented by the Cardiac Safety R

Research 116
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Vigilant monitoring is needed to manage cardiac risks in patients using antipsychotics, doctors say

Science Daily - Heart Disease

The use of the antipsychotic drugs quetiapine and haloperidol is associated with an increased risk of ventricular arrhythmias and sudden cardiac death (SCD) caused by drug-induced QT prolongation, reports a new study. Caution is advised to manage cardiac risks in patients prescribed these medications, the authors of the study and an accompanying editorial say.

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Truncated titin is structurally integrated into the human dilated cardiomyopathic sarcomere

Journal of Clinical Investigation - Cardiology

Heterozygous (HET) truncating variant mutations in the TTN gene (TTNtvs), encoding the giant titin protein, are the most common genetic cause of dilated cardiomyopathy (DCM). However, the molecular mechanisms by which TTNtv mutations induce DCM are controversial. Here, we studied 127 clinically identified DCM human cardiac samples with next-generation sequencing (NGS), high-resolution gel electrophoresis, Western blot analysis, and super-resolution microscopy in order to dissect the structural a

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Gout Linked to a Significantly Higher Likelihood of Migraines

HCPLive

Patients with gout had a 1.26-fold higher likelihood of experiencing migraines when compared with those without gout.

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New York hospital performs 1st 'domino' heart transplant on babies

Becker's Hospital Review - Cardiology

New York City-based NewYork-Presbyterian Morgan Stanley Children's Hospital performed the first "domino" heart transplant on babies, according to an American Hospital Association report.

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'Tootsie Roll' Introduced for Leaky Transcatheter Heart Valves

Med Page Today

(MedPage Today) -- Operators reported the initial success of a novel transcatheter technique for treating complex paravalvular leaks (PVLs) after transcatheter aortic valve replacement (TAVR) or transcatheter mitral valve replacement (TMVR) in.

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Age-related loss of Notch3 underlies brain vascular contractility deficiencies, glymphatic dysfunction, and neurodegeneration in mice

Journal of Clinical Investigation - Cardiology

Vascular aging affects multiple organ systems, including the brain, where it can lead to vascular dementia. However, a concrete understanding of how aging specifically affects the brain vasculature, along with molecular readouts, remains vastly incomplete. Here, we demonstrate that aging is associated with a marked decline in Notch3 signaling in both murine and human brain vessels.

Dementia 115
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Achieving Diabetes Remission, For No Matter How Long, Can Lower Kidney, Cardiovascular Risk

HCPLive

Evidence from the Look AHEAD study suggests achieving remission in type 2 diabetes is associated with risk reductions in chronic kidney disease and cardiovascular disease.

Diabetes 111
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Research shows how a tiny device in the ear canal can monitor heart health

Medical Xpress - Cardiology

A driving simulation study has shown we are one step closer to monitoring our heart health in real time via a tiny device worn in the ear.

Research 111
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Artificial Intelligence Helps Coronary CT Angiography and Accelerates the Development of Precision Medicine

DAIC

The application of AI technology in the diagnosis of cardiovascular diseases using coronary CT angiography (CCTA) has gradually deepened, and efficient and intelligent methods are optimizing and reshaping the clinical diagnosis pathways, including optimization of image quality, fully automated calculation of calcification score, coronary stenosis, quantitative and qualitative assessment of plaque components, quantification of perivascular and pericardiac fat, and calculation of non-invasive CT-d

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Medical Cannabis-Arrhythmia Link; Watch Out for Lipoprotein(a); New SAVR Alternative

Med Page Today

(MedPage Today) -- Medical marijuana was associated with an elevated risk of new-onset arrhythmia in a Danish population with chronic pain. (European Heart Journal) Severe drug-induced QT prolongation was fairly common in patients taking one of.

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Study Compares Clinical Efficacy of Febuxostat, Benzbromarone in Gout Treatment

HCPLive

A study compared the efficacy of febuxostat and benzbromarone in treating gout, emphasizing the lack of consensus in previous research and the need for future, well-designed studies.

Research 111
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Study shows a single session of aerobic exercise improves blood pressure in rheumatoid arthritis patients

Medical Xpress - Cardiology

A 30-minute walk at moderate intensity temporarily reduced blood pressure in women with rheumatoid arthritis, not only at rest but also under stress. This was the conclusion drawn from a study involving physical and cognitive tests conducted at the University of São Paulo (USP) in Brazil.

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Orthostatic hypotension onset after invasive procedure?

Dr. Smith's ECG Blog

Written by Willy Frick A man in his 70s with a history of HFrEF and sick sinus syndrome s/p dual chamber pacemaker placement was admitted for overnight observation following outpatient placement of a mitral valve clip. The procedure note indicates uncomplicated clip placement. The next morning, the following ECG was obtained. What do you think? The tracing shows sinus rhythm with PVCs and non-specific ST&T wave abnormality.

Pacemaker 111
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Impact of Bempedoic Acid on Total Cardiovascular Events

JAMA Cardiology

This prespecified analysis of the Cholesterol Lowering via Bempedoic Acid, an ATP Citrate Lyase (ACL)–Inhibiting Regimen (CLEAR) Outcomes trial investigates if bempedoic acid is associated with a reduction in the total burden of cardiovascular events in patients at high risk for cardiovascular disease.

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Patients with Gout Have Greater Risk of Benign Prostatic Hyperplasia

HCPLive

Benign prostatic hyperplasia was 1.13-fold higher in those with gout when compared with controls.

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American Heart Association New Policy Statement: Addressing Structural Racism Central to Reducing U.S. Cardiovascular Disease Disparities

DAIC

The American Heart Association has issued a new Policy Statement focused on the need to address structural racism as a central component to reducing cardiovascular disparities across the United States. Image courtesy: AHA christine.book Thu, 01/18/2024 - 13:33 January 18, 2024 — A new American Heart Association (AHA) policy statement examines the history of structural racism, and offers public policy considerations for several key social drivers of health disparities, including health care, heal

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Hypomorphic variants of SEL1L-HRD1 ER-associated degradation are associated with neurodevelopmental disorders

Journal of Clinical Investigation - Cardiology

Recent studies using cell type–specific knockout mouse models have improved our understanding of the pathophysiological relevance of suppressor of lin-12-like–HMG-CoA reductase degradation 1 (SEL1L-HRD1) endoplasmic reticulum–associated (ER-associated) degradation (ERAD); however, its importance in humans remains unclear, as no disease variant has been identified.

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3D in vitro human atherosclerosis model for high-throughput drug screening

Science Daily - Stroke

A groundbreaking 3D, three-layer nanomatrix vascular sheet that possesses multiple features of atherosclerosis has been applied for developing a high-throughput functional assay of drug candidates to treat this disease, researchers report.

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Rheumatoid Arthritis Quiz: Women’s Reproductive Years and RA

HCPLive

A number of factors related to reproduction can affect a woman’s risk of rheumatoid arthritis. Test your knowledge with this quiz.

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First Patients Enrolled in the Gore VBX Forward Clinical Study

DAIC

milla1cf Fri, 01/19/2024 - 10:43 January 19, 2024 — W. L. Gore & Associates, Inc. announced that the first patients have been enrolled in the Gore VBX FORWARD Clinical Study ( NCT05811364 ), a global prospective, multicenter, randomized controlled trial to compare the GORE VIABAHN VBX Balloon Expandable Endoprosthesis (VBX Stent Graft) to bare metal stenting for patients with complex iliac occlusive disease.

Stents 107
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Erectile Dysfunction Drugs Plus Nitrates Still a Losing Combination, Study Shows

Med Page Today

(MedPage Today) -- As expected, men taking nitrates for stable coronary artery disease (CAD) fared poorly if they added certain erectile dysfunction (ED) drugs to their medicine cabinet, a Swedish population-based study found. Compared with nitrate.