Journal of Clinical Investigation - Cardiology

JULY 1, 2024

Healthy adipose tissue is essential for normal physiology. There are 2 broad types of adipose tissue depots: brown adipose tissue (BAT), which contains adipocytes poised to burn energy through thermogenesis, and white adipose tissue (WAT), which contains adipocytes that store lipids. However, within those types of adipose, adipocytes possess depot and cell-specific properties that have important implications.

Obesity 139

Obesity Physiology 139

Med Page Today

JULY 1, 2024

(MedPage Today) -- At the November 2022 Obesity Week in San Diego, it was clear something big was happening. A late-breaking session released results of the STEP TEENS phase IIIa trial, showing 16% weight loss in adolescents with obesity treated.

Obesity 131

Obesity 131

American Heart News - Heart News

JULY 1, 2024

Statement Highlights: Palliative medication management focuses on providing relief from symptoms and enhancing quality of life for people with cardiovascular disease throughout the various stages of the disease. Decisions about initiating, adjusting.

Quality of Life 112

Quality of Life Cardiovascular Disease 112

Journal of Clinical Investigation - Cardiology

JULY 1, 2024

Diffuse midline glioma (DMG) H3K27-altered is one of the most malignant childhood cancers. Radiation therapy remains the only effective treatment yet provides a 5-year survival rate of only 1%. Several clinical trials have attempted to enhance radiation antitumor activity using radiosensitizing agents, although none have been successful. Given this, there is a critical need for identifying effective therapeutics to enhance radiation sensitivity for the treatment of DMG.

Pharmacology 106

Pharmacology Cancer 106

DAIC

JULY 1, 2024

Philip B. Adamson, MD, MSc, FACC, FESC, FRCP (Ed) milla1cf Mon, 07/01/2024 - 12:24 July 1, 2024 — CVRx, Inc. , a commercial-stage medical device company, announced three additions to its senior leadership team. Philip B. Adamson, MD, MSc, FACC, FESC, FRCP (Ed ) has been appointed as Chief Medical Officer, Bonnie Handke, RN, MBA will assume the role of Senior Vice President of Patient Access, Reimbursement, and Healthcare Economics, and Jennifer E.

Reimbursement 105

Reimbursement RN Heart Failure Laboratory 105

Journal of Clinical Investigation - Cardiology

JULY 1, 2024

Endothelial cells (ECs) in the descending aorta are exposed to high laminar shear stress, and this supports an antiinflammatory phenotype. High laminar shear stress also induces flow-aligned cell elongation and front-rear polarity, but whether these are required for the antiinflammatory phenotype is unclear. Here, we showed that caveolin-1–rich microdomains polarize to the downstream end of ECs that are exposed to continuous high laminar flow.

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98

Med Page Today

JULY 1, 2024

(MedPage Today) -- Routine ECGs for the general population had clinical utility in a study of Japan's unique health screening program, with screening results tied to subsequent health outcomes. Out of more than 3.5 million generally healthy working.

Outcomes 98

Outcomes 98

HCPLive

JULY 1, 2024

Across the Phase 2 ReCLAIM-2 trial, elamipretide demonstrated photoreceptor protection and the potential for visual function improvement in eyes with dry AMD.

98

98

Medical Xpress - Cardiology

JULY 1, 2024

Researchers have developed a "blood vessel-on-a-chip" for heart disease with the potential to change the future of drug testing and development. The technology could also reduce our reliance on animal testing.

Technology 97

Technology Heart Disease Research 97

HCPLive

JULY 1, 2024

A panel of ophthalmologists discuss strategies for managing AMD and DME patients who exhibit suboptimal responses to their current anti-VEGF therapy.

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95

Medical Xpress - Cardiology

JULY 1, 2024

Eating patterns that align with the Mediterranean diet or the dietary approaches to stop hypertension (DASH) diet could help lower cardiovascular disease risk in adults with type 1 diabetes, according to results from a six-year study.

Diabetes 80

Diabetes Diet Research Cardiovascular Disease 80

HCPLive

JULY 1, 2024

Family physician Schuderi shares how he helps patients manage PTSD symptoms ahead of Fourth of July fireworks.

111

111

Science Daily - Stroke

JULY 1, 2024

Scientists found the choroid plexus and cerebrospinal fluid play a key role in maintaining a pool of newly born neurons to repair the adult brain after injury.

Stroke 80

Stroke Strokes 80

HCPLive

JULY 1, 2024

These data suggest differences in Medicaid-accepting pediatric dermatologist access based on such factors as geographic area and density of pediatric dermatologists per county.

Medicaid 69

Medicaid Pediatrics 69

Medical Xpress - Cardiology

JULY 1, 2024

Over the past decade, 342 cardiology clinics have been acquired by private equity firms, with over 94% of those occurring between 2021 and 2023, according to a study published in the Journal of the American College of Cardiology and presented at the AcademyHealth 2024 Annual Research Meeting in Baltimore.

Research 75

Research 75

American College of Cardiology

JULY 1, 2024

Risk estimation for coronary heart disease (CHD) at the population level was not enhanced by correcting LDL-C for its content of lipoprotein(a) (Lp[a]), according to a study published July 1 in JACC.

Heart Disease 74

Heart Disease Article 74

Medical Xpress - Cardiology

JULY 1, 2024

A total of 135 batches of potassium chloride capsules have been recalled because the extended release capsules might not release.

Heart Attack 85

Heart Attack Heart attacks 85

American College of Cardiology

JULY 1, 2024

Bempedoic acid is similar with statin therapy at decreasing the risk of a first major vascular event per every 1 mmol/L reduction in LDL-C, according to a post hoc analysis of the CLEAR Outcomes trial, published in JACC.

Outcomes 73

Outcomes Article 73

Journal of Clinical Investigation - Cardiology

JULY 1, 2024

Mitochondria-related neurodegenerative diseases have been implicated in the disruption of primary cilia function. Mutation in an intrinsic mitochondrial complex I component NDUFAF2 has been identified in Leigh syndrome, a severe inherited mitochondriopathy. Mutations in ARMC9, which encodes a basal body protein, cause Joubert syndrome, a ciliopathy with defects in the brain, kidney, and eye.

64

64

Becker's Hospital Review - Cardiology

JULY 1, 2024

Surgeons at Virtua Health, a five-hospital system based in Camden, N.J., successfully performed its first left ventricular assist device implantation, the system announced July 1.

Hospital 59

Hospital 59

Journal of Clinical Investigation - Cardiology

JULY 1, 2024

Impairment of oligodendrocytes and myelin contributes to neurological disorders including multiple sclerosis (MS), stroke, and Alzheimer’s disease. Regeneration of myelin (remyelination) decreases the vulnerability of demyelinated axons, but this repair process commonly fails with disease progression. A contributor to inefficient remyelination is the altered extracellular matrix (ECM) in lesions, which remains to be better defined.

Stroke 63

Stroke Strokes 63

HCPLive

JULY 1, 2024

This June 2024 month in review spotlights HCPLive’s coverage of the latest renal news and research in IgA nephropathy, differences in care, and novel associations in nephrology.

Research 59

Research 59

Becker's Hospital Review - Cardiology

JULY 1, 2024

The American Heart Association named Stacey Rosen, MD, Northwell Health's senior vice president of women's health and executive director of the Katz Institute for Women's Health, its 2024-25 volunteer president-elect.

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59

HCPLive

JULY 1, 2024

Schiffman describes the current treatment landscape for alcohol-associated hepatitis and what larsucosterol might offer for these patients.

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69

American College of Cardiology

JULY 1, 2024

The incidence of graft failure in CABG is higher among women than men, and is associated with adverse cardiac events; however, the excess mortality risk in women was not mediated by graft failure, according to a study published July 1 in JACC.

Article 61

Article 61

HCPLive

JULY 1, 2024

This summary of major dermatology news covered in June highlights stories such as late-breaking data at RAD 2024, recent interviews, and recent FDA news.

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64

American College of Cardiology

JULY 1, 2024

What is the effect of semaglutide compared with placebo on N-terminal pro–B-type natriuretic peptide (NT-proBNP) levels in patients with heart failure and preserved ejection fraction (HFpEF)?

Preserved Ejection Fraction 58

Preserved Ejection Fraction Obesity Heart Failure Article 58

HCPLive

JULY 1, 2024

Neurocrine Biosciences was granted Priority Review designations for two crinecerfont NDAs focused on children, adolescents, and adults with classic CAH.

Congenital 64

Congenital 64

Open Heart

JULY 1, 2024

Background The extent to which differences in results from Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) and Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial (ROCKET) atrial fibrillation (AF)—the landmark trials for the approval of apixaban and rivaroxaban, respectively, for non-valvular AF—were influenced by differences in their protocols is deb

Atrial Fibrillation 52

Atrial Fibrillation Embolism Stroke Strokes 52

HCPLive

JULY 1, 2024

A review of the 20 novel drugs approved by the US Food and Drug Administration during the first half of 2024, with links to coverage from MJH Life Sciences publications.

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59

Frontiers in Cardiovascular Medicine

JULY 1, 2024

IntroductionThe incidence of metabolic disorders during pregnancy is increasing year by year, with diseases including hypertension and hyperlipidemia. Statins are the primary drugs for treating hyperlipidemia or atherosclerosis, yet some patients remain unresponsive to them, and pregnant women are prohibited from taking statins. Curculigoside is the major biologically active natural product present in Curculigo orchioides.MethodsIn this study, A high-fat mice model was developed to study the lip

Cholesterol 52

Cholesterol Pharmacology Atherosclerosis Cancer 52

Dr. S. Venkatesan MD

JULY 1, 2024

*This post may not be meant for cardiology fellows but for young students of medicine Have you ever thought about how a Giraffe’s heart can pump blood to the summit of a lengthy neck and perfuse the brain? Unlike a blue whale which has a huge heart, a Giraffe’s heart is not as big as one would Imagine, A Giraffe’s heart weighs.5 to. 6 % of total body mass.

Cardiomyopathy 52

Cardiomyopathy Aortic valve Aortic Blood Pressure 52

Frontiers in Cardiovascular Medicine

JULY 1, 2024

BackgroundCatastrophic Antiphospholipid Syndrome (CAPS), a severe systemic autoimmune disorder, predominantly causes life-threatening multi-organ failure, with a high mortality rate. It primarily affects small vessels, seldom impacting large vessels. Notably, acute massive pulmonary embolism (PE) with bilateral atrial thrombosis is an exceptional occurrence in CAPS.

Thrombosis 52

Thrombosis Embolism Pulmonary Laboratory 52

American Heart News - Heart News

JULY 1, 2024

Aspectos destacados de la declaración: El manejo de los medicamentos paliativos se enfoca en el alivio de los síntomas y en la mejora de la calidad de vida de las personas con enfermedades cardiovasculares en las distintas etapas de la enfermedad. La.

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52

Frontiers in Cardiovascular Medicine

JULY 1, 2024

Right ventricle (RV) failure is a common complication of many cardiopulmonary diseases. Since it has a significant adverse impact on prognosis, precise determination of RV function is crucial to guide clinical management. However, accurate assessment of RV function remains challenging owing to the difficulties in acquiring its intricate pathophysiology and imaging its complex anatomical structure.

Tricuspid 52

Tricuspid Pulmonary 52

HCPLive

JULY 1, 2024

Robust clinical data showed ustekinumab-ttwe demonstrated similar safety and efficacy compared with the reference product.

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64

Journal of Clinical Investigation - Cardiology

JULY 1, 2024

Mechanical stress from cardiomyocyte contraction causes misfolded sarcomeric protein replacement. Sarcomeric maintenance utilizes localized pools of mRNAs and translation machinery, yet the importance of localized translation remains unclear. In this issue of the JCI, Haddad et al. identify the Z-line as a critical site for localized translation of sarcomeric proteins, mediated by ribosomal protein SA (RPSA).

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