Journal of Clinical Investigation - Cardiology

OCTOBER 1, 2024

BACKGROUND Cystic kidney disease (CyKD) is a predominantly familial disease in which gene discovery has been led by family-based and candidate gene studies, an approach that is susceptible to ascertainment and other biases.METHODS Using whole-genome sequencing data from 1,209 cases and 26,096 ancestry-matched controls participating in the 100,000 Genomes Project, we adopted hypothesis-free approaches to generate quantitative estimates of disease risk for each genetic contributor to CyKD, across

Kidney Disease 119

Kidney Disease Research 119

HCPLive

OCTOBER 1, 2024

Subclinical atherosclerosis burden and its progression are independently linked to the risk of death from any cause in asymptomatic individuals.

Atherosclerosis 126

Atherosclerosis 126

Dr. Smith's ECG Blog

OCTOBER 1, 2024

== MY Comment , by K EN G RAUER, MD ( 8/30 /2024 ): == I was sent the ECG shown in Figure-1 — knowing only that the patient was being seen in the ED ( E mergency D epartment ). How would you interpret this tracing? Figure-1: The initial ECG in today's case. MY Initial Thoughts: In my experience — all-too-many emergency providers fail to appreciate the potential contribution that a brief ( 1-to-2 line ) history may convey when interpreting arrhythmias.

Tachycardia 102

Tachycardia Cardiogenic Shock Arrhythmia STEMI 102

ECG Cases

OCTOBER 1, 2024

In this ECG Cases blog we look at 5 cases of ECGs falsely labeled 'normal'. Can you spot the critical abnormality? Written by Jesse McLaren; Peer Reviewed and edited by Anton Helman. October 2024 Five patients presented with ECGs labeled ‘normal’. Can you use systematic ECG interpretation to identify the [.] The post ECG Cases 51 – ECGs falsely labeled “normal” appeared first on Emergency Medicine Cases.

Blog 100

Blog 100

HCPLive

OCTOBER 1, 2024

Pfizer has announced the voluntary withdrawal of voxelotor in all markets after a report found the benefits do not outweigh the risks for sickle cell disease.

Sickle Cell Disease 105

Sickle Cell Disease 105

Conquering CHD

OCTOBER 1, 2024

9.14.22-11.26.22 When we first learned that Austin would be admitted to Rocky Mountain Hospital for Children PICU for open heart surgery at 3 weeks old, we were nervous and anxious for what was ahead. However, nothing would truly prepare us for what the next 53 days would bring. The feeling of leaving your baby in the hands of another is daunting and emotional but we never doubted for one moment that the staff didn’t love him as if he was their own.

Open-Heart Surgery 98

Open-Heart Surgery Ultrasound VSD Blood Pressure 98

HCPLive

OCTOBER 1, 2024

Ruxolitinib cream offers an effective nonsteroidal treatment for mild to moderate atopic dermatitis, with proven efficacy and safety for sensitive skin areas.

98

98

HCPLive

OCTOBER 1, 2024

A greater portion of patients treated with bimekizumab achieved minimal clinically important differences than with placebo.

104

104

Science Daily - Stroke

OCTOBER 1, 2024

Deep brain stimulation may provide immediate improvement in arm and hand strength and function weakened by traumatic brain injury or stroke.

Stroke 98

Stroke Strokes 98

Med Page Today

OCTOBER 1, 2024

(MedPage Today) -- A look at the feasibility of coronary angiography and angioplasty procedures using the Meta Quest 3 virtual reality (VR) headset. (European Heart Journal) FDA approved flurpiridaz F-18 (Flyrcado), a radiotracer for positron.

Angioplasty 83

Angioplasty 83

Journal of Clinical Investigation - Cardiology

OCTOBER 1, 2024

Patients with autism spectrum disorder (ASD) frequently experience sleep disturbance. Genetic mutations in the neuroligin 3 (NLG3) gene are highly correlative with ASD and sleep disturbance. However, the cellular and neural circuit bases of this correlation remain elusive. Here, we found that the conditional knockout of Nlg3 (Nlg3-CKO) in the medial septum (MS) impairs social memory and reduces sleep.

80

80

Med Page Today

OCTOBER 1, 2024

(MedPage Today) -- Patients on GLP-1 receptor agonists had a low risk of food retention when an esophagogastroduodenoscopy (EGD) was combined with a colonoscopy, a small retrospective study found. Among more than 200 adults in the analysis, there.

75

75

Journal of Clinical Investigation - Cardiology

OCTOBER 1, 2024

Obesity is a growing public health concern that affects the longevity and lifestyle of all human populations including children and older individuals. Diverse factors drive obesity, making it challenging to understand and treat. While recent studies highlight the importance of GPCR signaling for metabolism and fat accumulation, we lack a molecular description of how obesogenic signals accumulate and propagate in cells, tissues, and organs.

Public Health 105

Public Health Obesity 105

JAMA Cardiology

OCTOBER 1, 2024

This randomized clinical trial assesses whether cardioverter-defibrillator implantation is more effective than amiodarone therapy for the primary prevention of all-cause mortality and secondary prevention of sudden cardiac death, hospitalization for heart failure, and use of a pacemaker among patients with chronic Chagas cardiomyopathy.

Defibrillator 77

Defibrillator Cardiomyopathy Sudden Cardiac Death Pacemaker 77

HCPLive

OCTOBER 1, 2024

Steve Nissen, MD, discusses how the cardiology community needs to learn from previous mistakes in uptake of LDL-C lowering therapies as it approaches an age of Lp(a)-lowering agents.

69

69

Journal of Clinical Investigation - Cardiology

OCTOBER 1, 2024

During antiretroviral therapy (ART), most people living with HIV-1 have undetectable HIV-1 RNA in their plasma. However, they occasionally present with new or progressive neurologic deficits and detectable HIV-1 RNA in the cerebrospinal fluid (CSF), a condition defined as neurosymptomatic HIV-1 CSF escape (NSE). We explored the source of neuropathogenesis and HIV-1 RNA in the CSF during NSE by characterizing HIV-1 populations and inflammatory biomarkers in CSF from 25 individuals with NSE.

Biomarkers 64

Biomarkers 64

Becker's Hospital Review - Cardiology

OCTOBER 1, 2024

Two Michigan hospitals had the highest excess readmission ratios for heart attack patients in the U.S. between July 1, 2019, and June 30, 2022, according to CMS data released July 31.

Heart Attack 64

Heart Attack Heart attacks Hospital CMS 64

HCPLive

OCTOBER 1, 2024

The AI model, SLIViT, improves accuracy and efficiency in interpreting 3D medical scans, outperforming traditional methods and reducing specialists' workload.

69

69

Physiologically Speaking

OCTOBER 1, 2024

Greetings! In case you missed it, here’s a short recap of the studies I covered in September in the Physiology Friday newsletter. Enjoy them for the first time or enjoy them again! As always, thanks for being a subscriber and a reader. It means the world. Physiologically Speaking is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.

Physiology 64

Physiology Exercise Atrial Fibrillation Article 64

Journal of Clinical Investigation - Cardiology

OCTOBER 1, 2024

Therapy-related clonal hematopoiesis (t-CH) is defined as clonal hematopoiesis detected in individuals previously treated with chemotherapy and/or radiation therapy. With the increased use of genetic analysis in oncological care, the detection of t-CH among cancer patients is becoming increasingly common. t-CH arises through the selective bottleneck imposed by chemotherapies and potentially through direct mutagenesis from chemotherapies, resulting in a distinct mutational landscape enriched with

Cancer 87

Cancer Research 87

HCPLive

OCTOBER 1, 2024

In this interview, Marghoob highlights some of the biggest diagnostic challenges faced by dermatologists and other providers when it comes to pigmented lesions.

64

64

JAMA Cardiology

OCTOBER 1, 2024

This study examines the projected population-level benefit of optimal guideline-directed medical therapy use globally among patients with heart failure with reduced ejection fraction.

Heart Failure 66

Heart Failure 66

HCPLive

OCTOBER 1, 2024

The designation was based on positive data from the phase 2b FASCINATE trial of denifanstat in noncirrhotic MASH with moderate to advanced fibrosis.

64

64

Journal of Clinical Investigation - Cardiology

OCTOBER 1, 2024

Severe viral pneumonia can induce rapid expansion of KRT5+ basal-like cells in small airways and alveoli; this forms a scar-like structure that persists in the injured alveoli and impedes normal alveolar epithelium regeneration. In this study, we investigated the mechanism by which viral infection induced this remodeling response. Through comparing different lung-injury models, we demonstrated that infection induced strong IFN-γ signal–stimulated dysplastic KRT5+ cell formation.

80

80

American College of Cardiology

OCTOBER 1, 2024

Guideline-directed medical therapy (GDMT) is essential for managing heart failure with reduced ejection fraction (HFrEF). The 2022 ACC/ AHA/HFSA guideline on the management of HF recommends using renin-angiotensin-aldosterone system inhibitors with a preference for angiotensin receptor-neprilysin inhibitors (ARNIs), beta-blockers, mineralocorticoid receptor antagonists, and sodium glucose cotransporter 2 (SGLT2) inhibitors to improve survival, symptoms, ventricular function and quality of life.

Heart Failure 61

Heart Failure Quality of Life Article 61

HCPLive

OCTOBER 1, 2024

A study links conversion therapy with worse mental health, such as PTSD and depression, showing a need for legislative action and support for LGBTQ+ individuals.

59

59

NEJM Journal Watch - Cardiology

OCTOBER 1, 2024

A scientific statement from the American Heart Association provides guidance on this recently U.S. FDA-approved procedure.

Hypertension 75

Hypertension 75

ECG Cases

OCTOBER 1, 2024

In this EM Cases podcast Anton chats with Dr. Peter Brindley and Dr. Leon Byker who have a deep interest in the Culture of Medicine to explore what culture in medicine is, why culture is so important, and then drive home 10 strategies to improving the culture in our departments emphasizing the importance of human connection, empathy, open communication, and a willingness to learn from mistakes in creating a positive and fulfilling work environment, so that we love our work, we love our departmen

Education 55

Education Outcomes 55

HCPLive

OCTOBER 1, 2024

This month in review spotlights HCPLive’s coverage of the top hepatic pipeline news and research from September, covering hepatitis, PBC, MASH/MASLD, and more.

Research 59

Research 59

American Heart News - Stroke News

OCTOBER 1, 2024

DALLAS, 1 de octubre de 2024 - Los derrames cerebrales pueden producirse a cualquier edad, lo que obliga a los supervivientes a superar cambios físicos, emocionales y cognitivos. Ya está abierto el plazo de presentación de candidaturas para los.

Stroke 55

Stroke Strokes 55

Becker's Hospital Review - Cardiology

OCTOBER 1, 2024

"Discover which state has the most top-ranked hospitals for angioplasty in the U.S. according to the WebMD Choice Awards, in partnership with Medscape.

Angioplasty 59

Angioplasty Hospital 59

Journal of Clinical Investigation - Cardiology

OCTOBER 1, 2024

Clonal hematopoiesis (CH), the expansion of hematopoietic stem cells and their progeny driven by somatic mutations in leukemia-associated genes, is a common phenomenon that rises in prevalence with advancing age to affect most people older than 70 years. CH remains subclinical in most carriers, but, in a minority, it progresses to a myeloid neoplasm, such as acute myeloid leukemia, myelodysplastic syndrome, or myeloproliferative neoplasm.

75

75

DAIC

OCTOBER 1, 2024

tim.hodson Tue, 10/01/2024 - 10:50 PHOTO CAPTION: The Elucid PlaqueIQ user interface is a fully interactive visualization of the patient’s coronary anatomy, showing specific plaque type and amount across various views to inform physician assessment of risk and patient-specific treatment pathway. The original CT image is preserved to provide further context.

Cardiovascular Disease 52

Cardiovascular Disease Plaque Quality of Life Myocardial Infarction 52

Journal of Clinical Investigation - Cardiology

OCTOBER 1, 2024

Social deficits represent a core symptom domain of autism spectrum disorder (ASD), which is often comorbid with sleep disturbances. In this issue of the JCI, Sun et al. explored a medial septum (MS) circuit linking these behaviors in a neuroligin 3 conditional knockout model of autism. They identified GABAergic neuron hyperactivity following neuroligin 3 deletion in the MS.

75

75

Open Heart

OCTOBER 1, 2024

Background Acute dyspnoea is common in acute care settings. However, identifying the origin of dyspnoea in the emergency department (ED) is often challenging. We aimed to investigate whether our artificial intelligence (AI)-powered ECG analysis reliably distinguishes between the causes of dyspnoea and evaluate its potential as a clinical triage tool for comparing conventional heart failure diagnostic processes using natriuretic peptides.

Pulmonary 52

Pulmonary Heart Failure 52

Journal of Clinical Investigation - Cardiology

OCTOBER 1, 2024

Cardiac mononuclear phagocytic cells (Cardiac MPCs) participate in maintaining homeostasis and orchestrating cardiac responses upon injury. However, the function of specific MPC subtypes and the related cell fate commitment mechanisms remain elusive in regenerative and nonregenerative hearts due to their cellular heterogeneities. Using spatiotemporal single-cell epigenomic analysis of cardiac MPCs in regenerative (P1) and nonregenerative (P10) mouse hearts after injury, we found that P1 hearts a

Myocardial Infarction 52

Myocardial Infarction Cardiac Function 52

Open Heart

OCTOBER 1, 2024

Background The prognosis of myocardial ischaemia with no obstructive coronary artery disease (INOCA) and its underlying vasomotor disorders, vasospastic angina (VSA) and microvascular angina (MVA), is not well defined. The aim of this study was to perform a systematic review and meta-analysis of studies evaluating the long-term prognosis of patients with INOCA.

Coronary Artery Disease 52

Coronary Artery Disease Outcomes Angina Myocardial Infarction 52