Fri.Nov 29, 2024

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What Should Your Blood Pressure Be?

Dr. Paddy Barrett

“What should my blood pressure be?” This is one of the most common questions I get as a cardiologist. The answer is pretty simple, but most people get this wrong, and doing so increases their future risk of heart attack and strokes. The problem is that high blood pressure is not some obscure risk that only impacts a small percentage of the population.

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Gene-screening method identifies cause of heart cell damage from chemotherapy

Medical Xpress - Cardiology

Using a gene-screening method they created, Stanford Medicine researchers may have discovered why an effective chemotherapy damages heart cells—and they have identified a drug that could keep the heart cells beating.

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ECG Basics Full Series

All About Cardiovascular System and Disorders

ECG basics full series, combining previous videos in this series. This will help you to go through the whole set without searching for individual videos in the series. Starts off with basic principles of ECG recording and interpretation. Takes you through more advanced topics, retaining the simple method of explanation. There are ample number of ECG illustrations with annotations available in this lecture.

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Schizophrenia with Violence Linked to Reduced Left Frontal Gray Matter, Higher TSH

HCPLive

A study found patients with schizophrenia exhibiting violence, vs. those who don’t, have less gray matter volume in the frontal lobe and greater thyroid-stimulating hormone levels.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Cerebral stroke in animal models with hypertension found to affect arteries in other body regions

Medical Xpress - Cardiology

A study coordinated by Dr. Francesc Jiménez-Altayó, researcher at the Institut de Neurociències of the UAB (INc-UAB) and at CIBERCV, shows that temporary lack of blood flow to the brain can lead to lasting changes in the small arteries of the abdomen in rats with high blood pressure. The research also explored the effects of a drug called SAHA in mitigating these changes, finding that it prevented some early alterations in the arteries and reduced long-term brain damage.

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Medicare’s New Mandatory Bundled-Payment Program — Are We Ready for TEAM?

The New England Journal of Medicine

CMS recently announced the newest iteration of bundled payments, the Transforming Episode Accountability Model. Several challenges will need to be monitored and potentially addressed during implementation.

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ASGR1 deficiency improves atherosclerosis but alters liver metabolism in ApoE-/- mice

Cardiovascular Diabetology

The asialoglycoprotein receptor 1 (ASGR1), a multivalent carbohydrate-binding receptor that primarily is responsible for recognizing and eliminating circulating glycoproteins with exposed galactose (Gal) or N-ace.

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Complete resection of a giant costal chondrosarcoma with reconstruction of the thoraco-abdominal wall: a case report

Journal of Cardiothoracic Surgery

Chondrosarcoma primarily occurs in the pelvis and femur, with occasional cases in the ribs. Surgical resection remains the main treatment method for costal chondrosarcoma. However, complete resection often lea.

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Patient Education Tips for CSU and Final Thoughts

HCPLive

Panelists discuss the importance of patient education and shared decision-making in selecting appropriate therapies for chronic spontaneous urticaria (CSU), addressing unmet needs in CSU management and the evolving nature of the field, while also offering practical advice for allergists based on their experiences and available data.

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What is a perimembranous VSD?

All About Cardiovascular System and Disorders

Perimembranous VSD is the commonest type of ventricular septal defect noted in children. There is a good chance of spontaneous closure of those detected in early childhood. Large VSDs can be associated with heart failure in infancy and may need surgery. Device closure is not that well established in perimembranous VSD as in case of muscular VSD.

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Novel Therapeutics in Development for CSU

HCPLive

Panelists discuss how the integration of advanced treatments such as biologics and Bruton tyrosine kinase (BTK) inhibitors can bridge the gap in managing chronic spontaneous urticaria (CSU) for patients unresponsive to antihistamines.

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Hepatic Tissue Alterations in STEMI: New Insights Into the Prognostic Significance of Cardio-Hepatic Interplay

Circulation: Cardiovascular Imaging

Circulation: Cardiovascular Imaging, Volume 17, Issue 12 , Page e017611, December 1, 2024.

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The Role of BTK Inhibition in CSU

HCPLive

Panelists discuss how Bruton tyrosine kinase’s (BTK) role in mediating mast cell degranulation makes it an ideal target for chronic spontaneous urticaria (CSU) treatment, as inhibiting BTK could effectively reduce histamine release and its associated symptoms.

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Left Atrial Wall Thickness Measured by a Machine Learning Method Predicts AF Recurrence After Pulmonary Vein Isolation

Journal of Cardiovascular Electrophysiology

ABSTRACT Background Left atrial (LA) remodeling plays a significant role in the progression of atrial fibrillation (AF). Although LA wall thickness (LAWT) has emerged as an indicator of structural remodeling, its impact on AF outcomes remains unclear. We aimed to determine the association between LAWT and AF recurrence after pulmonary vein isolation (PVI), as well as to evaluate the relationship between LAWT and LA fibrosis.

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Comparison of Procedural Outcomes of Lumenless Fixed-Helix Versus Stylet-Driven Extendable-Helix Lead Systems in Left Bundle Branch Pacing: COMPARE LBBP

Circulation: Arrhythmia and Electrophysiology

Circulation: Arrhythmia and Electrophysiology, Volume 17, Issue 12 , Page e013385, December 1, 2024. BACKGROUND:Left bundle branch pacing (LBBP) has emerged as a safe and effective alternative to right ventricular pacing. Traditionally, LBBP is performed with lumenless lead (LLL); however, the use of stylet-driven lead (SDL) is on rise. We aimed to assess acute success and procedural outcomes of SDL versus LLL for LBBP.METHODS:One hundred consecutive patients with bradyarrhythmia, indication of

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Understanding the Complex Genetics of Spontaneous Coronary Artery Dissection: A Guide for Clinicians

Circulation: Genomic and Precision Medicine

Circulation: Genomic and Precision Medicine, Volume 17, Issue 6 , Page e004800, December 1, 2024.

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Lesion Morphometry of the Pentaspline Pulsed Field Ablation Catheter: Understanding Catheter Pose, Rotation, and Dosing

Circulation: Arrhythmia and Electrophysiology

Circulation: Arrhythmia and Electrophysiology, Volume 17, Issue 12 , Page e013208, December 1, 2024. BACKGROUND:The pentaspline pulsed field ablation catheter achieves pulmonary vein isolation using 8 stacked, pose-specific applications with rotation. The morphology of pose-specific, single or double applications has not been described.METHODS:One or 2 applications were delivered to select veins and discrete atrial and ventricular sites in 9 swine.

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Patient Perceptions of Emerging Gene Therapies for Arrhythmogenic Right Ventricular Cardiomyopathy

Circulation: Genomic and Precision Medicine

Circulation: Genomic and Precision Medicine, Volume 17, Issue 6 , Page e004759, December 1, 2024. BACKGROUND:No disease-specific therapy currently exists for arrhythmogenic right ventricular cardiomyopathy (ARVC), a progressive cardiogenetic condition conferring elevated risk for ventricular arrhythmias, heart failure, and sudden cardiac death. Emerging gene therapies have the potential to fill this gap.

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Hospital and Post‐Discharge Mortality in Patients With Acute Coronary Syndrome and Ventricular Ectopy

Journal of Cardiovascular Electrophysiology

Analysis of VPDs in ACS patients reveals distinct morphological predictors of mortality. RBBB VPDs are associated with increased in-hospital mortality, while superior axis VPDs predict higher post-discharge mortality. This study highlights the importance of VPD morphology in risk stratification. ABSTRACT Introduction Ventricular premature depolarizations (VPDs) in the setting of acute coronary syndrome (ACS) were associated with increased hospital mortality in the early revascularization era.

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Is It Primetime for Finerenone in Heart Failure?

Circulation: Heart Failure

Circulation: Heart Failure, Ahead of Print.

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Progress of angiographic cardiac allograft vasculopathy in long-term transplanted patients: Longitudinal evaluation of its association with dyslipidemia patterns

The American Journal of Cardiology

Publication date: Available online 28 November 2024 Source: The American Journal of Cardiology Author(s): David Grundmann, Janina Neubarth-Mayer, Christoph Müller, Finn Becker, Daniel Reichart, Konstantin Stark, Ulrich Grabmaier, Simon Deseive, Konstantinos D.

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Hepatic Tissue Alterations in ST-Elevation Myocardial Infarction: Determinants and Prognostic Implications

Circulation: Cardiovascular Imaging

Circulation: Cardiovascular Imaging, Volume 17, Issue 12 , Page e017041, December 1, 2024. BACKGROUND:The presence and clinical significance of hepatic tissue alterations as assessed by cardiac magnetic resonance imaging in patients with ST-segmentelevation myocardial infarction (STEMI), are unclear. This study aimed to investigate associations of hepatic T1 patterns with myocardial tissue damage and clinical outcomes in patients suffering from STEMI.METHODS:We analyzed 485 patients with STEMI t

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Fasting vs Non-Fasting Before Cardiac Catheterization: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

The American Journal of Cardiology

Publication date: Available online 28 November 2024 Source: The American Journal of Cardiology Author(s): Muhammad Saad, Saad Ahmed Waqas, Jazza Aamir, Muhammad Umer Sohail, Ifrah Ansari, Anmol Mohan, Vikash Kumar, Chadi Alraies

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Sex-Specific Association Between Genetic Risk of Psychiatric Disorders and Cardiovascular Diseases

Circulation: Genomic and Precision Medicine

Circulation: Genomic and Precision Medicine, Volume 17, Issue 6 , Page e004685, December 1, 2024. BACKGROUND:Though epidemiological studies show increased cardiovascular disease (CVD) risks among individuals with psychiatric disorders, findings on sex differences in comorbidity have been inconsistent.METHODS:This genetic epidemiology study examined the sex-specific association between the genetic risk of 3 psychiatric disorders (major depression [MD], schizophrenia, and bipolar disorder), estima

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Recent MI at another facility. Now back in the ER with chest pain

Dr. Smith's ECG Blog

Written by Willy Frick A young woman with a history of paroxysmal nocturnal hemoglobinuria presented with acute substernal chest pain. Five days prior, she had a similar presentation to a different hospital. She underwent coronary angiography which showed thrombotic occlusion of an RPL branch s/p aspiration thrombectomy. The report describes heavy plaque in the proximal RCA by IVUS, but no lesions in the previously occluded RPL branch and no stent was deployed.

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Non-linear relationship between platelet count and 28-day mortality in critically ill patients with infective endocarditis: a retrospective cohort study from MIMIC IV database

Frontiers in Cardiovascular Medicine

BackgroundThe relationship between platelet count and 28-day mortality in critically ill patients with infective endocarditis (IE) is currently not well established.ObjectiveThis study aims to investigate the impact of platelet count on 28-day mortality in critically ill patients with infective endocarditis.MethodsA retrospective cohort study was conducted involving 450 participants diagnosed with infective endocarditis and admitted to intensive care units (ICU).

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Physiology Friday #246: Black Friday Discount + My Conversation on The Mind Muscle Connection Podcast

Physiologically Speaking

Greetings! Happy Black Friday to those who celebrate. Are you looking for a new health, fitness, or nutrition product for yourself or to give as a gift to family and friends? Here are a few Black Friday/Cyber Monday deals from brands I’m affiliated with and use myself. Save up to 60% on an Examine.com membership Get 30% off of your Ketone-IQ purchase 30% off of FSTFUEL electrolytes with the code BRADY30 at checkout 30% off of Presleep sleep supplement with the code BRADY30 at checkout 10%

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Comparison of patients undergoing protected high risk percutaneous coronary intervention using either intravascular lithotripsy or rotational atherectomy

Frontiers in Cardiovascular Medicine

BackgroundTreating heavily calcified vessels is a challenging task in patients with an impaired left ventricular ejection fraction. Percutaneous mechanical circulatory support (pMCS) is increasingly used in patients in high-risk percutaneous coronary intervention (HRPCI).MethodsIn this retrospective registry, we investigated 25 patients undergoing a protected HRPCI receiving either intravascular lithotripsy (IVL + pMCS; n = 11) or rotational atherectomy (RA + pMCS; n = 14).

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External Validation of COAPT Risk Score in Patients Undergoing Transcatheter Edge-To-Edge Repair of Severe, Functional Mitral Regurgitation: a Multicenter, Observational Italian-Polish Study

The American Journal of Cardiology

Publication date: Available online 28 November 2024 Source: The American Journal of Cardiology Author(s): Aleksandra Gąsecka, Karolina Jasińska-Gniadzik, Fabrizio D'Ascenzo, Filippo Angelini, Michał Łomiak, Jerzy Pręgowski, Zbigniew Chmielak, Piotr Kasprzyk, Jan Kasprzyk, Miłosz J.

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Identification of key genes in gout and atherosclerosis and construction of molecular regulatory networks

Frontiers in Cardiovascular Medicine

BackgroundGout is a type of chronic inflammatory disease linked to the accumulation of monosodium urate crystals, leading to arthritis. Studies have shown that patients with gout are more likely to develop atherosclerosis, but the specific mechanisms involved remain unknown. The purpose of the research was to explore the key molecules and potential mechanisms between gout and atherosclerosis.MethodsGene expression profiles for gout as well as atherosclerosis were obtained from the Gene Expressio

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Preclinical evaluation of vascular closure devices

Frontiers in Cardiovascular Medicine

Vascular closure devices (VCDs) are a diverse class of cardiovascular devices intended to achieve hemostasis following arteriotomy in the common femoral artery for diagnostic and therapeutic interventional procedures. While the preclinical evaluation of VCDs parallel that of many other cardiovascular devices, there are device-specific nuances and model-specific technical considerations in assessing in vivo performance and handling, determining safety, and satisfying regulatory requirements.