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ABSTRACT Sudden cardiac death (SCD) is a major public health challenge, resulting in significant loss of life each year. Effective prevention relies on identifying individuals at elevated risk; however, accurate prediction of SCD has proven difficult. The current clinical strategy relies on a static risk assessment, primarily using left ventricular ejection fraction (LVEF)<35% as a key criterion.
Veeral Sheth, MD, is joined by the CEO of Neurotech to discuss the historic approval of revakinagene taroretcel (ENCELTO) for macular telangiectasia type 2.
tim.hodson Mon, 03/24/2025 - 15:48 March 24, 2025 Imperative Care, Inc. recently announced U.S. Food and Drug Administration (FDA) 510(k) clearance of the 82 cm version of its Symphony 16F catheter. The catheter is designed to elevate care for patients with venous thrombosis, a serious condition caused by a blood clot forming in the veins of the legs or abdomen that can have a life-threatening impact if left untreated.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
DALLAS, March 24, 2025 Globally, the rate of death from chronic kidney disease increased 24% from 1990 to 2021, according to statistics published by the American Heart Association, a global force changing the future of health for all. The rise in.
A study found that genetics and environment both influence allergy risk, but environmental factors play a stronger role in the progression of allergic disease.
Focal coronary spasm is a recognised complication of pulsed field ablation (PFA) delivered within proximity of coronary arteries (1). There have been 2 recent case reports of focal spasm occurring during pulmonary vein isolation (PVI) for atrial fibrillation (AF) using PFA remote from coronary arteries (2,3). Our centre is a high volume PFA unit for AF ablation in the UK (47).
Focal coronary spasm is a recognised complication of pulsed field ablation (PFA) delivered within proximity of coronary arteries (1). There have been 2 recent case reports of focal spasm occurring during pulmonary vein isolation (PVI) for atrial fibrillation (AF) using PFA remote from coronary arteries (2,3). Our centre is a high volume PFA unit for AF ablation in the UK (47).
Among individuals without significant cardiovascular morbidity younger than 50 years, the use of cannabis is linked to adverse cardiovascular events, including a sixfold higher risk of a myocardial infarction (MI), fourfold increase risk of ischemic stroke.
In older adults, an acute respiratory syncytial virus (RSV) infection was significantly associated with an increased risk of cardiovascular events, in particular ischemic stroke and heart failure (HF) hospitalization.
These data highlight the long-term maintenance of bimekizumab responses among individuals with psoriasis, looking at bio-nave and bio-switched patients.
The objective was to assess the clinical efficacy of long non-coding RNA (lncRNA) alpha-2-macroglobulin-antisense 1 (A2M-AS1) in acute myocardial infarction (AMI).
A new study found that the time it takes to diagnose alpha-gal syndrome has improved from 5.3 years to 28 days since 2011, but disparities remain based on education level.
This study compares sleep duration and stroke risk between residents of China and the U.S. during and outside the COVID-19 pandemic, examining age as an interaction effect.
(MedPage Today) -- With radial artery (RA) grafts still underutilized in coronary artery bypass grafting (CABG) surgery, at least one barrier to this surgical approach may be addressed with medication, a pilot trial suggested. Testing the effects.
In U.S. adults 80 years and older taking antihypertensive agents for systolic blood pressure (SBP), intensive SBP control is associated with a reduced risk of death from cardiovascular disease, supporting guidelines for intensive BP control.
Little is known about the risk factors and prognosis of new-onset atrial fibrillation (NOAF) in patients with primary percutaneous coronary intervention (PCI).
Atrial fibrillation (AF) confers significant morbidity and mortality in the form of embolic stroke, heart failure, cognitive decline, and recurrent hospitalizations as well as health care costs.1 This risk of stroke can be reduced with oral anticoagulation, but despite this, there exists a significant risk of residual major adverse events, highlighting the need for a more comprehensive approach.
Atrial flutter (AFL) and atrial fibrillation (AF) are believed to carry the same risk of systemic thromboembolism however there is paucity of data concerning such risk in patients with AFL in comparison to AF.
Quadripolar coronary sinus (CS) leads are commonly employed to achieve left ventricular pacing. There are limited data on extraction of these leads relative to traditional unipolar or bipolar CS pacing leads.
Left bundle branch area pacing (LBBAP) involves deep septal lead deployment to capture the left bundle branch (LBB) or adjacent myocardium, which could compromise the septums structural integrity or pose injury to the septal vasculature. The potential long-term effects of these complications remain unclear.
Trans-right atrial appendage (RAA) pericardial insufflation of CO2 can improve safety of percutaneous epicardial access. Dedicated device solutions for safe, effective and standardized microperforation are needed.
Panelists discuss how Janus kinase (JAK) inhibitors such as upadacitinib, abrocitinib, and baricitinib offer rapid, oral treatment for moderate to severe atopic dermatitis, differing from injectable biologics in administration, broader immunosuppression, and risk of adverse events like thromboembolism. They provide effective symptom control but require safety monitoring.
Stroke, Ahead of Print. BACKGROUND:A novel genetic cerebral small vessel disease, linked to the insertion of a mobile genetic element in theCOL4A1gene has recently been identified. Notably, 8 out of the 10 families carrying this mutation were known to come from Brittany, a specific region in France, suggesting the possibility of a common ancestor and a founder effect.METHODS:Probands from each of the 10 families were analyzed with high-density SNP arrays.
Panelists discuss how the Measure Up 1 and 2 studies (Simpson 2022) showed that at 52 weeks, 82.0% to 84.9% of upadacitinib patients achieved EASI-75. Common adverse effects (AEs) included acne, cough, and headache, with 4.5% to 7.2% withdrawal rates.
Stroke, Ahead of Print. BACKGROUND:The modified Rankin Scale (mRS) is a key measure of functional outcomes in stroke trials. To minimize variability, structured tools like the Rankin Focused Assessment and central adjudication are recommended. This study compares local versus centrally adjudicated mRS scores in the MOST trial (Multi-Arm Optimization of Stroke Thrombolysis).METHODS:MOST was a phase 3, single-blind, randomized trial evaluating argatroban, eptifibatide, or placebo in addition to in
Circulation: Cardiovascular Quality and Outcomes, Ahead of Print. Cardiovascular health (CVH) is affected by genetic, social, and genomic factors across the life course, yet little research has focused on the interrelationships among them. An extensive body of work has documented the impact of social determinants of health at both the structural and individual levels on CVH, highlighting pathways in which racism, housing, violence, and neighborhood environments adversely affect CVH and contribut
Circulation: Cardiovascular Imaging, Ahead of Print. BACKGROUND:T2-weighted imaging is commonly used to measure myocardial salvage in reperfused myocardial infarction but is hindered by poor reproducibility and indistinct boundaries. Early gadolinium enhancement (EGE) emerges as an alternative for measuring the area at risk. This study aims to evaluate the determinants of the myocardial salvage index (MSI) derived from EGE and its prognostic implications.METHODS:We analyzed acute cardiac magneti
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