Ken Grauer, MD

MAY 31, 2024

I was sent the ECG in Figure-1 — without the benefit of any history. Is this VT? What is the 1st thing — that YOU would do? Figure-1: I was sent this ECG without any history. Is this VT? MY Thoughts on Today’s CASE: As tempting as it might be to reach for the defibrillator on seeing the ECG shown in Figure-1 — My initial reaction was different. At 1st glance , my impression from seeing ECG #1 — was that the rhythm is very fast and irregular — with a highly variable QRS morphology — and, without

Blog 165

Blog AFIB Defibrillator Article 165

Med Page Today

MAY 6, 2024

(MedPage Today) -- Higher olive oil intake was associated with a lower risk of dementia-related mortality, a prospective study of 90,000 healthcare professionals showed. Eating at least 7 g of olive oil daily -- about a half tablespoon --.

Dementia 145

Dementia 145

American Heart News - Heart News

MAY 29, 2024

Research Highlights: The benefits gained from better heart health may be related to a process involved in the aging of the body and its cells, researchers found in a study of more than 5,000 adults with a mean age of 56 years. People with rapid cell.

Research 133

Research 133

EMS 12-Lead

MAY 15, 2024

TCP in the ROSC Patient: False Electrical Capture at 75mA Josh Kimbrell, NRP @joshkimbre Judah Kreinbrook, EMT-P @JMedic2JDoc This is the second installment of a blog series showing how transcutaneous pacing (TCP) can be difficult and how you can improve your skills. We will be using redacted information from different cases where paramedics attempted TCP in the field.

Atrial Fibrillation 132

Atrial Fibrillation Bradycardia Pacemaker Cardiac Arrest 132

HCPLive

MAY 15, 2024

Deepak Bhatt, MD, MPH, MBA, reviews the efficacy and safety data of inclisiran, highlighting its long-term effects and noting that injection site reactions are among the most prominent adverse reactions associated with this medication.

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132

Medical Xpress - Cardiology

MAY 20, 2024

Jyothi Nagajyothi, Ph.D. and her laboratory at the Hackensack Meridian Center for Discovery and Innovation (CDI) have identified what may be the main mechanism for how chronic Chagas disease, a parasitic infection affecting millions of people worldwide, can cause irreversible and potentially fatal heart damage.

Laboratory 129

Laboratory Innovation 129

Ken Grauer, MD

MAY 16, 2024

The ECG in Figure-1 — was obtained from an older man who had just completed dialysis — and , is now complaining of abdominal discomfort that radiates to his chest. The consultant interpreted this tracing as “LBBB” ( L eft B undle B ranch B lock ) — but not indicative of anything acute. QUESTIONS: Do you agree with the consultant’s interpretation? How would YOU approach this case?

Blog 162

Blog STEMI 162

American Heart News - Heart News

MAY 1, 2024

Research Highlights: When adults became angry after remembering past experiences, the function of cells lining the blood vessels was negatively impaired, which may restrict blood flow. Previous research has found that this may increase the risk of.

Research 133

Research 133

Journal of Clinical Investigation - Cardiology

MAY 15, 2024

Lymphedema is a debilitating disease with no effective cure and affects an estimated 250 million individuals worldwide. Prior studies have identified mutations in piezo-type mechanosensitive ion channel component 1 (PIEZO1), angiopoietin 2 (ANGPT2), and tyrosine kinase with Ig-like and EGF-like domains 1 (TIE1) in patients with primary lymphedema. Here, we identified crosstalk between these molecules and showed that activation of the mechanosensory channel PIEZO1 in lymphatic endothelial cells (

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126

DAIC

MAY 14, 2024

Getty Images milla1cf Tue, 05/14/2024 - 13:00 May 14, 2024 — One of the most common genetic heart diseases worldwide, hypertrophic cardiomyopathy (HCM) causes the walls of the left ventricle to become thick and stiff. In about 70 percent of cases, patients with HCM experience obstruction to blood flow, which increases pressures in the heart and can lead to chest pain, shortness of breath and reduced exercise capacity.

Cardiomyopathy 126

Cardiomyopathy Exercise Chest Pain Quality of Life 126

Dr. Smith's ECG Blog

MAY 20, 2024

This was sent by an undergraduate (not yet in medical school, but applying now) who works as an ED technician (records all EKGs, helps with procedures, takes vital signs) and who reads this blog regularly. Edited by Smith He also sent me this great case. A 63 year old man with a history of hypertension, hyperlipidemia, prediabetes, and a family history of CAD developed chest pain, shortness of breath, and diaphoresis after consuming a large meal at noon.

Chest Pain 124

Chest Pain Blood Pressure Ischemia STEMI 124

Ken Grauer, MD

MAY 28, 2024

I recently recorded a series of 4 podcasts regarding KEY concepts in ECG interpretation. Easy LINKS — tinyurl.com/KG-ECG-Podcasts — [link] — Other ECG Audio PEARLS I previously made for my ECG Blog can be found in the right column of each page on this blog just below this icon — under, "ECG Audio PEARLS". My New E CG P odcasts ( 5/28/2024 ): These podcasts are part of the Mayo Clinic Cardiovascular CME Podcasts Series ( "Making Waves" ) — hosted by Dr.

Blog 147

Blog Arrhythmia Tachycardia CME 147

Med Page Today

MAY 5, 2024

(MedPage Today) -- NEW YORK CITY -- Some patients who newly started a GLP-1 receptor agonist quickly developed psychiatric symptoms, a few case reports detailed here. One case involved a female, age 42, with a history of bipolar I disorder.

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144

American Heart News - Heart News

MAY 20, 2024

Statement Highlights: More than 40% of adults in the United States live with obesity, and the percentage of people living with obesity continues to increase dramatically. While experts have learned a great deal about the causes of obesity and.

Obesity 132

Obesity 132

Cardiovascular Diabetology

MAY 2, 2024

Insulin resistance and chronic kidney disease are both associated with increased coronary artery disease risk. Many formulae estimating glucose disposal rate in type 1 diabetes infer insulin sensitivity from c.

Coronary Artery Disease 124

Coronary Artery Disease Diabetes Kidney Disease Research 124

ECG Cases

MAY 28, 2024

Once the diagnosis of nontraumatic subarachnoid hemorrhage (SAH) has been made, our job is not done. Mortality in SAH patients can be up to 30% even without neurological deficit. Paying attention to the time-sensitive details of ED management of SAH patients can have a significant impact on their outcome. In this second part of our 2-part podcast series on subarachnoid hemorrhage with Dr.

Hemorrhage 122

Hemorrhage Outcomes 122

Dr. Smith's ECG Blog

MAY 25, 2024

An elderly dialysis patient presented with chest pain. She has poor LV function. Previous echo 4 months ago (confirmed with ED bedside echo): The estimated left ventricular ejection fraction is 30%. Severely decreased LV function. Regional wall motion abnormality-inferior, inferolateral, septum, anterolateral, anterior and apex, lateral. Here is her ECG: Regular Wide Complex Tachycardia.

Tachycardia 121

Tachycardia Atrial Fibrillation Dysrhythmia Chest Pain 121

Journal of Clinical Investigation - Cardiology

MAY 15, 2024

The mammalian SUMO-targeted E3 ubiquitin ligase Rnf4 has been reported to act as a regulator of DNA repair, but the importance of RNF4 as a tumor suppressor has not been tested. Using a conditional-knockout mouse model, we deleted Rnf4 in the B cell lineage to test the importance of RNF4 for growth of somatic cells. Although Rnf4–conditional-knockout B cells exhibited substantial genomic instability, Rnf4 deletion caused no increase in tumor susceptibility.

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120

Med Page Today

MAY 30, 2024

(MedPage Today) -- Preeclampsia raised the risk of young-onset dementia, a prospective study of nearly 2 million women in France showed. Compared with pregnancies without hypertensive disorders, preeclampsia more than doubled the risk of dementia.

Dementia 139

Dementia Hypertension 139

American Heart News - Heart News

MAY 16, 2024

DALLAS, May 16, 2024 — Pregnancy-related deaths in the U.S. have risen 140% over the past three decades and cardiovascular disease is the leading cause.[1] Despite existing medical guidance on pregnancy and cardiovascular health, current trends in health.

Cardiovascular Disease 131

Cardiovascular Disease 131

DAIC

MAY 7, 2024

milla1cf Tue, 05/07/2024 - 12:54 May 7, 2024 — HonorHealth Research Institute ’s David G. Rizik , M.D., narrates and is a co-producer of a documentary focused on radiation and orthopedic injuries suffered by doctors and nurses who work in cardiac catheterization laboratories where they apply the very latest non-surgical technologies to treat the world’s leading cause of death, heart disease.

Nursing 119

Nursing Research Catheterization Laboratory Open-Heart Surgery 119

Science Daily - Stroke

MAY 21, 2024

Researchers show that nocturnal heat significantly increases the risk of stroke. The findings can contribute to the development of preventive measures: With them, the population can better protect themselves against the risks of climate change with increasingly frequent hot nights. In addition, knowledge of the consequences of hot nights can improve patient care.

Stroke 119

Stroke Strokes Patient Care Research 119

Dr. Smith's ECG Blog

MAY 27, 2024

Written by Jesse McLaren, with a very few edits by Smith A 60-year-old presented with chest pain. The ECG did not meet STEMI criteria, and the final cardiology interpretation was “ST and T wave abnormality, consider anterior ischemia”. But are there any other signs of Occlusion MI? There’s only minimal ST elevation in III, which does not meet STEMI criteria of 1mm in two contiguous leads.

Chest Pain 120

Chest Pain STEMI Myocardial Infarction Ischemia 120

Journal of Clinical Investigation - Cardiology

MAY 15, 2024

Lactylation has been recently identified as a new type of posttranslational modification occurring widely on lysine residues of both histone and nonhistone proteins. The acetyltransferase p300 is thought to mediate protein lactylation, yet the cellular concentration of the proposed lactyl-donor, lactyl-coenzyme A, is about 1,000 times lower than that of acetyl-CoA, raising the question of whether p300 is a genuine lactyltransferase.

Cancer 116

Cancer 116

Med Page Today

MAY 3, 2024

(MedPage Today) -- Plasma leptin levels were linked with Alzheimer's disease PET pathology in cognitively unimpaired older adults, a longitudinal cohort study in Korea showed. Over 2 years, lower baseline plasma leptin was associated with a greater.

Biomarkers 138

Biomarkers 138

Cardiovascular Diabetology

MAY 23, 2024

Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality in patients with Type 1 Diabetes (T1D). Early markers of CVD include increased carotid intima-media thickness (CIMT) and pulse.

Diabetes 115

Diabetes Ultrasound Cardiovascular Disease Research 115

CardiacWire

MAY 8, 2024

A new JAMA study revealed that a shocking 90% of US adults are at risk of developing cardiovascular-kidney-metabolic (CKM) syndrome, underscoring the need for preventative action before we face a wave of CKM-related heart disease. Officially published by the AHA six months ago, CKM syndrome defines the connections and risks associated with obesity, type 2 diabetes, chronic kidney disease, and cardiovascular disease.

Kidney Disease 116

Kidney Disease Obesity Risk Factors Diabetes 116

American Heart News - Heart News

MAY 14, 2024

Guideline Highlights: The new joint guideline from the American Heart Association and the American College of Cardiology provides recommendations to guide clinicians in the treatment of patients with lower extremity peripheral artery disease (PAD) and.

Peripheral Arterial Disease 115

Peripheral Arterial Disease Outcomes 115

Dr. Smith's ECG Blog

MAY 7, 2024

A 30-something presented with chest pain, palpitations, and SOB. He has had similar symptoms for 4 years, but has never been evaluated. Here is his presenting ECG, which was sent to me real time, along with the 2nd ECG below: Regular Narrow Fast without P-waves. PSVT. It is very difficult to tell if this is: 1) AVNRT or 2) orthodromic AVRT (Orthodromic AVRT = WPW with orthograde conduction down the AV node and retrograde up an accessory pathway) See Ken Grauer's discussion below in differentiati

Atrial Fibrillation 120

Atrial Fibrillation AFIB Ablation Chest Pain 120

DAIC

MAY 8, 2024

Feinstein Institutes’ Dr. Stavros Zanos is the senior author on the new bioelectronic medicine ultrasound paper. (Credit: Feinstein Institutes) milla1cf Wed, 05/08/2024 - 10:57 May 8, 2024 — Ultrasound could one day complement or even replace drugs to treat diseases. Bioelectronic medicine scientists at The Feinstein Institutes for Medical Research used noninvasive, splenic focused ultrasound stimulation (sFUS) and found they can reduce inflammation and improve symptoms of pulmonary arter

Ultrasound 115

Ultrasound Pulmonary Research Hypertension 115

Med Page Today

MAY 22, 2024

(MedPage Today) -- A diet high in ultra-processed foods upped the risk of cognitive impairment or stroke, data from the prospective REGARDS study showed. However, risk of either cognitive decline or stroke fell for people who had higher intake.

Diet 132

Diet Stroke Strokes 132

HCPLive

MAY 6, 2024

The final in our 3-part quiz series based on the NLA's 2024 update to their 2019 scientific statement on use of lipoprotein(a) in clinical practice focuses on treatment considerations and therapeutic options for elevated Lp(a).

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Becker's Hospital Review - Cardiology

MAY 23, 2024

A team of physicians at Rockford, Ill.-based Mercyhealth Javon Bea Hospital-Riverside participated in a unique stroke study that used patients' stem cells to promote tissue regeneration, it announced May 22.

Hospital 114

Hospital Stroke Strokes 114

Journal of Clinical Investigation - Cardiology

MAY 15, 2024

Elevated bone resorption and diminished bone formation have been recognized as the primary features of glucocorticoid-associated skeletal disorders. However, the direct effects of excess glucocorticoids on bone turnover remain unclear. Here, we explored the outcomes of exogenous glucocorticoid treatment on bone loss and delayed fracture healing in mice and found that reduced bone turnover was a dominant feature, resulting in a net loss of bone mass.

Outcomes 111

Outcomes 111

Dr. Smith's ECG Blog

MAY 5, 2024

An undergraduate (not yet in medical school) who works as an ED technician (records all EKGs, helps with procedures, takes vital signs) and who reads this blog regularly arrived at work and happened to glance down and see this previously recorded ECG on a table in the ED. It was recorded at 0530: What do you think? The young ED tech immediately suspected LAD OMI.

EKG Technician 117

EKG Technician Chest Pain Blog STEMI 117

DAIC

MAY 31, 2024

milla1cf Fri, 05/31/2024 - 07:00 May 31, 2024 — In the United States there are over 8 million active athletes. Given the rapid expansion of sports cardiology, cardiovascular care teams must understand contemporary care and practice management strategies for all athletes—from the elite to the exercise enthusiast. The ACC Care of the Athletic Heart conference , taking place in Washington, on June 6-8, aims to provide clinicians with guideline-driven, practical, cardiovascular care strategies to im

Cardiac Arrest 111

Cardiac Arrest Exercise Thrombosis Diet 111

Med Page Today

MAY 8, 2024

(MedPage Today) -- A mobile app used with an insulin pump that led to 224 injuries was recalled by Tandem Diabetes Care, the FDA announced today. The recall is for the 2.7 version of the Apple iOS t:connect mobile app, used in conjunction with.

Diabetes 119

Diabetes 119