Ken Grauer, MD

DECEMBER 23, 2023

The ECG in Figure-1 — was obtained from a patient with palpitations. The patient was hemodynamically stable in association with this rhythm. QUESTIONS: What is the rhythm in Figure-1 ? — How certain are you of your answer? — Why is QRS morphology changing ? Figure-1: The initial ECG in today's case. My Interpretation of the ECG in Figure-1: Since the patient is hemodynamically stable — there is time for systematic assessment of the rhythm.

Blog 176

Blog Tachycardia Tricuspid Atrial Flutter 176

Cardiovascular Diabetology

DECEMBER 18, 2023

Elevated glycated hemoglobin (HbA1c) is associated with a higher burden of subclinical atherosclerosis (SA). However, the association with SA of earlier insulin resistance markers is poorly understood. The stu.

Atherosclerosis 145

Atherosclerosis Research 145

Dr. Malcolm Kendrick

DECEMBER 10, 2023

10th December 2023 A very important study – please watch Very high low density lipoprotein levels with no impact on plaque progression I interrupt my series on what is wrong with the health service to bring you breaking news. I was sent the e-mail below, directing me to a short YouTube presentation by Dr Shawn Baker. It highlights a study which provides very strong evidence that a very high LDL (as seen in some people who go on a keto diet), has no impact on coronary artery plaque progression.

Plaque 145

Plaque Cholesterol Diet Diabetes 145

Cardiovascular Ultrasound

DECEMBER 13, 2023

Physical activity contributes to changes in cardiac morphology, which are known as “athlete’s heart”. Therefore, these modifications can be characterized using different imaging modalities such as echocardiogr.

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144

Med Page Today

DECEMBER 26, 2023

(MedPage Today) -- Four new risk factors for young-onset dementia were identified in the prospective U.K. Biobank study. Orthostatic hypotension, vitamin D deficiency, high C-reactive protein (CRP) levels, and social isolation emerged as new risk.

Risk Factors 142

Risk Factors Dementia 142

Journal of Clinical Investigation - Cardiology

DECEMBER 15, 2023

Ghrelin exerts key effects on islet hormone secretion to regulate blood glucose levels. Here, we sought to determine whether ghrelin’s effects on islets extend to the alteration of islet size and β cell mass. We demonstrate that reducing ghrelin — by ghrelin gene knockout (GKO), conditional ghrelin cell ablation, or high-fat diet (HFD) feeding — was associated with increased mean islet size (up to 62%), percentage of large islets (up to 854%), and β cell cross-sectional area (up to 51%).

Ablation 139

Ablation Diet Obesity Diabetes 139

Ken Grauer, MD

DECEMBER 29, 2023

QUESTION: HOW would YOU interpret the ECG in Figure-1 — if no clinical information was provided? Figure-1: The initial ECG in today's case. ( To improve visualization — I've digitized the original ECG using PMcardio ). = The H ISTORY in T oday's C ASE: The patient in today's case is a teenager who presented to the ED ( E mergency D epartment ) in cardiac arrest after electrocution.

Blog 175

Blog Cardiac Arrest Ischemia Hospital 175

Medical Xpress - Cardiology

DECEMBER 27, 2023

Sequence variants that protect against pericarditis have been discovered at a genomic locus encoding interleukin-1 immune cytokines. A newly approved drug treatment for pericarditis inhibits these cytokines, according to a new study.

Pericarditis 132

Pericarditis 132

American Heart News - Heart News

DECEMBER 6, 2023

Research Highlights: A study of married or partnered, middle-aged and older heterosexual couples in the U.S., England, China and India found that in 20% to 47% of the couples, both spouses/partners had high blood pressure. The prevalence of both.

Blood Pressure 132

Blood Pressure Research 132

Med Page Today

DECEMBER 6, 2023

(MedPage Today) -- About one in five healthy people ages 50 and older had an organ that was aging at an accelerated rate, which may increase mortality and signal organ-specific disease, a study of nearly 5,700 people suggested. In an analysis.

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Journal of Clinical Investigation - Cardiology

DECEMBER 15, 2023

A paucity of chemotherapeutic options for metastatic brain cancer limits patient survival and portends poor clinical outcomes. Using a CNS small-molecule inhibitor library of 320 agents known to be blood-brain barrier permeable and approved by the FDA, we interrogated breast cancer brain metastasis vulnerabilities to identify an effective agent. Metixene, an antiparkinsonian drug, was identified as a top therapeutic agent that was capable of decreasing cellular viability and inducing cell death

Cancer 133

Cancer Outcomes 133

Ken Grauer, MD

DECEMBER 1, 2023

== CLICK HERE — for a V ideo presentation of this case! ( 19:40 min. ) Below are slides used in my video presentation. For full discussion of this case — See ECG Blog #351 — == The ECG in Figure-1 — was obtained from a previously healthy older man who contacted EMS ( E mergency M edical S ervices ) because of "chest tightness" that began ~1 hour earlier.

Blog 167

Blog STEMI Ischemia 167

ECG Weekly Workout

DECEMBER 31, 2023

HPI: A 50-year-old man decides to get “his life in order” for the new year. He quits smoking, decides to eat healthier and exercise more, and to be more compliant with his blood pressure medications. A week into the new year he wakes up feeling weak and achy with nausea and vomiting. He is lightheaded when sitting or standing and has trouble getting out of bed.

Blood Pressure 130

Blood Pressure CME Exercise Bradycardia 130

Medical Xpress - Cardiology

DECEMBER 14, 2023

Cardiovascular diseases are the leading cause of death in the world according to the Global Burden of Disease study, with 18.6 million annual deaths in 2019, of which around 7.9 are attributable to diet. This means that diet plays a major role in the development and progression of these diseases.

Diet 132

Diet Cardiovascular Disease 132

HCPLive

DECEMBER 20, 2023

Analysis of the NUDGE-FLU study reveals electronic nudges designed to boost influenza vaccination were more effective in older adults without diabetes, highlighting the need for tailored approaches in diabetes populations.

Diabetes 129

Diabetes 129

Med Page Today

DECEMBER 22, 2023

(MedPage Today) -- The FDA continues its investigation into counterfeit semaglutide (Ozempic) products -- which may still be available for purchase -- and has already seized thousands of units, the agency announced Thursday. In its warning.

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Journal of Clinical Investigation - Cardiology

DECEMBER 15, 2023

Cell therapies such as tumor-infiltrating lymphocyte (TIL) therapy have shown promise in the treatment of patients with refractory solid tumors, with improvement in response rates and durability of responses nevertheless sought. To identify targets capable of enhancing the antitumor activity of T cell therapies, large-scale in vitro and in vivo clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 screens were performed, with the SOCS1 gene identified as a top T cell–enhancing

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Ken Grauer, MD

DECEMBER 8, 2023

== CLICK HERE — for a V ideo presentation of this case! (22:3 0 min. ) Below are slides used in my video presentation. For full discussion of this case — See ECG Blog #292 — == The 2 ECGs shown in Figure-1 were obtained from a man in his 30s — who presented to the ED ( E mergency D epartment ) with chest pain that began several hours earlier. ECG #2 was recorded 1 hour after ECG #1.

Blog 165

Blog Chest Pain STEMI Ischemia 165

Dr. Smith's ECG Blog

DECEMBER 5, 2023

Beyond STEMI: Diagnosing Acute Coronary Occlusion on the ECG. The Queen of Hearts AI app can do it for you. With explainability too.

STEMI 128

STEMI Webinar 128

American Heart News - Heart News

DECEMBER 19, 2023

DALLAS, Dec. 19, 2023 — Technologies that less invasively restore blood flow to blocked or narrowed arteries; a medicine that outsmarts high blood pressure’s development; and new evidence that diabetes drugs may offer heart health benefits to people that.

Technology 126

Technology Research Diabetes 126

HCPLive

DECEMBER 19, 2023

Among adults in middle- to high-income nations, awareness of diabetes as a cardiovascular risk factor remains a persistent issue.

Risk Factors 128

Risk Factors Diabetes 128

Med Page Today

DECEMBER 26, 2023

(MedPage Today) -- An intensive food-as-medicine program didn't improve glycemic control in adults with type 2 diabetes any better than usual care in a randomized clinical trial. After 6 months, both groups had a similar drop in HbA1c -- 1.5.

Diabetes 128

Diabetes 128

Dr. Malcolm Kendrick

DECEMBER 8, 2023

8th December 2023 Nothing can simply be ‘good enough’. Before beginning this blog, I thought I would introduce you to the first two laws of regulation ‘ regulation-omics’ : I know that many of the things that are obliterating productivity in the NHS are happening in all health care services, everywhere. A couple of blogs back I mentioned a US study which looked at all the guidelines primary care practitioners (PCPs) are now required to follow.

Blood Pressure 126

Blood Pressure Blog Document Hypertension 126

Ken Grauer, MD

DECEMBER 15, 2023

== CLICK HERE — for a V ideo presentation of this case! ( 18:00 min. ) Below are slides used in my video presentation. For full discussion of this case — See ECG Blog #392 — == The ECG in Figure-1 was obtained from a man in his 60s — who described the sudden onset of "chest tightness" that began 20 minutes earlier, but who now ( at the time this ECG was recorded ) — was no longer having symptoms.

Blog 152

Blog STEMI Ischemia Chest Pain 152

Dr. Smith's ECG Blog

DECEMBER 24, 2023

Written by Pendell Meyers A woman in her 20s with connective tissue disorder and history of aortic root and valve repair presented with palpitations. Here is her triage ECG: What do you think? Atrial flutter with 2:1 conduction. The atrial flutter rate is approximately 200 bpm, with 2:1 AV conduction resulting in ventricular rate almost exactly 100 bpm.

Atrial Flutter 126

Atrial Flutter Blog Aortic Dysrhythmia 126

Science Daily - Heart Disease

DECEMBER 13, 2023

Individuals infected with COVID-19 are also at an increased risk of suffering from heart rhythm disturbances, such as atrial fibrillation, according to a new study.

COVID-19 126

COVID-19 Heart Rhythm Atrial Fibrillation 126

ECG Guru

DECEMBER 18, 2023

If a wide complex tachycardia occurs, the probability is very high that it is a ventricular tachycardia (approx. 80%, in patients with a previous myocardial infarction (.) approx. 90%). Here we see a broad complex tachycardia that looks like an RBBB + LAFB, which is regular. In this constellation, 3 causes must be considered: 1. fascicular tachycardia from the left posterior fascicle of the left tawara fascicle (QRS width usually only around 130 ms, but sometimes significantly longer). 2.

Myocardial Infarction 124

Myocardial Infarction Tachycardia 124

Med Page Today

DECEMBER 14, 2023

(MedPage Today) -- Sleep regularity in midlife and at older ages may be a novel dementia risk factor, data from 88,000 people in Great Britain suggested. Day-to-day consistency in sleep-wake patterns showed a U-shaped association with incident.

Dementia 127

Dementia Risk Factors 127

Physiologically Speaking

DECEMBER 29, 2023

Greetings! Welcome to the Physiology Friday newsletter. This newsletter is brought to you by Examine.com — the best place on the internet for health and nutrition information — and my new eBook, “VO2 Max Essentials.” Details can be found at the end of the post! Physiologically Speaking is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.

Physiology 124

Physiology Exercise Circulation Research 124

HCPLive

DECEMBER 12, 2023

Peter Lio, MD, reviews the contraindications of JAK inhibitors in AD and approaches for monitoring patients who are prescribed a JAK inhibitor.

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Medical Xpress - Cardiology

DECEMBER 21, 2023

What role do omega-6 fatty acids play in cardiovascular disease and diabetes? Scientists from Mannheim, together with researchers from Heidelberg, Frankfurt, and Hangzhou in China, have investigated the breakdown of omega-6 fatty acids and gained new insights into how their oxidation products influence the metabolism.

Research 123

Research Cardiovascular Disease Diabetes 123

Dr. Smith's ECG Blog

DECEMBER 11, 2023

Occlusion myocardial infarction is a clinical diagnosis Written by Willy Frick (@Willyhfrick). Willy is a cardiology fellow with a keen interest in the ECG in OMI. A woman in her late 70s presented with left arm pain. The arm pain started the day prior when she was at the dentist's office for a root canal. Her systolic blood pressure at the dentist was over 200 mm Hg.

Myocardial Infarction 123

Myocardial Infarction Chest Pain STEMI Blood Pressure 123

Journal of Clinical Investigation - Cardiology

DECEMBER 13, 2023

Increased extracellular matrix (ECM) stiffness has been implicated in esophageal adenocarcinoma (EAC) progression, metastasis, and resistance to therapy. However, the underlying protumorigenic pathways are yet to be defined. Additional work is needed to develop physiologically relevant in vitro 3D culture models that better recapitulate the human tumor microenvironment and can be used to dissect the contributions of matrix stiffness to EAC pathogenesis.

Physiology 119

Physiology Cancer 119

Med Page Today

DECEMBER 24, 2023

(MedPage Today) -- Living with diabetes, Carlton "PeeWee" Gautney Jr. relied on a digital device about the size of a deck of playing cards to pump insulin into his bloodstream. The pump, manufactured by device maker Medtronic, connected plastic.

Diabetes 119

Diabetes 119

Dr. Malcolm Kendrick

DECEMBER 28, 2023

29th December 2023 The underlying forces In the last few blogs, I have been writing about the proliferation of guidelines, targets, and regulatory work in the NHS. Hopefully I have managed to give you a sense of how much time and effort these pile on to everyday work. Time and effort which eats away at clinical time, erodes morale and drives down productivity.

Hospital 116

Hospital Blog Blood Pressure Inpatient 116

HCPLive

DECEMBER 26, 2023

Stacie Bell, PhD, emphasizes the importance of collaborative or multidisciplinary care in patients with SLE.

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Medical Xpress - Cardiology

DECEMBER 12, 2023

A new artificial intelligence (AI) model designed by Scripps Research scientists could help clinicians better screen patients for atrial fibrillation (or AFib)—an irregular, fast heartbeat that is associated with stroke and heart failure. The model picks up on tiny variations in a person's normal heartbeat that signify AFib risk, which standard screening tests cannot detect.

AFIB 117

AFIB Atrial Fibrillation Heart Failure Research 117