Mon.Jun 10, 2024

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Atrium Health Sanger Heart & Vascular Institute Performs Landmark Heart Valve Surgery

DAIC

milla1cf Mon, 06/10/2024 - 17:58 June 10, 2024 — Atrium Health Sanger Heart & Vascular Institute has successfully completed the first commercial tricuspid clip procedure in the Carolinas, performed in May at Atrium Health Carolinas Medical Center. This achievement marks a significant milestone in the treatment of tricuspid regurgitation (TR), offering new hope to patients who are not candidates for traditional open-heart surgery.

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FDA Grants Accelerated Approval to Elafibranor (Iqirvo) for PBC

HCPLive

The accelerated approval is based on data from the phase 3 ELATIVE trial demonstrating a reduction in alkaline phosphatase with elafibranor.

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New Expert Consensus Turns Cardiac CT Imaging into Measurable Standards

DAIC

Getty Images milla1cf Mon, 06/10/2024 - 18:02 June 10, 2024 — New expert consensus from the Society of Cardiovascular Computed Tomography (SCCT) reviews previously published qualitative and semi-quantitative measurements – including clinical guidelines like CAD-RADS 2.0 and disease classification scores such as the CT SYNTAX score for coronary revascularization – to create a comprehensive synopsis concerning quantitative CCTA methods.

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Pavel Strnad, MD: Noninvasive Testing, Candidate Biomarkers in AATD-Associated Liver Disease

HCPLive

Strnad explains key findings from research presented at the EASL Congress regarding noninvasive testing and biomarkers in AATD-LD based on phase 2 fazirsiran clinical trials.

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FDA Expands Use of RSV Vaccine to Include More Adults

Med Page Today

(MedPage Today) -- The FDA expanded the approval of GSK's respiratory syncytial virus (RSV) vaccine (Arexvy) to include adults ages 50 to 59 at risk of RSV-related lower respiratory tract disease (LRTD) due to underlying conditions, the company.

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Statins for heart disease prevention could be recommended for far fewer Americans if new risk equation is adopted

Science Daily - Heart Disease

If national guidelines are revised to incorporate a new risk equation, about 40% fewer people could meet criteria for cholesterol-lowering statins to prevent heart disease. The study examines the potential impact of widespread adoption of the PREVENT equations, which were released by the American Heart Association in November 2023 to update physicians' go-to calculators for assessing patients' 10-year risk of heart attack or stroke.

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Jay Tolsma Sets the Bar for 20 Years

Cassling

From Field Service Engineer (FSE) to Account Executive (AE), Jay Tolsma’s role has evolved over his 20-year career with Cassling, but what hasn’t changed is Jay’s dedication to the job and his colleagues.

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Does a beet a day keep heart disease away?

Science Daily - Heart Disease

After women go through menopause, their risk of heart disease increases dramatically. Researchers studied whether beetroot juice, which is rich in nitrate, can improve how blood vessels function. The results showed that daily consumption of beetroot juice by postmenopausal women may improve blood vessel function enough to reduce future heart disease risk.

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Atrium Health treating CAD patients using drug-coated balloon

Becker's Hospital Review - Cardiology

Charlotte, N.C.-based Atrium Health Sanger Heart & Vascular Institute is among the first institutions in the Carolinas to treat coronary artery disease using a newly FDA-approved device made by Boston Scientific.

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Disturbed blood flow can damage the vessel wall in cases of aortic dilation

Science Daily - Heart Disease

Abnormal blood flow in the aorta is linked to inflammation and breakdown of the vessel wall in conditions where the aorta is dilated. The findings can contribute to better diagnosis and open up new ways to assess the risk of serious and usually fatal complications, such as rupture of the aorta.

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Study reveals target for reversing scar tissue after heart attack

Medical Xpress - Cardiology

A new study by investigators at Massachusetts General Hospital (MGH) reveals an important step to help the human heart regenerate after myocardial infarction (MI).

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Novel radiotracer produces high quality images of 'Alzheimer's disease of the heart'

Science Daily - Heart Disease

A newly developed radiotracer can generate high quality and readily interpretable images of cardiac amyloidosis, a condition referred to as the 'Alzheimer's disease of the heart.' As the first amyloid-specific and pan-amyloid binding radiotracer designed for planar and SPECT/CT imaging, 99mTc-p5+14 could play an important role in early detection and treatment of cardiac amyloidosis.

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Jonathan Silverberg, MD, PhD, MPH: LEVEL UP Aids in Clinical Decision-Making for Atopic Dermatitis

HCPLive

Jonathan Silverberg, MD, PhD, MPH, discusses how the results of the LEVEL UP trial impact treatment decisions for patients with moderate-to-severe atopic dermatitis.

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Discovery unveils key to heart development in womb, unravels cause of spongy heart disease

Science Daily - Heart Disease

Having explored how the heart is formed in utero, a researcher is reporting how cells and molecules act during that early formation and what might cause the heart disease called left ventricular non-compaction or spongy heart, for which patients often require heart transplants.

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Treating Sleep-Related Anxiety with Michael Grandner, PhD

HCPLive

Grandner highlights the importance of focusing on insomnia treatment for sleep-related anxiety—not anxiety treatment.

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Study reveals target for reversing scar tissue after heart attack

Science Daily - Heart Disease

New research discovers a potential path to prevent permanent scarring and heart failure following a myocardial infarction.

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Unraveling Atopic Dermatitis, with Lisa Swanson, MD

HCPLive

Lisa Swanson, MD, discusses the pathogenesis of atopic dermatitis and why she does not recommend elimination diets for her pediatric patients.

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JACC Series Focuses on Pollution, Climate Change and CV Health

American College of Cardiology

"Comprehensive strategies to mitigate pollution and climate change are paramount to protect the environment and safeguard human health globally," say leading global experts as part of a two-part JACC Focus Seminar on pollution and cardiovascular disease.

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Recommended Targets When Treating Ulcerative Colitis/Crohn’s Disease in Clinic

HCPLive

Silvio Danese, MD, PhD; Bruce Sands, MD, and Jean-Frederic Colombel, MD, discuss their preferred recommended targets for managing ulcerative colitis (UC) or Crohn's disease (CD), emphasizing the aggressive approach required to achieve these targets effectively.

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Established TAVR Platforms Evolving for Lifetime Management

Med Page Today

(MedPage Today) -- NEW YORK CITY -- With valve-in-valve procedures becoming a key concern for patients with aortic stenosis, familiar transcatheter aortic valve replacement (TAVR) devices are being tweaked to facilitate future operations that.

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Roflumilast Cream 0.15% Safe for Long-Term Use in Atopic Dermatitis Patients

HCPLive

In this open-label extension trial presented at RAD 2024, the long-term safety and efficacy results of roflumilast cream in adults and children with eczema was highlighted.

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PFA Shows Promise in Reducing AA Burden in AFib

American College of Cardiology

Pulsed field ablation (PFA) was shown to be effective in treating patients with paroxysmal atrial fibrillation (AFib), with more patients free from atrial arrhythmias (AA) when compared with patients treated with thermal ablation, according to results from a secondary analysis of the ADVENT trial. The results of the single-blind study were presented at Heart Rhythm 2024 and simultaneously published in JACC.

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Open-Label Data Suggests No Increased Risk of Infections with Long-Term Dupilumab Use

HCPLive

An analysis of data from the LIBERTY AD trial presented at RAD 2024 details the risk of infections observed with dupilumab use with up to 5 years of follow-up.

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Novel radiotracer produces high quality images of 'Alzheimer's disease of the heart'

Medical Xpress - Cardiology

A newly developed radiotracer can generate high quality and readily interpretable images of cardiac amyloidosis, a condition referred to as the "Alzheimer's disease of the heart." As the first amyloid-specific and pan-amyloid binding radiotracer designed for planar and SPECT/CT imaging, 99mTc-p5+14 could play an important role in early detection and treatment of cardiac amyloidosis.

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Secukinumab and Bimekizumab for Hidradenitis Suppurativa

HCPLive

Patients with HS are getting a long-awaited influx of targeted therapies. Jennifer L. Hsiao, MD, discusses their immediate impact.

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New blood test could prevent sudden child deaths caused by hereditary heart condition

Medical Xpress - Cardiology

A new blood test that could identify children with a potentially fatal heart condition has been developed by researchers at UCL and Great Ormond Street Hospital (GOSH).

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Stephen Congly, MD: Impact of Generic Nucelos(t)ide Analogues on HBV Treatment Spending

HCPLive

Congly explains key findings from his cross-sectional study of costs associated with HBV treatment in patients on Medicaid and the economic impact of generic versus originator use.

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Titration of Medications After Discharge for Acute HF

American College of Cardiology

What is the safety, tolerability, and efficacy of high-intensity care (HIC) following hospital discharge for acute heart failure (HF) based on estimated clinical risk scores?

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Ruxolitinib Consistent in Safety, Tolerability Over 52-Weeks in Children with Extensive Atopic Dermatitis

HCPLive

Treating eczema twice-daily with ruxolitinib cream, 1.5% led to positive results for children in the age range of 2 to 11 years.

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REBALANCE-HF: Splanchnic Nerve Ablation For Volume Redistribution in HFpEF

American College of Cardiology

Splanchnic ablation for volume management (SAVM) in heart failure with preserved ejection fraction (HFpEF) was discussed as a late-breaking trial at the Heart Failure Society of America (HFSA) Annual Scientific Meeting 2023 in Cleveland, Ohio.

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The JAK Inhibitor Safety Conversation

HCPLive

Matthew Zirwas, MD, provides advice to dermatologists discussing the safety of JAK inhibitor therapies due to their controversial black box warning.

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Pulmonary Arterial Hypertension Treatment

American College of Cardiology

What is the comparative effectiveness of therapies targeting the different treatment pathways in pulmonary arterial hypertension (PAH)?

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Treat-to-target in Inflammatory Bowel Disease

HCPLive

Medical experts in inflammatory bowel disease (IBD) define the concept of "treat-to-target" within the context of IBD and provide current recommendations on treatment targets for ulcerative colitis and Crohn's disease, the two main forms of IBD.

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Trends in the incidence, mortality and clinical outcomes in patients with ventricular septal rupture following an ST-elevation myocardial infarction

Coronary Artery Disease Journal

Background Despite improvements in outcomes of ST elevation myocardial infarction (STEMI), ventricular septal rupture (VSR) remains a known complication, carrying high mortality. The contemporary incidence, mortality, and management of post-STEMI VSR remains unclear. Methods The National Inpatient Sample database (2009–2020) was used to study trends in admissions and outcomes of post-STEMI VSR over time.

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LEVEL UP: Upadacitinib Bests Dupilumab for Moderate-to-Severe Atopic Dermatitis

HCPLive

LEVEL UP data presented at RAD 2024 provide additional insight into the phase 3b/4 trial comparing upadacitinib and dupilumab in atopic dermatitis beyond the primary endpoint.

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Clinical Outcomes of Percutaneous Transcatheter Release of Stuck Mechanical Mitral Valve With Cerebral Embolic Protection

Circulation: Cardiovascular Interventions

Circulation: Cardiovascular Interventions, Ahead of Print. BACKGROUND:Surgery or fibrinolysis is the currently available evidence-based treatment for obstructive mechanical valve thrombus. We reported the feasibility and short-term outcomes of percutaneous transcatheter therapy with cerebral embolic protection. Mid- and long-term outcomes remain unknown.METHODS:From 2020 to 2023, 24 patients underwent percutaneous transcatheter release of stuck leaflets with cerebral embolic protection for obstr

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‘Can We Achieve Atopic Dermatitis Remission with Current Therapies?’ with Raj Chovatiya, MD, PhD

HCPLive

In this interview, Chovatiya spoke about his second RAD 2024 talk regarding achieving remission with currently available eczema treatments.

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