Mon.Jun 17, 2024

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Another deadly triage ECG missed, and the waiting patient leaves before being seen. What is this nearly pathognomonic ECG?

Dr. Smith's ECG Blog

Written by Bobby Nicholson, MD 67 year old male with history of hypertension and hyperlipidemia presented to the Emergency Department via ambulance with midsternal nonradiating chest pain and dyspnea on exertion. Pain improved to 1/10 after EMS administers 324 mg aspirin and the following EKG is obtained at triage. What do you think? If this EKG were handed to you to screen from triage without any clinical information, what would you think?

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Chronic high blood pressure during pregnancy doubled between 2008 and 2021 in the U.S.

American Heart News - Heart News

Research Highlights: The number of individuals in the United States who had chronic hypertension or chronic high blood pressure during pregnancy doubled between 2008 and 2021, according to a nationwide review of private health insurance.

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Rise in Chronic Hypertension in Pregnancy While Treatment Stagnates

Med Page Today

(MedPage Today) -- There was a steady increase in the prevalence of chronic hypertension in pregnancy over the last two decades, with some accompanying changes in treatment, a nationwide cohort study found. From 2008 to 2021, the prevalence of.

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Elutia Announces FDA Clearance of EluPro: The First Antibiotic-Eluting BioEnvelope Designed to Protect Patients with Implantable Cardiac Pacemakers and Defibrillators

DAIC

milla1cf Mon, 06/17/2024 - 20:38 June 17, 2024 — Elutia Inc. , a pioneer in drug-eluting biomatrix products, today announced that its Antibiotic-Eluting BioEnvelope, EluPro (referred to as CanGaroo during development), has received clearance from the U.S. Food and Drug Administration ( FDA ). Specifically designed to prevent post-operative complications for devices such as pacemakers and defibrillators, EluPro incorporates powerful antibiotic therapy combined with advanced tissue engineering to

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Researchers say AI accurately screens heart failure patients for clinical trial eligibility

Medical Xpress - Cardiology

Generative Artificial Intelligence (Gen AI) can rapidly and accurately screen patients for clinical trial eligibility, according to a new study from Mass General Brigham researchers. Such technology could make it faster and cheaper to evaluate new treatments and, ultimately, help bring successful ones to patients.

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aycan becomes a reseller and technology partner of AI4MedImaging

DAIC

milla1cf Mon, 06/17/2024 - 20:34 June 17, 2024 — aycan , a recognized leader in medical imaging, announced today a reseller and technology partnership with AI4MedImaging, a company that specializes in applying artificial intelligence ( AI ) to medical imaging. aycan launched its official partnership with AI4MedImaging this week by offering their groundbreaking AI4CMR solution, a Software as a Medical Device (SaMD) that aims to automate the interpretation of cardiac magnetic resonance imaging (CM

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Biological Agents Reduce PsA Risk More Than Methotrexate in Psoriasis

HCPLive

Patients with psoriasis on biological agents might have a lower PsA risk than those on methotrexate, but patients on topical therapy have an even lower risk, a study found.

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Chromosomal 3q amplicon encodes essential regulators of secretory vesicles that drive secretory addiction in cancer

Journal of Clinical Investigation - Cardiology

Cancer cells exhibit heightened secretory states that drive tumor progression. Here, we identified a chromosome 3q amplicon that serves as a platform for secretory regulation in cancer. The 3q amplicon encodes multiple Golgi-resident proteins, including the scaffold Golgi integral membrane protein 4 (GOLIM4) and the ion channel ATPase secretory pathway Ca2+ transporting 1 (ATP2C1).

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Intensive Blood Pressure Control in Individuals With Hypertension

JAMA Cardiology

This randomized clinical trial investigates the effectiveness and safety of a nonphysician-led, multifaceted, intensive blood pressure intervention in younger and older individuals with hypertension.

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TNX-102 SL Significantly Reduces Daily Pain, Improves Fibromyalgia Symptoms

HCPLive

At EULAR, Tonix Pharmaceuticals presented the phase 3 RESILIENT trial which met the primary endpoint of TNX-102 SL reducing daily pain intensity.

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Engineers develop face screening tool that detects stroke in seconds

Medical Xpress - Cardiology

A new smartphone face-screening tool could help paramedics to identify stroke in seconds—much sooner and more accurately than is possible with current technologies.

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Crizanlizumab for retinal vasculopathy with cerebral leukoencephalopathy in a phase II clinical study

Journal of Clinical Investigation - Cardiology

Background Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S) is a rare, autosomal dominant, universally fatal disease without effective treatment options. This study explores the safety and preliminary efficacy of crizanlizumab, a humanized monoclonal antibody against P-selectin approved for the prevention of sickle cell crises, in slowing retinal nonperfusion and preserving vision in patients with RVCL-S.METHODS Eleven patients with RVCL-S with confirme

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Chronic high blood pressure during pregnancy doubled between 2008 and 2021 in the U.S.

Science Daily - Heart Disease

The number of individuals in the U.S. who had chronic hypertension or chronic high blood pressure during pregnancy doubled between 2008 and 2021.

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Face screening tool detects stroke in seconds

Science Daily - Stroke

A new smartphone face-screening tool could help paramedics to identify stroke in seconds -- much sooner and more accurately than is possible with current technologies. Strokes, which affect millions of people globally, occur when the blood supply to part of the brain is interrupted or reduced, which prevent brain tissue from getting oxygen and nutrients.

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Research into structures of ape hearts provide insight into human evolution

Science Daily - Heart Disease

Researchers have discovered new insights into the human heart's structure, revealing its evolutionary history. This study enhances understanding of heart development and its implications for treating heart disease.

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Too few patients get timely heart failure diagnosis: Study

Becker's Hospital Review - Cardiology

Patients with heart failure, or suspected of having it, are not being diagnosed quickly enough, according to a study involving 8,000 patients, which was presented June 15 at the Heart Failure Association of the European Society of Cardiology.

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Diabetes Dialogue: June 2024 Updates in Diabetes Tech and Type 1 Diabetes

HCPLive

This episode covers the clearance of 2 new OTC CGMs from Abbott, JDRF becoming Breakthrough T1D, and the FDA clearance of the CamAPS FX for people with T1D

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A Pathway to Better Blood Pressure Control

JAMA Cardiology

“You can always depend on Americans to do the right thing—after they’ve tried everything else.” Winston Churchill was not thinking of US health care in this famous quote often attributed to him.

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Positive Interim Analyses of Phase 2b Studies Show Promise for Volixibat in PBC, PSC

HCPLive

Interim analyses of a pair of phase 2b studies highlight the IBAT inhibitor’s potential in adults with primary biliary cholangitis and primary sclerosing cholangitis.

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RNF213 Variants, Vasospastic Angina, and Risk of Fatal Myocardial Infarction

JAMA Cardiology

This genetic association study evaluated genetic variants associated with increased risk of vasospastic angina.

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Epigenetic regulation of tumor immunity

Journal of Clinical Investigation - Cardiology

Although cancer has long been considered a genetic disease, increasing evidence shows that epigenetic aberrations play a crucial role in affecting tumor biology and therapeutic response. The dysregulated epigenome in cancer cells reprograms the immune landscape within the tumor microenvironment, thereby hindering antitumor immunity, promoting tumor progression, and inducing immunotherapy resistance.

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Little Progress in Women Authorship in Four Major CV Journals Over Past Decade

American College of Cardiology

Women continue to be underrepresented as authors of cardiovascular publications, according to the results of a study of a decade's worth of papers from four cardiovascular journals, published in JACC.

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Unraveling the Mechanisms of Valvular Heart Disease to Identify Medical Therapy Targets: A Scientific Statement From the American Heart Association

Circulation

Circulation, Ahead of Print. Valvular heart disease is a common cause of morbidity and mortality worldwide and has no effective medical therapy. Severe disease is managed with valve replacement procedures, which entail high health care–related costs and postprocedural morbidity and mortality. Robust ongoing research programs have elucidated many important molecular pathways contributing to primary valvular heart disease.

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Acute-to-chronic glycemic ratio as an outcome predictor in ischemic stroke in patients with and without diabetes mellitus

Cardiovascular Diabetology

Elevated plasma glucose levels are common in patients suffering acute ischemic stroke (AIS), and acute hyperglycemia has been defined as an independent determinant of adverse outcomes. The impact of acute-to-c.

Stroke 59
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Chronic high blood pressure during pregnancy doubled between 2008 and 2021 in the US: Study

Medical Xpress - Cardiology

The number of individuals in the U.S. who had chronic hypertension or chronic high blood pressure during pregnancy doubled between 2008 and 2021, while the prescribing and filling of antihypertensive medication during pregnancy remained low but stable at 60%, according to research published in Hypertension.

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Weight change and risk of incident type 2 diabetes: short, medium and long-term follow-up in tehran lipid and glucose study

Cardiovascular Diabetology

Despite the high burden of obesity and Type 2 diabetes (T2DM) in the Middle East/West Asia region, the effect of weight change on the development of T2DM is poorly addressed. Therefore, we aimed to assess the.

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Study Finds Differences in High-Genetic Barrier Nucleos(t)ide Analogue Efficacy for HBV

HCPLive

The network meta-analysis found tenofovir disoproxil fumarate was more likely to achieve virologic response at week 48, while entecavir was superior for 48-week biochemical response.

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Using novel discourse treatment to improve communication in people with aphasia

Science Daily - Stroke

A new study has found that a novel discourse treatment improved the communication abilities of people with aphasia, a language disorder commonly resulting from stroke.

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Licit use of illicit drugs for treating depression: the pill and the process

Journal of Clinical Investigation - Cardiology

Psilocybin, MDMA, and ketamine have emerged as potentially effective treatments for rapid amelioration of the symptoms of mood and related psychiatric disorders. All clinical data collected so far with regard to psilocybin or MDMA, which have reported positive outcomes for treating depression, anxiety, posttraumatic stress disorder, and drug or alcohol use disorders, have involved clinician-assisted intervention.

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Frederic Lavie, MD, PhD: cDAPSA Demonstrates Efficacy in Monitoring Disease Activity in PsA

HCPLive

Results revealed cDAPSA can help providers accurately measure the level of disease activity in patients and predict whether the patient will have radiographic progression.

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Association between preprocedural serum potassium level and atrial fibrillation recurrence after catheter ablation

HeartRhythm

The association between serum potassium and atrial fibrillation (AF) recurrence after catheter ablation remains unclear.

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Phase 3 Upadacitinib Trial Shows Promising Results for Giant Cell Arteritis Treatment

HCPLive

Daniel Blockmans, MD, PhD, discussed the results of a phase 3 trial that revealed upadacitinib significantly improved outcomes in patients with giant cell arteritis.

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Two-stage hybrid surgical repair for aortic arch pathology with a shaggy aorta: a case report

Journal of Cardiothoracic Surgery

The surgical treatment strategy for aortic arch pathology with a shaggy aorta must be determined on a case-by-case basis because of the risk of catastrophic complications, such as brain infarction and spinal c.

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Study: Average US Diet is Improving, But Remains Suboptimal for Many

HCPLive

Analysis of NHANES data from 1999 to 2020 provides some evidence of diet quality improvement but highlights low rates of adults achieving ideal diet quality.

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Pacemaker-induced atrial fibrillation reconsidered—associations with different pacing sites and prevention approaches

Frontiers in Cardiovascular Medicine

The incidence of atrial fibrillation (AF) is significantly higher in patients with pacemakers than in the general population, which could be due to patient characteristics and the diagnostic tool of the pacemaker in detecting atrial high-rate episodes and subclinical AF, but also to the pacemaker itself providing AF-promoting conditions. It is well known that high ventricular pacemaker burden increases the likelihood of AF occurrence.

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Psoriasis Linked to Device-Related Infective Endocarditis Risk Among Those with Pacemakers

HCPLive

These data may require large-scale studies to duplicate the findings, evaluating individuals with psoriasis who had PPM for IE antibiotic prophylaxis.

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Exploring global research trends in Chinese medicine for atherosclerosis: a bibliometric study 2012–2023

Frontiers in Cardiovascular Medicine

BackgroundWhile Traditional Chinese Medicine (TCM) boasts an extensive historical lineage and abundant clinical expertise in addressing atherosclerosis, this field is yet to be penetrated adequately by bibliometric studies. This study is envisaged to evaluate the contemporary scenario of TCM in conjunction with atherosclerosis over the preceding decade while also identifying forthcoming research trends and emerging topics via the lens of bibliometric analysis.MethodsLiterature pertaining to TCM