Tue.Jan 30, 2024

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Drug-Related Endocarditis: A First Stab at Recommendations for Surgeons

Med Page Today

(MedPage Today) -- SAN ANTONIO -- In response to the opioid epidemic, a primer to treating infective endocarditis (IE) specifically related to drug use was released by the Society of Thoracic Surgeons (STS). A workforce on the surgical management.

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Women With Alcohol-Related Liver Disease Face Greater Risk of Mortality Than Men

HCPLive

Although there was a greater prevalence of ALD and MetALD among male study participants, females had a greater risk of mortality from both SLD phenotypes, highlighting a potentially greater impact of alcohol consumption on women with liver disease than men.

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Machine learning informs a new tool to guide treatment for acute decompensated heart failure

Science Daily - Heart Disease

A recent study utilized a machine learning-based approach to identify, understand, and predict diuretic responsiveness in patients with acute decompensated heart failure (ADHF).

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Cost and Needing Time off Work Prevent Some Older Adults from Undergoing Surgery

HCPLive

Regarding elective surgery, more than half of older adults in a survey study expressed concerns about pain and discomfort, as well as difficulty in recovery. Common concerns included costs, COVID-19 exposure, and time needed to be off work.

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Familial Hypercholesterolemia Variant and Cardiovascular Risk in Individuals With Elevated Cholesterol

JAMA Cardiology

This pooled cohort study assesses the risk of coronary heart disease associated with familial hypercholesterolemia variants in individuals with moderately to severely elevated low-density lipoprotein cholesterol.

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Cardiology Ups Diversity; Universal CVD Risk Predictor; 93-Year-Old Cardiologist

Med Page Today

(MedPage Today) -- More women and Black and Hispanic trainees are entering cardiovascular disease and cardiovascular subspecialty fellowships. (JAMA Cardiology) A poll found that over half of U.S. adults don't know that heart disease is the leading.

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VX-548 Significantly Reduces Moderate to Severe Acute Pain, Phase III Program Data Reveal

HCPLive

VX-548 demonstrated a more rapid onset to meaningful pain relief post-surgery compared with placebo.

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More Trending

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In Your 40s to 60s And Worried About Heart Disease? Here Is What You Can Do.

Dr. Paddy Barrett

‘ Snipers Alley ’ I had never heard the term before, but lots of my patients were using it, and it seemed to motivate them into action. ‘ Snipers Alley ’, it turns out, is an age between 40-60, where mostly males were having fatal heart attacks. These patients were not overly bothered about having a heart attack at age 80, but usually, one of their friends, aged 52 or so, had just had a heart attack, and they did not want to be next.

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Cardiology Case Report: Shortness of Breath Plus Erythrocytosis

HCPLive

This cardiology case report from Brady Pregerson, MD, features a woman in her 50s presenting with 3 days of body swelling and dyspnea. Check out the EKG and see if you can determine the correct diagnosis!

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Medical Treatment Strategies for Hypertrophic Cardiomyopathy

The American Journal of Cardiology

Hypertrophic cardiomyopathy (HCM) is a heterogeneous genetic heart disease inherited in an autosomal dominant pattern with an estimated prevalence of …

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The Future of AD Treatment

HCPLive

Melodie Young NP and Andrea Nguyen, PA look into the future of AD management.

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Hypertrophic Cardiomyopathy: The Patient Perspective–Turning Tragedy into Action

The American Journal of Cardiology

Publication date: Available online 29 January 2024 Source: The American Journal of Cardiology Author(s): Lisa Salberg

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TAVR Rates Exceed SAVR in Practice, Linked to Worse Survival in Older Adults

HCPLive

A recent statewide analysis in California found TAVR rates exceed SAVR for severe aortic stenosis, despite contradicting consensus guideline recommendations.

TAVR 72
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Mechanisms of RBM20 Cardiomyopathy: Insights From Model Systems

Circulation: Genomic and Precision Medicine

Circulation: Genomic and Precision Medicine, Ahead of Print. RBM20 (RNA-binding motif protein 20) is a vertebrate- and muscle-specific RNA-binding protein that belongs to the serine-arginine-rich family of splicing factors. TheRBM20gene was first identified as a dilated cardiomyopathy–linked gene over a decade ago. Early studies inRbm20knockout rodents implicated disrupted splicing of RBM20 target genes as a causative mechanism.

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Odds of Depression and Anxiety Significantly Increased in Patients with Arthritis

HCPLive

Patients with inflammatory arthritis demonstrated significantly increased odds of depression and anxiety health care encounters and use of anxiolytics and antidepressants.

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Transaortic removal of a large primary sarcoma from the left ventricle assisted by strategic partial resection and endoscopic guidance: a case report

Journal of Cardiothoracic Surgery

Surgical resection remains the mainstay of treatment for cardiac sarcoma, a rare but lethal disease. Achieving complete removal of a large-sized left ventricular sarcoma remains a challenge even with various s.

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Gene-Specific CHIP Subtype Significantly Associated with HFpEF Risk

HCPLive

Across two large, diverse cohorts, TET2 CHIP was associated with a more than 2-fold higher risk of incident HF with preserved ejection fraction.

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Comparison of the safety and effectiveness of the four-hook needle and hook wire for the preoperative positioning of localization ground glass nodules

Journal of Cardiothoracic Surgery

With the implementation of lung cancer screening programs, an increasing number of pulmonary nodules have been detected.Video-assisted thoracoscopic surgery (VATS) could provide adequate tissue specimens for p.

Cancer 52
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Roflumilast Topical Foam, 0.3% and Full STRATUM Results, with Andrew Blauvelt, MD, MBA

HCPLive

In an interview, Andrew Blauvelt, MD, MBA, provides further perspective on the approval of roflumilast topical foam, 0.3% (Zoryve) and full publication of phase 3 STRATUM data.

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Short and mid-term outcomes of valve-sparing, aortic root reimplantation (David’s procedure)

Journal of Cardiothoracic Surgery

In the current study, we aimed to report the short- and mid-term outcomes of patients undergoing valve-sparing aortic root reimplantation (VSARR) and our center’s experience with the procedure.

Aortic 52
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Unintentional Weight Loss Could Signal Elevated Risk of Cancer in Next 12 Months

HCPLive

Study with 150,000 adults reveals 10% or more of unintentional weight loss associated with an elevated rate of cancer diagnosis within the next 12 months.

Cancer 59
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Thymoma negatively affects the neurological outcome of myasthenia gravis after thymectomy: a propensity score matching study

Journal of Cardiothoracic Surgery

Thymoma and myasthenia gravis (MG) interact with each other. This study aimed to evaluate the effects of thymoma on neurological outcome of MG patients after thymectomy using the propensity score matching (PSM.

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CBT May Normalize Fronto-Parietal Activation in Unmedicated Pediatric Anxiety

HCPLive

After undergoing cognitive behavioral therapy, unmedicated pediatric patients with anxiety disorder experienced changes in activation in the fronto-parietal network regions including left and right supplementary motor area, middle frontal gyrus, and superior parietal lobule.

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Plasma Ferritin Levels and Incident HF in Older Adults

American College of Cardiology

What is the association between plasma ferritin in older adults and incident heart failure (HF), HF phenotypes, and cardiac structure and function measures?

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PlasmaBlade-assisted surgical septal myectomy: technique and our experience

Frontiers in Cardiovascular Medicine

Background The pulsed-electron avalanche knife (PEAK) PlasmaBlade provides an atraumatic, scalpel-like cutting precision and electrocautery-like hemostasis. PlasmaBlade operates near body temperature, and its long, thin, and malleable tip can overcome the limitations of a surgical knife. In this study, we aimed to evaluate our clinical experience and histopathological outcomes of septal myectomy using PlasmaBlade.

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4 cardiology firsts in 1 month

Becker's Hospital Review - Cardiology

Discover the latest cardiology breakthroughs from NewYork-Presbyterian, Tufts Medical Center, Mon Health, and Duke in this Becker's report from January.

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Systematic approach to obtain axillary arterial access for pediatric heart catheterizations

Frontiers in Cardiovascular Medicine

Background Axillary arterial access (AAA) in pediatric heart catheterizations is undervalued. Methods We retrospectively reviewed children with congenital heart diseases (CHDs) who received trans-axillary arterial catheterizations between January 2019 and February 2023. We aimed ultrasound-guided punctures in the proximal two-thirds of axillary arteries with diameters ≥2 mm to insert 7 cm/4 Fr short introducers.

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Validation of a Protein Risk Score for Mortality in HF

American College of Cardiology

Can a protein risk score be developed and validated to predict risk for mortality in patients with heart failure (HF)?

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Up against the wall - emergency double myocardial rupture repair

Journal of Cardiothoracic Surgery

Left ventricular free wall rupture (LVFWR) and interventricular septal rupture (VSR) are potentially catastrophic mechanical complications after acute myocardial infarction (AMI). When they occur together, “do.

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Ventricular Septal Defect as a Complication of Bipolar Radiofrequency Ablation for Ventricular Tachycardia

HeartRhythm

Radiofrequency catheter ablation of ventricular arrhythmias may be unsuccessful if the thermal destruction of myocardial tissue does not reach the critical part of the reentrant circuit. In the case of deep intramural or intraseptal ventricular arrhythmias, adjunctive ablative approaches for deeper lesions may be employed, including bipolar ablation, intracoronary vessel alcohol injection, ablation with hypotonic irrigant such as half-normal saline, and stereotactic body radiation.1–4 Bipolar ab

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Assessing the impact of atrial fibrillation on symptoms and quality of life in hypertrophic cardiomyopathy

Journal of Cardiovascular Electrophysiology

Abstract Introduction In hypertrophic cardiomyopathy (HCM), atrial fibrillation (AF) has historically been regarded to have a deleterious impact on clinical course, strongly associated with progressive heart failure (HF) symptoms. However, there is a paucity of information regarding the impact of AF on HCM employing validated quality of life (QoL) surveys.

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Does Spatio-Temporal Dispersion Indicate a Patient-unique Fingerprint or a Generic Characteristic of Persistent Atrial Fibrillation?

HeartRhythm

Identifying signatures or metrics to guide patient-specific atrial fibrillation (AF) ablation approaches is paramount for improving outcomes beyond pulmonary vein isolation. These approaches assume that patients exhibit different wavefront dynamics requiring tailored ablation approaches. One such metric for identifying regions that could be targeted during ablation therapy identifies areas with electrogram dispersion1.

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Parabiosis Discriminates the Circulating, Endothelial, and Parenchymal Contributions of Endogenous Tissue-Type Plasminogen Activator to Stroke

Stroke Journal

Stroke, Ahead of Print. BACKGROUND:Intravenous injection of alteplase, a recombinant tPA (tissue-type plasminogen activator) as a thrombolytic agent has revolutionized ischemic stroke management. However, tPA is a more complex enzyme than expected, being for instance able to promote thrombolysis, but at the same time, also able to influence neuronal survival and to affect the integrity of the blood-brain barrier.

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Duration of Atrial Fibrillation Persistence: Implications for Recurrence Risk after Catheter Ablation and Efficacy of Additional Substrate Ablation

HeartRhythm

The optimal duration of atrial fibrillation (AF) persistence for predicting poor outcomes post-catheter ablation of longstanding-persistent AF (LsAF) and the best ablation strategy for these patients remain unclear.

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Preeclampsia-Associated Cardiovascular Risk Factors 6 Months and 2 Years After Pregnancy: The P4 Study

Hypertension Journal

Hypertension, Ahead of Print. BACKGROUND:Increased cardiovascular risk following preeclampsia is well established and there are signs of early cardiovascular aging 6 months postpartum. This study assessed whether blood pressure (BP) and other cardiovascular measures are abnormal 2 years postpartum in the same cohort to determine ongoing risk markers.METHODS:Six months and 2 years postpartum, BP was measured using sphygmomanometry, 24-hour ambulatory BP monitoring, and noninvasive central BP.

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Continuous Variant Re-Classification: An Effective Tool in the Ongoing Quest to Escape Genetic Purgatory

HeartRhythm

Genotype, albeit to varying degrees, impacts the diagnosis, risk-stratification, and management of many genetic heart diseases (GHDs).1 Accordingly, since the start of the new millennium, genetic testing has evolved from a research-based investigational test to a class I recommended, standard of care clinical test for patients with inherited cardiac channelopathies and cardiomyopathies such as arrhythmogenic cardiomyopathy, catecholaminergic polymorphic ventricular tachycardia, dilated cardiomyo

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Epigenetic Contributions to Clinical Risk Prediction of Cardiovascular Disease

Circulation: Genomic and Precision Medicine

Circulation: Genomic and Precision Medicine, Ahead of Print. BACKGROUND:Cardiovascular disease (CVD) is among the leading causes of death worldwide. The discovery of new omics biomarkers could help to improve risk stratification algorithms and expand our understanding of molecular pathways contributing to the disease. Here, ASSIGN—a cardiovascular risk prediction tool recommended for use in Scotland—was examined in tandem with epigenetic and proteomic features in risk prediction models in ≥12 65