Tue.Mar 26, 2024

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Young adults with migraine, other nontraditional risk factors may have higher stroke risk

American Heart News - Heart News

Research Highlights: Nontraditional risk factors for stroke were significantly associated with the development of strokes in adults younger than ages 35 to 45. Migraine was the most important nontraditional risk factor for stroke among both men and.

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A rare morphology of the cardiac fibroma in a child: a case report

Frontiers in Cardiovascular Medicine

Here we report a rare morphology of a cardiac fibroma in a child. A 2-year and 8-month-old toddler came for “chronic constipation” and was found to have a heart murmur on cardiac auscultation. Further transthoracic echocardiography suggested “a strong echogenic mass in the left ventricular wall, with some part of “a string of beads” in shape extending into left ventricle outflow tract”, which was atypical for either a tumor, thrombus or vegetation.

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Study finds high prevalence of hidden brain changes in people with heart disease

Science Daily - Heart Disease

A new analysis involving over 13,000 people has found changes to blood vessels in the brain that can increase the risk of stroke and dementia are common in people with a range of heart conditions, regardless of whether they have experienced a stroke.

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UC San Diego Health First in Region to Implant Dual Chamber, Leadless Pacemaker

DAIC

UC San Diego Health is the first in San Diego to successfully implant the world’s first dual chamber and leadless pacemaker system to help treat people with abnormal heart rhythms. Holding the device and pictured above is Ulrika Birgersdotter-Green, MD, cardiologist and director of pacemaker and ICD services at UC San Diego Health. Credit: Kyle Dykes / UC San Diego Health milla1cf Tue, 03/26/2024 - 11:01 March 26, 2024 — UC San Diego Health is the first health system in San Diego to successful

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Young adults with migraine, other nontraditional risk factors may have higher stroke risk

Science Daily - Heart Disease

Nontraditional risk factors such as migraines are as important as traditional risk factors like high blood pressure for adults younger than ages 35-45, finds new study.

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Esperion Announces Data from CLEAR Outcomes Sub-Groups as Poster Presentations, Moderated Session and Industry Expert Theatre to be Presented at ACC.24

DAIC

milla1cf Tue, 03/26/2024 - 13:00 March 26, 2024 — Esperion announced the acceptance of three CLEAR ( C holesterol L owering via B e mpedoic acid, an A CL-Inhibiting R egimen ) Outcomes subgroup analyses as poster presentations at th e 2024 American College of Cardiology’s Annual Scientific Session ( ACC.24 ) in Atlanta, Georgia. Additionally, the Company will participate in a moderated session in partnership with UT Southwestern Medical Center, host an industry expert theater, and have a comm

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Study finds high prevalence of hidden brain changes in people with heart disease

Medical Xpress - Cardiology

A new analysis involving over 13,000 people has found changes to blood vessels in the brain that can increase the risk of stroke and dementia are common in people with a range of heart conditions, regardless of whether they have experienced a stroke.

Dementia 101

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Prognostic Models for Mortality and Morbidity in Heart Failure With Preserved Ejection Fraction

JAMA Cardiology

This prognostic study investigates if models that incorporate routinely collected clinical and laboratory information can predict morbidity and mortality in patients with heart failure and preserved ejection fraction.

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Bristol Myers Squibb to Present Data at on CAMZYOS (mavacamten) for obstructive hypertrophic cardiomyopathy (HCM) at American College of Cardiology Annual Scientific Session, ACC.24

DAIC

Bristol Myers Squibb has announced that it will present data on CAMZYOS (mavacamten) for NYHA class II-III obstructive hypertrophic cardiomyopathy at the American College of Cardiology (ACC) Annual Scientific Session & Expo, ACC.24, taking place April 6-8, 2024 in Atlanta, Georgia. Image courtesy: Getty Images christine.book Tue, 03/26/2024 - 11:07 March 26, 2024 — Bristol Myers Squibb has announced that it will present data on CAMZYOS (mavacamten) for NYHA class II-III obstructive hypertrophic

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Arnold Schwarzenegger's Surgery; Bird Flu in U.S. Milk; Light Pollution and Strokes

Med Page Today

(MedPage Today) -- Note that some links may require registration or subscription. Arnold Schwarzenegger underwent surgery for a pacemaker, saying he's become "a little bit more of a machine." (People) Pope Francis skipped the homily during Palm.

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FDA Issues Warning for Topical Analgesics with High Levels of Lidocaine

HCPLive

The FDA identified high concentration of lidocaine across marketed, over-the-counter topical products from 6 different companies.

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Two new mutations identified as possible causes of rare blood disorder

Medical Xpress - Cardiology

Researchers have uncovered two novel gene mutations that may be responsible for a rare blood disorder. The mutations are found on the GNE gene and impact an enzyme, also called GNE, that is involved in the synthesis of sialic acid and a process called sialylation, which is critical for brain development. The mutations were first identified in a pediatric patient with macrothrombocytopenia, also called a giant platelet disorder, because of the enlarged size of blood platelets.

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Hemoglobin Levels Predict Renal Outcomes in Diabetic Kidney Disease

HCPLive

A study in China identified a negative and non-linear relationship between hemoglobin levels and a renal composite end point in patients with DKD.

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A Revised Definition of Left Bundle Branch Block Using Time to Notch in Lead I

JAMA Cardiology

This diagnostic study aims to develop and validate a simple new criterion, time to notch longer than 75 milliseconds in lead I on electrocardiography, to identify left bundle branch block based on electrophysiological studies of human patients.

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Depression May Develop as Early as 5 Years After a Stroke

HCPLive

In a recent UK study, more than half of stroke survivors developed depression within 18 years.

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A man in his 50s with shortness of breath

Dr. Smith's ECG Blog

Sent by Tom Fiero, written by Pendell Meyers A man in his 50s presented with acute shortness of breath. Unfortunately we do not have access to the patients presenting vital signs. Here is his ECG: Original image, suboptimal quality Quality improved with PM Cardio digitization The ECG is highly suggestive of acute right heart strain, with sinus tachycardia, S1Q3T3, and T wave inversions in anterior and inferior with morphology consistent with acute right heart strain.

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Story of magnesium for torsade de pointes

HeartRhythm

Torsade de pointes (TdP) was not a rare arrhythmia in Israel during the 1970s–1980s as many patients, mainly with atrial fibrillation (AF), were treated with QT-prolonging antiarrhythmic drugs. We published several articles on the use of cardiac pacing and intravenous (IV) isoproterenol in patients who developed TdP from quinidine, disopyramide, or amiodarone.

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JACC and JACC: Clinical Electrophysiology to Combine Efforts on Heart Rhythm

American College of Cardiology

Editorial Boards for JACC and JACC: Clinical Electrophysiology (JACC: CEP) will integrate their efforts to attract and publish the best electrophysiology (EP) content and produce the greatest patient impact, as one of the first initiatives of incoming JACC Editor-in-Chief Harlan M. Krumholz, MD, SM, FACC.

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Non-neuronal cholinergic system in the heart influences its homeostasis and an extra-cardiac site, the blood-brain barrier

Frontiers in Cardiovascular Medicine

The non-neuronal cholinergic system of the cardiovascular system has recently gained attention because of its origin. The final product of this system is acetylcholine (ACh) not derived from the parasympathetic nervous system but from cardiomyocytes, endothelial cells, and immune cells. Accordingly, it is defined as an ACh synthesis system by non-neuronal cells.

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Cardiovascular risks and COVID-19: New research confirms the benefits of vaccination

Medical Xpress - Cardiology

COVID-19 is a respiratory disease. Yet, from the earliest days of the pandemic, the cardiovascular risks associated with SARS-CoV-2 infection were clear: individuals with severe cases of COVID-19 often died from cardiovascular complications, and those with pre-existing cardiovascular disease were more likely to have severe illness or die.

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A case report on pheochromocytoma mimicking as fulminant myocarditis—a diagnostic challenge

Frontiers in Cardiovascular Medicine

We present an exceptional case of a 53-year-old female, initially misdiagnosed with fulminant myocarditis, but later correctly diagnosed with pheochromocytoma. The presentation of the patient included a spectrum of symptoms such as headache, chest discomfort, palpitations, and dyspnea, following the intake of Domperidone. Two weeks prior to admission, the patient had experienced episodes of diarrhea and a low-grade fever.

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Timing of Complete Multivessel Revascularization in NSTE-ACS Patients

American College of Cardiology

What are clinical outcomes among patients presenting with non–ST-segment elevation acute coronary syndrome (NSTE-ACS) and multivessel coronary artery disease (MVD) and undergoing immediate complete revascularization (ICR) compared to staged complete revascularization (SCR)?

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Evaluation of vascular aging on measures of cardiac function and mechanical efficiency: insights from in-silico modeling

Frontiers in Cardiovascular Medicine

Introduction This study evaluated the hypothesis that vascular aging (VA) reduces ventricular contractile function and mechanical efficiency (ME) using the left ventricular pressure-volume (PV) construct. Methods A previously published in-silico computational model (CM) was modified to evaluate the hypothesis in two phases. In phase I, the CM included five settings of aortic compliance ( C A ) from normal to stiff, studied at a heart rate of 80 bpm, and phase II included the normal to stiff C A

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Dermatology Dialogue Service Led to Patient, Clinician Satisfaction in Reducing Wait Lists

HCPLive

In this analysis from the UK, the DDPS led to improved pathway management which also achieved lower service demand and smaller waiting lists for dermatologists.

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Red Meat-CVD Link Questioned; Drone AEDs to Bystanders; OCT-FFR in One Step?

Med Page Today

(MedPage Today) -- A Mendelian randomization study challenged the notion that red and processed meats can cause cardiovascular disease and type 2 diabetes. (European Journal of Preventive Cardiology) The American Heart Association voiced its support.

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Treating Anxiety, Depression in Heart Disease Patients Reduces Hospitalization

HCPLive

The hospitalization risk was reduced to up to 75% for patients with heart disease treated with both antidepressants and psychotherapy to manage anxiety or depression symptoms.

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6 in 10 stroke survivors will struggle with depression years later, study finds

Medical Xpress - Cardiology

A new study says 6 out of every 10 stroke survivors wind up struggling with depression later in their lives.

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Blood-Based Colorectal Cancer Screening Projected to Fall Short Compared to FIT, Colonoscopy

HCPLive

A hypothetical triennial blood-based screening test meeting Centers for Medicare and Medicaid Services coverage criteria was cost-effective versus no screening but not compared to FIT, sDNA-FIT, or colonoscopy.

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Deep-learning model based on chest X-ray helps predict MACE

Medical Xpress - Cardiology

A deep-learning model based on a chest radiograph (CXR) for cardiovascular disease (CVD) risk (CXR CVD-Risk) predicts major adverse cardiovascular events (MACE) beyond the clinical standard, according to a study published in the Annals of Internal Medicine.

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From JACC: Aortic Valve Calcium and the Long-Term Risk of Incident Severe AS

American College of Cardiology

In this interview, Richard A. Chazal MD, MACC and Michael J. Blaha, MD, MPH discuss Prevalence of Aortic Valve Calcium and the Long-Term Risk of Incident Severe Aortic Stenosis.

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Childhood sedentariness found to accelerate premature vascular damage

Medical Xpress - Cardiology

An increase in sedentary time from childhood is associated with worsening arterial stiffness, a surrogate for premature vascular damage, a new study shows. However, light physical activity could reduce the risk. The study was conducted in collaboration between Oxford University, the Universities of Bristol and Exeter, and the University of Eastern Finland, and the results were published in Acta Physiologica.

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Lessons Learned From the BEST-CLI and BASIL-2 Trials

American College of Cardiology

The BEST-CLI (Best Endovascular Versus Best Surgical Therapy in Patients With CLTI) and BASIL-2 (Bypass versus Angioplasty for Severe Ischemia of the Leg-2) trial results provide insight into revascularization strategies among patients with chronic limb threatening ischemia (CLTI),

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Bimekizumab Demonstrates Similar, Greater Efficacy Compared with Guselkumab in PsA

HCPLive

Bimekizumab initiation resulted in greater or comparable efficacy regarding minimal disease activity and achievement of ACR50/70 compared with guselkumab.

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Develop of endocavitary suction device for MiECC on minimally invasive mitral valve surgery

Journal of Cardiothoracic Surgery

The minimally invasive extracorporeal circulation (MiECC) system was developed to minimize the contact of blood with air and foreign surfaces during conventional cardiopulmonary bypass (CPB). It is also aimed.

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Diabetes Dialogue: T1D Glycemic Improvement and CRISTAL at ATTD 2024

HCPLive

In this peisode, hosts disucss top news and updates in automated insulin delivery from ATTD 2024, with a focus on new data from the T1D Exchange and a read-out from the CRISTAL study.

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Comparison of the effects of using feedback devices for training or simulated cardiopulmonary arrest

Journal of Cardiothoracic Surgery

High-quality chest compression is essential for successful cardiac arrest resuscitation. High-quality cardiopulmonary resuscitation (CPR) can effectively improve the survival rate of patients with cardiopulmon.

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Impact of First-Line Therapy on Long-Term Outcomes in nAMD and DME

HCPLive

Experts discuss the importance of optimizing first-line therapies in the treatment of retinal diseases like neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME).