Sun.Oct 27, 2024

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Kidney Compass: Semaglutide for Nondiabetic Kidney Disease, with Hiddo Heerspink, PhD, PharmD, at Kidney Week 2024

HCPLive

Hiddo Heerspink, PhD, PharmD, joins the podcast during Kidney Week 2024 to discuss the SMART trial and the potential of semaglutide in people with kidney disease without diabetes.

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Prehospital activation: De-activated on ED arrival by Cardiologist because "It's not a STEMI"

Dr. Smith's ECG Blog

This was submitted by a paramedic, Hailey Kennedy A late 50s male called 911 following 2 hours of chest pain that started while working at his desk. He reported the crushing chest pain radiated down his left arm. Pt took an antacid with no relief and decided to call at the request of his wife. Here is his EMS ECG: What do you think? This was sent to me with no clinical information, and my initial impression viewing it on my phone was "It’s a tricky one.

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Going Beyond Hearing Aids for Equal Care Access

Med Page Today

(MedPage Today) -- As a physician who is hard of hearing, I was excited to learn about FDA's authorization of Apple's newest AirPods, which will come with the capability to convert into hearing aids. If the AirPods live up to their promise, individuals.

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Is it Possible to Identify Patients at Risk of Idiopathic Ventricular Fibrillation?

HeartRhythm

Sudden cardiac death (SCD) remains a major health problem in all continents. It usually affects older patients suffering from coronary artery disease and cardiomyopathies. However, a morphologically normal heart during autopsy has been a frequent finding, ranging from 40% to 78% in victims aged 10 to 49 years old (1-5). This group of patients defines the sudden arrhythmic death syndrome (SADS) where the cause of death is unknown.

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“Hedging” during diagnostic uncertainty

Heart Sisters

What can patients do when we suspect that a doctor’s words or behaviours when delivering a diagnosis seem uncertain?

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What Are Some Other Methods To Manage Skin Cancer Outside of Biopsies?

HCPLive

In this interview, Neal Bhatia, MD, and Laura Korb Ferris, MD, PhD, spoke on their Fall Clinical Conference talk titled ‘Beyond the Biopsy: Other Methods To Help Us Manage Skin Cancer.

Cancer 64
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The effect of empagliflozin on circulating endothelial progenitor cells in patients with diabetes and stable coronary artery disease

Cardiovascular Diabetology

Diabetes mellitus (DM) is associated with premature atherosclerotic disease, coronary artery disease (CAD) and chronic heart failure (HF), leading to increased morbidity and mortality. Sodium-Glucose Co-transp.

More Trending

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America’s Growing CVD Problem

CardiacWire

It’s well known that heart disease is the U.S.’s top cause of death, and our rising CVD rates have been widely covered, but a look back on some of the biggest stories of 2024 suggests that cardiovascular disease is about to become a much bigger problem. Heart Disease in 2050 – The AHA warned of massive heart disease increases by 2050, spanning CVD (+60%), diabetes (+100%), obesity (+70%), hypertension (+44%), heart failure (+66%), and stroke (+100%).

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Basile Njei, MD, MPH, PhD: Increasing Lean MASLD Awareness, Improving Screening

HCPLive

Njei points to the need for improved lean MASLD screening, citing findings from his research about its prevalence and the burden of undiagnosed disease.

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Tricuspid Valve Treatments Safe, Effective and Improve Quality of Life

American College of Cardiology

Two devices approved by the U.S. Food and Drug Administration (FDA) this year for tricuspid regurgitation (TR) are safe, effective and improve quality of life (QOL) at one year, according to studies published in JACC and simultaneously being presented at TCT 2024.

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Infliximab Improves Ulcerative Colitis, Crohn's Disease Regardless of Immunosuppressants

HCPLive

Post hoc analyses from the LIBERTY trials support infliximab as either a monotherapy or combination therapy for ulcerative colitis or Crohn's disease.

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Comprehensive echocardiographic and biomarker assessment of patients with diabetic ketoacidosis

Cardiovascular Diabetology

Systemic stress, inflammation, and hydroelectrolytic and acid‒base abnormalities observed during diabetic ketoacidosis (DKA) can cause changes in the heart and even induce cardiovascular damage. We aimed to ev.

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Prognostic value of multimodality imaging in the contemporary management of cardiac sarcoidosis

Open Heart

Background Echocardiography, cardiac magnetic resonance and cardiac 18 fluorodeoxyglucose positron emission tomography (FDG-PET) imaging play key roles in the diagnosis and management of cardiac sarcoidosis (CS), but the relative value of each modality in predicting outcomes has yet to be determined. This study sought to determine the prognostic importance of multimodality imaging data over and above demographic characteristics and left ventricular ejection fraction (LVEF).

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Vitamin D Deficiency Linked to Worse IBD Hospital Outcomes

HCPLive

New ACG 2024 data show patients with both IBD and vitamin D deficiency face longer, more expensive hospital stays, as well as risk of colectomy.

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Mitral-specific cardiac damage score (m-CDS) predicts risk of death in functional mitral regurgitation: a study from the National Echo Database of Australia

Open Heart

Aims We set out to explore associations between a ‘mitral-specific’ cardiac damage score (m-CDS) and survival outcomes in mitral regurgitation (MR) and compare the performance of the m-CDS and an ‘aortic-specific’ CDS (a-CDS) in patients with MR within the large National Echo Database of Australia. Methods Among 620 831 unique adults investigated with echocardiography, there were 17 658 individuals (3.1%) with moderate or greater functional MR (aged 76±13 years, 51%

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Timothy Ritter, MD: Real-World Data Supporting Fecal Microbiota for Recurrent C Diff

HCPLive

Ritter reviews findings from 2 real-world studies supporting the safety and efficacy of live-jslm (Rebyota) for recurrent C Diff infection.

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T-TEER for Severe TR: Full TRILUMINATE Pivotal Cohort Outcomes

American College of Cardiology

What is the clinical impact of tricuspid regurgitation (TR) reduction with tricuspid transcatheter edge-to-edge repair (T-TEER)?

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AIMS65 Could Predict Treated Gastrointestinal Bleed Death, Rebleed Risks

HCPLive

New late-breaking ACG 2024 data supports AIMS65 as a risk factor tool for patients undergoing anticoagulant reversal.

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Is pulmonary vascular remodeling an intermediate link between hyperglycemia and adverse outcomes in patients with idiopathic pulmonary arterial hypertension? Insights from a multi-center cohort study

Cardiovascular Diabetology

Hyperglycemia upon admission is associated with poor prognosis of many cardiovascular diseases. However, the relationship of stress hyperglycemia ratio (SHR), admission blood glucose (ABG), and hemoglobin A1c.

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Collaboration, Intralesional Therapies for Skin Cancer, with Laura K. Ferris, MD, PhD, and Neal Bhatia, MD

HCPLive

This interview features a discussion with Bhatia and Ferris regarding the necessity of collaboration between dermatologists and oncologists for skin cancer.

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Managing Leakage from Post-Release Device Shift During Left Atrial Appendage Closure Using a Disc Occluder

HeartRhythm

A LAmbre disc occluder (LifeTech Scientific, Shenzhen, China), size 24–30 mm (comprising a 24-mm fixed umbrella and a 30-mm sealing disc) was deployed in a wing-shaped left atrial appendage (LAA), with its sealing disc closely attached to the pulmonary ridge (PR; red dashed line) before release. Post-release, as shown in Figure 1A and the Supplemental Video, while the umbrella remained in place within the landing zone, the upper part of the sealing disc (yellow dotted line) shifted away from the

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Brian Lacy, MD, PhD: Rethinking Motility Testing with a Noninvasive Wireless Patch System

HCPLive

Lacy explains limitations to current motility measurements and reviews findings from his study exploring the potential of a wireless motility patch system.

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Therapeutic Benefits of Phenytoin in Calmodulinopathy: A Rare and Challenging Case Report

HeartRhythm

Calmodulinopathy is a rare genetic disorder caused by mutations in the calmodulin genes, often presenting with malignant ventricular arrhythmias during infancy or early childhood.1,2 Despite aggressive management with standard therapies, the prognosis remains poor. We present a case of a neonate with severe QTc prolongation due to a CALM1 gene variant.

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12-Month APPEAR-C3G Data Highlight Potential of Iptacopan in C3 Glomerulopathy

HCPLive

The APPEAR-C3G trial’s 12-month data show Novartis’ iptacopan significantly reduced proteinuria in C3G, with sustained renal improvements and stable eGFR.

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Risk of Cardiac Arrhythmias and Outcomes with Perioperative FLOT vs CROSS Regimens for Esophageal Adenocarcinoma

HeartRhythm

Esophageal cancer is the sixth leading cause of cancer-related mortality worldwide; with esophageal adenocarcinoma being the more common subtype in the West. For patients with localized or locally advanced esophageal adenocarcinoma, esophagectomy is necessary for pursuing a curative intent approach. One of the standard approaches typically involves neoadjuvant concurrent chemoradiation with carboplatin and paclitaxel followed by esophagectomy, as established by the phase III CROSS trial [1].

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Carla Nester, MD: 12-Month Data Informs Potential of Iptacopan in C3 Glomerulopathy

HCPLive

Carla Nester, MD, discusses her perspective on the APPEAR-C3G 12-month data from ASN Kidney Week 2024.

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TCT 2024 Gets Underway With New Science Simultaneously Published Across JACC Journals

American College of Cardiology

New science presented at TCT 2024 and simultaneously published across the family of JACC Journals sheds light on topics including photon-counting detector-computed tomography (PCD-CT), new and emerging technologies for treating patients with cardiovascular diseases, fractional flow reserve (FFR) and resting full-cycle ratio for predicting myocardial ischemia, intravascular ultrasound (IVUS)-guided PCI in patients with diabetes and acute coronary syndrome (ACS), left atrial appendage occlusion (L

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Zegocractin Significantly Improves Acute Pancreatitis Symptoms in Phase 2 CARPO

HCPLive

The CRAC channel inhibitor zegocractin significantly improved acute pancreatitis patients' time to eating food and risk of respiratory failure in new data.

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Predictors of Late Recurrence after Second Catheter Ablation for Persistent Atrial Fibrillation

HeartRhythm

Little has been reported on the predictors of late recurrence (LR) after second radiofrequency catheter ablation (RFCA) for persistent atrial fibrillation (AF).

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Well-Conducted Real-World Evidence Studies Can Complement Essential Evidence From Clinical Trials

Circulation

Circulation, Volume 150, Issue 18 , Page 1412-1415, October 29, 2024.

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November 2024 Stroke Highlights

Stroke Journal

Stroke, Volume 55, Issue 11 , Page 2589-2589, November 1, 2024.

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Highlights From the Circulation Family of Journals

Circulation

Circulation, Volume 150, Issue 18 , Page 1469-1474, October 29, 2024.

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Stroke Literature Synopses (Preclinical)

Stroke Journal

Stroke, Volume 55, Issue 11 , Page e310-e311, November 1, 2024.

Stroke 40
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Centennial Collection: Hypertrophic Cardiomyopathy

Circulation

Circulation, Volume 150, Issue 18 , Page 1395-1397, October 29, 2024.

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Oral Anticoagulation in Device Patients With Atrial High-Rate Episodes: Shared Decision-Making After ARTESIA and NOAH-AFNET-6

Circulation

Circulation, Volume 150, Issue 18 , Page 1398-1400, October 29, 2024.

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A Rhythm Hidden in the Details

Circulation

Circulation, Volume 150, Issue 18 , Page 1475-1477, October 29, 2024.