December, 2024

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ECG Blog #462 — Why so Slow. ?

Ken Grauer, MD

I was sent the ECG in Figure-1 told only that the patient was an older adult who reported dizziness with activity. QUESTIONS: What is the rhythm? ( HINT: There are at least 4 important findings that should be noted ). Is there AV block? Figure-1: The initial ECG in today's case. ( To improve visualization I've digitized the original ECG using PMcardio ).

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Cognitive Performance Falls as Metal Exposure Rises

Med Page Today

(MedPage Today) -- Traces of nine essential metals and non-essential metals in urine were linked with lower cognitive performance and the risk of future dementia, a large prospective study showed. The study assessed concentrations of the essential.

Dementia 138
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Higher ratio of plant protein to animal protein may improve heart health

Science Daily - Heart Disease

Eating a diet with a higher ratio of plant-based protein to animal-based protein may reduce the risk of cardiovascular disease (CVD) and coronary heart disease (CHD), according to a new study. According to the researchers, these risk reductions are likely driven by the replacement of red and processed meats with plant proteins. The researchers also observed that a combination of consuming more plant protein and higher protein intake overall provided the most heart health benefits.

Diet 108
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New evidence on the relationship between moderate wine consumption and cardiovascular health

Science Daily - Stroke

Light and moderate consumption of wine is associated with a lower risk of cardiovascular complications, according to a multicenter study. The study is based on the analysis of a biomarker of wine intake -- specifically, tartaric acid, present in grapes. It was carried out in 1,232 participants in the PREDIMED project, a major scientific epidemiological study in nutrition on the effects of the Mediterranean diet on cardiovascular health.

Diet 108
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Experts' Perspectives: Top Stories in Cardiology for 2024

HCPLive

To celebrate the close of 2024, we surveyed top cardiologist on what they view as the biggest storyline in their field from the past year.

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Lifestyle Risk Factors Predict Coronary Calcification among Male Endurance Athletes

Physiologically Speaking

Coronary artery calcium (CAC) is a measure of atherosclerosis and a strong predictor of cardiovascular disease. While CAC is typically associated with traditional risk factors such as age, hypertension, and smoking, paradoxically elevated CAC scores have been observed in male endurance athletes despite their otherwise healthy profiles. This has raised concerns that long-term, high-volume exercise might be detrimental to heart health.

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Research suggests coffee may protect against cognitive decline in people with atrial fibrillation

Medical Xpress - Cardiology

Drinking multiple cups of coffee a day may help prevent cognitive decline in people with atrial fibrillation (AFib or AF), according to new research published in the Journal of the American Heart Association.

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Can the heart heal itself? New study says it can

Science Daily - Heart Disease

Physician-scientists found that a subset of artificial heart patients can regenerate heart muscle, which may open the door to new ways to treat and perhaps someday cure heart failure.

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Five Tests To Assess Your Heart Health In The New Year.

Dr. Paddy Barrett

I am a little odd. At least, according to my wife, anyway. I love Mondays and January. Everyone else seems to dislike these calendar milestones, but for me, they represent a fresh start and the opportunity to reassess the work that needs to be done. As we approach the end of the year and prepare to set out into the next one, the most common New Year resolutions are often health-related.

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This Year in Medicine 2024: Stories that Defined Healthcare

HCPLive

An overview and landing page for future installments from HCPLive's 8th annual This Year in Medicine Series.

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Mexican American women less likely to take stroke prevention medications as prescribed

American Heart News - Heart News

Research Highlights: An analysis of more than 1,300 stroke survivors found that women were less likely than their male counterparts to take medications, such as cholesterol-lowering statins and blood thinning medications to prevent blood clots, to.

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The muscle stem cell case of Benjamin Button: rejuvenating muscle regenerative capacity through nutraceuticals

Journal of Clinical Investigation - Cardiology

Aging negatively affects the capacity of muscle stem cells (MuSCs) to regenerate muscle. In this issue of the JCI, Ancel, Michaud, and colleagues used a high-content imaging screen to identify nicotinamide and pyridoxine as promoters of MuSC function. The combination of the two compounds promoted MuSC function in vivo in aged mice and in primary cells isolated from older individuals.

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New Study Teases Out Chocolate and Diabetes Connection

Med Page Today

(MedPage Today) -- Eating more dark chocolate was associated with a lower risk of type 2 diabetes, an analysis of prospective cohort studies suggested. Among participants across three studies of healthcare workers, those who consumed ≥5.

Diabetes 119
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Using an AI tool, researchers find poor vascular health accelerates brain aging

Medical Xpress - Cardiology

Using an AI tool, researchers at Karolinska Institutet have analyzed brain images from 70-year-olds and estimated their brains' biological age. They found that factors detrimental to vascular health, such as inflammation and high glucose levels, are associated with an older-looking brain, while healthy lifestyles were linked to brains with a younger appearance.

Research 109
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The heart has its own 'brain'

Science Daily - Heart Disease

New research shows that the heart has a mini-brain -- its own nervous system that controls the heartbeat. A better understanding of this system, which is much more diverse and complex than previously thought, could lead to new treatments for heart diseases.

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SURMOUNT-5: Tirzepatide Bests Semaglutide in Head-to-Head Weight Loss Trial

HCPLive

Data from SURMOUNT-5, a head-to-head trial, demonstrate tirzepatide offered greater weight loss benefits than semaglutide.

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Finally – the end (of the trial process)

Dr. Malcolm Kendrick

And so, we reach the final end to the court case. You may think it all finished months ago, not so. The final, final act is when we have the reading of the Statement in Open Court (SIOC). This took place Thursday the 5 th of December 2024. Which is five years and nine months after the articles in the Mail on Sunday were published. I could not talk or write about the SIOC before it happened, or the Judge would be most upset and angry.

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Intermountain hospital earns vascular recognition

Becker's Hospital Review - Cardiology

Salt Lake City-based Intermountain Health's St. Mary's Regional Hospital in Grand Junction, Colo., has become the first community hospital in the nation to receive vascular verification from the American College of Surgeons and the Society for Vascular Surgery.

Hospital 104
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Daily Chores May Provide Cardiovascular Protection in Women Who Don't Exercise

Med Page Today

(MedPage Today) -- Short, intense bouts of physical activity during daily life were associated with a lower risk of major adverse cardiovascular events (MACE) in non-exercising women, according to an observational study. A median 3.4 minutes of.

Exercise 115
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Reprogramming cells for heart repair: New method transforms ordinary fibroblasts into mature cardiomyocytes

Medical Xpress - Cardiology

Cardiovascular disease continues to lead as the primary cause of death across the globe, taking millions of lives every year. Damage caused by these diseases is particularly difficult to repair, since the heart has minimal ability to regenerate itself. But what if we could reprogram the body's own cells to restore damaged tissue?

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Tiny, daily bursts of vigorous incidental physical activity could almost halve cardiovascular risk in middle-aged women

Science Daily - Heart Disease

An average of four minutes of incidental vigorous physical activity a day could almost halve the risk of major cardiovascular events, such as heart attacks, for middle-aged women who do not engage in structured exercise, according to new research.

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FDA Finds Obeticholic Acid (Ocaliva) Linked to Serious Liver Injury in Noncirrhotic PBC

HCPLive

An FDA review of postmarket clinical trial data revealed an increased risk of liver injury with obeticholic acid in patients with PBC without cirrhosis.

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Engineering extracellular vesicles for targeted therapeutics in cardiovascular disease

Frontiers in Cardiovascular Medicine

Extracellular vesicles (EVs) are nanosized particles secreted by cells that play crucial roles in intercellular communication, especially in the context of cardiovascular diseases (CVDs). These vesicles carry complex cargo, including proteins, lipids, and nucleic acids, that reflects the physiological or pathological state of their cells of origin. Multiomics analysis of cell-derived EVs has provided valuable insights into the molecular mechanisms underlying CVDs by identifying specific proteins

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What can you find with continuous ST monitoring in the ED?

Dr. Smith's ECG Blog

This was written by one of our fine residents, who will soon be an EMS fellow: Michael Perlmutter Case A mid-50s male came to the ED with a burning sensation that was acutely worse while at home. He had recently returned from overseas travel where these symptoms had been intermittently bothersome over the preceding weeks and had been attributed to heartburn.

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Tirzepatide Officially Off FDA's Shortage List

Med Page Today

(MedPage Today) -- The shortage of the diabetes and obesity injectable tirzepatide (Mounjaro, Zepbound) has been resolved, the FDA announced Thursday. As a result, compounders will have a grace period of 60 to 90 days to wrap up production and.

Obesity 105
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There are more heart attacks on Christmas than any other day of the year

Medical Xpress - Cardiology

We sing about how Christmas brings "tidings of comfort and joy," but the holiday also brings something not so "merry and bright.

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Research study shows the cost-effectiveness of AI-enhanced heart failure screening

Science Daily - Heart Disease

Earlier research showed that primary care clinicians using AI-ECG tools identified more unknown cases of a weak heart pump, also called low ejection fraction, than without AI. New study findings suggest that this type of screening is also cost-effective in the long term, especially in outpatient settings.

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Use of Ibuprofen, Other NSAIDs During Pregnancy Could Increase Risk of Childhood CKD

HCPLive

Gestational exposure to certain NSAIDs during different trimesters of pregnancy was associated with an increased risk of childhood CKD.

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Best Supplements For Heart Health.

Dr. Paddy Barrett

As a cardiologist, I am frequently asked about supplements and heart health. In general, I am not a fan. Personally, I take two supplements. Whey protein for hitting my daily protein targets. Creatine for improving exercise performance and muscle mass. Neither of these supplements is for improving ‘heart health’ During the winter months, I will occasionally take vitamin D if my levels are low, but generally, if I get enough time outside, even during the winter months, I do not need t

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SGLT2 inhibition and adipose tissue metabolism: current outlook and perspectives

Cardiovascular Diabetology

Sodium-glucose co-transporter 2 inhibitors (SGLT2i) have emerged as important agents for the treatment of type 2 diabetes mellitus (T2DM). SGLT2 inhibitors have been associated with improved cardiovascular out.

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Less Sleep During and After Pregnancy May Spell Future Heart Troubles

Med Page Today

(MedPage Today) -- Persistently short sleep duration during and after pregnancy was tied to a greater risk for adverse cardiometabolic outcomes, a secondary analysis of cohort study data showed. Women who said they slept fewer than 7 hours a night.

Outcomes 101
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New technology 'sees' how cholesterol causes heart attacks

Medical Xpress - Cardiology

The U.S. government's premier research body has made an important discovery that could help create new drugs to lower "bad" cholesterol, and hopefully prevent heart attacks and stroke.

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Anti-inflammatory effects of glucagon-like peptide-1 (GLP-1) in coronary artery disease: a comprehensive review

Frontiers in Cardiovascular Medicine

Coronary artery disease (CAD)cardiovascular condition occuring due to atherosclerotic plaque accumulation in the epicardial arteriesis responsible for disabilities of millions of people worldwide and remains the most common single cause of death. Inflammation is the primary pathological mechanism underlying CAD, since is involved in atherosclerotic plaque formation.

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Diabetes Dialogue: Exploring New Horizons in Incretin Therapy for Diabetes and Weight Loss

HCPLive

In this episode, hosts discuss the efficacy of MariTide for obesity, a head-to-head comparison of semaglutide vs. tirzepatide, and concerns about GLP-1 agonist compounding.

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Tirzepatide Triumphant Over Semaglutide

CardiacWire

Topline results from the SURMOUNT-5 trial found Eli Lillys tirzepatide led to far greater weight loss than Novo Nordisks semaglutide, giving Lilly a boost in the race to become Americas go-to GLP-1. Semaglutide and tirzepatide both originally received FDA approval for treating adults with T2D, with those approvals later extending to weight loss management.

Obesity 90
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New insights about how 'bad' cholesterol works in the body

Science Daily - Heart Disease

Scientists have made a significant breakthrough in understanding how 'bad' cholesterol, known as low-density lipoprotein-cholesterol or LDL-C, builds up in the body. The researchers were able to show for the first time how the main structural protein of LDL binds to its receptor -- a process that starts the clearing of LDL from the blood -- and what happens when that process gets impaired.

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Overlooked Stories of 2024

Med Page Today

(MedPage Today) -- MedPage Today's enterprise and investigative team covers a lot of ground. We jump in when there's breaking news in healthcare. We write second-day stories on the implications of that news. We craft compelling feature stories.

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