Mon.Mar 24, 2025

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New Insight: Exploring ENCELTO for MacTel with Rich Small, CEO of Neurotech

HCPLive

Veeral Sheth, MD, is joined by the CEO of Neurotech to discuss the historic approval of revakinagene taroretcel (ENCELTO) for macular telangiectasia type 2.

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Static Versus Dynamic Risk of Sudden Cardiac Death: Implications for Improvement of Prediction and Prevention

Journal of Cardiovascular Electrophysiology

ABSTRACT Sudden cardiac death (SCD) is a major public health challenge, resulting in significant loss of life each year. Effective prevention relies on identifying individuals at elevated risk; however, accurate prediction of SCD has proven difficult. The current clinical strategy relies on a static risk assessment, primarily using left ventricular ejection fraction (LVEF)<35% as a key criterion.

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TMS Reduces Pain, Yields Functional Improvements in Women With Fibromyalgia

HCPLive

Analgesic effects lasted up to week 8 while function improvements lasted until week 16 in a new randomized, controlled trial.

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Imperative Care Expands Precision Thrombectomy Portfolio

DAIC

tim.hodson Mon, 03/24/2025 - 15:48 March 24, 2025 Imperative Care, Inc. recently announced U.S. Food and Drug Administration (FDA) 510(k) clearance of the 82 cm version of its Symphony 16F catheter. The catheter is designed to elevate care for patients with venous thrombosis, a serious condition caused by a blood clot forming in the veins of the legs or abdomen that can have a life-threatening impact if left untreated.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Genetics and Environment Both Play a Role in Childhood Allergy Progression

HCPLive

A study found that genetics and environment both influence allergy risk, but environmental factors play a stronger role in the progression of allergic disease.

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Rise in kidney disease underscores critical heart-kidney connection

American Heart News - Heart News

DALLAS, March 24, 2025 Globally, the rate of death from chronic kidney disease increased 24% from 1990 to 2021, according to statistics published by the American Heart Association, a global force changing the future of health for all. The rise in.

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Diffuse right coronary artery spasm occurring forty-five minutes post pulsed field ablation for atrial fibrillation

HeartRhythm

Focal coronary spasm is a recognised complication of pulsed field ablation (PFA) delivered within proximity of coronary arteries (1). There have been 2 recent case reports of focal spasm occurring during pulmonary vein isolation (PVI) for atrial fibrillation (AF) using PFA remote from coronary arteries (2,3). Our centre is a high volume PFA unit for AF ablation in the UK (47).

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Cannabis Use Substantially Increases Risk of Heart Attack

American College of Cardiology

Among individuals without significant cardiovascular morbidity younger than 50 years, the use of cannabis is linked to adverse cardiovascular events, including a sixfold higher risk of a myocardial infarction (MI), fourfold increase risk of ischemic stroke.

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Rise in kidney disease underscores critical heart–kidney connection

Medical Xpress - Cardiology

Globally, the rate of death from chronic kidney disease increased 24% from 1990 to 2021, according to statistics published by the American Heart Association. The rise in kidney disease rates is a major concern for cardiovascular health around the world. Kidney disease increases heart disease risk, yet as many as 9 in 10 U.S. adults with chronic kidney disease do not know they have it.

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Prevalence of Left Atrial Thrombus in Patients with Atrial Flutter in Comparison to Atrial Fibrillation

HeartRhythm

Atrial flutter (AFL) and atrial fibrillation (AF) are believed to carry the same risk of systemic thromboembolism however there is paucity of data concerning such risk in patients with AFL in comparison to AF.

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Understanding the Role of PPAR Agonists in PBC Care, with Aparna Goel, MD

HCPLive

Goel explains the importance of second-line therapies and describes the role PPARs play in PBC treatment, including 2 newly approved therapies.

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RSV Elevates Risk of Adverse CV Events

American College of Cardiology

In older adults, an acute respiratory syncytial virus (RSV) infection was significantly associated with an increased risk of cardiovascular events, in particular ischemic stroke and heart failure (HF) hospitalization.

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Psoriasis Lesion Improvement at Week 16 Maintained to Week 52 with Bimekizumab

HCPLive

These data highlight the long-term maintenance of bimekizumab responses among individuals with psoriasis, looking at bio-nave and bio-switched patients.

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The role of long non-coding RNA A2M-AS1 in early diagnosis and prognosis evaluation of acute myocardial infarction

Journal of Cardiothoracic Surgery

The objective was to assess the clinical efficacy of long non-coding RNA (lncRNA) alpha-2-macroglobulin-antisense 1 (A2M-AS1) in acute myocardial infarction (AMI).

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Alpha-Gal Syndrome Diagnosis Time Drops 70-Fold, But Disparities Persist

HCPLive

A new study found that the time it takes to diagnose alpha-gal syndrome has improved from 5.3 years to 28 days since 2011, but disparities remain based on education level.

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Comparative analysis of sleep duration and stroke prevalence in China and the U.S. before and during COVID-19

Journal of Cardiothoracic Surgery

This study compares sleep duration and stroke risk between residents of China and the U.S. during and outside the COVID-19 pandemic, examining age as an interaction effect.

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Challenges and Innovations in Wilson Disease, with Michael Schilsky, MD

HCPLive

Schilsky describes lingering challenges and unmet needs in Wilson disease and highlights recent innovations in monitoring and diagnosis.

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Different Post-CABG Meds May Help Radial Artery Graft Patency

Med Page Today

(MedPage Today) -- With radial artery (RA) grafts still underutilized in coronary artery bypass grafting (CABG) surgery, at least one barrier to this surgical approach may be addressed with medication, a pilot trial suggested. Testing the effects.

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Exploring the Evolution of IOL Technology with Sumitra Khandelwal, MD

HCPLive

Khandelwal discusses advancements in intraocular lens (IOL) categories and the patient's role in choosing more innovative options.

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Apixaban reduces clot risk in dialysis patients after vascular procedure: Study

Medical Xpress - Cardiology

A recent study from National Taiwan University Hospital shows that apixaban, a blood-thinning medication, can help prevent blood clots in dialysis patients after a procedure to clear blocked vascular access. Dialysis patients rely on vascular accesslike fistulas or graftsto filter their blood, but clots can form and block these pathways, making dialysis impossible.

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Tildrakizumab Effective for Psoriasis, Yet Patients Note Specific Points of Dissatisfaction

HCPLive

In this analysis, French investigators highlight patient and clinician perspectives on 1-year use of tildrakizumab for moderate-to-severe psoriasis.

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Does Intensive SBP Control Reduce CVD Mortality in Adults Aged 80+?

American College of Cardiology

In U.S. adults 80 years and older taking antihypertensive agents for systolic blood pressure (SBP), intensive SBP control is associated with a reduced risk of death from cardiovascular disease, supporting guidelines for intensive BP control.

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Examining the Role of Advocacy in Ophthalmology with Michael X. Repka, MD

HCPLive

Repka dives into the role of advocacy in shaping ophthalmologic policies and ensuring equitable patient care.

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Poor neighborhoods, health care barriers are factors for heart disease risk in Black mothers

Medical Xpress - Cardiology

Living in a disadvantaged neighborhood contributes to a rare form of heart failure known as peripartum cardiomyopathy, a potentially deadly disease that disproportionately affects Black mothers.

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Fostering Advocacy Efforts in Ophthalmology with Michael X. Repka, MD

HCPLive

Repka describes the complications of the US healthcare system and how to advance interactions in advocacy efforts.

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A Dedicated Radiofrequency Microcatheter Assembly For Trans-Right Atrial Appendage Pericardial Carbon Dioxide Insufflation To Facilitate Epicardial Access

HeartRhythm

Trans-right atrial appendage (RAA) pericardial insufflation of CO2 can improve safety of percutaneous epicardial access. Dedicated device solutions for safe, effective and standardized microperforation are needed.

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Navigating Evolutions, Uncertainties in PBC Care, with Craig Lammert, MD

HCPLive

Lammert describes the clinical impact of having 2 new second-line PBC therapies, challenges to their uptake, and areas where more research is needed.

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FDA approves new drug to treat heart conditions

Medical Xpress - Cardiology

The U.S. Food and Drug Administration (FDA) has approved a new drug for a serious heart condition that affects thousands of people.

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Rapid Efficacy and Safety Considerations With the Use of JAK Inhibitors in Atopic Dermatitis Care

HCPLive

Panelists discuss how Janus kinase (JAK) inhibitors such as upadacitinib, abrocitinib, and baricitinib offer rapid, oral treatment for moderate to severe atopic dermatitis, differing from injectable biologics in administration, broader immunosuppression, and risk of adverse events like thromboembolism. They provide effective symptom control but require safety monitoring.

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Cuproptosis, a form of cell death, may link copper imbalance and atherosclerosis

Medical Xpress - Cardiology

Atherosclerosis (AS) is a chronic inflammatory disease characterized by the buildup of lipids and immune cells in arterial walls, increasing the risk of cardiovascular conditions. While multiple factors contribute to AS, recent research highlights the role of copper, an essential trace element, in disease progression.

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Safety Protocols With JAK Inhibitors

HCPLive

Panelists discuss how the Measure Up 1 and 2 studies (Simpson 2022) showed that at 52 weeks, 82.0% to 84.9% of upadacitinib patients achieved EASI-75. Common adverse effects (AEs) included acne, cough, and headache, with 4.5% to 7.2% withdrawal rates.

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Outcomes and anticoagulant management for new-onset atrial fibrillation in patients with ST-elevation myocardial infarction following primary percutaneous coronary intervention: Findings from a national multicenter registry and meta-analysis

HeartRhythm

Little is known about the risk factors and prognosis of new-onset atrial fibrillation (NOAF) in patients with primary percutaneous coronary intervention (PCI).

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Identity-by-Descent Analysis Uncovering a Founder Event in a Novel Hereditary Small Vessel Cerebral Disease

Stroke Journal

Stroke, Ahead of Print. BACKGROUND:A novel genetic cerebral small vessel disease, linked to the insertion of a mobile genetic element in theCOL4A1gene has recently been identified. Notably, 8 out of the 10 families carrying this mutation were known to come from Brittany, a specific region in France, suggesting the possibility of a common ancestor and a founder effect.METHODS:Probands from each of the 10 families were analyzed with high-density SNP arrays.

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New-onset atrial fibrillation in acute coronary syndrome: To anticoagulate or not?

HeartRhythm

Atrial fibrillation (AF) confers significant morbidity and mortality in the form of embolic stroke, heart failure, cognitive decline, and recurrent hospitalizations as well as health care costs.1 This risk of stroke can be reduced with oral anticoagulation, but despite this, there exists a significant risk of residual major adverse events, highlighting the need for a more comprehensive approach.

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Comparison of Local and Centrally Adjudicated Modified Rankin Scale Scores in the MOST Trial

Stroke Journal

Stroke, Ahead of Print. BACKGROUND:The modified Rankin Scale (mRS) is a key measure of functional outcomes in stroke trials. To minimize variability, structured tools like the Rankin Focused Assessment and central adjudication are recommended. This study compares local versus centrally adjudicated mRS scores in the MOST trial (Multi-Arm Optimization of Stroke Thrombolysis).METHODS:MOST was a phase 3, single-blind, randomized trial evaluating argatroban, eptifibatide, or placebo in addition to in

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Transvenous extraction of quadripolar coronary sinus pacing leads

HeartRhythm

Quadripolar coronary sinus (CS) leads are commonly employed to achieve left ventricular pacing. There are limited data on extraction of these leads relative to traditional unipolar or bipolar CS pacing leads.

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