Sun.Nov 03, 2024

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Alzheimer's Progression May Be Slowed by Targeted Magnetic Pulses, Study Suggests

Med Page Today

(MedPage Today) -- Investigational transcranial magnetic stimulation that targeted a brain network involved in memory slowed progression in mild-to-moderate Alzheimer's disease, data from a small phase II study suggested. At 1 year, noninvasive.

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The long lost denture: a rare case of an acquired, non-malignant tracheo-oesophageal fistula

Journal of Cardiothoracic Surgery

Ingested dental prosthesis are susceptible to impaction in the gastrointestinal tract due to their sharp edges, size and contour. Delays in presentation arise from the lack of clear history of ingestion and mi.

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Cholesterol and eggs: what’s a heart patient to believe? Registered Dietitian Cheryl Strachan tells all!

Heart Sisters

What’s the deal with eggs if you have heart concerns? Registered Dietitian Cheryl Strachan wades through conflicting studies for us.

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The Cardiac Intensive Care Unit at Age 60

Circulation

Circulation, Volume 150, Issue 19 , Page 1481-1483, November 5, 2024.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Decongestion in acute heart failure: Is it time to change diuretic‐centred paradigm?

European Journal of Heart Failure

Guideline directed medical therapy (GDMT)-centred decongestion in heart failure (HF). ACEi, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; ARNi, angiotensin receptorneprilysin inhibitor; CVP, central venous pressure; MRA, mineralocorticoid receptor antagonist; PCWP, pulmonary capillary wedge pressure; RAAS, reninangiotensinaldosterone system; SGLT-2i, sodiumglucose cotransporter 2 inhibitor; SNS, sympathetic nervous system.

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Safety of catheter ablation for atrial fibrillation in patients with liver cirrhosis

Journal of Cardiovascular Electrophysiology

Abstract Background and Aims Atrial fibrillation is the most prevalent cardiac arrhythmia, and catheter ablation (CA) has emerged as a viable treatment option for selected patients. However, its safety profile in liver cirrhosis (LC) populations remains underexplored. Methods This was an observational analysis of the National Inpatient Sample Database 20162020; we analyzed adult encounters undergoing CA for atrial fibrillation who had a concomitant diagnosis of LC.

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Left atrial function during exercise stress echocardiography as a sign of paroxysmal/persistent atrial fibrillation

Cardiovascular Ultrasound

Atrial cardiomyopathy is closely associated with atrial fibrillation (AF), and some patients exhibit no dysfunction at rest but demonstrate evident changes in left atrial (LA) function and LA volume during exe.

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Association between the plasma ceramide and coronary microvascular resistance

Cardiovascular Diabetology

Plasma ceramide plays a potentially significant role in the pathogenesis of coronary microvascular dysfunction. However, the relationship between plasma ceramide and coronary microvascular resistance in patien.

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Advanced presentation of cardiac hemangioma

Journal of Cardiothoracic Surgery

Cardiac hemangioma is a rare, benign vascular primary tumor. Clinical presentation is either asymptomatic or with symptoms due to its location and spatial interaction with adjacent structures. The authors pres.

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Rheumatology Month in Review: October 2024

HCPLive

The rheumatology month in review emphasizes new data on secukinumab, gout clinical decision making, and addressing sleep issues in fibromyalgia.

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Transseptal Transcatheter Valve-in-Valve Mitral Valve Implantation: Ready for Prime Time

Circulation

Circulation, Volume 150, Issue 19 , Page 1505-1507, November 5, 2024.

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Catheter‐based ablation to improve outcomes in patients with atrial fibrillation and heart failure with preserved ejection fraction: Rationale and design of the CABA‐HFPEF‐DZHK27 trial

European Journal of Heart Failure

Abstract Aims Atrial fibrillation (AF) is common in heart failure (HF) and negatively impacts outcomes. The role of ablation-based rhythm control in patients with AF and HF with preserved (HFpEF) or mildly reduced ejection fraction (HFmrEF) is not known. The CABA-HFPEF-DZHK27 (CAtheter-Based Ablation of atrial fibrillation compared to conventional treatment in patients with Heart Failure with Preserved Ejection Fraction) trial will determine whether early catheter ablation for AF can prevent adv

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Treating Reproductive-Aged Women With Glucagon-Like Peptide-1 Receptor Agonists: What Are the Clinical Considerations?

Circulation

Circulation, Volume 150, Issue 19 , Page 1487-1489, November 5, 2024.

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Nurse‐led diuretic titration via a point‐of‐care urinary sodium sensor in patients with acute decompensated heart failure (EASY‐HF): A single‐centre, randomized, open‐label study

European Journal of Heart Failure

EASY-HF: readily available urinary sodium analysis in patients with acute decompensated heart failure (ADHF). GFR, glomerular filtration rate; NTproBNP, N-terminal pro-B-type natriuretic peptide; POC, point of care; RCT, randomized controlled trial; SOC, standard of care; UNa, urinary sodium concentration. Aims Early evaluation of the natriuretic response is recommended to guide diuretic therapy in acute decompensated heart failure (ADHF).

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Electrophysiological curiosity. Can you spot it?

Dr. Smith's ECG Blog

Written by Magnus Nossen ( with comments and laddergram by Ken Grauer ) The patient in today’s case is a man in his 60s — who presented with palpitations and lightheadedness. He had no history of syncope. The patient had hypertension, but was otherwise healthy. Due to the reported symptoms, he was admitted for observation and put on telemetry monitoring.

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Development and validation of a machine learning‐based approach to identify high‐risk diabetic cardiomyopathy phenotype

European Journal of Heart Failure

Development and validation of a machine-learning approach to identify diabetic cardiomyopathy. A, A velocity; ARIC, Atherosclerosis Risk in Communities; CHS, Cardiovascular Health Study; CVD, cardiovascular disease; DbCM, diabetic cardiomyopathy; DeepNN, deep neural network; E, E velocity; EHR, electronic health record; HF, heart failure; LA, left atrial; LVEDV, left ventricular end-diastolic volume; LV, left ventricular; NT-proBNP, N-terminal pro-B-type natriuretic peptide; T2D, type 2 diabetes

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TCT 2024’s Top TAVR Studies

CardiacWire

This year’s TCT conference saw a deluge of TAVR studies examining everything from the efficacy of valve designs to TAVR’s impact on aortic and tricuspid regurgitation. Out of all these TAVR studies, the four that could have the greatest clinical impact focused on interventional timing and the risk of comorbidities and procedural complications. The EARLY TAVR trial shined the brightest spotlight on TAVR timing, finding that earlier intervention in patients with asymptomatic severe AS may be more

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Arrhythmogenicity of monophasic and biphasic PFA waveforms in a porcine model

Journal of Cardiovascular Electrophysiology

Abstract Objective The potential risk of inducing ventricular arrhythmias was explored by employing pulsed field ablation (PFA) through the administration of both monophasic and biphasic waveform deliveries. Methods PFA was applied to specific locations in the right ventricle (RV, n  = 5 sites) in swine ( n  = 2), utilizing identical settings with consistent amplitude, pulse width, and a number of pulses for both monophasic and biphasic waveforms.