Wed.Jul 24, 2024

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Persistent Anxiety Tied to Future Dementia

Med Page Today

(MedPage Today) -- Persistent anxiety raised the risk of all-cause dementia in older adults, a longitudinal study showed. Both chronic anxiety (HR 2.80, 95% CI 1.35-5.72, P=0.01) and new-onset anxiety (HR 3.20, 95% CI 1.40-7.45, P=0.01) were tied.

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Increasing cardiac ketones may help heart failure in mouse study

American Heart News - Heart News

Research Highlights: In mice with heart failure with preserved ejection fraction (HFpEF), increasing ketone supply to the heart allowed their hearts to utilize more ketones and produce more energy. Researchers hope this study may help to improve our.

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Stroke recovery: It's in the genes

Science Daily - Stroke

New research has found that specific genes may be related to the trajectory of recovery for stroke survivors, providing doctors insights useful for developing targeted therapies.

Stroke 109
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The Case for Keto for Type 1 Diabetes with Andrew Koutnik, Ph.D.

Physiologically Speaking

Greetings! Today’s interview is with Andrew Koutnik, Ph.D. Andrew is a research scientist at Sansum Diabetes Research Institute, where he’s investigating metabolic therapies for health and disease. His mission is to optimize metabolic health and patient outcomes for people living with type 1 diabetes. Andrew is unique because he himself has type 1 diabetes.

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Volta Medical Enters into Joint Development Agreement with GE HealthCare to Support Electrophysiologists Treating Atrial Fibrillation

DAIC

Volta Medical has announced it has entered into a Joint Development Agreement with GE Healthcare to enhance arrhythmia procedures with artificial intelligence (AI)-driven electrophysiology technologies. The collaboration, according to a written statement issued by the company, aims to address challenges in capturing and analyzing cardiac signals to help physicians enhance patient outcomes for atrial fibrillation procedures.

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Serum Complement Levels Demonstrate Prognostic Value in IgA Nephropathy

HCPLive

Integrating serum C3 and C4 levels into existing prognostic scores led to better prediction accuracy and may help optimize risk stratification in patients with IgAN.

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FibriCheck Enters US Market with FDA Clearance

DAIC

mtaschetta-millane Wed, 07/24/2024 - 11:34 July 24, 2024 — After a rigorous investigation procedure by the Food and Drug Administration, FibriCheck is now FDA-cleared (K232804). This is an important milestone which supports FibriCheck’s further development in the U.S. market. The FDA-clearance also allows FibriCheck to improve current U.S. care pathways and to provide millions of Americans with the ability to just use their smartphone to obtain easy and accurate heart rhythm measurements.

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Hemophilia A Gene Therapy Displays Superiority in Phase 3 AFFINE Trial

HCPLive

Giroctocogene fitelparvovec achieved primary and key secondary objectives of superiority compared to routine prophylaxis in hemophilia A treatment.

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Increasing Prediabetes remission for type 2 diabetes

Science Daily - Heart Disease

In mice with heart failure with preserved ejection fraction (HFpEF), increasing ketone supply to the heart allowed their hearts to utilize more ketones and produce more energy.

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Epidemiology of cardiometabolic health in Latin America and strategies to address disparities

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 25 July 2024; doi:10.1038/s41569-024-01058-2 Cardiovascular diseases are the leading cause of death in Latin America and the Caribbean (LAC), precipitated by the unique milieu of population growth, rapid urbanization, socioeconomic disparities and prevalent cardiometabolic risk factors. Brant and colleagues summarize trends in cardiometabolic health in LAC and discuss tailored, innovative solutions to address the growing burden of disease in the regio

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Study shows everyday activities aren't enough to protect against stroke

Medical Xpress - Cardiology

Research conducted at the University of Gothenburg shows that the physical activities we do as we go about our lives, at work or in the home, aren't enough to protect us from having a stroke. However, exercising in our free time and using active modes of transport are associated with a decreased risk of stroke. The study is published in JAMA Network Open.

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Improving Schizophrenia Management: A Patient's Call to Care Providers

HCPLive

Schizophrenia experts discuss the stigma and misconceptions surrounding schizophrenia as well as current treatment options.

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Wearable devices may increase health anxiety, atrial fibrillation study finds

Medical Xpress - Cardiology

Using a wearable device, such as a smart watch, to track health data and symptoms, is supposed to help people monitor their health and address symptoms as quickly as possible to spur positive health outcomes. But for people with atrial fibrillation, also known as Afib, using a wearable device to monitor the heart rate and to alert wearers of an irregular heartbeat might not be as helpful as wearers think.

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Pooled Cohort Equation Bests Life's Essential 8, Simple 7 for Predicting Long-Term CVD Risk

HCPLive

UAB research shows AHA’s Life’s Essential 8 and Simple 7 scores aid public health but are less effective than pooled cohort equations for predicting individual cardiovascular risk.

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Mouse study finds increasing cardiac ketones may help treat heart failure

Medical Xpress - Cardiology

Increasing ketone supply to the heart in mice with heart failure with preserved ejection fraction (HFpEF) allowed their hearts to utilize more ketones and produce more energy, according to preliminary research presented today at the American Heart Association's Basic Cardiovascular Sciences Scientific Sessions 2024. The meeting is in Chicago, July 22–25, 2024, and offers the latest research on innovations and discovery in cardiovascular science.

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Early Intervention, Lifelong Prevention: Targeting Subclinical ASCVD in Young Adults

American College of Cardiology

Cardiovascular disease (CVD) remains the leading cause of death and disability worldwide. Early intervention and strict control of modifiable CV risk factors in adolescents and young adults will likely reduce the significant morbidity, mortality, and socioeconomic burden associated with the condition.

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New study identifies a key role for pharmacists in stroke risk reduction

Medical Xpress - Cardiology

According to Dr. Roopinder Sandhu, MD, MPH, atrial fibrillation (Afib) is the most common heart rhythm disorder encountered in clinical practice, and the leading cause of stroke in older individuals. Sandhu, a cardiac electrophysiologist and the Director of the Women's Cardiovascular Health Initiative at the Cumming School of Medicine, University of Calgary, says despite the availability of blood thinners that are highly effective and safe to reduce the risk of stroke, major gaps in the delivery

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Study Links Air Pollution Exposure During Pregnancy to Reduced Lung Function in Childhood

HCPLive

These data highlighted the association of moderate air pollution exposure during pregnancy, infancy, and early childhood on pulmonary function at school age.

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Elevating Your Medical Expertise, The Essential Training for Doctors to Excel

ADN Center of Excellence

As a dedicated medical professional, you're well aware that the journey to excellence in healthcare is a continuous one. The rapid pace of medical advancements and evolving patient expectations demand that doctors constantly refine their skills and expand their knowledge. At ADN Center of Excellence , we understand the challenges you face and are committed to providing the training you need to excel in your field.

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Magenta Medical Adds $105M, Targets MCS Disruption

CardiacWire

Israeli heart pump startup Magenta Medical wrapped up a $105M financing round to advance clinical programs supporting its Elevate left ventricular assist device, a percutaneous heart pump that Magenta believes could disrupt the mechanical circulatory support (MCS) segment. The miniature Elevate device is folded and delivered percutaneously through the femoral artery (8 Fr inner diameter, 10 Fr sheath), passing through the aorta and aortic valve, before self-expanding in patients’ hearts where it

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Positive Outcomes Observed Among Those With COPD in Nurse, Allied Health–Led Clinic

HCPLive

This model and its service components may be implemented in the future to allow for improvements to primary care programs, with the goal being benefits to patients with COPD.

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Lp(a) and Coronary Plaque Progression

American College of Cardiology

What is the association of lipoprotein(a) (Lp[a]) levels with long-term coronary artery plaque progression, development of high-risk plaque, and pericoronary adipose tissue inflammation?

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Semaglutide May Reduce Rates of Diabetic Retinopathy Outcomes

HCPLive

A database analysis linked semaglutide use to notable reductions in the rates of diabetic macular edema and vitreous hemorrhage in diabetic retinopathy.

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Elevating Your Medical Expertise, The Essential Training for Doctors to Excel

ADN Center of Excellence

As a dedicated medical professional, you're well aware that the journey to excellence in healthcare is a continuous one. The rapid pace of medical advancements and evolving patient expectations demand that doctors constantly refine their skills and expand their knowledge. At ADN Center of Excellence , we understand the challenges you face and are committed to providing the training you need to excel in your field.

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KM04416 suppressed lung adenocarcinoma progression by promoting immune infiltration

Journal of Cardiothoracic Surgery

Lung adenocarcinoma (LUAD) is a malignant tumor originating from the bronchial mucosa or glands of the lung, with the fastest increasing morbidity and mortality. Therefore, the prognosis of lung cancer remains.

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Screening for carotid atherosclerosis: development and validation of a high-precision risk scoring tool

Frontiers in Cardiovascular Medicine

ObjectiveThis study aimed to investigate the prevalence of carotid atherosclerosis (CAS), especially among seniors, and develop a precise risk assessment tool to facilitate screening and early intervention for high-risk individuals.MethodsA comprehensive approach was employed, integrating traditional epidemiological methods with advanced machine learning techniques, including support vector machines, XGBoost, decision trees, random forests, and logistic regression.ResultsAmong 1,515 participants

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The impact of bleeding on outcomes following lung transplantation: a retrospective analysis using the universal definition of perioperative bleeding

Journal of Cardiothoracic Surgery

Lung transplantation (LT) represents a high-risk procedure for end-stage lung diseases. This study describes the outcomes of patients undergoing LT that require massive transfusions as defined by the universal.

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Case Report: Patent ductus arteriosus with tuberous sclerosis complex

Frontiers in Cardiovascular Medicine

A 33-year-old patient presented with a chief complaint of patent ductus arteriosus (PDA) persisting for over 30 years. Physical examination revealed bilateral facial angiofibromas, multiple nail fibromas, intraoral fibromas, and a ’shagreen patch’ on the left lumbar region. Genetic testing was performed using a peripheral venous blood sample, which confirmed the diagnosis of Tuberous Sclerosis Type 2 (TSC2).

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ECG Podcasts on 12-Lead & Arrhythmias — Pearls, Pitfalls, OMI & AI and Lots More

Dr. Smith's ECG Blog

I recently recorded a series of 4 podcasts regarding KEY concepts in ECG interpretation. Easy LINK — [link] — My New E CG P odcasts ( 5/28/2024 ): These podcasts are part of the Mayo Clinic Cardiovascular CME Podcasts Series ( "Making Waves" ) — hosted by Dr. Anthony Kashou. They are found on the Mayo Clinic Cardiovasciular CME site. You can adjust the speed of the recording ( If the speed is "slow" for you — increasing to 1.25 speed should be optimal for you!

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Biomechanical factors and atherosclerosis localization: insights and clinical applications

Frontiers in Cardiovascular Medicine

Although the entire vascular bed is constantly exposed to the same risk factors, atherosclerosis manifests a distinct intra-individual pattern in localization and progression within the arterial vascular bed. Despite shared risk factors, the development of atherosclerotic plaques is influenced by physical principles, anatomic variations, metabolic functions, and genetic pathways.

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Impact of Small Aortic Annuli on the Performance of Transcatheter Aortic Valve Replacement Bioprostheses: An Updated Meta-analysis of Recent Studies

The American Journal of Cardiology

Publication date: Available online 23 July 2024 Source: The American Journal of Cardiology Author(s): Gianluca Di Pietro, Riccardo Improta, Francesco Bruno, Ovidio De Filippo, Pier Pasquale Leone, Marco Nebiolo, Federico Giacobbe, David Caporusso, Lucia Ilaria Birtolo, Alfonso Ielasi, Abdel-Wahab Mohamed, Kay Woon Ho, Kentaro Meguro, Jerome Ferrara, Ron Waksman, Thomas Pilgrims, Raymond G McKay, Moritz Seiffert, Mancone Massimo, Gaetano Maria De Ferrari

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Chronic Thromboembolic Pulmonary Hypertension: the therapeutic assessment

Frontiers in Cardiovascular Medicine

Chronic Thromboembolic Pulmonary Hypertension (CTEPH) is a severe and complex condition that evolves from unresolved pulmonary embolism, leading to fibrotic obstruction of pulmonary arteries, pulmonary hypertension, and potential right heart failure. The cornerstone of CTEPH management lies in a multifaceted therapeutic approach tailored to individual patient profiles, reflecting the disease's heterogeneity.

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Myocardial Work by Speckle Tracking Echocardiography in Heart Transplant Recipients: Association between Global Work Efficiency and Coronary Allograft Vasculopathy

The American Journal of Cardiology

Publication date: Available online 23 July 2024 Source: The American Journal of Cardiology Author(s): Giulio Cacioli, Michele Ciabatti, Ernesto Cristiano, Claudia Notari, Ilaria Papisca, Giada Distefano, Giovanni Menafra, Paola Lilla Della Monica, Mariano Antonio Feccia, Amedeo Pergolini, Viviana Maestrini, Fabio Sbaraglia, Federico Ranocchi, Francesco Musumeci

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Identification and validation of CCL5 as a key gene in HIV infection and pulmonary arterial hypertension

Frontiers in Cardiovascular Medicine

BackgroundThe relationship between human immunodeficiency virus (HIV) infection and pulmonary arterial hypertension (PAH) has garnered significant scrutiny. Individuals with HIV infection have a higher risk of developing PAH. However, the specific mechanism of HIV-associated PAH remains unclear. Our study aims at investigating the shared biomarkers in HIV infection and PAH and predicting the potential therapeutic target for HIV-associated PAH.MethodsData for HIV infection and PAH were downloaded

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Tampa General researchers develop new heart transplant device

Becker's Hospital Review - Cardiology

Discover the innovative device developed by Tampa General Hospital researchers that extends the viability of transplant hearts by three hours

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Navigating Early Management Strategies in Acute Myocardial Infarction With Cardiogenic Shock

The American Journal of Cardiology

Publication date: Available online 23 July 2024 Source: The American Journal of Cardiology Author(s): Kahtan Fadah, Helayna Abraham, Subhash Banerjee, Debabrata Mukherjee

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Novel Genotyping Test Enables Real-Time PCR Detection of SERPINA1 Variants in AATD

HCPLive

The homogenous genotyping test combines allele-specific tailed primers with SYBR-Green to facilitate fast and accurate detection of PI*S and PI*Z alleles of SERPINA1.

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