Mon.Jan 13, 2025

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Dementia Cases to Double in the U.S.

Med Page Today

(MedPage Today) -- Dementia cases in the U.S. are expected to double in the next four decades, a new analysis suggested. In a racially and geographically diverse sample, the lifetime risk of dementia was estimated at 42% (95% CI 41-43) with incidence.

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Comparative efficacy of different drugs in acute heart failure with renal dysfunction: a systematic review and network meta-analysis

Frontiers in Cardiovascular Medicine

ObjectiveThis network meta-analysis was to compare the efficacy of different drugs on cardiac function, renal function, and clinical outcomes in patients with acute heart failure (AHF) accompanied by renal dysfunction.MethodsPubMed, EMBASE, Cochrane Library, and Web of Science were searched to screen all clinical trials of AHF between January 1st 2001 and March 31th 2024.

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Newest AUC Provide Clinical Guidance on Cardiac Implantable Electronic Devices

American College of Cardiology

New multi-society Appropriate Use Criteria (AUC) published in JACC focus on cardiac implantable electronic devices (CIEDs), specifically implantable cardioverter-defibrillators (ICDs), cardiac resynchronization therapy (CRT), and pacing. The updated criteria address a broad spectrum of clinical scenarios and key areas where new data are available or new procedures and technologies have resulted in changes in practice since the original AUC on CIEDs were published in 2013.

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CTVS Celebrates Super Doctors and Top Doctors

CTVS

Cardiothoracic and Vascular Surgeons is proud to share that several of our physicians received important accolades closing out 2024 and ushering in 2025. For several years, our team of cardiothoracic and vascular surgeons has been humbled to receive recognition as Texas Monthly Super Doctors and Austin Monthly Top Doctors.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Variability in Pediatric Transplant Center Immunosuppression Practices Impact Rejection Rates

HCPLive

Pediatric liver transplant centers with greater within-center variability in induction type had higher rates of 1-year rejection.

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Stroke Mimics at 30 Years: Where We Have Been, Where We Are Now, and Where We Are Going

Stroke Journal

Stroke, Ahead of Print. Stroke mimics and chameleons remain a major challenge to the clinician and clinical investigator. Misdiagnosis of stroke can result in significant harm to our patients, as well as unnecessary financial costs to the health care systems internationally. The approach to stroke mimics and chameleons has evolved over time with the development of clinical scales and technology.

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Brain connectome phenotype linked to cerebrovascular disease can track cognitive decline

Science Daily - Stroke

Researchers have uncovered novel insights into how brain function disruptions related to cerebrovascular disease (CeVD) interact with Alzheimer's disease (AD) pathology to impact neurodegeneration and cognition in older adults.

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Revised Hyperfiltration Formula Incorporates Age-Related Renal Function Decline

HCPLive

The new definition uses both age and GFR without body surface area correction to determine the threshold value for hyperfiltration.

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SGARBOSSA CRITERIA

ECG Guru

This ECG was sent to me by a friend, I don't know if he did it himself. The question was whether a heart attack can be recognized here. The patient is a 55-year-old man who has typical angina pectoris lasting more than 1 hour. What can you answer?

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OCU400 Improves 2-Year Vision in Retinitis Pigmentosa in Phase 1/2 Trial

HCPLive

All participants with RP treated with OCU400 gene therapy achieved vision improvement or preservation at 2 years of the Phase 1/2 trial.

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Effective CRISPR modulation of complex non-coding RNA loci

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 14 January 2025; doi:10.1038/s41569-025-01117-2 In this Tools of the Trade article, Francesca Vacante and Andrew Baker describe a CRISPR-based approach to target the regulatory regions of non-coding RNAs.

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Diabetes Dialogue: The Evolving Role of Registered Dietitian Nutritionists in Obesity

HCPLive

Hosts are joined by a registered dietitian and practicing endocrinologist to discuss dietitians' role in managing patients receiving incretin therapies.

Obesity 69
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ACC CardiaCast: Pulse Check: Palliative Care in Patients with Heart Disease: Serious Conversations in the Critical Care Trenches

American College of Cardiology

In this episode, Andrea Price, MS, AACC hosts Alex Tabone, PA-C, AACC, Alix Barnes, MD, and Sharon Dickinson, PA-C, FACC to share insights for serious conversations in the critical care trenches.

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Baricitinib Effective, Safe Over 52 Weeks for Severe Alopecia Areata

HCPLive

These data highlight the long-term efficacy of baricitinib, a JAK 1/2 inhibitor, for patients with severe alopecia areata in a real-world setting.

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Engineering extracellular vesicles for therapeutic delivery in ischaemic stroke

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 14 January 2025; doi:10.1038/s41569-025-01122-5 In this Tools of the Trade article, Birch describes how extracellular vesicles can be engineered to deliver therapeutic microRNAs for the treatment of ischaemic stroke.

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Gout Flare State Definitions Help Describe Disease Burden

HCPLive

However, gout flare states of patient acceptable symptom state, low disease activity, or not achieving either were not associated with EQ-5D-3L or HAQ.

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Cardiac resynchronization therapy via left bundle branch pacing in heart failure with complete left bundle branch block: is the defibrillator needed?

Frontiers in Cardiovascular Medicine

AimsThis retrospective cohort study aimed to investigate the efficacy of dual-chamber left Bundle branch pacing (LBBP) as an alternative therapy for heart failure patients with complete left bundle branch block (CLBBB) and indications for defibrillator with cardiac resynchronization therapy (CRT-D).Methods34 patients met inclusion criteria were enrolled in the study.

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Patient Care Experiences Worsens After Private Equity Acquisition of Hospitals

HCPLive

In a recent study, participants reported worse patient care experience and staff responsiveness following the private equity acquisition of hospitals.

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Optimal timing of pharmacoinvasive strategy and its impact on clinical and economic outcomes in patients with ST-elevation myocardial infarction: a real-world perspective

Frontiers in Cardiovascular Medicine

BackgroundThe pharmacoinvasive (PhI) strategy is the standard-of-care for ST-elevation myocardial infarction (STEMI) patients when primary percutaneous coronary intervention (pPCI) is unfeasible. Optimal timing for post-fibrinolytic PCI (lysis-PCI) remains elusive. Therefore, this study aimed to assess the clinical and economic impacts of early vs. delayed lysis-PCI in patients with STEMI.MethodsThis retrospective cohort study included 1,043 STEMI patients classified by lysis-PCI timing.

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CMS to cover implantable heart failure device

Becker's Hospital Review - Cardiology

"CMS proposes Medicare and Medicaid coverage for implantable pulmonary artery pressure sensors to manage heart failure. Final decision to be published on Jan.

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Establishment and validation of a nomogram for coronary artery lesions in children with Kawasaki disease

Frontiers in Cardiovascular Medicine

BackgroundThe nomogram is a powerful and robust tool in disease risk prediction that summarizes complex variables into a visual model that is interpretable with a quantified risk probability. In the current study, a nomogram was developed to predict the occurrence of coronary artery lesions (CALs) among patients with Kawasaki disease (KD). This is especially valuable in the early identification of the risk of CALs, which will lead to proper diagnosis and treatment to reduce their associated comp

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Iowa hospital halts open-heart surgeries

Becker's Hospital Review - Cardiology

MercyOne Siouxland Medical Center in Sioux City, Iowa, has indefinitely paused its open-heart surgery program.

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Prognostic implication of right ventricular-pulmonary artery coupling in valvular heart disease

Frontiers in Cardiovascular Medicine

Valvular heart disease (VHD) leading to inadequate hemodynamic circulation is a major cause of cardiovascular morbidity and mortality worldwide. Right ventricular-pulmonary artery (RVPA) coupling integrates the ability of RV contractility to adapt to increased pulmonary arterial afterload. If the right ventricle cannot adapt to the elevated afterload by increasing its contractile function, RV-PA uncoupling occurs.

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Vanderbilt sets heart transplant world record

Becker's Hospital Review - Cardiology

"Vanderbilt Transplant Center sets world record with 174 heart transplants in 2024, including pediatric procedures.

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Intra-Arterial Lytics After Successful Stroke Thrombectomy Did Not Improve Outcomes

Med Page Today

(MedPage Today) -- For stroke patients undergoing mechanical thrombectomy, adjunctive intra-arterial thrombolytics fell short for further improving outcomes in two randomized trials. First, in POST-UK, there was a trend toward better odds of an.

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Women's Choice Award honors 465 hospitals for stroke care

Becker's Hospital Review - Cardiology

The Women's Choice Award released its annual list of best hospitals Dec. 15, recognizing nearly 1,500 facilities nationwide for exceptional women's healthcare.

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Iron Therapy Boosts Hemoglobin Levels in Deficient Patients with Obesity

HCPLive

A new study highlights notable obesity-associated disruptions of iron metabolism, with higher hemoglobin and serum ferritin levels in pre-obese and obese cohorts.

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CORA: Your Cardiothoracic Online Resource Assistant

Society of Thoracic Surgeons - Technology

CORA: Your Cardiothoracic Online Resource Assistant kgilmartin Mon, 01/13/2025 - 09:39

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Low RSV Exposure In Childrens’ First Year Does Not Reduce Asthma Care Needs

HCPLive

These findings on asthma healthcare utilization resulted from the lack of a winter peak in RSV during the first months of the COVID-19 pandemic.

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The Prevalence and Predictors of Atrioventricular Blocks in Syrian Patients Reporting to the Emergency Department During the Ongoing Conflict: A Cross‐Sectional Study

Journal of Cardiovascular Electrophysiology

ABSTRACT Background Atrioventricular block (AVB) is a cardiac conduction disorder that can lead to significant clinical outcomes, particularly in resource-limited and conflict-affected regions. In Syria, healthcare infrastructure has been severely impacted by ongoing conflict, potentially affecting the prevalence and management of AVB. Methods We conducted a cross-sectional study at Tishreen University Hospital in Latakia, Syria, with patients >40 who presented to the emergency department (ED

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Emerging Therapies: a look at the current data: ALIGN

HCPLive

Panelists discuss how the ALIGN trial data inform the development and potential impact of emerging therapies for IgA nephropathy, particularly focusing on their efficacy in reducing proteinuria and addressing disease pathology.

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The Role of RyR2 Mutations in Congenital Heart Diseases: Insights Into Cardiac Electrophysiological Mechanisms

Journal of Cardiovascular Electrophysiology

ABSTRACT Ryanodine receptor 2 (RyR2) protein, a calcium ion release channel in the sarcoplasmic reticulum (SR) of myocardial cells, plays a crucial role in regulating cardiac systolic and diastolic functions. Mutations in RyR2 and its dysfunction are implicated in various congenital heart diseases (CHDs). Studies have shown that mutations in the RYR2 gene, which encodes the RyR2 protein, are linked to several cardiac arrhythmias, including catecholaminergic polymorphic ventricular tachycardia (C

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Emerging Therapies: a look at the current data: APPLAUSE

HCPLive

Panelists discuss how the ALIGN trial data inform the development and potential impact of emerging therapies for IgA nephropathy, particularly focusing on their efficacy in reducing proteinuria and addressing disease pathology.

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Six‐Month Emergent Readmissions Following Hospitalization for Atrial Fibrillation Amid the Syrian Conflict: A Real‐World Observational Cohort Study

Journal of Cardiovascular Electrophysiology

ABSTRACT Background Atrial fibrillation (AF) is the most common arrhythmia worldwide. However, data regarding readmissions following index admission for AF in the developing world are not well described. This study assessed the rate, predictors, and trends of 6-month readmission after index admission for AF in Syria. Methods We included adult patients who had an index admission with AF to Latakia's tertiary center between July 2021 and November 2023.

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Time in Target Range for Blood Pressure and Adverse Health Outcomes: A Systematic Review

Hypertension Journal

Hypertension, Ahead of Print. BACKGROUND:Blood pressure (BP) time in target range (TTR) reflects the proportion of time that BP measurement is within a specified target range. We aim to summarize the evidence for relationships between TTR and adverse health outcomes.METHODS:Seven databases were searched. After quality assessment and data extraction, meta-analyses were performed to generate pooled estimates of the association (hazard ratios) between TTR and health outcomes.

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Long RP Tachycardia and Short RP Tachycardia: Is the Nodoventricular Pathway a Culprit or an Innocent Bystander?

Journal of Cardiovascular Electrophysiology

ABSTRACT We encountered a single case in which a transition between orthodromic reciprocating tachycardia with a concealed nodoventricular pathway and atrioventricular nodal reentrant tachycardia with a bystander nodoventricular pathway was observed.