Sat.Oct 19, 2024 - Fri.Oct 25, 2024

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New guideline: Preventing a first stroke may be possible with screening, lifestyle changes

American Heart News - Stroke News

Guideline Highlights: Each year in the U.S., over half a million people have a first stroke; however, up to 80% of strokes may be preventable. The new primary prevention of stroke guideline from the American Stroke Association urges health care.

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Kidney Compass: Navigating Clinical Trials

HCPLive

Kidney Compass: Navigating Clinical Trials is a multimedia podcast from HCPLive hosted by Brendon Neuen, MBBS, PhD, and Shikha Wadhwani, MD, MS, aimed at exploring the latest in clinical trials and updates in nephrology.

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A Win

Dr. Malcolm Kendrick

21st October 2024 Finally, the dust settles. Zoë and I won our case against the Mail on Sunday. The judgement came out a few weeks ago, but the legal wrangling continued – and still continues. The Mail on Sunday did print an apology. Legally, they do not have to print an apology, but they did, which says something. There is still a statement in open court to come (SIOC).

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Physiology Friday #241: How Caffeine Dose and Timing Affect Our Sleep Physiology

Physiologically Speaking

Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post! Physiologically Speaking is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.

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ECG Blog #453 — Is this Wellens' Syndrome?

Ken Grauer, MD

The ECG in Figure-1 was obtained from a middle-aged man who presented with a 2 week history of progressively increasing CP ( C hest P ain ) with exertion. He had his most severe episode of CP the day before he was seen with this ECG. His CP was much less compared to the day before — but it had not yet completely resolved. An initial Troponin drawn less than 1 hour after the ECG in Figure-1 was recorded was over 10,000.

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Risk of cardiovascular disease linked to long-term exposure to arsenic in community water supplies

Science Daily - Heart Disease

Long-term exposure to arsenic in water may increase cardiovascular risk and especially heart disease risk even at exposure levels below the federal regulatory limit, according to new research. A study describes exposure-response relationships at concentrations below the current regulatory limit and substantiates that prolonged exposure to arsenic in water contributes to the development of ischemic heart disease.

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New Phase 3b Findings Show Guselkumab Leads to Significant Skin Clearance for Psoriasis

HCPLive

These data demonstrated guselkumab’s success for the majority of patients with low body surface area (BSA) moderate plaque psoriasis and special site involvement.

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ECG Blog #452 — Is this Wide QRS Rhythm VT?

Ken Grauer, MD

The patient whose ECG is shown in Figure-1 — presented with acute dyspnea and hypotension. QUESTION: In Figure-1 — Is the rhythm VT? — How certain are you of your answer? Figure-1: The initial ECG in today's case. ( To improve visualization — I've digitized the original ECG using PMcardio ). == MY Thoughts on the ECG in Figure-1: Although at first glance, the ECG in Figure-1 appears to be wide — this is a false initial impression!

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Study offers ‘compelling evidence’ for continuous stroke care improvement

American Heart News - Stroke News

Research Highlights: A retrospective look at Get With The Guidelines® - Stroke registry data from 2003 to 2022 finds substantial and sustained improvements in acute stroke care among those in the quality improvement program. Researchers found.

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Jennifer Lai Yee, MD, PhD, MPH: Honing in on Sparsentan’s Benefit in Genetic FSGS

HCPLive

Yee discussed how the data show a benefit in this hard-to-treat population, which was not seen in the heterogeneous FSGS group.

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Ozempic Linked With Lower Risk of Alzheimer's Diagnosis

Med Page Today

(MedPage Today) -- Semaglutide (Ozempic) was tied to a reduced risk of Alzheimer's disease diagnoses in people with type 2 diabetes, observational data showed. In emulation target trials involving more than 1 million eligible diabetes patients.

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New guideline: Preventing a first stroke may be possible with screening, lifestyle changes

Science Daily - Heart Disease

Updated clinical recommendations, including lifestyle changes, prevention strategies and treatment options, to reduce the risk of a first stroke have been outlined in a new guideline.

Stroke 105
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Conventional computer ECG algorithm misses another potentially deadly abnormality. How does AI perform?

Dr. Smith's ECG Blog

Written by Pendell Meyers A woman in her 70s with with multiple medical comorbidities began to have episodes of weakness and pre-syncope off and on for several days, then suffered three episodes of syncope within a few hours. She was brought to an Emergency Department for evaluation. On arrival she was awake, alert, and asymptomatic, with normal vital signs except for heart rate in the low 50s.

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Looking Ahead: Previewing IgAN at ASN Kidney Week 2024, with Jonathan Barratt, PhD

HCPLive

Jonathan Barratt, PhD, discusses his excitement surrounding data and programming at the American Society of Nephrology's Kidney Week 2024, with a focus on IgAN.

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IV Fluid Shortage May Impact Surgeries Around the U.S. for Weeks

Med Page Today

(MedPage Today) -- Surgery schedules around the country may be washed out for several more weeks while a crucial IV and sterile fluids factory remains shut down for hurricane-related damage. People often plan non-emergency surgeries in the fall.

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Live well, think well: Research shows healthy habits tied to brain health

Science Daily - Heart Disease

In middle-aged people, having risk factors like blood pressure, blood sugar and cholesterol that are not well-controlled combined with not following certain healthy habits including exercise, diet and sleep, are linked to a higher risk of stroke, dementia or depression later in life, according to a new study. These results do not prove that not having healthy habits increases the risk of these conditions, they only show an association.

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EM Quick Hits 60 Post-Tonsillectomy Hemorrhage, Post-CABG Infections, Bougie Tips, Pelvic Fracture Bleeds, Debriefing: Why, When & How

ECG Cases

On this month's EM Quick Hits podcast: Kevin Wasko on post-tonsillectomy hemorrhage management, Brit Long on assessment and management of post-CABG surgical incision infections, Anand Swaminathan on evidence, pitfalls and tips on using Bougies, Leah Flannigan on when to suspect vascular injury in patients with low energy mechanism pelvic fractures, Andrew Petrosoniak on debriefing after cases: why, when and how.

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DUPLEX: Sparsentan Could Offer Greater Benefit in Genetic FSGS

HCPLive

A posthoc analysis of the DUPLEX trial suggests patients with genetic FSGS may experience a more pronounced and sustained antiproteinuric response with sparsentan.

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Poor Sleep at Age 40 Linked to Accelerated Brain Aging

Med Page Today

(MedPage Today) -- Poor sleep at age 40 was associated with accelerated brain aging patterns at age 55, longitudinal data showed. A dose-response relationship emerged between the number of poor sleep characteristics early in midlife and brain.

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Immunotherapy blocks scarring, improves heart function in mice with heart failure

Science Daily - Heart Disease

Researchers have reduced scar formation and improved heart function in mouse models of heart failure using a monoclonal antibody treatment, similar to that approved by the FDA to treat other conditions. The findings point to the possibility of developing such immunotherapies for heart failure in patients who have experienced a heart attack or other injury.

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What’s New in Ultrasound Tech – 2025 Edition

Cassling

While you weren’t looking, a lot has been happening in the field of ultrasound! New technologies, new workflows, new best practices. Over just a few short years, the potential uses of ultrasound have grown exponentially, and that means exciting things for you and your imaging team. Join us as we take a look at the latest developments in ultrasound you may have missed, even if you’re working on equipment that’s just a couple years old.

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Schizophrenia Tied to 4-Fold Increase in Sudden Cardiac Death Risk

HCPLive

A study found people with schizophrenia have a 4-fold higher risk of sudden cardiac death compared to the general population, underscoring the need for cardiometabolic care.

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Case Against Perioperative Beta-Blockers Grows Stronger

Med Page Today

(MedPage Today) -- PHILADELPHIA -- Any beta-blocker use was associated with a higher risk of postoperative stroke, according to research that also found that these medications may factor into racial disparities in stroke risk to some degree.

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Experimental drug engineered to prevent heart failure after heart attacks

Science Daily - Heart Disease

An experimental therapeutic monoclonal antibody therapy could become the first to directly enhance tissue repair in the heart following a heart attack.

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Nueva guía: Prevenir un primer derrame cerebral puede ser posible con una prueba de detección y cambios en el estilo de vida

American Heart News - Stroke News

Aspectos destacados de la guía: Cada año en los EE. UU., más de medio millón de personas sufren un primer ataque o derrame cerebral; sin embargo, hasta el 80% de ellos podrían prevenirse. La nueva guía de prevención primaria de derrame cerebral de la.

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Incident Migraine is Linked to Healthy Cardiovascular System

HCPLive

A new study found that individuals with healthier cardiovascular systems are more likely to develop migraines, linking incident migraine to lower cardiovascular risk.

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Preeclampsia Flagged by Common Lab Values

Med Page Today

(MedPage Today) -- PHILADELPHIA -- Existing blood tests may help identify pregnant women at risk of developing preeclampsia, researchers found from a retrospective chart review. Calculated from lab values taken at admission for labor, the fibrinogen.

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Rapid Cardiovascular Response to Belzutifan in HIF2A-Mediated Paraganglioma

The New England Journal of Medicine

Many patients with pheochromocytoma and paraganglioma have hypertension from tumor-derived catecholamines. The HIF-2α inhibitor belzutifan rapidly reduced blood pressure and excess catecholamine levels.

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Primary Prevention Takes Center Stage at the 19th Annual Cardiometabolic Health Congress (CMHC)

Cardiometabolic Health Congress

The 19th Annual CMHC transformed Boston into the epicenter of cardiometabolic health and risk reduction from October 17-19, 2024, bringing together healthcare professionals from around the globe for the largest event of its kind in the US. The Hilton Boston Park Plaza became a hub of innovation, education, and collaboration, uniting nearly 500 clinicians under a shared mission: to redefine cardiometabolic care.

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Shawn Kwatra, MD: Making the Connection Between Prurigo Nodularis, Atopic Dermatitis, and Itch

HCPLive

In this interview, Kwatra highlighted several key takeaways from his talks on prurigo nodularis, atopic dermatitis, and itch at the Fall Clinical Dermatology Conference.

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Stroke Prevention Guideline Adds Recs for GLP-1 Drugs, Gender-Affirming Care

Med Page Today

(MedPage Today) -- The American Heart Association and the American Stroke Association updated guidelines for the primary prevention of stroke, emphasizing primary care screening, lifestyle management, and risk factor control. The guideline, published.

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Efficacy of atorvastatin on renal function in patients with contrast-induced nephropathy after percutaneous coronary intervention

Journal of Cardiothoracic Surgery

At present, the clinical methods for preventing and treating contrast-induced nephropathy (CIN) are limited, and statins can play a better role during this process. So, we aimed to assess the atorvastatin on r.

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Updated stroke prevention guidelines: 8 things to know

Becker's Hospital Review - Cardiology

The American Heart Association and American Stroke Association have updated the organizations' stroke prevention guidelines to include gender-focused insights and GLP-1 recommendations. The new guidelines were published Oct. 21 in Stroke.

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Ladan Zand, MD: Obinutuzumab a Promising Option for Refractory, Primary FSGS

HCPLive

Zand discussed interim 12-month findings from an open-label, phase 2 trial currently ongoing for patients with refractory primary focal segmental glomerulosclerosis.

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A Case of Broca's Aphasia

Med Page Today

(MedPage Today) -- On Sept. 14, 2000, at the age of 72, Lester Schwartz, a psychoanalyst working in New York City, underwent a simple operation for a benign fatty tumor in his stomach. He woke up the next morning in the hospital and realized he.

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Sodium-glucose cotransporter 2 inhibitors and cardiovascular events among patients with type 2 diabetes and low-to-normal body mass index: a nationwide cohort study

Cardiovascular Diabetology

Patients with low-to-normal body mass index (BMI; < 25.0 kg/m2) were underrepresented in major randomized controlled trials on sodium-glucose cotransporter 2 (SGLT2) inhibitors for type 2 diabetes. The present st.

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New formation of neurons from stem cell niche disrupted after stroke

Science Daily - Stroke

Researchers studied what happens immediately after a stroke in the stem cell niche known as the subventricular zone, using a mouse model. This revealed a mechanism that results in fewer newborn neurons from the stem cell niche surviving after stroke, thereby significantly limiting the neurogenic reaction of the subventricular zone to repair the brain.

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