Ken Grauer, MD
MARCH 1, 2024
I was sent the 2 ECGs shown in Figure-1 — which were recorded from an elderly man whose heart beat "has been irregular for years". No clear history for recent chest pain — but the patient "has not been well" for the previous week. Regarding the 2 ECGs in Figure-1 : ECG #1 is the initial tracing obtained at the scene by the EMS ( E mergency M edical S ystems ) team — in association with an alert but markedly hypotensive patient.
American Heart News - Heart News
MARCH 1, 2024
DALLAS, March 1, 2024 – Losing an extra hour of sleep may not be the worst thing that could happen when you “spring forward” at the start of daylight saving time. According to the American Heart Association, celebrating one hundred years of lifesaving.
Journal of Clinical Investigation - Cardiology
MARCH 1, 2024
Long-term organ transplant survival remains suboptimal, and life-long immunosuppression predisposes transplant recipients to an increased risk of infection, malignancy, and kidney toxicity. Promoting the regulatory arm of the immune system by expanding Tregs may allow immunosuppression minimization and improve long-term graft outcomes. While low-dose IL-2 treatment can expand Tregs, it has a short half-life and off-target expansion of NK and effector T cells, limiting its clinical applicability.
Cardiovascular Diabetology
MARCH 1, 2024
Platelets play an important role in the development of cardiovascular disease (CVD). Mean platelet volume (MPV) is considered as biological marker of platelets activity and function. The aim of the present stu.
Journal of Clinical Investigation - Cardiology
MARCH 1, 2024
Patients with chronic inflammatory disorders such as psoriasis have an increased risk of cardiovascular disease and elevated levels of LL37, a cathelicidin host defense peptide that has both antimicrobial and proinflammatory properties. To explore whether LL37 could contribute to the risk of heart disease, we examined its effects on lipoprotein metabolism and show that LL37 enhanced LDL uptake in macrophages through the LDL receptor (LDLR), scavenger receptor class B member 1 (SR-B1), and CD36.
DAIC
MARCH 1, 2024
Sumeet Chugh, MD. Photo by Cedars-Sinai milla1cf Fri, 03/01/2024 - 08:25 March 1, 2024 — Two new studies by Cedars-Sinai investigators support using artificial intelligence (AI) to predict sudden cardiac arrest-a health emergency that in 90% of cases leads to death within minutes. “Sudden cardiac arrest is a mostly lethal condition, and prevention will make the biggest impact, but we need to find novel clinical tools to make that possible,” said Sumeet Chugh, MD , director of the Division of A
HCPLive
MARCH 1, 2024
In the February edition of Dermatology Month in Review, new acne guidelines released by AAD, an FDA decision on nemolizumab, and an interview on potentially the first oral IL-23 inhibitor for psoriasis were among the major stories.
Cardiovascular Update brings together the best content for cardiovascular medicine professionals from the widest variety of industry thought leaders.
Becker's Hospital Review - Cardiology
MARCH 1, 2024
Findley, Ohio-based Blanchard Valley Health System is cutting its open-heart surgery program and will instead transfer patients to other systems as needed.
DAIC
MARCH 1, 2024
Getty Images milla1cf Fri, 03/01/2024 - 08:32 March 1, 2024 — Prenatal stress is a potential risk factor for cardiovascular disease in offspring later in life. In a new study published in JACC: Heart Failure , maternal loss of a partner or child shortly before or during pregnancy was found to be associated with increased risk of heart failure up to middle-age in the child.
Journal of Clinical Investigation - Cardiology
MARCH 1, 2024
Nuclear factor of activated T-cells 5 (NFAT5), an osmo-sensitive transcription factor, can be activated by isotonic stimuli, such as infection. It remains unclear, however, whether NFAT5 is required for damage-associated molecular pattern–triggered (DAMP-triggered) inflammation and immunity. Here, we found that several DAMPs increased NFAT5 expression in macrophages.
HCPLive
MARCH 1, 2024
The newest version of ChatGPT accurately responded to most multiple-choice questions on ophthalmic cases but performed better on non-image–based questions.
Journal of Clinical Investigation - Cardiology
MARCH 1, 2024
Converging studies demonstrate the dysfunction of the dopaminergic neurons following chronic opioid administration. However, the therapeutic strategies targeting opioid-responsive dopaminergic ensembles that contribute to the development of opioid withdrawal remain to be elucidated. Here, we used the neuronal activity-dependent Tet-Off system to label dopaminergic ensembles in response to initial morphine exposure (Mor-Ens) in the ventral tegmental area (VTA).
Dr. Smith's ECG Blog
MARCH 1, 2024
This 60 yo male had an apparent tonic clonic seizure. He had no history of seizures. He was unconscious for 8 minutes and slowly awoke in the ambulance, complaining of nausea only. First responders found him to be very tachycardic , confused, perserverating and with no memory of the event. There was tongue biting. Lightheadedness continued. The tachycardia was gone by the time paramedics arrived.
Journal of Clinical Investigation - Cardiology
MARCH 1, 2024
Two coding variants of apolipoprotein L1 (APOL1), called G1 and G2, explain much of the excess risk of kidney disease in African Americans. While various cytotoxic phenotypes have been reported in experimental models, the proximal mechanism by which G1 and G2 cause kidney disease is poorly understood. Here, we leveraged 3 experimental models and a recently reported small molecule blocker of APOL1 protein, VX-147, to identify the upstream mechanism of G1-induced cytotoxicity.
American Heart News - Heart News
MARCH 1, 2024
DALLAS, 1 de marzo de 2024 – Es posible que perder una hora extra de sueño no sea lo peor que podría pasar cuando se “adelanten los relojes” al comienzo del horario de verano. Según la American Heart Association (la Asociación Americana del Corazón), que.
Journal of Clinical Investigation - Cardiology
MARCH 1, 2024
Pulmonary surfactant is a lipoprotein complex lining the alveolar surface to decrease the surface tension and facilitate inspiration. Surfactant deficiency is often seen in premature infants and in children and adults with respiratory distress syndrome. Mechanical stretch of alveolar type 2 epithelial (AT2) cells during lung expansion is the primary physiological factor that stimulates surfactant secretion; however, it is unclear whether there is a mechanosensor dedicated to this process.
HCPLive
MARCH 1, 2024
Results showed 95.8% of patients who were treated for HCV with DAA therapy and underwent renal transplantation did not experience HCV recurrence.
Journal of Clinical Investigation - Cardiology
MARCH 1, 2024
Nonalcoholic fatty liver disease (NAFLD) encompasses a disease continuum from simple steatosis to nonalcoholic steatohepatitis (NASH). However, there are currently no approved pharmacotherapies for NAFLD, although several drugs are in advanced stages of clinical development. Because of the complex pathophysiology and heterogeneity of NAFLD, the identification of potential therapeutic targets is clinically important.
HCPLive
MARCH 1, 2024
Jairath discusses disease clearance and optimal treatment targeting in UC, highlighting what the ongoing VERDICT trial hopes to add to our understanding of improving patient outcomes.
Journal of Clinical Investigation - Cardiology
MARCH 1, 2024
Ca2+-activated BK channels in renal intercalated cells (ICs) mediate luminal flow–induced K+ secretion (FIKS), but how ICs sense increased flow remains uncertain. We examined whether PIEZO1, a mechanosensitive Ca2+-permeable channel expressed in the basolateral membranes of ICs, is required for FIKS. In isolated cortical collecting ducts (CCDs), the mechanosensitive cation-selective channel inhibitor GsMTx4 dampened flow-induced increases in intracellular Ca2+ concentration ([Ca2+]i), whereas th
American College of Cardiology
MARCH 1, 2024
The history behind the ACC Women in Cardiology (WIC) Member Section reaches back 30 years and is a captivating narrative of empowerment, innovation, resilience and, ultimately, progress.
Journal of Clinical Investigation - Cardiology
MARCH 1, 2024
Spinocerebellar ataxia type 3 (SCA3) is an adult-onset neurodegenerative disease caused by a polyglutamine expansion in the ataxin-3 (ATXN3) gene. No effective treatment is available for this disorder, other than symptom-directed approaches. Bile acids have shown therapeutic efficacy in neurodegenerative disease models. Here, we pinpointed tauroursodeoxycholic acid (TUDCA) as an efficient therapeutic, improving the motor and neuropathological phenotype of SCA3 nematode and mouse models.
HCPLive
MARCH 1, 2024
The rheumatology month in review highlights cognitive dysfunction in patients with fibromyalgia, explores the impact of obesity on treatment response in rheumatoid arthritis, and evaluates work-related challenges faced by patients with psoriatic arthritis.
Journal of Clinical Investigation - Cardiology
MARCH 1, 2024
Early gestational loss occurs in approximately 20% of all clinically recognized human pregnancies and is an important cause of morbidity. Either embryonic or maternal defects can cause loss, but a functioning and receptive uterine endometrium is crucial for embryo implantation. We report that the switch/sucrose nonfermentable (SWI/SNF) remodeling complex containing polybromo-1 (PBRM1) and Brahma-related gene 1 (BRG1) is essential for implantation of the embryonic blastocyst on the wall of the ut
American College of Cardiology
MARCH 1, 2024
The ACC isn't the only cardiovascular society celebrating a milestone anniversary in 2024. Both the American Heart Association (AHA) and Association of Black Cardiologists (ABC) are celebrating 100 years and 50 years, respectively.
Journal of Clinical Investigation - Cardiology
MARCH 1, 2024
Early-life seizures (ELSs) can cause permanent cognitive deficits and network hyperexcitability, but it is unclear whether ELSs induce persistent changes in specific neuronal populations and whether these changes can be targeted to mitigate network dysfunction. We used the targeted recombination of activated populations (TRAP) approach to genetically label neurons activated by kainate-induced ELSs in immature mice.
HCPLive
MARCH 1, 2024
The approval of the AGENT Drug-Coated Balloon is based on the AGENT IDE trial and was announced by Boston Scientific on March 01, 2024.
Cardiometabolic Health Congress
MARCH 1, 2024
The not-so-sudden rise of weight loss ”wonder” drugs for T2D and obesity This World Obesity Day, March 4, 2024, weight loss drugs dominate discussions and raise new questions for clinicians. Glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) have been used to treat type 2 diabetes (T2D) since the approval of Byetta (exenatide) in 2005.
HCPLive
MARCH 1, 2024
A new study found menopausal hormone therapy was associated with a significant reduction in depressive symptoms over time with a greater reduction combined with antidepressants.
Journal of Clinical Investigation - Cardiology
MARCH 1, 2024
Immune tolerance to allogenic transplanted tissues remains elusive, and therapeutics promoting CD4+FOXP3+ Tregs are required to achieve this ultimate goal. In this issue of the JCI, Efe and colleagues engineered an Fc domain fused to a human mutein IL-2 (mIL-2–Fc) bearing mutations that confer preferential binding to the high-affinity IL-2 receptor expressed on Tregs.
American College of Cardiology
MARCH 1, 2024
Despite decreasing rates of permanent pacemaker implantation (PPI) after TAVR, substantial site-level variation persists, suggesting the need for quality improvement initiatives like replicating best practices from high-performing sites and increased guideline-based education, according to a recent study published in JACC: Cardiovascular Interventions.
HCPLive
MARCH 1, 2024
These findings suggest much lower prices can be achieved for medications, with better alignment to the benefits of different biological psoriasis treatments
Journal of Clinical Investigation - Cardiology
MARCH 1, 2024
A proportion of somatic mutations in tumors create neoepitopes that can prime T cell responses that target the MHC I–neoepitope complexes on tumor cells, mediating tumor control or rejection. Despite the compelling centrality of neoepitopes to cancer immunity, we know remarkably little about what constitutes a neoepitope that can mediate tumor control in vivo and what distinguishes such a neoepitope from the vast majority of similar candidate neoepitopes that are inefficacious in vivo.
HCPLive
MARCH 1, 2024
Older adults who are ≥ 90 years old, have dementia, are frail, and are undergoing vascular surgery have greater hospital readmission rates within 180 days.
Learning + Leading
MARCH 1, 2024
The healthcare sector is evolving rapidly, with staffing and retention at the forefront of many organizations' strategic planning. In response, data-driven approaches are increasingly being adopted to refine recruitment and training processes. The National Healthcareer Association ® (NHA) provides valuable resources that align with these data-centric strategies, aiding healthcare employers in their quest to build resilient and skilled teams.
HCPLive
MARCH 1, 2024
This month’s biosimilars month in review highlights the evolving landscape of biosimilars, emphasizing their potential benefits in terms of safety, cost-effectiveness, and increased treatment options, while recognizing the importance of addressing challenges in adoption and perception.
Cassling
MARCH 1, 2024
Fluoroscopy-guided procedures are the leading source of occupational ionizing radiation exposure for electrophysiologic (EP) personnel. High cumulative doses of X-ray radiation might increase the risk for malignancies, early development of cataracts and orthopedic problems due to the heavy weight of lead aprons. Reducing high scatter radiation exposure during medical procedures is the principal task of many professional societies and advisory groups.
Expert insights. Personalized for you.
186 
Let's personalize your content