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Researchers from Mass General Brigham and collaborating institutions have developed a non-invasive approach to manipulate cardiac tissue activity by using light to stimulate an innovative ink incorporated into bioprinted tissue. Their goal is to develop a technique that can be used to repair the heart. Their findings in preclinical models, published in Science Advances, show the transformative potential of non-invasive therapeutic methods to control electrically active tissues.
Researchers have successfully repaired damaged mouse hearts using a protein from zebrafish. They discovered that the protein Hmga1 plays a key role in heart regeneration in zebrafish. In mice, this protein was able to restore the heart by activating dormant repair genes without causing side effects, such as heart enlargement. This study marks an important step toward regenerative therapies to prevent heart failure.
By Smith with comments from our electrophysiologist, Rehan Karim. (And of course Ken's comments at the bottom) An elderly obese woman with cardiomyopathy, Left bundle branch block, and chronic hypercapnea presented hypoxic with altered mental status. She was intubated. Bedside cardiac ultrasound showed moderately decreased LV function. CT of the chest showed no pulmonary embolism but bibasilar infiltrates.
IntroductionThere is growing evidence that patients with SARS-CoV-2 (The severe acute respiratory syndrome coronavirus 2) may have a variety of cardiovascular complications in the post-acute phase of COVID-19, but these manifestations have not yet been comprehensively characterized.MethodsWe performed a systematic review and meta-analysis of primary research papers which evaluated individuals at least four weeks after confirmed COVID-19 diagnosis and reported on cardiovascular disease prevalence
Introduction ST-elevation myocardial infarction (STEMI) is one of the most prevalent presentations in young patients. It is essential to emphasise that each minute of delay in providing medical care is negatively correlated to the patient’s prognosis. The present study was carried out to evaluate the ischaemia-reperfusion times in patients ≤40 years of age versus individuals >40 years of age and their association with mortality and major adverse cardiac event (MACE) over the long
Press Release Patients Who Received Ross Procedure Demonstrate Excellent Survival Rates after 20 Years January 26, 2025 KCummings Sun, 01/26/2025 - 13:40 LOS ANGELES January 26, 2024 Young patients who have undergone the Ross procedure for aortic valve disease have shown excellent long-term survival, the majority without the need for additional surgery two decades later.
Walking in a winter wonderland may sound serene and peaceful, but shoveling your sidewalks to take that walk could quickly change delightful to deadly. According to the American Heart Association, the world's leading nonprofit organization focused on heart and brain health for all, research shows that the exertion of shoveling snow may lead to an increased risk of a heart attack or sudden cardiac arrest.
Researchers have developed a way of bioprinting tissues that change shape as a result of cell-generated forces, in the same way that it happens in biological tissues during organ development. The breakthrough science focused on replicating heart tissues, bringing research closer to generating functional, bioprinted organs, which would have broad applications in disease modelling, drug screening and regenerative medicine.
Researchers have developed a way of bioprinting tissues that change shape as a result of cell-generated forces, in the same way that it happens in biological tissues during organ development. The breakthrough science focused on replicating heart tissues, bringing research closer to generating functional, bioprinted organs, which would have broad applications in disease modelling, drug screening and regenerative medicine.
On this month's EM Quick Hits podcast: Anand Swaminathan on optimizing RSI medication timing, Brittany Ellison ED boarding challenges in older patients and solutions to ED crowding and flow, Dave Jeromeon managing prolonged tourniquet application, Nour Khatib and Phil Gillick on a rural peer support case, Jesse McLaren on ECG reciprocal changes in acute coronary occlusion, and Melody Ngon practical nutrition tips for shift workers.
Brevity? [Not my strong point] Today, it is almost as if it never happened. The time of COVID-19 (which I shall simply call Covid from here on). It came, it went, it is now ancient history. Hardly anyone wants to talk about it anymore. Why not? I suppose you could say, whats the point? You cant do anything about it. What is done, is done. True, but maybe you can help to prevent most damaging things from happening again.
Press Release New Study Finds Mechanical Valves Offer Superior Long-Term Survival for Aortic Valve Replacement Patients Aged 60 and Younger January 25, 2025 KCummings Sat, 01/25/2025 - 13:33 LOS ANGELESJanuary 25, 2025A late-breaking study presented today at the 2025 Society of Thoracic Surgeons (STS) Annual Meeting reveals that mechanical aortic valve replacements (AVRs) provide significant long-term survival benefits for patients aged 60 and younger compared to bioprosthetic valves.
IntroductionVentricular assist devices (VADs) are lifesavers for people with advanced heart failure. The design of these devices has undergone drastic changes over time with the latest designs being far more efficient, small, lightweight, and more user-friendly. This study aims to analyze publications using bibliometric analysis and see the progress and identify key themes, trends, and collaboration networks.MethodData relevant to this study were obtained from Scopus and Web of Science databases
People with pockets of fat hidden inside their muscles are at a higher risk of dying or being hospitalized from a heart attack or heart failure, regardless of their body mass index, according to new research. This 'intermuscular' fat is highly prized in beef steaks for cooking. However, little is known about this type of body fat in humans, and its impact on health.
Nature Reviews Cardiology, Published online: 20 January 2025; doi:10.1038/s41569-025-01118-1 The past 20 years have witnessed remarkable progress in the evolution of transcatheter procedures for the treatment of adult patients with congenital heart disease. In this Review, Rods-Cabau and colleagues provide a comprehensive overview of the available transcatheter interventions for these patients, focusing on their current indications and associated outcomes.
Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post. You can find more products I’m affiliated with on my website. Physiologically Speaking is a reader-supported publication.
Circulation, Ahead of Print. BACKGROUND:The American Heart Association (AHA), in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, nutrition, sleep, and obesity) and health factors (cholesterol, blood pressure, glucose control, and metabolic syndrome) that contribute to cardiovascular health.
Zane had three open heart surgeries before he turned 3. And surprisingly, he had a more routine care journey than his brother, Zeke. Zeke and Zane were both diagnosed with hypoplastic left heart syndrome (HLHS) before birth. As far as congenital heart diseases go, HLHS falls on the rarer end of the spectrum. The odds that either boy would have the condition are low roughly 1 in every 3,800 babies are born with it.
What is inside the Heart Health Formula? A step-step guide to: - Understanding Heart Disease. - Defining Heart Disease Risk. - Reducing Heart Disease Risk. When I set out on my journey over a decade ago to put together a system to do this comprehensively, it did not exist in a way that I found useful. So, I created a system myself. The Heart Health Formula is made up of 3 main modules.
In this 12-lead ECG there is a bradycardic rhythm, which is regular, heart rate about 45 bpm. The QRS complexes are narow. What is this rhythm called? There are no P waves present, and no flutter or fibrillation waves can be seen. There are 2 possibilities: 1. There is a sinus arrest with a junctional escape rhythm. The junctional rhythm either cannot conduct retrograde to the atria (therefore no inverted retrograde P wave can be seen) or the retrograde P wave is hidden in the QRS complex (atria
A presentation at this years Society of Thoracic Surgeons (STS) conference suggests mechanical valves might lead to better survival compared to bioprosthetic valves in patients aged 60 or younger undergoing SAVR even though it seems like theyre going out of style. Mechanical SAVR valves have been around in one form or another since the 1960s, but have fallen out of favor in recent years.
Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post. You can find more products I’m affiliated with on my website. Physiologically Speaking is a reader-supported publication.
Nature Reviews Cardiology, Published online: 28 January 2025; doi:10.1038/s41569-025-01128-z Two studies published in Nature report the structure of apolipoprotein B100 on LDL using high-resolution, artificial intelligence-assisted cryo-electron microscopy and uncover its precise molecular interfaces with the LDL receptor. Dimers of LDL particles connected by a pair of receptors are also visualized for the first time.
Panelists discuss how the coexistence of heart disease and chronic obstructive pulmonary disease (COPD) requires careful management as these conditions significantly impact each other. In stable COPD, cardiovascular complications are a leading cause of mortality, whereas acute exacerbations can worsen heart function. Key treatable traits in COPD-associated pulmonary hypertension include hypoxemia, inflammation, and right ventricular dysfunction.
High blood pressure is one of the biggest killers on the planet. As a risk factor, it is responsible for more early deaths than any other risk factor 1. It impacts over 1 billion people. But here is the real problem. It is silent. Most people do not know when they have high blood pressure. And even when they do, it is usually not managed correctly. Getting this wrong is costing lives on a global scale.
A summary of current and novel biomarkers and their potential stages of release in cardiogenic shock. The diagram illustrates the proposed release of the biomarkers during the different stages of cardiogenic shock: progression from cardiac dysfunction/stress, through to inflammation and end-organ dysfunction. It is believed that a self-propagating spiral of events follows as a result of hypoperfusion, ischaemia and inflammation, leading to end-organ dysfunction.
Atherosclerosis (ASVD) remains a leading driver of cardiovascular disease (CVD), a global health challenge that claims millions of lives each year. But what if prevention could rewrite the narrative? Explore actionable, evidence-based strategies to combat traditional and emerging risk factors, with a focus on precision approaches and primordial prevention.
Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post. You can find more products I’m affiliated with on my website. Physiologically Speaking is a reader-supported publication.
Nature Reviews Cardiology, Published online: 02 January 2025; doi:10.1038/s41569-024-01109-8 In this Review, Lavine and colleagues describe the known subsets of cardiac macrophages, highlighting newly identified macrophage states and associated cellular neighbourhoods, and discuss the roles of cardiac macrophages in homeostasis and disease, including in inflammation, fibrosis, age-associated pathologies, mechanosensing, efferocytosis, angiogenesis, arrhythmias and transplant allograft survival.
A research team in the Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, the University of Hong Kong (HKUMed), found that hip fractures not only result in both physical and psychological injuries, but may also induce adverse cardiovascular events. In particular, hip fracture patients with pre-existing cardiac conditions are associated with a significantly higher risk of cardiovascular events (CVEs) and mortality, poorer prognosis, and greater health service utilization.
The Heart Health Formula is everything you need to address your risk of heart disease. If you are looking to: Lower high cholesterol. Lower high blood pressure. Lose visceral fat. Assess for genetic risks of heart disease. Understand what tests best define risk. And much more. The Heart Health Formula has these covered and so much more. In addition to the 9 hours of content covering these topics, the Heart Health Formula comes with two free bonuses.
tim.hodson Tue, 01/07/2025 - 10:01 Jan. 7, 2025 FIRE1 recently announced it has received Breakthrough Device Designation from the U.S. Food and Drug Administration (FDA) and has been accepted into the FDAs Total Product Lifecycle Advisory Program (TAP). FIRE1s Norm heart failure management system offers a unique approach for patients to manage heart failure.
In the age of technology, wearable devices have revolutionized how we approach health and wellness. From fitness trackers to smartwatches, these gadgets offer users real-time insights into their physical well-being. Among their many benefits, wearable tech has proven to be a game-changer in monitoring heart health, particularly for individuals managing cardiovascular conditions or preparing for minimally invasive or bloodless heart surgery.
Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post. You can find more products I’m affiliated with on my website. Physiologically Speaking is a reader-supported publication.
Atherosclerosisa key driver of cardiovascular disease (CVD)continues to be a significant global health issue. While advances in treatment have reduced mortality in some regions, the atherosclerosis prevention remains challenging. Explore the growing burden of CVD, the rise of new risk factors, and barriers to prevention: The Rising Global Burden of Cardiovascular Disease CVD is now the leading cause of death worldwide, with low- and middle-income countries (LMICs) experiencing the highest burd
Panelists discuss how dysbiosis of the lung microbiome can exacerbate chronic obstructive pulmonary disease (COPD) through increased inflammation and altered immune responses. In contrast, chest CT imaging is indicated for patients with severe COPD, suspected comorbidities, surgical planning, or unexplained symptoms despite standard treatment. These factors highlight the complexity of COPD management.
Although GLP-1s have proven to significantly help with weight loss and cardiometabolic disorders, a new Nature Medicine study shed light on the drugs potential side-effects. GLP-1s have skyrocketed in popularity due to their weight loss impact, while their potential heart benefits could make GLP-1s a common cardiology drug. However, little is known about the long-term risks of this wonder drug class due to its relatively short time on the market and a lack of studies on the topic.
ObjectiveTo quantify the risk of heart diseases (HD) and determine the relationship between physical activity (PA) dimensions and HD among Chinese middle-aged and older individuals.MethodsUsing data from the China Health and Retirement Longitudinal Study (CHARLS, 2018), 16,927 participants were included in this study. Multivariate logistic regression was performed to determine the association between HD risk and PA dimensions, including volume, intensity, frequency, and duration.
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