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Light and moderate consumption of wine is associated with a lower risk of cardiovascular complications, according to a multicenter study. The study is based on the analysis of a biomarker of wine intake -- specifically, tartaric acid, present in grapes. It was carried out in 1,232 participants in the PREDIMED project, a major scientific epidemiological study in nutrition on the effects of the Mediterranean diet on cardiovascular health.
Eating a diet with a higher ratio of plant-based protein to animal-based protein may reduce the risk of cardiovascular disease (CVD) and coronary heart disease (CHD), according to a new study. According to the researchers, these risk reductions are likely driven by the replacement of red and processed meats with plant proteins. The researchers also observed that a combination of consuming more plant protein and higher protein intake overall provided the most heart health benefits.
I am a little odd. At least, according to my wife, anyway. I love Mondays and January. Everyone else seems to dislike these calendar milestones, but for me, they represent a fresh start and the opportunity to reassess the work that needs to be done. As we approach the end of the year and prepare to set out into the next one, the most common New Year resolutions are often health-related.
And so, we reach the final end to the court case. You may think it all finished months ago, not so. The final, final act is when we have the reading of the Statement in Open Court (SIOC). This took place Thursday the 5 th of December 2024. Which is five years and nine months after the articles in the Mail on Sunday were published. I could not talk or write about the SIOC before it happened, or the Judge would be most upset and angry.
Topline results from the SURMOUNT-5 trial found Eli Lillys tirzepatide led to far greater weight loss than Novo Nordisks semaglutide, giving Lilly a boost in the race to become Americas go-to GLP-1. Semaglutide and tirzepatide both originally received FDA approval for treating adults with T2D, with those approvals later extending to weight loss management.
Curtain etal1 performed an analysis of the VALIANT (Valsartan in Acute Myocardial Infarction) and PARADISE-MI (Prospective ARNi vs ACE Inhibitor Trial to Determine Superiority in Reducing Heart Failure Events After MI) trials to evaluate whether risk of sudden cardiac arrest (SCA) following acute myocardial infarction (MI) has changed over time. Patients recruited to these trials had left ventricular ejection fraction (LVEF) <40% following acute MI.
Circulation, Ahead of Print. Smokeless oral nicotine products are addictive, and their use has potential adverse effects on some but not all biomarkers of cardiovascular risk. The use of some types of these products, for instance, is associated with an increased mortality risk in those with ischemic heart or cerebrovascular disease. Similarly, smokeless tobacco has the potential to increase the risk of oral cancer, but the risks depend on the chemical composition of the product.
tim.hodson Tue, 12/03/2024 - 16:52 Nov. 18, 2024 — In November, Esperion presented an analysis from the CLEAR Outcomes study focused on patients with Peripheral Artery Disease (PAD) who were unable or unwilling to take statin medications. These data were presented at the 2024 American Heart Association Scientific Sessions, in Chicago, IL. Additionally, two exploratory analyses from the CLEAR Outcomes trial and a real-world analysis of bempedoic acid usage were presented at the conference.
tim.hodson Tue, 12/03/2024 - 16:52 Nov. 18, 2024 — In November, Esperion presented an analysis from the CLEAR Outcomes study focused on patients with Peripheral Artery Disease (PAD) who were unable or unwilling to take statin medications. These data were presented at the 2024 American Heart Association Scientific Sessions, in Chicago, IL. Additionally, two exploratory analyses from the CLEAR Outcomes trial and a real-world analysis of bempedoic acid usage were presented at the conference.
"Frustrated, lost and confused." That was the main feedback I got from thousands of readers when I asked them about their experience working with existing healthcare systems to implement a plan to prevent heart disease. This is not good. Heart disease is the leading cause of death worldwide, and with the right approaches, 80% or more can be prevented at an early age.
Heart bypass surgery, formally known as coronary artery bypass graft (CABG) surgery, is a life-saving procedure that helps improve blood flow to the heart when coronary arteries become blocked or narrowed. This surgery involves creating new pathways for blood to flow to the heart muscle by bypassing the blocked sections of the arteries. While this procedure can significantly enhance heart function and reduce symptoms of heart disease, it does come with potential risks and complications.
"When Connie Jorsvik was a cardiac nurse, it always seemed like more women than men were admitted to her hospital after Christmas. Many of these women had been experiencing cardiac symptoms for days - and even weeks. Women tend to put off seeking treatment because we so often put ourselves last on our priority list - and there is no bigger time for everyone else's priorities than the holidays!
In China and other Asian nations, traditional medicine has long been utilized in the treatment of cardiovascular diseases (CVD). While Chinese authorities have incorporated traditional Chinese medicine (TCM) treatment experiences as a supplementary guide for CVD, its international recognition remains limited due to a scarcity of high-quality and reliable randomized controlled trials (RCTs) evidence.
Greetings! In case you missed it, here are all of the studies I covered in the November 2024 installments of the Physiology Friday newsletter. Enjoy (or re-enjoy) these summaries, and don’t forget to share them with someone you think might learn from or be interested in them. Thanks for reading! Physiologically Speaking is a reader-supported publication.
Degenerative mitral valve disease is common. Up to a quarter of patients with degenerative mitral valve disease may be asymptomatic despite having severe valve regurgitation. Current guideline indications for intervention in asymptomatic patient are centred on left ventricular dimensions and ejection fraction and may include consideration in atrial fibrillation, pulmonary hypertension and those with left atrial dilatation.
The magic of the holidays often comes with hidden challenges for our hearts. Rich foods, packed calendars, and holiday pressures can derail even our best health intentions. Yet maintaining heart health doesn’t mean sacrificing the festivities. Simple, mindful choices during the holiday season can protect your cardiovascular health and lay the foundation for a lively year ahead.
(MedPage Today) -- Traces of nine essential metals and non-essential metals in urine were linked with lower cognitive performance and the risk of future dementia, a large prospective study showed. The study assessed concentrations of the essential.
tim.hodson Thu, 12/05/2024 - 11:59 Dec. 4, 2024 – Cleerly has successfully closed its latest Series C extension funding round, raising a total of $106 million. This funding round was led by global software investor Insight Partners and joined by Battery Ventures with participation from pre-existing investors. With this new funding, Cleerly will continue to scale its commercial growth and clinical evidence generation, helping health care professionals improve outcomes for patients across
BackgroundIn the era of fluoroless catheter ablation (CA), achieving a successful transseptal puncture (TSP) presents a significant challenge. We introduce a novel technique for zero-fluoroscopy and cost-effective needle-free TSP.Case summaryWe describe two cases where a GMS-1 guidewire (0.025 inch, pigtail configuration; Toray Medical Co., Ltd., Japan) was utilized for TSP.
Greetings! Today, I’m cross-posting an article (with permission) from performance coach Jonah Rosner. I’ve been following Jonah on social media for a while and love his digestible and practical content on being a better runner and athlete. In this post, he outlines 4 strategies that you can use to prevent bone injuries from happening while training.
We would like to inform you that the deadline for submitting articles for the special collection on Artificial Intelligence in Cardiovascular Health has been extended to March 1, 2024. This special collection aims to explore advancements, applications, and challenges of artificial intelligence in the context of cardiovascular health, promoting the dissemination of knowledge and scientific innovations in the field.
(MedPage Today) -- A three-step process underscores new clinical practice guidelines for primary and specialty care clinicians to evaluate patients who may have cognitive impairment or dementia due to Alzheimer's or a related disease. In broad.
Physician-scientists found that a subset of artificial heart patients can regenerate heart muscle, which may open the door to new ways to treat and perhaps someday cure heart failure.
BackgroundHeart failure (HF) is a leading cause of morbidity and mortality worldwide. Various factors can exacerbate disease progression in patients with HF and negatively impact treatment outcomes. This study aims to evaluate the pooled prevalence and contributing factors associated with poor heart failure treatment outcomes in Ethiopia.MethodsA systematic review and meta-analysis were conducted using five databases: Google Scholar, ScienceDirect, Hinari, PubMed, and Scopus.
Exposing the failures of peer review, Dr. Anis Rassi Jr. MD, PhD, recently published his letter to JAMA Cardiology in Sensible Medicine about glaring issues with the CHAGASICS trial. Dr. Rassi was one of the primary authors and designers of CHAGASICS, but resigned his authorship prior to publishing due to concerns about the study. CHAGASICS aimed to uncover if ICDs were more effective than amiodarone therapy for Chagas cardiomyopathy, finding that ICDs did show some benefits but didnt reduce all
Impella 5.5 with SmartAssist tim.hodson Wed, 12/18/2024 - 14:06 Dec. 12, 2024 Physicians have a new treatment option for many of the sickest pediatric patients with heart failure andcardiogenic shock. Johnson & Johnson MedTech has announcedthat the U.S. Food and Drug Administration (FDA) has expanded the indications for the Impella 5.5 with SmartAssist and Impella CP with SmartAssist heart pumps, granting premarket approval (PMA) for use in specific pediatric patients with symptomatic acute deco
Speed of ultrasound in body tissues is around: A. 20,000 meters per second B. 1500 meters per second C. 340 meters per second D. 10,000 meters per second Correct answer: B. 1500 meters per second Speed of ultrasound is almost that in water, though there is some difference between various tissues. Reflections of ultrasound occur at interfaces between tissues and between blood and tissues, due to the difference in velocity.
Sudden cardiac arrest may occur in various conditions when someone, while active (playing basketball or walking with friends), collapses and passes out. Their blood pressure drops, and often their heart stops. This may be caused by a lethal arrhythmia, which is when the heart beats abnormally and does not efficiently pump anymore. If the heart is not pumping, blood is not getting to the brain, and that's what causes the collapse.
Despite improvements in clinical outcomes of acute myocardial infarction (AMI), mortality rates remain high, indicating the need for further understanding of the pathogenesis and developing more effective cardiac protection strategies. Extracellular vesicles (EVs) carry proteins and noncoding RNAs (ncRNAs) derived from different cardiac cell populations, mainly including cardiomyocytes, endothelial cells, endothelial progenitor cells, cardiac progenitor cells, cardiosphere-derived cells, immune
(MedPage Today) -- In January, we reported on the FDA clearing GLP-1 receptor agonists of suicidality risk following a preliminary evaluation. In this report, we follow up on what has happened since. Not long after the FDA wrapped its preliminary.
Earlier research showed that primary care clinicians using AI-ECG tools identified more unknown cases of a weak heart pump, also called low ejection fraction, than without AI. New study findings suggest that this type of screening is also cost-effective in the long term, especially in outpatient settings.
Here is a state of the art review article on peripartum cardiomyopathy from NEJM that came out in Jan 2024. It is one of the comprehensive article on the topic. Everyone will relish, and would like to preserve it as well. Click on the image for the PDF of the article.Sharing here purely for the academic purpose with the courtesy and thanks to NEJM group.
Journal of the American Heart Association, Ahead of Print. BackgroundInfective endocarditis (IE) is still a fatal disease, and given its rarity, ongoing updates to patient characteristics and outcomes of IE are essential for providing precision diagnoses and effective treatments. This study sought to examine temporal trends in the clinical characteristics and inhospital occurrence of adverse outcomes of IE.Methods and ResultsUsing the Japan nationwide administrative database, we identified patie
IntroductionBased on office blood pressure (BP) values, hypertension is categorized into three stages: stage 1 (140159/9099mmHg), stage 2 (160179/100109mmHg), and stage 3 (180/110mmHg). Malignant hypertension (MHT) is characterized by extreme BP elevation (systolic blood pressure above 200mmHg and diastolic blood pressure above 130mmHg) and acute microvascular damage affecting various organs, particularly the retinas, brain, and kidneys.ObjectivesThe pathogenesis, predisposing variables, therapy
(MedPage Today) -- Persistently short sleep duration during and after pregnancy was tied to a greater risk for adverse cardiometabolic outcomes, a secondary analysis of cohort study data showed. Women who said they slept fewer than 7 hours a night.
An average of four minutes of incidental vigorous physical activity a day could almost halve the risk of major cardiovascular events, such as heart attacks, for middle-aged women who do not engage in structured exercise, according to new research.
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