Fri.Nov 29, 2024

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Gene-screening method identifies cause of heart cell damage from chemotherapy

Medical Xpress - Cardiology

Using a gene-screening method they created, Stanford Medicine researchers may have discovered why an effective chemotherapy damages heart cells—and they have identified a drug that could keep the heart cells beating.

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Recent MI at another facility. Now back in the ER with chest pain

Dr. Smith's ECG Blog

Written by Willy Frick A young woman with a history of paroxysmal nocturnal hemoglobinuria presented with acute substernal chest pain. Five days prior, she had a similar presentation to a different hospital. She underwent coronary angiography which showed thrombotic occlusion of an RPL branch s/p aspiration thrombectomy. The report describes heavy plaque in the proximal RCA by IVUS, but no lesions in the previously occluded RPL branch and no stent was deployed.

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Schizophrenia with Violence Linked to Reduced Left Frontal Gray Matter, Higher TSH

HCPLive

A study found patients with schizophrenia exhibiting violence, vs. those who don’t, have less gray matter volume in the frontal lobe and greater thyroid-stimulating hormone levels.

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What Should Your Blood Pressure Be?

Dr. Paddy Barrett

“What should my blood pressure be?” This is one of the most common questions I get as a cardiologist. The answer is pretty simple, but most people get this wrong, and doing so increases their future risk of heart attack and strokes. The problem is that high blood pressure is not some obscure risk that only impacts a small percentage of the population.

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Discussing New Updates to GOLD 2025 Report, with Gerard Criner, MD

HCPLive

During his interview, Criner discusses several notable updates to the 2025 Global Initiative for Chronic Obstructive Lung Disease (GOLD) Report regarding COPD care.

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Physiology Friday #246: Black Friday Discount + My Conversation on The Mind Muscle Connection Podcast

Physiologically Speaking

Greetings! Happy Black Friday to those who celebrate. Are you looking for a new health, fitness, or nutrition product for yourself or to give as a gift to family and friends? Here are a few Black Friday/Cyber Monday deals from brands I’m affiliated with and use myself. Save up to 60% on an Examine.com membership Get 30% off of your Ketone-IQ purchase 30% off of FSTFUEL electrolytes with the code BRADY30 at checkout 30% off of Presleep sleep supplement with the code BRADY30 at checkout 10%

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ECG Basics Full Series

All About Cardiovascular System and Disorders

ECG basics full series, combining previous videos in this series. This will help you to go through the whole set without searching for individual videos in the series. Starts off with basic principles of ECG recording and interpretation. Takes you through more advanced topics, retaining the simple method of explanation. There are ample number of ECG illustrations with annotations available in this lecture.

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What is a perimembranous VSD?

All About Cardiovascular System and Disorders

Perimembranous VSD is the commonest type of ventricular septal defect noted in children. There is a good chance of spontaneous closure of those detected in early childhood. Large VSDs can be associated with heart failure in infancy and may need surgery. Device closure is not that well established in perimembranous VSD as in case of muscular VSD.

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Novel Therapeutics in Development for CSU

HCPLive

Panelists discuss how the integration of advanced treatments such as biologics and Bruton tyrosine kinase (BTK) inhibitors can bridge the gap in managing chronic spontaneous urticaria (CSU) for patients unresponsive to antihistamines.

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Non-linear relationship between platelet count and 28-day mortality in critically ill patients with infective endocarditis: a retrospective cohort study from MIMIC IV database

Frontiers in Cardiovascular Medicine

BackgroundThe relationship between platelet count and 28-day mortality in critically ill patients with infective endocarditis (IE) is currently not well established.ObjectiveThis study aims to investigate the impact of platelet count on 28-day mortality in critically ill patients with infective endocarditis.MethodsA retrospective cohort study was conducted involving 450 participants diagnosed with infective endocarditis and admitted to intensive care units (ICU).

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The Role of BTK Inhibition in CSU

HCPLive

Panelists discuss how Bruton tyrosine kinase’s (BTK) role in mediating mast cell degranulation makes it an ideal target for chronic spontaneous urticaria (CSU) treatment, as inhibiting BTK could effectively reduce histamine release and its associated symptoms.

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Medicare’s New Mandatory Bundled-Payment Program — Are We Ready for TEAM?

The New England Journal of Medicine

CMS recently announced the newest iteration of bundled payments, the Transforming Episode Accountability Model. Several challenges will need to be monitored and potentially addressed during implementation.

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Progress of angiographic cardiac allograft vasculopathy in long-term transplanted patients: Longitudinal evaluation of its association with dyslipidemia patterns

The American Journal of Cardiology

Publication date: Available online 28 November 2024 Source: The American Journal of Cardiology Author(s): David Grundmann, Janina Neubarth-Mayer, Christoph Müller, Finn Becker, Daniel Reichart, Konstantin Stark, Ulrich Grabmaier, Simon Deseive, Konstantinos D.

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Comparison of patients undergoing protected high risk percutaneous coronary intervention using either intravascular lithotripsy or rotational atherectomy

Frontiers in Cardiovascular Medicine

BackgroundTreating heavily calcified vessels is a challenging task in patients with an impaired left ventricular ejection fraction. Percutaneous mechanical circulatory support (pMCS) is increasingly used in patients in high-risk percutaneous coronary intervention (HRPCI).MethodsIn this retrospective registry, we investigated 25 patients undergoing a protected HRPCI receiving either intravascular lithotripsy (IVL + pMCS; n = 11) or rotational atherectomy (RA + pMCS; n = 14).

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External Validation of COAPT Risk Score in Patients Undergoing Transcatheter Edge-To-Edge Repair of Severe, Functional Mitral Regurgitation: a Multicenter, Observational Italian-Polish Study

The American Journal of Cardiology

Publication date: Available online 28 November 2024 Source: The American Journal of Cardiology Author(s): Aleksandra Gąsecka, Karolina Jasińska-Gniadzik, Fabrizio D'Ascenzo, Filippo Angelini, Michał Łomiak, Jerzy Pręgowski, Zbigniew Chmielak, Piotr Kasprzyk, Jan Kasprzyk, Miłosz J.

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Identification of key genes in gout and atherosclerosis and construction of molecular regulatory networks

Frontiers in Cardiovascular Medicine

BackgroundGout is a type of chronic inflammatory disease linked to the accumulation of monosodium urate crystals, leading to arthritis. Studies have shown that patients with gout are more likely to develop atherosclerosis, but the specific mechanisms involved remain unknown. The purpose of the research was to explore the key molecules and potential mechanisms between gout and atherosclerosis.MethodsGene expression profiles for gout as well as atherosclerosis were obtained from the Gene Expressio

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Fasting vs Non-Fasting Before Cardiac Catheterization: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

The American Journal of Cardiology

Publication date: Available online 28 November 2024 Source: The American Journal of Cardiology Author(s): Muhammad Saad, Saad Ahmed Waqas, Jazza Aamir, Muhammad Umer Sohail, Ifrah Ansari, Anmol Mohan, Vikash Kumar, Chadi Alraies

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Preclinical evaluation of vascular closure devices

Frontiers in Cardiovascular Medicine

Vascular closure devices (VCDs) are a diverse class of cardiovascular devices intended to achieve hemostasis following arteriotomy in the common femoral artery for diagnostic and therapeutic interventional procedures. While the preclinical evaluation of VCDs parallel that of many other cardiovascular devices, there are device-specific nuances and model-specific technical considerations in assessing in vivo performance and handling, determining safety, and satisfying regulatory requirements.

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Is It Primetime for Finerenone in Heart Failure?

Circulation: Heart Failure

Circulation: Heart Failure, Ahead of Print.