Wed.Dec 20, 2023

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Clinical characteristics, treatment, and blood pressure control in patients with hypertension seen by primary care physicians in Spain: the IBERICAN study

Frontiers in Cardiovascular Medicine

Objectives To determine the clinical profile, according to the history of hypertension, the risk of developing hypertension, current antihypertensive treatment and BP control rates in patients with hypertension from the IBERICAN cohort. Methods IBERICAN is an ongoing prospective cohort study, whose primary objective is to determine the frequency, incidence, and distribution of CVRF in the adult Spanish population seen in primary care settings.

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Electronic 'Nudges' to Improve Influenza Vaccine Uptake May Be Less Effective in Patients with Diabetes

HCPLive

Analysis of the NUDGE-FLU study reveals electronic nudges designed to boost influenza vaccination were more effective in older adults without diabetes, highlighting the need for tailored approaches in diabetes populations.

Diabetes 129
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MMRI Publishes Breakthrough Study Detailing a Novel Approach to Minimize Damage After a Heart Attack

DAIC

Jason McCarthy, Ph.D., associate professor of biomedical research and translational medicine at MMRI. Image courtesy of MMRI milla1cf Wed, 12/20/2023 - 15:57 December 20, 2023 — Jason R. McCarthy, Ph.D. , associate professor of biomedical research and translational medicine and scientific operations director at MMRI , recently published an innovative manuscript titled, Biomimetic Nanomaterials for the Immunomodulation of the Cardiosplenic Axis Post-Myocardial Infarction.

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Rheumatoid Arthritis Quiz: Cardiovascular Disease in RA

HCPLive

How great are the risks of cardiovascular disease for patients with rheumatoid arthritis? Test your knowledge with this quiz.

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Long-term effects of blood pressure 130–139/80–89 mmHg on all-cause and cardiovascular mortality among Chinese adults with different glucose metabolism

Cardiovascular Diabetology

This study aimed to investigate the risks of all-cause and cardiovascular mortality associated with blood pressure (BP) levels of 130–139/80–89 mmHg in Chinese adults with different glucose metabolism, during.

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Study finds natto consumption inhibits arteriosclerosis by altering intestinal microflora, suppressing inflammation

Medical Xpress - Cardiology

Natto is widely recognized for inhibiting arteriosclerosis, yet its underlying mechanism remains elusive. Researchers led by the University of Tsukuba studied the effects of natto on arteriosclerosis in mice. The findings, published in Scientific Reports showed that consuming natto induced changes in the intestinal microflora, suppressing inflammation and preventing arteriosclerosis.

Research 110
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Spinal cord injury causes acute and systemic muscle wasting

Science Daily - Stroke

Acute spinal cord injury (SCI) patients lose body weight and muscle mass, despite being on a high-calorie diet while in the intensive care unit. Their muscle wasting is substantial and extends beyond what can explained by inactivity or denervation (loss of nerve supply) alone. Research sheds new light and decodes early muscle loss after SCI to provide an unprecedent first understanding that muscle wasting is rapid and severe; a systemic phenomenon and glucocorticoid dependent.

Diet 110

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Study unveils a role of mitochondria in dietary fat processing

Science Daily - Stroke

Researchers discover a new mechanism controlling the uptake of lipids from digested food.

Research 109
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Analysis Reveals Causal Association Between Hypothyroidism and Type 1 Diabetes

HCPLive

Mendelian randomization analyses demonstrated a causal relationship between hypothyroidism and diabetes, along with its related microvascular complications.

Diabetes 107
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Smidt Heart Institute Opens Aortic Surveillance Clinic

DAIC

Experts at the Smidt Heart Institute's new Aortic Surveillance Clinic will monitor patients with aortic aneurysms (illustrated here) or enlarged aortas. Image by Getty milla1cf Wed, 12/20/2023 - 16:02 December 20, 2023 — The Smidt Heart Institute at Cedars-Sinai has opened an Aortic Surveillance Clinic for the evaluation and long-term monitoring of patients with enlarged aortas, or aortic aneurysms, for whom surgery may not be necessary.

Aortic 105
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Determining the Best Medical Image Sharing Platform for Your Team

NOVARAD

Healthcare and technology have become inseparable companions in today’s world, and medical imaging is one area where this partnership really shines. It’s become a powerhouse of diagnosis and treatment, but as with any powerhouse, keeping it running smoothly is challenging.

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Study discovers novel biomarker for vascular aging and neurodegeneration

Medical Xpress - Cardiology

Decreased activity of a specific signaling pathway in brain vessels was linked to a decline in vascular function and subsequent neurodegeneration, according to a recent Northwestern Medicine study published in the Journal of Clinical Investigation.

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The Future of IgA Nephropathy Treatment

HCPLive

Jonathan Barratt, PhD, FRCP, and Brad Rovin, MD, discuss the future of IgAN treatment, highlighting the BlyS/APRIL axis.

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All about mTOR (Part II): Amino Acids, mTOR, and Athletes

Physiologically Speaking

Greetings. Last week’s post was a guest post from Gabe King. Physiologically Speaking is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Gabe is currently pursuing a BSc in Dietetics and is the owner of Summit Sports Nutrition, a company that, through science and empirical data, aims to optimize the nutrition of endurance athletes.

Cancer 98
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SUSTAINED VENTRICULAR TACHYCARDIA

ECG Guru

A sustained VT is a ventricular rhythm with a frequency of more than 100 beats per minute that usually lasts at least 30 seconds or must be terminated earlier due to hemodynamic instability. We see here a wide complex tachycardia with a frequency of approx. 105-110 beats per minute that lasts for a good minute. It begins with a premature QRS complex without a premature P wave.

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Kidney dysfunction linked to heart failure with preserved ejection fraction

Medical Xpress - Cardiology

Mild and moderate kidney dysfunction are associated with left ventricular diastolic dysfunction and heart failure with preserved ejection fraction (HFpEF), according to a study published online Nov. 27 in ESC Heart Failure.

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ECG Cases 47 – ECG Interpretation in Toxicology

ECG Cases

In this ECG Cases Dr. Jesse McLaren delves into ECG interpretation in toxicology and the poisoned patient using his HEARTS approach in 7 case examples. Heart rate/rhythm: consider antidotes for brady/tachy-arrhythmias, and for sinus tachycardia consider fluids for vasodilation and benzodiazepines for agitation. Electrical conduction and axis: consider sodium bicarb for QRS > 100 especially if RBBB or terminal rightward shift, and magnesium for QTc> 500.

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Air pollution increases heart attacks in nonsmokers, study finds

Medical Xpress - Cardiology

Air pollution is associated with significant increases in heart attacks among nonsmokers, according to a study presented at the European Society of Cardiology Congress 2022, held from Aug. 26 to 29 in Barcelona, Spain.

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Sustained VT

ECG Guru

A sustained VT is a ventricular rhythm with a frequency of more than 100 beats per minute that usually lasts at least 30 seconds or must be terminated earlier due to hemodynamic instability. We see here a wide complex tachycardia with a frequency of approx. 105-110 beats per minute that lasts for a good minute. It begins with a premature QRS complex without a premature P wave.

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Common Carotid Artery Stenosis Degree as a Predictor of Cardiovascular Disease in a General Population: The Suita Study

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundThe utility of screening for the degree of common carotid artery (CCA) stenosis as a predictor of cardiovascular disease (CVD) in a general population remains unclear.Methods and ResultsWe studied 4775 Japanese men and women whose CCA was measured using bilateral carotid ultrasonography at baseline (April 1994–August 2001).

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Vanderbilt, Deaconess open transplant, heart failure clinic

Becker's Hospital Review - Cardiology

Nashville, Tenn.-based Vanderbilt Transplant Center partnered with Evansville, Ind.-based Deaconess Health System to open a new transplant clinic in Newburgh, Ind.

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American Gastroenterological Association Releases First Pouchitis Management Guideline

HCPLive

The guideline includes 9 conditional recommendations to support practitioners in the management of pouchitis and inflammatory pouch disorders.

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European Society of Cardiology Core Curriculum for cardio?oncology

European Journal of Heart Failure

Abstract Cardio-oncology is a rapidly growing field of cardiovascular (CV) medicine that has resulted from the continuously increasing clinical demand for specialized CV evaluation, prevention and management of patients suffering or surviving from malignant diseases. Dealing with CV disease in patients with cancer requires special knowledge beyond that included in the general core curriculum for cardiology.

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Cardiologist offers advice on the best cooking fats for healthy cholesterol levels

Medical Xpress - Cardiology

Are you trying to remember which fat is the good fat to use in the kitchen? If you are confused about whether to use unsaturated fats, polyunsaturated, monounsaturated or saturated fats when cooking, it's understandable. It can be confusing.

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Cannabis Use and Incident Atrial Fibrillation in a Longitudinal Cohort

HeartRhythm

Cannabis use is increasing worldwide. While prior studies have reported an association between cannabis use and a higher risk of atrial fibrillation (AF), most were cross-sectional and generally relied on diagnostic coding to identify cannabis users, which may not be representative of the typical, recreational cannabis user.

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Added value of 3D echocardiography in the diagnosis and prognostication of patients with right ventricular dysfunction

Frontiers in Cardiovascular Medicine

Recent inroads into percutaneous-based options for the treatment of tricuspid valve disease has brought to light how little we know about the behavior of the right ventricle in both health and disease and how incomplete our assessment of right ventricular (RV) physiology and function is using current non-invasive technology, in particular echocardiography.

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The Lupus Approach: CAR-T Begins the Jump from Blood Cancers to Autoimmune Disease

HCPLive

Throughout 2023, interest in the application of CAR-T and other cell therapies to autoimmune disease skyrocketed, with a multitude of clinical trials being initiated by various companies.

Cancer 72
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Drug shown to block artery fat takes a major step forward

Medical Xpress - Cardiology

Scientists at the University of Aberdeen have demonstrated the further success of a drug previously reported to "block" fat in the arteries.

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No Golden Pills: Long Covid Clinical Research Faces Long Climb

HCPLive

Clinicians and investigators alike navigate waning protection against the complex disease to push precedent-setting research and identify new care options.

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Diagnostic value of high sensitivity cardiac troponin T (hs-cTnT) in dialysis patients with myocardial infarction

Frontiers in Cardiovascular Medicine

Background As a sensitive diagnostic marker for myocardial infarction (MI) in people with normal renal function, elevated high sensitivity cardiac troponin T (hs-cTnT) was often found in chronic kidney disease (CKD) patients requiring dialysis. However, the accuracy of baseline hs-cTnT in the diagnosis of MI (including Type 1 MI (T1MI) and Type 2 MI (T2MI)) in dialysis patients is still controversial.

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FDA Awards Full Approval to Budesonide (Tarpeyo) in Treatment of IgA Nephropathy

HCPLive

Budesonide is the first treatment to receive approval from the FDA for reducing the loss of kidney function in adults with primary IgAN.

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Comparison of esketamine versus dexmedetomidine for attenuation of cardiovascular stress response to double-lumen tracheal tube intubation: a randomized controlled trial

Frontiers in Cardiovascular Medicine

Introduction The insertion of a double-lumen tracheal tube may cause a transient but more intense sympathetic response. We examined the effects of esketamine vs. dexmedetomidine as an adjuvant to anesthesia induction to blunt double lumen tracheal (DLT) intubation induced cardiovascular stress response. Methods In a randomized, double-blind trial, 78 adult patients scheduled for elective thoracotomy under general anesthesia requiring DLT intubation were enrolled.

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Zuranolone Introduces Convenience to Postpartum Depression Care

HCPLive

The FDA approved zuranolone for postpartum depression in August, and the drug recently hit the market for patients this month. Experts are celebrating its delivery of care and rapid response rate.

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Interrater variability of ML-based CT-FFR during TAVR-planning: influence of image quality and coronary artery calcifications

Frontiers in Cardiovascular Medicine

Objective To compare machine learning (ML)-based CT-derived fractional flow reserve (CT-FFR) in patients before transcatheter aortic valve replacement (TAVR) by observers with differing training and to assess influencing factors. Background Coronary computed tomography angiography (cCTA) can effectively exclude CAD, e.g. prior to TAVR, but remains limited by its specificity.

TAVR 64
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Brain lesions in former football players linked to vascular, brain changes

Science Daily - Stroke

Signs of injury to the brain's white matter called white matter hyperintensities, as seen on brain scans, may be tied more strongly to vascular risk factors, brain shrinkage, and other markers of dementia in former tackle football players than in those who did not play football.

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SGLT2 Inhibitors Associated with Lower Risk of Sight-Threatening Retinopathy

HCPLive

SGLT2 inhibitors show a reduced risk of retinopathy compared with DPP-4 inhibitors, pioglitazone, and sulfonylureas among patients with type 2 diabetes.

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Eagle’s Eye View: What is the Safety and Tolerability of Inclisiran in Treating Hypercholesterolemia?

American College of Cardiology

In this week’s View, Dr. Eagle explores longitudinal changes in pulmonary artery pressure late in life using data from the ARIC study. He then discusses the safety and tolerability of inclisiran for treatment of hypercholesterolemia.