October, 2024

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ECG Blog #451 — Premature Closure.

Ken Grauer, MD

I was sent the ECG shown in Figure-1 — told only that the patient was a middle-aged man with septicemia. QUESTIONS: Is this rhythm too fast to be sinus tachycardia? Are flutter waves hidden within the QRS and T waves? Are we seeing the retrograde P waves of AVNRT? Is this ATach ( A trial T achycardia )? Figure-1: The initial ECG in today's case. MY Thoughts on Today’s CASE: In my opinion — none of the above answers are optimal to describe the rhythm in Figure-1.

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New guideline: Preventing a first stroke may be possible with screening, lifestyle changes

American Heart News - Stroke News

Guideline Highlights: Each year in the U.S., over half a million people have a first stroke; however, up to 80% of strokes may be preventable. The new primary prevention of stroke guideline from the American Stroke Association urges health care.

Strokes 143
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Type 2 Diabetes Diagnoses Emerge in Teens Months After COVID

Med Page Today

(MedPage Today) -- Children and teens had an increased risk of being diagnosed with type 2 diabetes after COVID-19 infection, a retrospective cohort study of over 600,000 youth suggested. Adolescents 10 to 19 years old had a 55% higher risk for.

COVID-19 145
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COVID-19 infection appeared to increase risk of heart attack & stroke up to 3 years later

American Heart News - Heart News

Research Highlights: An analysis of UK Biobank health data that included adults who had mild to severe COVID-19 before vaccines were available found an increased risk of heart attack, stroke and death among those adults during the nearly three-year.

COVID-19 145
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History of COVID-19 found to double long-term risk of heart attack, stroke and death

Medical Xpress - Cardiology

A history of COVID-19 can double the risk of heart attack, stroke or death according to new research led by Cleveland Clinic and the University of Southern California.

COVID-19 145
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Kidney Compass: Semaglutide for Nondiabetic Kidney Disease, with Hiddo Heerspink, PhD, PharmD, at Kidney Week 2024

HCPLive

Hiddo Heerspink, PhD, PharmD, joins the podcast during Kidney Week 2024 to discuss the SMART trial and the potential of semaglutide in people with kidney disease without diabetes.

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Spatiotemporal transcriptomic mapping of regenerative inflammation in skeletal muscle reveals a dynamic multilayered tissue architecture

Journal of Clinical Investigation - Cardiology

Tissue regeneration is orchestrated by macrophages that clear damaged cells and promote regenerative inflammation. How macrophages spatially adapt and diversify their functions to support the architectural requirements of actively regenerating tissue remains unknown. In this study, we reconstructed the dynamic trajectories of myeloid cells isolated from acutely injured and early stage dystrophic muscles.

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More Trending

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ASA Advises No Longer Holding GLP-1 Agents Prior to Surgery for Most Patients

Med Page Today

(MedPage Today) -- Most patients should not stop taking GLP-1 receptor agonists prior to elective surgery, according to updated guidance from several medical societies, including the American Society of Anesthesiologists (ASA). This recommendation.

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Heart failure, atrial fibrillation & coronary heart disease linked to cognitive impairment

American Heart News - Heart News

Statement Highlights: Previous studies have found that 14-81% of patients with heart failure experience some degree of cognitive impairment affecting language, memory or executive function. Evidence also indicates that people with atrial fibrillation.

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Standing more may not reduce cardiovascular disease risk, could increase circulatory issues

Medical Xpress - Cardiology

Standing has gained popularity among people looking to offset the harms of a sedentary lifestyle often caused by spending long days sitting in front of the computer, television or driving wheel. Standing desks have become a popular option among office workers, and in other industries like retail, workers may opt to stand instead of sit.

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Kidney Compass: Navigating Clinical Trials

HCPLive

Kidney Compass: Navigating Clinical Trials is a multimedia podcast from HCPLive hosted by Brendon Neuen, MBBS, PhD, and Shikha Wadhwani, MD, MS, aimed at exploring the latest in clinical trials and updates in nephrology.

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See what happens when a left main thrombus evolves from subtotal occlusion to total occlusion.

Dr. Smith's ECG Blog

Written by Magnus Nossen The patient in today's case is a male in his 70s with hypertension and type II diabetes mellitus. His wife contacted the ambulance service after the patient experienced an episode of loss of consciousness. The syncope lasted about 2-3 minutes according to his wife. He woke up alert and with chest pain which he also had experienced intermittently over the previous few days.

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Hospitals with highest, lowest 30-day mortality rates for heart attack patients

Becker's Hospital Review - Cardiology

New York City-based NYU Langone hospital had the lowest 30-day mortality rate for heart attack patients in the U.S. between July 1, 2020 and June 30, 2023, according to CMS data released July 31.

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Poor Sleep at Age 40 Linked to Accelerated Brain Aging

Med Page Today

(MedPage Today) -- Poor sleep at age 40 was associated with accelerated brain aging patterns at age 55, longitudinal data showed. A dose-response relationship emerged between the number of poor sleep characteristics early in midlife and brain.

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Physiology Friday #241: How Caffeine Dose and Timing Affect Our Sleep Physiology

Physiologically Speaking

Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post! Physiologically Speaking is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.

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Standing desks are not the answer to decreasing blood pressure, clinical trial shows

Medical Xpress - Cardiology

Alternating between sitting and standing at work decreases sedentary behavior, but it has no effect on lowering blood pressure, according to a study led by a West Virginia University epidemiologist. Researchers also found that too much standing during work may have negative effects on cardiovascular health.

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Initial prescriptions of sedatives among older stroke survivors may include too many pills

American Heart News - Heart News

Research Highlights: Within 90 days after having an ischemic (clot-caused) stroke, about 5% of stroke survivors ages 65 and older were prescribed benzodiazepines (depressants that relieve anxiety, muscle spasms, produce sedation and reduce seizures).

Strokes 122
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Sodium-glucose cotransporter 2 inhibitors and cardiovascular events among patients with type 2 diabetes and low-to-normal body mass index: a nationwide cohort study

Cardiovascular Diabetology

Patients with low-to-normal body mass index (BMI; < 25.0 kg/m2) were underrepresented in major randomized controlled trials on sodium-glucose cotransporter 2 (SGLT2) inhibitors for type 2 diabetes. The present st.

Diabetes 120
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Long COVID inflammation damages the heart, study finds

Science Daily - Heart Disease

New research has found inflammatory markers in the blood of long COVID patients which could explain why many experience ongoing cardiovascular issues.

Research 128
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Ozempic Linked With Lower Risk of Alzheimer's Diagnosis

Med Page Today

(MedPage Today) -- Semaglutide (Ozempic) was tied to a reduced risk of Alzheimer's disease diagnoses in people with type 2 diabetes, observational data showed. In emulation target trials involving more than 1 million eligible diabetes patients.

Diabetes 122
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Prehospital activation: De-activated on ED arrival by Cardiologist because "It's not a STEMI"

Dr. Smith's ECG Blog

This was submitted by a paramedic, Hailey Kennedy A late 50s male called 911 following 2 hours of chest pain that started while working at his desk. He reported the crushing chest pain radiated down his left arm. Pt took an antacid with no relief and decided to call at the request of his wife. Here is his EMS ECG: What do you think? This was sent to me with no clinical information, and my initial impression viewing it on my phone was "It’s a tricky one.

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New laser light diagnostic tool quickly detects earliest sign of heart attack

Medical Xpress - Cardiology

With heart attacks, every second counts. A new blood test diagnoses them in minutes rather than hours and could be adapted as a tool for first responders and people at home.

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Exploring the Interplay Between Chronic Kidney Disease and Cardiovascular Disease

HCPLive

In this first of this 5-part series, Lerma and Lala-Trindade discuss the interplay between chronic kidney disease and cardiovascular disease.

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Lower your cholesterol early, and stick with it!

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 18 October 2024; doi:10.1038/s41569-024-01095-x Consumption of a high-fat diet leads to the progressive growth of atherosclerotic lesions. Two new studies document that, despite similar overall exposure to high-fat diet over a lifetime, an intermittent consumption of high-fat diet early in life accelerates atherosclerosis compared with continuous consumption of a high-fat diet.

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Risk of cardiovascular disease linked to long-term exposure to arsenic in community water supplies

Science Daily - Heart Disease

Long-term exposure to arsenic in water may increase cardiovascular risk and especially heart disease risk even at exposure levels below the federal regulatory limit, according to new research. A study describes exposure-response relationships at concentrations below the current regulatory limit and substantiates that prolonged exposure to arsenic in water contributes to the development of ischemic heart disease.

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Cardiac Arrest Drug Administration Route a Toss Up

Med Page Today

(MedPage Today) -- Intraosseous vascular access for the administration of epinephrine during out-of-hospital cardiac arrest wasn't better than going for the veins first, two separate randomized trials showed. In the PARAMEDIC-3 trial conducted.

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Arm position effect on blood pressure readings: 5 things to know

Becker's Hospital Review - Cardiology

Insufficient arm support can lead to an overestimated blood pressure reading of almost 7mmHG and a potential misdiagnosis of hypertension, according to a study published Oct. 7 in JAMA Internal Medicine.

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Study offers ‘compelling evidence’ for continuous stroke care improvement

American Heart News - Stroke News

Research Highlights: A retrospective look at Get With The Guidelines® - Stroke registry data from 2003 to 2022 finds substantial and sustained improvements in acute stroke care among those in the quality improvement program. Researchers found.

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Shawn Kwatra, MD: Making the Connection Between Prurigo Nodularis, Atopic Dermatitis, and Itch

HCPLive

In this interview, Kwatra highlighted several key takeaways from his talks on prurigo nodularis, atopic dermatitis, and itch at the Fall Clinical Dermatology Conference.

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Quantifying variant contributions in cystic kidney disease using national-scale whole-genome sequencing

Journal of Clinical Investigation - Cardiology

BACKGROUND Cystic kidney disease (CyKD) is a predominantly familial disease in which gene discovery has been led by family-based and candidate gene studies, an approach that is susceptible to ascertainment and other biases.METHODS Using whole-genome sequencing data from 1,209 cases and 26,096 ancestry-matched controls participating in the 100,000 Genomes Project, we adopted hypothesis-free approaches to generate quantitative estimates of disease risk for each genetic contributor to CyKD, across

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Low-level lead poisoning is still pervasive in the US and globally

Science Daily - Heart Disease

Chronic, low-level lead poisoning is a major risk factor for cardiovascular disease in adults and cognitive deficits in children, even at levels previously thought to be safe, Low-level lead poisoning is a risk factor for preterm. Annually 5.5 million deaths from cardiovascular disease attributed to low-level lead poisoning; accounts for a loss of 765 million IQ points in children.

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Colchicine Goes Belly-Up in a More Definitive Heart Attack Trial

Med Page Today

(MedPage Today) -- Any cardiovascular protection from colchicine in heart attack survivors seemed to be debunked with a better-powered randomized trial, researchers found. Between acute MI patients randomized to colchicine or placebo right after.

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50 top hospitals for cardiac surgery: Healthgrades

Becker's Hospital Review - Cardiology

Healthgrades published its 2025 Specialty Excellence Awards recipients Oct. 22. Of those recipients, 50 hospitals were recognized for delivering superior clinical outcomes in cardiac surgery.

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AstraZeneca Adds Lp(a) Candidate with CSPC Licensing Move

CardiacWire

AstraZeneca expanded its cardiovascular pipeline this week, signing an exclusive license agreement for CSPC Pharmaceutical Group’s Lp(a) disruptor candidate, YS2302018. The deal comes with a $100M upfront investment that could reach $1.92B depending on further milestones. YS2302018 is a small molecule Lipoprotein (a) disruptor intended to treat dyslipidemia patients by preventing the formation of excess blood lipids.

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Exploring the Role, History of Lipoprotein Apheresis, with Laurence Sperling, MD, and Eugenia Gianos, MD

HCPLive

Laurence Sperling, MD, and Eugenia Gianos, MD, discuss the historical context and underutilization of lipoprotein apheresis in part 1 of a 3-part video series.

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The clinical effect of thoracoscopic segmentectomy in the treatment of lung malignancies less than 2CM in diameter

Journal of Cardiothoracic Surgery

To investigate the clinical effect of thoracoscopic segmentectomy in the treatment of lung malignancies less than 2CM in diameter. In this retrospective study, a total of 103 patients with lung cancer who received outpatient or inpatient treatment from December 2020 to May 2022 were selected and divided into the lobectomy group (n = 48) and the segmentectomy group (n = 55) according to different surgical methods.

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Researchers identify 'sweet spot' for safe surgery after heart attack

Science Daily - Heart Disease

New research suggests older adults wait 3-6 months after a heart attack before elective noncardiac surgery to reduce the risk of serious complications like stroke or another heart attack.