Subclinical Atherosclerosis Burden Shapes All-Cause Mortality Risk
HCPLive
OCTOBER 1, 2024
Subclinical atherosclerosis burden and its progression are independently linked to the risk of death from any cause in asymptomatic individuals.
Tue.Oct 01, 2024
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Deep brain stimulation instantly improves arm and hand function post-brain injury
Science Daily - Stroke
OCTOBER 1, 2024
Deep brain stimulation may provide immediate improvement in arm and hand strength and function weakened by traumatic brain injury or stroke.
Nominate a stroke hero today: 2025 Stroke Hero Awards open for submissions
American Heart News - Stroke News
OCTOBER 1, 2024
DALLAS, Oct. 1, 2024 - Strokes can strike at any age, challenging survivors to overcome physical, emotional and cognitive changes. Nominations are open now for the 2025 Stroke Hero Awards from the American Stroke Association, a division of the.
VT in a Sick Patient? Paired with 2 old cases (see it at the bottom)
Dr. Smith's ECG Blog
OCTOBER 1, 2024
== MY Comment , by K EN G RAUER, MD ( 8/30 /2024 ): == I was sent the ECG shown in Figure-1 — knowing only that the patient was being seen in the ED ( E mergency D epartment ). How would you interpret this tracing? Figure-1: The initial ECG in today's case. MY Initial Thoughts: In my experience — all-too-many emergency providers fail to appreciate the potential contribution that a brief ( 1-to-2 line ) history may convey when interpreting arrhythmias.
Bridging Innovation & Patient Care: The Growing Role of AI
Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Quantifying variant contributions in cystic kidney disease using national-scale whole-genome sequencing
Journal of Clinical Investigation - Cardiology
OCTOBER 1, 2024
BACKGROUND Cystic kidney disease (CyKD) is a predominantly familial disease in which gene discovery has been led by family-based and candidate gene studies, an approach that is susceptible to ascertainment and other biases.METHODS Using whole-genome sequencing data from 1,209 cases and 26,096 ancestry-matched controls participating in the 100,000 Genomes Project, we adopted hypothesis-free approaches to generate quantitative estimates of disease risk for each genetic contributor to CyKD, across
ECG Cases 51 – ECGs falsely labeled “normal”
ECG Cases
OCTOBER 1, 2024
In this ECG Cases blog we look at 5 cases of ECGs falsely labeled 'normal'. Can you spot the critical abnormality? Written by Jesse McLaren; Peer Reviewed and edited by Anton Helman. October 2024 Five patients presented with ECGs labeled ‘normal’. Can you use systematic ECG interpretation to identify the [.] The post ECG Cases 51 – ECGs falsely labeled “normal” appeared first on Emergency Medicine Cases.
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VR Headsets in Cath Lab; ICDs & Driving Rules; How Cardiologist Got to Space
Med Page Today
OCTOBER 1, 2024
(MedPage Today) -- A look at the feasibility of coronary angiography and angioplasty procedures using the Meta Quest 3 virtual reality (VR) headset. (European Heart Journal) FDA approved flurpiridaz F-18 (Flyrcado), a radiotracer for positron.
Voxelotor for Sickle Cell Disease Recalled After Safety Concerns
HCPLive
OCTOBER 1, 2024
Pfizer has announced the voluntary withdrawal of voxelotor in all markets after a report found the benefits do not outweigh the risks for sickle cell disease.
Use of artificial intelligence-powered ECG to differentiate between cardiac and pulmonary pathologies in patients with acute dyspnoea in the emergency department
Open Heart
OCTOBER 1, 2024
Background Acute dyspnoea is common in acute care settings. However, identifying the origin of dyspnoea in the emergency department (ED) is often challenging. We aimed to investigate whether our artificial intelligence (AI)-powered ECG analysis reliably distinguishes between the causes of dyspnoea and evaluate its potential as a clinical triage tool for comparing conventional heart failure diagnostic processes using natriuretic peptides.
Ruxolitinib Cream Offers Safe, Durable Option for Patients with Atopic Dermatitis
HCPLive
OCTOBER 1, 2024
Ruxolitinib cream offers an effective nonsteroidal treatment for mild to moderate atopic dermatitis, with proven efficacy and safety for sensitive skin areas.
Austin Thomas Erb
Conquering CHD
OCTOBER 1, 2024
9.14.22-11.26.22 When we first learned that Austin would be admitted to Rocky Mountain Hospital for Children PICU for open heart surgery at 3 weeks old, we were nervous and anxious for what was ahead. However, nothing would truly prepare us for what the next 53 days would bring. The feeling of leaving your baby in the hands of another is daunting and emotional but we never doubted for one moment that the staff didn’t love him as if he was their own.
Amiodarone or Implantable Cardioverter-Defibrillator in Chagas Cardiomyopathy
JAMA Cardiology
OCTOBER 1, 2024
This randomized clinical trial assesses whether cardioverter-defibrillator implantation is more effective than amiodarone therapy for the primary prevention of all-cause mortality and secondary prevention of sudden cardiac death, hospitalization for heart failure, and use of a pacemaker among patients with chronic Chagas cardiomyopathy.
Ciliary localization of GPR75 promotes fat accumulation in mice
Journal of Clinical Investigation - Cardiology
OCTOBER 1, 2024
Obesity is a growing public health concern that affects the longevity and lifestyle of all human populations including children and older individuals. Diverse factors drive obesity, making it challenging to understand and treat. While recent studies highlight the importance of GPCR signaling for metabolism and fat accumulation, we lack a molecular description of how obesogenic signals accumulate and propagate in cells, tissues, and organs.
Food Retention Risk Low for GLP-1 Users When Endoscopy Is Combined With Colonoscopy
Med Page Today
OCTOBER 1, 2024
(MedPage Today) -- Patients on GLP-1 receptor agonists had a low risk of food retention when an esophagogastroduodenoscopy (EGD) was combined with a colonoscopy, a small retrospective study found. Among more than 200 adults in the analysis, there.
Renal Denervation for Managing Hypertension
NEJM Journal Watch - Cardiology
OCTOBER 1, 2024
A scientific statement from the American Heart Association provides guidance on this recently U.S. FDA-approved procedure.
Global Impact of Optimal Implementation of Guideline-Directed Medical Therapy in Heart Failure
JAMA Cardiology
OCTOBER 1, 2024
This study examines the projected population-level benefit of optimal guideline-directed medical therapy use globally among patients with heart failure with reduced ejection fraction.
Autism-associated neuroligin 3 deficiency in medial septum causes social deficits and sleep loss in mice
Journal of Clinical Investigation - Cardiology
OCTOBER 1, 2024
Patients with autism spectrum disorder (ASD) frequently experience sleep disturbance. Genetic mutations in the neuroligin 3 (NLG3) gene are highly correlative with ASD and sleep disturbance. However, the cellular and neural circuit bases of this correlation remain elusive. Here, we found that the conditional knockout of Nlg3 (Nlg3-CKO) in the medial septum (MS) impairs social memory and reduces sleep.
UCLA Investigators Develop AI Model to Improve 3D Imaging for Disease Predictions
HCPLive
OCTOBER 1, 2024
The AI model, SLIViT, improves accuracy and efficiency in interpreting 3D medical scans, outperforming traditional methods and reducing specialists' workload.
Physiology Friday September in Review
Physiologically Speaking
OCTOBER 1, 2024
Greetings! In case you missed it, here’s a short recap of the studies I covered in September in the Physiology Friday newsletter. Enjoy them for the first time or enjoy them again! As always, thanks for being a subscriber and a reader. It means the world. Physiologically Speaking is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.
Steve Nissen, MD: Optimizing Lp(a) Management by Learning from Missteps with LDL-C
HCPLive
OCTOBER 1, 2024
Steve Nissen, MD, discusses how the cardiology community needs to learn from previous mistakes in uptake of LDL-C lowering therapies as it approaches an age of Lp(a)-lowering agents.
Ep 198 Understanding and Improving Culture in Emergency Medicine: Key Insights
ECG Cases
OCTOBER 1, 2024
In this EM Cases podcast Anton chats with Dr. Peter Brindley and Dr. Leon Byker who have a deep interest in the Culture of Medicine to explore what culture in medicine is, why culture is so important, and then drive home 10 strategies to improving the culture in our departments emphasizing the importance of human connection, empathy, open communication, and a willingness to learn from mistakes in creating a positive and fulfilling work environment, so that we love our work, we love our departmen
FDA Approves Stelara Biosimilar Ustekinumab-aauz (Otulfi)
HCPLive
OCTOBER 1, 2024
The approval marks the fourth biosimilar approved for ustekinumab, for all approved indications.
Hospitals with highest, lowest heart attack readmission rates
Becker's Hospital Review - Cardiology
OCTOBER 1, 2024
Two Michigan hospitals had the highest excess readmission ratios for heart attack patients in the U.S. between July 1, 2019, and June 30, 2022, according to CMS data released July 31.
Major Diagnostic Challenges for Pigmented Lesions, with Ashfaq Marghoob, MD
HCPLive
OCTOBER 1, 2024
In this interview, Marghoob highlights some of the biggest diagnostic challenges faced by dermatologists and other providers when it comes to pigmented lesions.
Distinct landscape and clinical implications of therapy-related clonal hematopoiesis
Journal of Clinical Investigation - Cardiology
OCTOBER 1, 2024
Therapy-related clonal hematopoiesis (t-CH) is defined as clonal hematopoiesis detected in individuals previously treated with chemotherapy and/or radiation therapy. With the increased use of genetic analysis in oncological care, the detection of t-CH among cancer patients is becoming increasingly common. t-CH arises through the selective bottleneck imposed by chemotherapies and potentially through direct mutagenesis from chemotherapies, resulting in a distinct mutational landscape enriched with
Denifanstat Receives Breakthrough Therapy Designation for Noncirrhotic MASH
HCPLive
OCTOBER 1, 2024
The designation was based on positive data from the phase 2b FASCINATE trial of denifanstat in noncirrhotic MASH with moderate to advanced fibrosis.
Endovascular Ablation of the Greater Splanchnic Nerve in HFpEF
JAMA Cardiology
OCTOBER 1, 2024
This randomized clinical trial investigates the feasibility, safety, and efficacy of endovascular right-sided splanchnic nerve ablation for volume management in heart failure with preserved ejection fraction (HFpEF).
For the FITs | High Cost of Heart Failure Treatment: Stories From the Frontline
American College of Cardiology
OCTOBER 1, 2024
Guideline-directed medical therapy (GDMT) is essential for managing heart failure with reduced ejection fraction (HFrEF). The 2022 ACC/ AHA/HFSA guideline on the management of HF recommends using renin-angiotensin-aldosterone system inhibitors with a preference for angiotensin receptor-neprilysin inhibitors (ARNIs), beta-blockers, mineralocorticoid receptor antagonists, and sodium glucose cotransporter 2 (SGLT2) inhibitors to improve survival, symptoms, ventricular function and quality of life.
Neurosymptomatic HIV-1 CSF escape is associated with replication in CNS T cells and inflammation
Journal of Clinical Investigation - Cardiology
OCTOBER 1, 2024
During antiretroviral therapy (ART), most people living with HIV-1 have undetectable HIV-1 RNA in their plasma. However, they occasionally present with new or progressive neurologic deficits and detectable HIV-1 RNA in the cerebrospinal fluid (CSF), a condition defined as neurosymptomatic HIV-1 CSF escape (NSE). We explored the source of neuropathogenesis and HIV-1 RNA in the CSF during NSE by characterizing HIV-1 populations and inflammatory biomarkers in CSF from 25 individuals with NSE.
Top-ranked hospitals for angioplasty, by state
Becker's Hospital Review - Cardiology
OCTOBER 1, 2024
"Discover which state has the most top-ranked hospitals for angioplasty in the U.S. according to the WebMD Choice Awards, in partnership with Medscape.
Hepatology Month in Review: September 2024
HCPLive
OCTOBER 1, 2024
This month in review spotlights HCPLive’s coverage of the top hepatic pipeline news and research from September, covering hepatitis, PBC, MASH/MASLD, and more.
Viral infection induces inflammatory signals that coordinate YAP regulation of dysplastic cells in lung alveoli
Journal of Clinical Investigation - Cardiology
OCTOBER 1, 2024
Severe viral pneumonia can induce rapid expansion of KRT5+ basal-like cells in small airways and alveoli; this forms a scar-like structure that persists in the injured alveoli and impedes normal alveolar epithelium regeneration. In this study, we investigated the mechanism by which viral infection induced this remodeling response. Through comparing different lung-injury models, we demonstrated that infection induced strong IFN-γ signal–stimulated dysplastic KRT5+ cell formation.
Conversion Practice Linked to Poor Mental Health Among Sexual, Gender Minority Adults
HCPLive
OCTOBER 1, 2024
A study links conversion therapy with worse mental health, such as PTSD and depression, showing a need for legislative action and support for LGBTQ+ individuals.
Nomine hoy a un héroe del derrame cerebral: Ya está abierto el plazo de presentación de candidaturas para los Stroke Hero Awards 2025
American Heart News - Stroke News
OCTOBER 1, 2024
DALLAS, 1 de octubre de 2024 - Los derrames cerebrales pueden producirse a cualquier edad, lo que obliga a los supervivientes a superar cambios físicos, emocionales y cognitivos. Ya está abierto el plazo de presentación de candidaturas para los.
FDA Grants 510(k) Clearance to PlaqueIQ Imaging Analysis Software
HCPLive
OCTOBER 1, 2024
Elucid has received 510(k) clearance for its PlaqueIQ™ imaging analysis software to help physicians diagnose cardiovascular disease.
Clonal hematopoiesis and hematological malignancy
Journal of Clinical Investigation - Cardiology
OCTOBER 1, 2024
Clonal hematopoiesis (CH), the expansion of hematopoietic stem cells and their progeny driven by somatic mutations in leukemia-associated genes, is a common phenomenon that rises in prevalence with advancing age to affect most people older than 70 years. CH remains subclinical in most carriers, but, in a minority, it progresses to a myeloid neoplasm, such as acute myeloid leukemia, myelodysplastic syndrome, or myeloproliferative neoplasm.
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