Tue.Mar 12, 2024

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Contemporary approach to cardiogenic shock care: a state-of-the-art review

Frontiers in Cardiovascular Medicine

Cardiogenic shock (CS) is a time-sensitive and hemodynamically complex syndrome with a broad spectrum of etiologies and clinical presentations. Despite contemporary therapies, CS continues to maintain high morbidity and mortality ranging from 35 to 50%. More recently, burgeoning observational research in this field aimed at enhancing the early recognition and characterization of the shock state through standardized team-based protocols, comprehensive hemodynamic profiling, and tailored and selec

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HFSA Calls Attention to Prevalence, Impact of Cognitive Impairment Among Heart Failure Patients

HCPLive

Eiran Gorodeski, MD, MPH, discusses a recent scientific statement composed on behalf of the Heart Failure Society of America highlighting the impact of cognitive impairment on patients with heart failure.

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Insulin resistance/hyperinsulinemia: an important cardiovascular risk factor that has long been underestimated

Frontiers in Cardiovascular Medicine

Cardiovascular mortality is still excessively high, despite the considerable progress made in the prevention and treatment of cardiovascular diseases. Although many cardiovascular risk factors (such as arterial hypertension, hypercholesterolemia, diabetes, etc.), identified in the general population, are being promptly treated, to date little consideration is given to a cardiovascular risk factor which we believe has largely demonstrated in the scientific literature of the last three decades tha

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Quantitative Coronary Angiography vs Intravascular Ultrasonography to Guide Drug-Eluting Stent Implantation

JAMA Cardiology

This randomized clinical trial compares 12-month event rates using quantitative coronary angiography guidance during percutaneous coronary intervention with those after intravascular ultrasonography–guided stent implantation.

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Modelling pre-eclampsia and its cardiovascular effects

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 13 March 2024; doi:10.1038/s41569-024-01006-0 In this Tools of the Trade article, Olivera describes a rat model of pre-elampsia that has been instrumental for investigating potential long-term cardiovascular effects in offspring.

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Diagnostic Imaging Strategies for Patients With Stable Chest Pain and Intermediate Risk of Coronary Artery Disease

American College of Cardiology

The goal of the DISCHARGE trial was to evaluate computed tomography (CT) compared with invasive coronary angiography among patients with stable chest pain and intermediate pretest probability of obstructive coronary artery disease.

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Risk factors, prevention, and therapy of intraluminal stent thrombosis in frozen elephant trunk prostheses—what we know so far

Frontiers in Cardiovascular Medicine

Intraluminal thrombus formation (ILT) is a recently discovered and highly clinically relevant complication after frozen elephant trunk implantation in cardiovascular surgery. In this phenomenon, a thrombus forms within the lumen of the stent graft component of the frozen elephant trunk prosthesis and puts the patient at risk for downstream embolization with visceral or lower limb ischemia.

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Role and mechanism of miRNA in cardiac microvascular endothelial cells in cardiovascular diseases

Frontiers in Cardiovascular Medicine

The occurrence and development of myocardial dysfunction are associated with damage in the cardiac microvascular endothelial cells (CMECs), which can regulate nutrient exchange and oxy-gen-carbon cycling to protect cardiomyocytes. Interventions targeting microRNAs (miRNAs) can effectively mitigate CMEC injury and thus improve cardiovascular diseases.

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CDC Opioid Guidelines Linked to Negative Consequences in Sickle Cell Disease

HCPLive

The 2016 CDC guidelines led to significant decreases in opioid prescriptions and an increase in pain-related healthcare utilization for people with sickle cell disease.

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Case Report: Heart aneurysm of unknown origin in a two-year-old child diagnosed in the course of Multisystem Inflammatory Syndrome in Children

Frontiers in Cardiovascular Medicine

We present a case of a 22-month-old boy with a hypokinetic and thin-walled aneurysm of the left ventricle apex. The lesion was diagnosed during routine echocardiography examination in the course of MIS-C, and its occurrence due to MIS-C is plausible. Cardiac magnetic resonance imaging revealed an akinetic aneurysm of the LV apex with a full-wall ischemic scar.

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The healthiest habits cardiologists keep

Becker's Hospital Review - Cardiology

Discover the lifestyle of cardiologists: from exercise habits to work-life balance, a recent Medscape survey reveals insights on this specialty's well-being.

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Pegozafermin Enters Phase 3 Clinical Trial Program for MASH, Fibrosis

HCPLive

The phase 3 ENLIGHTEN program will consist of 2 phase 3 trials evaluating the safety and efficacy of pegozafermin in patients with MASH.

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JACC State-of-the-Art Review: Racial and Ethnic Disparities in Perioperative Health Care Among Patients Undergoing Cardiac Surgery

American College of Cardiology

In this interview, Adam J. Milam, MD, PhD, and Clyde W.Yancy, MD, MSc, MACC, discuss the JACC State-of-the-Art Review: Racial and Ethnic Disparities in Perioperative Health Care Among Patients Undergoing Cardiac Surgery.

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Thrombotic Adverse Events Frequent After Emicizumab for Hemophilia A

HCPLive

An analysis of an FDA adverse event database found thrombotic adverse events were more frequently reported with emicizumab than those of FVIII products.

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Axillary vein as an alternative venous access site for VV-ECMO cannulation: a case report

Journal of Cardiothoracic Surgery

Ultrasound-guided percutaneous axillary vein cannulation can reduce cannulation failure and mechanical complications, is as safe and effective as internal jugular vein cannulation, and is superior to subclavia.

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Phase 3 Data Shows Pimavanserin for Schizophrenia is No Better Than Placebo

HCPLive

Acadia Pharmaceuticals decided to stop conducting further clinical trials with pimavanserin for negative symptoms of negative due to topline results.

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Acute type a aortic intramural hematoma complicated with preoperative hemopericardium: early and late surgical outcome analyses

Journal of Cardiothoracic Surgery

Acute type A aortic intramural hematoma (ATAIMH) is a variant of acute type A aortic dissection (ATAAD), exhibiting an increased risk of hemopericardium and cardiac tamponade. It can be life-threatening withou.

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Getinge Announces US FDA 510(k) Clearance for Vasoview Hemopro 3 Endoscopic Vessel Harvesting (EVH) solution

DAIC

Getinge has announced the U.S. Food and Drug Administration’s (FDA) 510(k) clearance of the Vasoview Hemopro 3, the latest addition to the medtech company’s endoscopic vessel harvesting (EVH) solutions. Image courtesy: Getinge christine.book Tue, 03/12/2024 - 11:41 March 12, 2024 — Getinge has announced the U.S. Food and Drug Administration ’s ( FDA ) 510(k) clearance of the Vasoview Hemopro 3, the latest addition to the medtech company’s endoscopic vessel harvesting (EVH) solutions.

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The association of regional block with intraoperative opioid consumption in patients undergoing video-assisted thoracoscopic surgery: a single-center, retrospective study

Journal of Cardiothoracic Surgery

Regional block, such as thoracic epidural analgesia (TEA), thoracic paravertebral block (TPVB), or serratus anterior plane block (SAPB) has been recommended to reduce postoperative opioid use in recent guideli.

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Stereotaxis Announces Regulatory Submissions of the MAGiC Ablation Catheter in Europe and the United States

DAIC

Physicians at Vilnius University Hospital. milla1cf Tue, 03/12/2024 - 16:44 March 12, 2024 — Stereotaxis , a pioneer and global leader in surgical robotics for minimally invasive endovascular intervention, announced that regulatory submissions were made recently in both Europe and the United States for the MAGiC catheter. These submissions follow successful initial clinical results in an ongoing trial.

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Children with Atopic Dermatitis May Be Shorter in Height

HCPLive

New global data suggest children with moderate to severe atopic dermatitis may experience stunted growth due to the effect of their disease on sleep, as well as use of certain therapies.

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New Late-breaking Data from Medtronic Evolut Low Risk Trial Demonstrate Strong Clinical and Cost-effectiveness Benefits of TAVR Platform

DAIC

milla1cf Tue, 03/12/2024 - 16:48 March 12, 2024 — Medtronic plc , a global leader in healthcare technology, today announced two late-breaking data presentations on four-year outcomes from the Evolut Low Risk Trial. A cost-effectiveness analysis demonstrates the positive economic value of transcatheter aortic valve replacement (TAVR) using Evolut TAVR compared to surgical aortic valve replacement (SAVR) for low-risk patients.

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LVAD Monitoring App Recall; ADHD Drug & CVD Risk; Value of ATTR Treatments?

Med Page Today

(MedPage Today) -- The FDA announced the class I recall of an Abbott app used to monitor patients using the HeartMate 3 Left Ventricular Assist Device (LVAD), as well as updated guidance related to the troublesome "Stop Pump" command; the recall.

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FDA Announces Abbott Recall of HeartMate Touch Communication System for Unintentional Pump Start and Stop

DAIC

The U.S. Food and Drug Administration (FDA) announced that Abbott is recalling its HeartMate Touch System (version 1.0.32) for risk of unexpected pump stop or start. Issues may occur if the HeartMate Touch System is disconnected from a patient’s HeartMate Controller while a “pump stop” command is running. People who have the implantable HeartMate 3 Left Ventricular Assist Device may be affected. christine.book Tue, 03/12/2024 - 09:40 March 12, 2024 — The U.S.

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Atrial Functional Substrates for the Prediction of Atrial Fibrillation Recurrence after Pulmonary Vein Isolation

The American Journal of Cardiology

Publication date: Available online 12 March 2024 Source: The American Journal of Cardiology Author(s): Masaharu Masuda, Yasuhiro Matsuda, Hiroyuki Uematsu, Mitsutoshi Asai, Shin Okamoto, Takayuki Ishihara, Kiyonori Nanto, Takuya Tsujimura, Yosuke Hata, Naoko Higashino, Sho Nakao, Toshiaki Mano

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Very early invasive strategy in higher risk non-ST-elevation acute coronary syndrome: the RAPID NSTEMI trial

Heart BMJ

Objective To investigate whether a very early invasive strategy (IS)±revascularisation improves clinical outcomes compared with standard care IS in higher risk patients with non-ST-elevation acute coronary syndrome (NSTE-ACS). Methods Multicentre, randomised, controlled, pragmatic strategy trial of higher risk patients with NSTE-ACS, defined by Global Registry of Acute Coronary Events 2.0 score of ≥118, or ≥90 with at least one additional high-risk feature.

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Andrew F. Alexis, MD, MPH: Findings on Lebrikizumab for Patients with Atopic Dermatitis, Skin of Color

HCPLive

Alexis spoke in this AAD interview about his team’s results regarding lebrikizumab for adults and adolescents with moderate-to-severe atopic dermatitis and skin of color.

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Beta-blockers and renin-angiotensin system inhibitors for Takotsubo syndrome recurrence: a network meta-analysis

Heart BMJ

Introduction Takotsubo syndrome (TTS) is an acute heart failure syndrome, featured by transient left ventricular systolic dysfunction. Recurrences of TTS are not infrequent and there is no standard preventive therapy. The aim of this study was to evaluate in a network meta-analysis if beta-blockers (BB) and ACE inhibitors/angiotensin receptor blockers (ACEi/ARBs), in combination or not, can effectively prevent TTS recurrences.

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Building a Psoriasis Knockout Regimen Around Risankizumab, with Andrew Blauvelt, MD, MBA

HCPLive

Blauvelt discusses the future research of higher-dose risankizumab for patients with psoriasis—and why it may be "disruptive in the treatment space.

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Inclusivity in randomised clinical trials: myth or reality?

Heart BMJ

In this issue of Heart, Castelijns et al aimed to apply the inclusion and exclusion criteria from the Cardiovascular Outcomes for People Using Anticoagulation Strategies, Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance trials, Prevention of Cardiovascular Events in Patients with Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction and Dual Antiplatelet Therapy to patients included

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Guselkumab Outperforms Ustekinumab in Indirect Comparison PsA Analysis

HCPLive

Both biologic-naĂŻve and biologic-experience patients receiving guselkumab demonstrated significantly higher ACR20 when compared with ustekinumab.

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Worldwide Trends in Underweight and Obesity

American College of Cardiology

What are the trends in the estimated prevalence of underweight and obesity from 1990 to 2022 among adults and children across 200 countries and territories?

Obesity 53
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Lazy Eye in Children Could Predict Cardiovascular, Metabolic Risk Later in Life

HCPLive

Study links childhood amblyopia with increased risk of cardiometabolic dysfunction in adulthood.

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Memorial Hermann renames heart institute

Becker's Hospital Review - Cardiology

Houston-based Memorial Hermann Health System and Memorial Hermann Foundation renamed the system's heart institute after the late real estate entrepreneur Larry Johnson.

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Two Dosing Regimens of Deuruxolitinib Led to Regrowth of Hair for Alopecia Areata

HCPLive

These data presented at AAD 2024 highlight deuruxolitinib’s efficacy in the treatment of adults with moderate-to-severe alopecia areata.

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Cardiogenic Shock in Older Adults: Key Points

American College of Cardiology

The following are key points to remember from an American Heart Association Scientific Statement on cardiogenic shock (CS) in older adults, which focuses on age-associated risks and approach to management.

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Women with Depression Have Greater Cardiovascular Risk Than Men

HCPLive

A new study found women (1.64) had a greater hazard ratio of depression for CVD than men (1.39).

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