Wed.Feb 05, 2025

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How AI-Powered ECG Analysis is Advancing Cardiometabolic Research: Our Latest Study with University Hospital Basel

Cardiomatics

At Cardiomatics, we are committed to advancing cardiac research with AI-driven ECG analysis. We are proud to share our latest study, conducted with University Hospital Basel, and published in Diabetes Care. This marks our fourth collaboration, and we are eager to do more! The study explores how metformin can protect against the harmful effects of glucocorticoids (GCs).

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Evolocumab: Sooner or Later?

CardiacWire

Sooner certainly seems to be better than later when it comes to treating LDL-C levels with the PCSK9 inhibitor evolocumab (Amgen’s Repatha), and according to a recent JACC study , thats especially true for older patients. People aged 75 years make up ~65% of all deaths linked to cardiovascular disease, with age being one of the primary risk factors for ASCVD.

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Assessing the performance of zero-shot visual question answering in multimodal large language models for 12-lead ECG image interpretation

Frontiers in Cardiovascular Medicine

Large Language Models (LLM) are increasingly multimodal, and Zero-Shot Visual Question Answering (VQA) shows promise for image interpretation. If zero-shot VQA can be applied to a 12-lead electrocardiogram (ECG), a prevalent diagnostic tool in the medical field, the potential benefits to the field would be substantial. This study evaluated the diagnostic performance of zero-shot VQA with multimodal LLMs on 12-lead ECG images.

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Drinking ketones improves heart health, study suggests

Science Daily - Heart Disease

Drinking ketones improves heart health, a new small-scale study has found.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Atrial fibrillation and cognitive impairment: mechanisms, influencing factors, and prospects

Frontiers in Cardiovascular Medicine

IntroductionAtrial fibrillation (AF) is a prevalent cardiac arrhythmia and a significant contributor to cardioembolic stroke, a condition closely linked to cognitive decline. However, research reveals that AF itself is independently associated with an increased risk of cognitive impairment. This high incidence of cognitive decline in AF patients may result from various mechanisms, including reduced cerebral perfusion, microembolism, decreased cardiac output, and chronic inflammation.MethodsThis

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Clot-buster meds & mechanical retrieval equally reduce disability from some strokes

American Heart News - Stroke News

Research Highlights: Mechanically retrieving a blood clot blocking a medium- or small-sized brain artery was no better at reducing disability 90 days after a stroke than standard care alone (including clot-busting medication if indicated). While.

More Trending

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FDA Fast Tracks CAR-T Therapy for Lupus

HCPLive

ADI-001 now has FDA Fast Track Designation for relapsed/refractory lupus nephritis and systemic lupus erythematosus with extrarenal involvement.

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Case Report: A case of transcatheter aortic valve replacement in a patient with a small aortic annulus using the Acurate Neo2

Frontiers in Cardiovascular Medicine

Small aortic annulus poses a major challenge in aortic valve replacement due to the increased risk of prosthesispatient mismatch (PPM) and increased surgical risk. In recent years, transcatheter aortic valve replacement (TAVR) has emerged as a popular alternative to the traditional surgical aortic valve replacement. We present the case of an 80-year-old woman with a small aortic annulus who underwent TAVR using a self-expanding transcatheter heart valve Acurate Neo2 after an non-ST-segment eleva

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Later-onset menopause linked to healthier blood vessels, lower heart disease risk

Science Daily - Heart Disease

New research shows that women who hit menopause later in life have healthier blood vessels and mitochondria and a different composition of metabolites in their blood than those who stop menstruating earlier. The study helps explain why late-onset menopause is linked to lower risk of heart attacks and strokes.

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Milestone Events by Recessive Dystrophic Epidermolysis Bullosa Subtype Identified

HCPLive

These data point to milestone event frequency and prevalence by subtype of RDEB, highlighting such events as dysphagia and squamous cell carcinoma.

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Endovascular Therapy Hits a Wall for Stroke Clots Lodged in Mid-Size Vessels

Med Page Today

(MedPage Today) -- LOS ANGELES -- Contrary to expectations, the benefits of endovascular thrombectomy (EVT) did not extend to strokes related to mid-size vessel occlusions, as shown independently by two randomized trials. EVT failed to improve.

Stroke 68
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Inhaled Triple Therapy Needs Better Integration into Asthma Care

HCPLive

Despite being aware of its value in treating asthma, specialists were uncertain about integrating ITT into patient care.

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Long‐term follow‐up of the TRED‐HF trial: Implications for therapy in patients with dilated cardiomyopathy and heart failure remission

European Journal of Heart Failure

Long-term follow-up (FU) of the TRED-HF trial: persistent high-risk of relapse following therapy withdrawal in recovered dilated cardiomyopathy (DCM), likely contributed to by low-dose therapy and exposure to external triggers. LVEF, left ventricular ejection fraction. Abstract Aims In TRED-HF, 40% of patients with recovered dilated cardiomyopathy (DCM) relapsed in the short term after therapy withdrawal.

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High HDL-C Levels Linked to Notable Risk of Glaucoma, Study Finds

HCPLive

Elevated HDL-C raised glaucoma risk, particularly for participants aged 55 years, contrary to its typical beneficial role in cardiovascular health.

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Decreased Left Ventricular Systolic Function during the Late Phase after Response to Cardiac Resynchronization Therapy

HeartRhythm

Cardiac resynchronization therapy (CRT) improves cardiac function in patients with heart failure (HF) and dyssynchrony. However, a subset of responders develops a delayed decline in left ventricular (LV) systolic function, referred to as delayed negative reverse remodeling (DNRR).

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Impact of Tapinarof Cream Approval for Atopic Dermatitis, with Adelaide Hebert, MD

HCPLive

Adelaide Hebert, MD, discusses the impact of the recent approval for tapinarof cream in the management of atopic dermatitis.

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Cardiac Rehab & Heart Failure, CV Care & Cancer Survivors, Bioprosthetic AVR vs Mechanical AVR in Younger Patients

American College of Cardiology

In this weeks View, Dr. Eagle looks at cardiac rehabilitation for people with heart failure. He then discusses managing cardiovascular (CV) disease in cancer survivors who have completed cancer therapy.

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Medical Ethics Unpacked: GLP-1 Allocation and Challenges of Equitable Access

HCPLive

Drs. Levine and Sisti discuss the ethical challenges of GLP-1 drug allocation, exploring fairness, disparities, and policy solutions for obesity and diabetes treatment.

Obesity 69
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Children's Hospital Los Angeles opens new cardiac imaging suite

Becker's Hospital Review - Cardiology

"Discover the latest in pediatric cardiac imaging at Children's Hospital Los Angeles, now equipped with the only low-field MRI machine in California.

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Metabolic Surgery’s Benefit for MASH-Related Cirrhosis, with Soba Laique, MD

HCPLive

Laique reviews data supporting the use of metabolic surgery in patients with obesity and cirrhotic MASH.

Obesity 64
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HCA hospital increases cardiac, vascular surgical capacity

Becker's Hospital Review - Cardiology

Davie-based HCA Florida Healthcare's Mercy Hospital in Miami has opened four new operating rooms, including one dedicated to cardiac and vascular care.

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DURAVYU Hits Primary Phase 2 Endpoint, Reduces Treatment Burden in DME

HCPLive

Both doses of DURAVYU extended the time to the first supplemental injection versus aflibercept control in the Phase 2 VERONA trial.

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Efficacy and safety of angiotensin receptor–neprilysin inhibition in heart failure patients with end‐stage kidney disease on maintenance dialysis: A systematic review and meta‐analysis

European Journal of Heart Failure

Meta-analysis on the main outcomes of angiotensin receptorneprilysin inhibitor (ARNI) in heart failure (HF) patients with end-stage kidney disease (ESKD) on dialysis. CI, confidence interval; DBP, diastolic blood pressure; HFmrEF, heart failure with mildly reduced ejection fraction; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; LVDd, left ventricular end-diastolic diameter; LVEF, left ventricular ejection fraction; LVMI, left ventricu

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Simvastatin, Rifaximin Combination Shows No Benefit for Decompensated Liver Cirrhosis

HCPLive

Findings from the LIVERHOPE trial suggest adding simvastatin and rifaximin to standard therapy does not reduce ACLF occurrence.

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Bridging the Gap: Training and Infrastructure Solutions for Mechanical Thrombectomy in Low- and Middle-Income Countries

Stroke Journal

Stroke, Ahead of Print.

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FDA Accepts BLA for Golimumab Biosimilar for Inflammatory Conditions

HCPLive

Golimumab, marketed under the names Simponi and Simponi Aria, is approved for RA, PsA, AS, and UC.

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Recombinant GDF11 Promotes Recovery in a Rat Permanent Ischemia Model of Subacute Stroke

Stroke Journal

Stroke, Ahead of Print. Background:Stroke remains a leading cause of death and disability, underscoring the urgent need for treatments that enhance recovery. Growth Differentiation Factor 11 (GDF11), a member of the TGF- superfamily, is a circulating protein involved in cellular development and tissue repair. GDF11 has gained attention for its potential regenerative properties in aging and disease contexts, making it a candidate for stroke recovery therapies.Methods:The therapeutic benefits of r

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AI-Enabled, Wearable Sensor Useful for Reducing Scratching in Atopic Dermatitis

HCPLive

These data suggest a wearable haptic feedback sensor powered by artificial intelligence may function as a supportive therapeutic device for those with atopic dermatitis.

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CD4+ T Cells Expressing Viral Proteins Induce HIV-Associated Endothelial Dysfunction and Hypertension Through Interleukin 1α–Mediated Increases in Endothelial NADPH Oxidase 1

Circulation

Circulation, Ahead of Print. BACKGROUND:Although combination antiretroviral therapy has increased life expectancy in people living with HIV, it has led to a marked increase in the prevalence of hypertension, the cause of which is unknown. Despite combination antiretroviral therapy, HIV-derived proteins remain expressed and produced by CD4+T lymphocytes in people living with HIV.

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Monlunabant Misses Primary Endpoint in Phase 2 Diabetic Kidney Disease Trial

HCPLive

Completion of the trial was announced in a financial update from Novo Nordisk, who explained the trial missed its primary endpoint for uACR improvement.

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ACC Rallies Behind Introduction of Medicare Payment Legislation to Revert 2.8% Cut, Add Inflationary Update

American College of Cardiology

Legislation introduced in Congress on Jan. 31 would revert the 2.8% Medicare payment cut imposed by the 2025 Medicare Physician Fee Schedule and institute a 2% inflationary update, providing financial relief to physician practices across the country and preserving access to vital health care services.

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Psychiatry Month in Review: January 2025

HCPLive

This Month in Review highlights the top psychiatry news in January.

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Atherosclerotic Cardiovascular Disease Risk Prediction in Systemic Lupus Erythematosus

American College of Cardiology

Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of death in patients with systemic lupus erythematosus (SLE). Although overall mortality in SLE has decreased over the previous decades, a similar decrease in magnitude for CVD-related mortality in these patients has not been seen.

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Stereotactic Arrhythmia Radioablation (STAR) for refractory ventricular tachycardia– the initial Australian experience

HeartRhythm

Stereotactic arrhythmia radioablation (STAR) is a novel, noninvasive technique for the management of refractory ventricular tachycardia (VT).

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Dual Uncommon Atrioventricular Connections in a Patient With Wolff‐Parkinson‐White Syndrome

Journal of Cardiovascular Electrophysiology

ABSTRACT Background Accessory pathways (APs) from the atrial appendage are uncommon and primarily described on the right side. Furthermore, connections involving the left atrial appendage (LAA) are even rarer. Methods and Results This case report describes a 27-year-old female with recurrent supraventricular tachycardia (SVT) due to Wolff-Parkinson-White (WPW) syndrome.

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Which Ablation Strategy Is the Most Effective for Treating Persistent Atrial Fibrillation? A Systematic Review and Bayesian Network Meta-Analysis of Randomized Controlled Trials

HeartRhythm

There is no consensus on the most efficient ablation strategy for patients with persistent atrial fibrillation (PerAF).