Mon.Jul 22, 2024

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New research explores alcohol’s impact on the heart

American Heart News - Heart News

Research Highlights: Two new, basic research studies in rodents (mice and rats) analyzed the impacts that alcohol may have on the heart. In a mouse study, abnormal heart rhythms that can occur after a pattern of repeated simulation of binge drinking.

Research 135
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Pay People, and They Will Go to Cardiac Rehab

Med Page Today

(MedPage Today) -- It might take giving people money directly for them to participate in cardiac rehabilitation, a randomized trial showed. Eligible patients in Vermont of lower socioeconomic status had cardiac rehab adherence rates shoot up if.

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Renowned Cardiologist Behind ‘Go Red for Women’ Campaign, Nieca Goldberg, MD, Announces Return to Practice at NYU Langone

DAIC

Nieca Goldberg, MD, board-certified cardiologist, educator, author, and advocate for women’s health, has announced she is returning to practice at NYU Langone Health, where she also serves as Clinical Associate Professor, Department of Medicine at NYU Grossman School of Medicine. Image courtesy: Finn Partners christine.book Mon, 07/22/2024 - 11:36 July 22, 2024 — Nieca Goldberg, MD , a board-certified cardiologist, educator, author, and advocate for women’s health, has announced that she is retu

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Empagliflozin protects against heart failure with preserved ejection fraction partly by inhibiting the senescence-associated STAT1–STING axis

Cardiovascular Diabetology

Heart failure with preserved ejection fraction (HFpEF) is a mortal clinical syndrome without effective therapies. Empagliflozin (EMPA) improves cardiovascular outcomes in HFpEF patients, but the underlying mec.

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Lower Income Associated with Greater Mortality Risk in Chronic Liver Disease

HCPLive

The analysis of NHANES data found individuals with viral hepatitis and NAFLD as well as lower income and no college education were at a greater risk of mortality.

Education 105
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People Without Diabetes Make Up Growing Share of GLP-1 Users

Med Page Today

(MedPage Today) -- The proportion of new users of GLP-1 receptor agonists without type 2 diabetes markedly increased over the past decade, and particularly since 2020, according to a nationwide population-based study of prescribing trends. Overall.

Diabetes 111
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New study identifies two proteins that may contribute to stroke recurrence

Science Daily - Heart Disease

A new study has identified new genetic and molecular risk factors that may reveal new pathways for treating patients after they experience their first stroke. The study identified CCL27 and TNFRSF14, two proteins that are associated with subsequent MACE, but not initial strokes. These proteins are known to activate inflammation, which plays a key role in the development of strokes and many chronic conditions and diseases.

Strokes 100

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Defining Iron Deficiency

HCPLive

The panel provides a broad overview of the treatment of patients with iron deficiency, highlighting diagnostic practices.

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Rapid Uptitration of GDMT and HF Outcomes

American College of Cardiology

What is the relationship between intensive uptitration of guideline-directed medical therapy (GDMT) for heart failure (HF) during the early post-discharge period, and what are the outcomes?

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Surge in New GLP-1 Prescriptions Driven by Semaglutide's Popularity, Study Shows

HCPLive

An analysis using records from 40 million US patients highlights the surge in new GLP-1 receptor agonist use, with semaglutide dominating new prescriptions since 2020.

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George Washington University appoints cardiac surgery chief

Becker's Hospital Review - Cardiology

"George Washington University appoints Steven Boyce, MD as chief of Division of Cardiac Surgery and professor of surgery at GW School of Medicine and Health

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Antiphospholipid Syndrome Antibodies Linked to TNF Inhibitor Treatment of Psoriasis

HCPLive

These findings represent the first comprehensive research into the greater frequency of APS autoantibodies linked with treating psoriasis with TNF inhibitors.

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Prognostic significance of triglyceride-glucose index in acute coronary syndrome patients without standard modifiable cardiovascular risk factors

Cardiovascular Diabetology

A significant percentage of patients with acute coronary syndrome (ACS) without standard modifiable cardiovascular risk factors (SMuRFs) are being identified. Nonetheless, the prognostic influence of the TyG i.

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Management of complications associated with percutaneous left atrial appendage closure with or without ablation: experience from 512 cases over a 4-year period

Frontiers in Cardiovascular Medicine

BackgroundPercutaneous left atrial appendage closure (LAAC) serves as an alternative prophylactic strategy for patients with non-valvular atrial fibrillation (AF) who cannot undergo anti-coagulation therapy. Proper management of associated complications is crucial to enhancing the procedure's success rate and mitigating perioperative risks and adverse events during follow-up.AimsThis study aims to summarize our center's experience and strategies in managing procedural-related complications encou

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J&J Submits sNDA for Esketamine Monotherapy in Treatment-Resistant Depression

HCPLive

Johnson & Johnson submits a supplemental New Drug Application to the FDA for the approval of esketamine as a monotherapy for adults with treatment-resistant depression.

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Adherence to optimal medical therapy and control of cardiovascular risk factors in patients after ST elevation myocardial infarction in Mexico

Frontiers in Cardiovascular Medicine

IntroductionIn developing countries, there is a notable scarcity of real-world data on adherence to optimal medical therapy (OMT) and its correlation with major cardiovascular adverse events (MACEs) after ST-elevation myocardial infarction (STEMI). Our study focuses on addressing this gap by evaluating adherence to OMT, examining its influence on the risk of MACEs after STEMI, and assessing subsequent cardiovascular risk factor control in Mexico.MethodsWe conducted a prospective observational st

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Is There a Troponin Cutpoint to Predict Mortality in Procedural, Spontaneous MI?

American College of Cardiology

Among patients who underwent a PCI, the increased risk of death was similar at one year among those who had a procedural myocardial infarction (pMI) and those who had a spontaneous myocardial infarction (spMI) when their troponin level was >35x the upper reference level (URL).

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Discovery of delayed gas production after implantation of a continuous-flow left ventricular assist device and a preliminary exploration of the mechanisms of its occurrence

Frontiers in Cardiovascular Medicine

ObjectiveTo characterize the gas production phenomenon in the animal model of left ventricular assist device (LVAD), and study its mechanism.MethodsAn in vitro bubble precipitation experiment was conducted, and the blood samples of Parma spp. animals were divided into ordinary group and oxygen-enriched group according to whether they were oxygenated or not at the time of blood collection, and a static control group was set up respectively.

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Clinical Quiz: Systemic JIA Treatment Recommendations from 2021 ACR JIA Guidelines

HCPLive

Test your knowledge of systemic juvenile idiopathic arthritis (JIA) treatment recommendations from the 2021 ACR guideline on JIA with this quiz.

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Advanced magnetic resonance imaging in human placenta: insights into fetal growth restriction and congenital heart disease

Frontiers in Cardiovascular Medicine

Placental function plays a crucial role in fetal development, as it serves as the primary interface for delivery of nutrients and oxygen from the mother to fetus. Magnetic resonance imaging (MRI) has significantly improved our ability to visualize and understand the placenta's complex structure and function. This review provides an up-to-date examination of the most common and novel placental MRI techniques.

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Circadian Syndrome Superior Predictor to Metabolic Syndrome of Prevalent Psoriasis

HCPLive

These data suggest that the introduction of the concept of circadian syndrome contributes to greater understanding of risk management for those with psoriasis.

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Blood proteins predict the risk of developing more than 60 diseases

Science Daily - Heart Disease

The researchers report the ability of protein 'signatures' to predict the onset of 67 diseases including multiple myeloma, non-Hodgkin lymphoma, motor neurone disease, pulmonary fibrosis, and dilated cardiomyopathy.

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Health Consequences of Climate Change with Janelle Bludorn, PA-C, MS

HCPLive

Bludorn joins Lungcast to review the increasing effects and signs of heat-related illness amid record-high temperatures.

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Acute hepatotoxicity of intravenous amiodarone in a Becker muscular dystrophy patient with decompensated heart failing and ABCB4 gene mutation: as assessed for causality using the updated RUCAM

Journal of Cardiothoracic Surgery

Cardiac dysfunction, including arrhythmias, may be one of the main clinical manifestations of Becker muscular dystrophy (BMD). Amiodarone is widely used to treat arrhythmia. However, multi-systemic toxicity ca.

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Dilraj Grewal, MD: Development of MNV in Geographic Atrophy in GATHER Trials

HCPLive

Eyes with GA that developed MNV in the GATHER trials experienced a slower growth rate with avaincaptad pegol than with sham treatment.

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Intensive Blood Pressure Treatment Shows Benefits for High-Risk Patients

Cardiology Update

A study published in The Lancet reveals that targeting a systolic blood pressure of less than 120 mm Hg significantly reduces cardiovascular events in high-risk patients, compared to the standard target of less than 140 mm Hg. This multicenter open-label, blinded-outcome, randomized trial ( NCT04030234 ), offers new insights into hypertension management.

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Margaret Chang, MD: Two-Year Outcomes of the PDS for Diabetic Retinopathy

HCPLive

Patients treated with PDS with ranibizumab refilled every nine months maintained vision improvements and experienced consistent safety over two years.

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A New Risk Model to Improve Stratification of Intermediate-Risk Patients For Primary Prevention?

American College of Cardiology

A new blood-based lipodomic-enhanced risk score (LRS) augmenting the Framingham Risk Score (FRS) may be superior to the FRS alone in improving stratification of intermediate-risk patients for primary prevention.

Article 56
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Treatment and Patient Reported Outcomes in Atopic Dermatitis

HCPLive

Christopher Bunick, MD, PhD, examines patient satisfaction upon achieving primary study endpoints in clinical trials and highlights the significance of patient-reported outcomes (PROs) in both clinical trial designs and patient care.

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AI-Enhanced Patient Evaluation: Key Points

American College of Cardiology

The following are key points to remember from a state-of-the-art article describing how artificial intelligence (AI) applications can improve patient evaluation by combining clinical expertise with technologic advancements.

Article 48
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Head-to-head Study of Upadacitnib and Dupilumab in Atopic Dermatitis (Level Up)

HCPLive

An atopic dermatitis expert describes the results of the Level Up study, a phase 3b/4 trial comparing upadacitinib and dupilumab, which were recently presented at RAD 2024, focusing on the primary and secondary outcomes of the study.

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Pulsed Field or Conventional Thermal Ablation for Paroxysmal Atrial Fibrillation

American College of Cardiology

The goal of the ADVENT trial was to compare the safety and efficacy of pulsed field catheter ablation for symptomatic paroxysmal atrial fibrillation (AF) with that of conventional thermal ablation techniques (radiofrequency or cryoballoon).

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FDA Approves Soliris Biosimilar Eculizumab-aagh (Epysqli)

HCPLive

The approval was based on the clinical, non-clinical, and analytical data proving eculizumab-aagh's bioequivalence to the reference drug.

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JRC-CVT Statement

Alliance of Cardiovascular Professionals

JRC-CVT-Statement JRC-CVT recognizes the advancements in simulation technology and thus the importance of simulation as an adjunct to student hands-on training that at one time could only be acquired during the time spent in the clinical site. The Standards and Guidelines for the Accreditation of Educational Programs in Cardiovascular Technology do not identify either a … Continue reading JRC-CVT Statement The post JRC-CVT Statement appeared first on ACVP Online.

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Risankizumab Induction, Maintenance Therapy Improves Clinical Remission Rates in UC

HCPLive

Data from INSPIRE and COMMAND were used to support risankizumab’s FDA approval for ulcerative colitis, demonstrating the IL-23 inhibitor’s impact on clinical remission.

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Idiopathic ventricular arrhythmia originating from the vicinity of lateral tricuspid annulus: the precise origin and anatomical concerns

HeartRhythm

Although the electrcardiographic and electrophysiological properties of ventricular arrhythmias (VA) from the vicinity of lateral tricuspid annulus (TA) have been reported in previous studies, their precise site of origin have not been addressed.

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Phase 2 Data Shows KP1077 Meaningfully Improves Idiopathic Hypersomnia Symptoms

HCPLive

The phase 2 findings set up the foundation to design a phase 3 trial evaluating KP1077 for idiopathic hypersomnia.

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