July, 2024

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ECG Blog #437 — A 2-Part Answer.

Ken Grauer, MD

I was sent the ECG in Figure-1 — but without the benefit of any history. QUESTIONS: How would YOU interpret this tracing? WHY do I say there is, "A 2-Part Answer?" Figure-1: The initial ECG in today's case. ( To improve visualization — I've digitized the original ECG using PMcardio ). MY Thoughts on Today's CASE: As important as providing a brief, relevant history is for optimal clinical ECG interpretation — Cases like the one today often prove even more educational, because we are not given any

Blog 155
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Data-independent LC-MS/MS analysis of ME/CFS plasma reveals a dysregulated coagulation system, endothelial dysfunction, downregulation of complement machinery

Cardiovascular Diabetology

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic condition that is characterized by unresolved fatigue, post-exertion symptom exacerbation (PESE), cognitive dysfunction, or.

Research 145
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COVID May Affect Type 1 Diabetes in Kids, and Not in a Good Way

Med Page Today

(MedPage Today) -- COVID-19 may accelerate progression of presymptomatic type 1 diabetes in youth, a German study suggested. Incidence of clinical type 1 diabetes nearly doubled after the pandemic started among 591 youth ages 1 to 16 known to.

COVID-19 145
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Survey Details General Public's Eroding Trust Level with Healthcare After COVID-19

HCPLive

Trust in physicians and hospitals dropped from over 70% in 2020 to under 50% in 2024, with declines seen across all demographics, a new survey shows.

COVID-19 140
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White adipocytes in subcutaneous fat depots require KLF15 for maintenance in preclinical models

Journal of Clinical Investigation - Cardiology

Healthy adipose tissue is essential for normal physiology. There are 2 broad types of adipose tissue depots: brown adipose tissue (BAT), which contains adipocytes poised to burn energy through thermogenesis, and white adipose tissue (WAT), which contains adipocytes that store lipids. However, within those types of adipose, adipocytes possess depot and cell-specific properties that have important implications.

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New research explores alcohol’s impact on the heart

American Heart News - Heart News

Research Highlights: Two new, basic research studies in rodents (mice and rats) analyzed the impacts that alcohol may have on the heart. In a mouse study, abnormal heart rhythms that can occur after a pattern of repeated simulation of binge drinking.

Research 135
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Study identifies 18 proteins linked to heart failure, frailty

Medical Xpress - Cardiology

An analysis of blood samples from thousands of study participants, led by researchers at UT Southwestern Medical Center, revealed 18 proteins associated with both heart failure and frailty, conditions that commonly develop in late life. Their findings, published in JAMA Cardiology, could lead to new strategies to jointly predict risk, administer preventive approaches, or treat these conditions, which often occur together.

More Trending

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Persistent Anxiety Tied to Future Dementia

Med Page Today

(MedPage Today) -- Persistent anxiety raised the risk of all-cause dementia in older adults, a longitudinal study showed. Both chronic anxiety (HR 2.80, 95% CI 1.35-5.72, P=0.01) and new-onset anxiety (HR 3.20, 95% CI 1.40-7.45, P=0.01) were tied.

Dementia 138
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Top Gene Therapy News at ASRS 2024

HCPLive

A recap of the 5 most popular topics related to gene therapy in ophthalmology coming from the 42nd American Society of Retina Specialists meeting.

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HeartBeam’s Artificial Intelligence Algorithm Combined with Vectorcardiography (VCG) Outperforms Expert Cardiologists in Detecting Arrhythmias

DAIC

mtaschetta-millane Mon, 07/15/2024 - 11:18 July 15, 2024 — HeartBeam, Inc. , a medical technology company focused on transforming cardiac care through the power of personalized insights, today announced new study data demonstrating that HeartBeam AI combined with vectorcardiography (VCG) outperformed an expert panel of heart rhythm cardiologists in detecting atrial flutter.

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Palliative care beneficial to manage symptoms, improve quality of life for people with CVD

American Heart News - Heart News

Statement Highlights: Palliative medication management focuses on providing relief from symptoms and enhancing quality of life for people with cardiovascular disease throughout the various stages of the disease. Decisions about initiating, adjusting.

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Localized translation and sarcomere maintenance requires ribosomal protein SA in mice

Journal of Clinical Investigation - Cardiology

Cardiomyocyte sarcomeres contain localized ribosomes, but the factors responsible for their localization and the significance of localized translation are unknown. Using proximity labeling, we identified ribosomal protein SA (RPSA) as a Z-line protein. In cultured cardiomyocytes, the loss of RPSA led to impaired local protein translation and reduced sarcomere integrity.

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Study discovers connection between between heart and brain in KBG syndrome

Medical Xpress - Cardiology

A new study sheds light on a medical question scientists have long wondered: why do 40% of children with the rare neurodevelopmental disorder KBG syndrome have heart defects? The research now points to a critical link between the heart and the brain. The research is published in the journal Nature Communications.

Research 121
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New Alzheimer's Mimic Identified

Med Page Today

(MedPage Today) -- A new memory-loss syndrome that mimics the clinical features of Alzheimer's disease was identified, researchers said. "We propose a set of clinical criteria for a limbic-predominant amnestic neurodegenerative syndrome [LANS.

Research 138
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Long COVID Linked to Significantly Worse Rheumatic Disease Activity

HCPLive

Patients with inflammatory arthritis experiencing “long COVID” reported significantly worse disease activity.

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Artificial Intelligence Speeds Up Heart Scans, Leading to Efficiency and Improving Outcomes

DAIC

Pankaj Garg, MD mtaschetta-millane Fri, 07/12/2024 - 11:14 July 12, 2024 — Researchers have developed a groundbreaking method for analyzing heart MRI scans with the help of artificial intelligence , which could save valuable NHS time and resources, as well as improve care for patients. The teams from the Universities of East Anglia (UEA), Sheffield and Leeds created an intelligent computer model that utilizes AI to examine heart images from MRI scans in a specific view known as the four-chamber

Outcomes 122
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Increasing cardiac ketones may help heart failure in mouse study

American Heart News - Heart News

Research Highlights: In mice with heart failure with preserved ejection fraction (HFpEF), increasing ketone supply to the heart allowed their hearts to utilize more ketones and produce more energy. Researchers hope this study may help to improve our.

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Early surgery to prevent embolic events in patients with infective endocarditis: a comprehensive review

Journal of Cardiothoracic Surgery

Infective endocarditis (IE) is a dangerous and lethal illness with high mortality rates. One of the main indications for surgery according to the guidelines is prevention of embolic events. However, uncertaint.

Embolism 119
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Two researchers to receive first-ever Ralph L. Sacco Scholarships for Brain Health

American Heart News - Stroke News

DALLAS and MINNEAPOLIS, July 2, 2024 — The American Academy of Neurology and the American Heart Association have awarded the first-ever Ralph L. Sacco Scholarships for Brain Health to two researchers, Patrick Devlin, Ph.D., of Houston, Texas, and Cyprien.

Research 120
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Dementia Risk Drops With Shingrix Vaccine

Med Page Today

(MedPage Today) -- The recombinant shingles vaccine (Shingrix) was associated with a larger reduction in dementia than the live shingles vaccine (Zostavax), an analysis of more than 200,000 U.S. older adults showed. Over a 6-year follow-up period.

Dementia 133
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What are treatment options for this rhythm, when all else fails?

Dr. Smith's ECG Blog

Written By Magnus Nossen — with edits by Ken Grauer and Smith. The patient in today’s case is a previously healthy 40-something male who contacted EMS due to acute onset crushing chest pain. The pain was 10/10 in intensity radiating bilaterally to the shoulders and also to the left arm and neck. The below ECG was recorded. The ECG shows obvious STEMI(+) OMI due to probable proximal LAD occlusion.

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Rapid and Accurate Prediction Model for Cardiac Arrest Treatment

DAIC

R-EDByUS score features variables using only prehospital resuscitation data. Image courtesy of Takenobu Shimada, Osaka Metropolitan University (CC BY 4.0, [link] mtaschetta-millane Mon, 07/29/2024 - 09:09 July 29, 2024 — When it comes to treating cardiac arrest, acting quickly can mean the difference between life and death. Researchers from Osaka Metropolitan University have developed a new scoring model, using only prehospital resuscitation data, that accurately predicts neurological outcomes o

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30-year risk of cardiovascular disease may help inform blood pressure treatment decisions

American Heart News - Heart News

Research Highlights: A comparison of two tools for calculating cardiovascular disease risk found that if only the current 10-year risk thresholds are applied, fewer adults may be recommended for blood pressure-lowering medication. The tools, The.

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SGLT2 Inhibitor, GLP-1 RA Combination Improves Cardiovascular, Kidney Outcomes in Diabetes

HCPLive

Findings from a meta-analysis examining 12 trials including more than 70,000 patients with diabetes support combining SGLT2 inhibitors and GLP-1 RAs.

Diabetes 119
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30-year risk of cardiovascular disease may help inform blood pressure treatment decisions

Science Daily - Heart Disease

According to a new study, both 30-year risk for cardiovascular disease in addition to 10-year risk may be considered in making decisions about when to initiate high blood pressure medication.

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Semaglutide May Be Linked to Condition That Causes Blindness

Med Page Today

(MedPage Today) -- Use of the GLP-1 receptor agonist semaglutide (Ozempic, Wegovy) may be linked with an increased risk of the second most common form of optic neuropathy, a retrospective study suggested. Over a mean follow-up of nearly 3 years.

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Resuscitated from ventricular fibrillation. Should the cath lab be activated?

Dr. Smith's ECG Blog

This patient was witnessed by bystanders to collapse. They started CPR. EMS arrived and found him in Ventricular Fibrillation (VF). He was defibrillated into VT. He then underwent dual sequential defibrillation into asystole. After 1 mg of epinephrine they achieved ROSC. Total prehospital meds were epinephrine 1 mg x 3, amiodarone 300 mg and 100 mL of 8.4% sodium bicarbonate.

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The Case for Keto for Type 1 Diabetes with Andrew Koutnik, Ph.D.

Physiologically Speaking

Greetings! Today’s interview is with Andrew Koutnik, Ph.D. Andrew is a research scientist at Sansum Diabetes Research Institute, where he’s investigating metabolic therapies for health and disease. His mission is to optimize metabolic health and patient outcomes for people living with type 1 diabetes. Andrew is unique because he himself has type 1 diabetes.

Diabetes 115
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Risks of anxiety, suicide attempt may rise significantly after cardiovascular hospitalization

American Heart News - Heart News

Research Highlights: In this study, people hospitalized with heart disease, stroke or other cardiovascular diseases were 83% more likely to be diagnosed with a psychiatric disorder, such as anxiety and depression, and had a higher risk of suicide.

Hospital 115
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Few Youth Receive Lipid Screening, Highlighting Missed Opportunity to Reduce CVD Risk

HCPLive

Despite recommendations, an analysis of more than 3.2 million youths suggests fewer than 15% of children/adolescents receive lipid screening.

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Artificial intelligence speeds up heart scans, saving doctors' time, and could lead to better treatment for heart conditions

Science Daily - Heart Disease

Researchers have developed a groundbreaking method for analysing heart MRI scans with the help of artificial intelligence, which could save valuable time and resources, as well as improve care for patients.

Research 116
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Mediterranean Diet Good for Kids, Teens Too

Med Page Today

(MedPage Today) -- The Mediterranean diet improved cardiometabolic health among kids and teens, a meta-analysis of randomized clinical trials affirmed. Interventions following the diet's characteristic emphasis on fruit, vegetables, olive oil.

Diet 133
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Australian Medtech EMVision Unveils Backpack-Sized Brain Scanner to Empower First Responders

DAIC

EMVision's First Responder device aims to fundamentally transform stroke and traumatic brain injury outcomes for all patients, regardless of their location, by delivering sophisticated neurodiagnostic technology directly to the point of care (Photo: Business Wire) mtaschetta-millane Tue, 07/23/2024 - 10:36 July 23, 2024 — EMVision , an Australian medical device company focused on the development and commercialization of innovative portable brain scanning technology, has today unveiled its First

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Consequences of ionizing radiation exposure to the cardiovascular system

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 10 July 2024; doi:10.1038/s41569-024-01056-4 In this Review, Wu and co-workers describe the consequences of radiation exposure on the cardiovascular system, drawing insights from individuals exposed to whole-body radiation (including nuclear and medical workers) and from patients with cancer undergoing radiation therapy.

Cancer 116
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A prehospital ECG in a patient with chest pain. The paramedics tell me it is normal.

Dr. Smith's ECG Blog

I was working at triage when the medics brought this patient who is 65 yo and has had chest pain for 12 hours. They recorded a prehospital ECG at 2112 and said that it was “normal”. It had already been crumpled up and put in the waste basket. So I uncrumpled it: What do you think? You need to click on it to enlarge it to view it well I was suspicious for inferior and posterior OMI (Large T-wave in aVF, slight STE in lead III with inverted T-wave in aVL, and a slightly downsloping ST with negativ

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Vaping Low Nicotine (<5%) Linked to Acute Compensatory Puffing

HCPLive

A new study found using e-cigarettes with partial nicotine reduction was linked to greater puffing time, puff duration, and total inhaled volume than 5% nicotine concentration.

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Combining popular diabetes drugs offers complementary heart and kidney benefits

Science Daily - Heart Disease

New research shows combined use of sodium glucose co-transporter 2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP1-RAs) is likely to offer additional protection against heart and kidney disease in patients with diabetes.

Diabetes 112