Mon.Oct 28, 2024

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Methods to Manage Psoriasis Using Oral Therapies, with Andrea Murina, MD

HCPLive

In her Fall Clinical interview, Murina highlighted several key takeaways related to her talk titled ‘Managing Psoriasis with Oral Therapy: 2024 & Beyond.

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Major Win for Preemptive TAVR in Symptomless Aortic Stenosis

Med Page Today

(MedPage Today) -- Transcatheter aortic valve replacement (TAVR) yielded clinical benefit when given early in the disease process while patients still had no symptoms or other indication for aortic valve replacement, according to the EARLY TAVR.

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The clinical effect of thoracoscopic segmentectomy in the treatment of lung malignancies less than 2CM in diameter

Journal of Cardiothoracic Surgery

To investigate the clinical effect of thoracoscopic segmentectomy in the treatment of lung malignancies less than 2CM in diameter. In this retrospective study, a total of 103 patients with lung cancer who received outpatient or inpatient treatment from December 2020 to May 2022 were selected and divided into the lobectomy group (n = 48) and the segmentectomy group (n = 55) according to different surgical methods.

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Cerebral Embolic Protection by Geographic Region

JAMA Cardiology

This randomized clinical trial evaluates regional differences in the association between stroke outcomes and cerebral embolic protection.

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Heart failure mortality declining in Sweden

Science Daily - Heart Disease

A new study shows that heart failure mortality has decreased in Sweden over the last 20 years.

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Study links polygenic scores to hypertension treatment outcomes

Medical Xpress - Cardiology

University of Alabama at Birmingham researchers have discovered that a genetic risk score can predict how Black individuals with hypertension respond to the blood pressure medication chlorthalidone and their likelihood of developing treatment-resistant hypertension.

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DCB-BIF: DCB vs. NCB in Patients With Coronary Bifurcation Lesions

American College of Cardiology

In patients with coronary bifurcation lesions undergoing provisional stenting, main vessel stenting with a drug-coated balloon (DCB) for a compromised side branch resulted in lower rates of major cardiovascular events at one year compared with use of a noncompliant balloon (NCB) for the side branch, according to findings from the DCB-BIF trial presented at TCT 2024 and simultaneously published in JACC.

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Kidney Compass: FLOW Insights from Kidney Week 2024, with Katherine Tuttle, MD

HCPLive

Katherine Tuttle, MD, joins the podcast for a deep dive into the latest FLOW data from Kidney Week 2024.

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Analysis highlights impact of rapid first shock after cardiac arrest

Medical Xpress - Cardiology

It is well known that acting quickly in the event of a cardiac arrest is important, but what does a quick initial shock with a defibrillator mean exactly for patients' chances of survival? Researchers from Amsterdam UMC analyzed the data of 3,723 patients who had a cardiac arrest outside the hospital and concluded that for the first shock, every minute reduces the chance of survival by 6%.

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HELP-PCI: Unfractionated Heparin at First Medical Contact vs. the Cathlab

American College of Cardiology

Pretreatment of STEMI patients with a loading-dose of unfractionated heparin (UFH) at first medical contact (FMC) vs. in the catheterization lab (cathlab) was associated with improved spontaneous reperfusion of the infarct-related artery (IRA) without increasing the risk of major bleeding.

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World Stroke Day: Understanding and Combating the "Silent Killer"

ADN Center of Excellence

On October 29th, the global community observes World Stroke Day , an occasion dedicated to raising awareness about one of the most formidable threats to global health: stroke. Often called the "silent killer," stroke is a leading cause of death and disability worldwide. Its insidious nature often occurring without warning has profound implications for patient outcomes, underscoring the need for proactive prevention, rapid response, and advanced treatment strategies.

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Cardiac rehab 'critical' for preventing secondary CVD: Study

Becker's Hospital Review - Cardiology

Patient participation in cardiac rehabilitation programs is an essential part of reducing the risk of a second cardiovascular disease, according to a study published Oct. 26 in Cureus.

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Response to: Correspondence on 'Long-term prognosis of low high-sensitivity cardiac troponin T in the emergency department compared with the general population by Sikandari et al

Heart BMJ

We thank Sikandari et al for their comments regarding the long-term prognosis of patients with chest pain who present in the emergency department with low or undetectable high-sensitivity cardiac troponin T (hs-cTnT) concentrations. 1 Two issues are raised in the comment which we would like to respond to. The authors of the comment propose that the inclusion of patients with elevated hs-cTnT concentrations would better help clinicians categorise risk assessment, since the risk of adverse cardiov

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TAVR UNLOAD: Preemptive TAVR Not Superior to CASS in Patients With HFrEF and Moderate AS

American College of Cardiology

Findings from the TAVR UNLOAD trial found preemptive TAVR was not superior to clinical aortic stenosis surveillance (CASS) for the hierarchical occurrence of all-cause death, disabling stroke, disease-related hospitalizations and heart failure equivalents, and change in quality of life among patients with moderate aortic stenosis (AS) and heart failure with reduced ejection fraction (HFrEF) who are already receiving guideline-directed medical therapy (GDMT).

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Diagnosis and management of resistant hypertension

Heart BMJ

Resistant hypertension is a condition where blood pressure levels remain elevated above target despite changes in lifestyle and concurrent use of at least three antihypertensive agents, including a long-acting calcium channel blocker (CCB), a blocker of the renin-angiotensin system (ACE inhibitor or angiotensin receptor blocker) and a diuretic. To be diagnosed as resistant hypertension, maintaining adherence to therapy is required along with confirmation of blood pressure levels above target by

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Discussing Unmet Needs for Skin Cancer with Laura K. Ferris, MD, PhD, and Neal Bhatia, MD

HCPLive

In this interview at Fall Clinical Dermatology, Ferris and Bhatia highlighted several elements of skin cancer detection and management as well as unmet needs of patients.

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Percutaneous coronary intervention plus medical therapy versus medical therapy alone in chronic coronary syndrome: a propensity score-matched analysis from the Swedish Coronary Angiography and Angioplasty Registry

Heart BMJ

Background Percutaneous coronary intervention (PCI) is frequently used for patients with chronic coronary syndrome (CCS). However, the role of PCI beyond symptom relief in CCS remains controversial. The objective of this study was to determine whether PCI is associated with better outcomes, compared with medical therapy (MT) alone. Methods We conducted a retrospective cohort study.

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When Should We Treat Elevated Inpatient Blood Pressure?

American College of Cardiology

There is an absence of definitive randomized controlled trial data to guide inpatient blood pressure (BP) treatment. Consequently, this paucity of data has resulted in clinical equipoise, in which the benefits and risks of various treatment approaches are unclear.

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GLP-1 RAs Increase Residual Gastric Content But Pose Low Medical Risk During Endoscopy

HCPLive

Braden Kuo, MD, explains how GLP-1 RA use increases residual gastric content but does not significantly impact negative endoscopy outcomes.

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Evaluation of TAVR Compared to Surveillance for Patients With Asymptomatic Severe Aortic Stenosis

American College of Cardiology

The goal of the EARLY TAVR trial was to evaluate transcatheter aortic valve replacement (TAVR) compared with clinical surveillance among patients with asymptomatic severe aortic stenosis (stage C aortic stenosis).

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Excessive occupational sitting increases risk of cardiovascular events among working individuals with type 1 diabetes in the prospective Finnish Diabetic Nephropathy Study

Cardiovascular Diabetology

Sedentary behavior, such as excessive sitting, increases risk of cardiovascular disease and premature mortality in the general population, but this has not been assessed in type 1 diabetes. Occupational sittin.

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Stent-Like Hybrid on Track for Lofty Long-Term Goals in PCI

Med Page Today

(MedPage Today) -- For percutaneous coronary intervention (PCI) on de novo lesions, the DynamX bioadaptor not only matched drug-eluting stents (DES) in early performance but seemed to keep stent-related events from accruing after 6 months, according.

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Correspondence on 'Long-term prognosis of low high-sensitivity cardiac troponin T in the emergency department compared with the general population by Cyon et al

Heart BMJ

We congratulate the authors Love Cyon et al for their published article ‘Long-term prognosis of low high-sensitivity cardiac troponin T in the emergency department compared with the general population’ 1 We want to highlight some important points that should be addressed. First, the authors excluded the population with high levels of high-sensitive cardiac troponin T (hs-cTnT (≥14 ng/L), which has been shown to have a greater risk of adverse cardiac outcomes. 2 Another study by

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Comparison of Noncompliant Balloon With Drug-Coating Balloon Angioplasties for Side Branch After Provisional Stenting for Patients With True Coronary Bifurcation Lesions

American College of Cardiology

The goal of the DCB-BIF trial was to assess the efficacy of drug-coated balloon (DCB) angioplasty of residual side branch stenosis in coronary bifurcation lesions treated with a provisional stenting strategy.

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Health, burnout and well-being of UK cardiology trainees: insights from the British Junior Cardiologists Association Survey

Heart BMJ

Background Cardiology training is demanding and associated with high workloads. Poor lifestyle and health among clinicians may stretch workforces and impact patient care. It has not been established what impact training in cardiology has on the doctors undertaking it. We aimed to establish the prevalence of physical and mental illness, burnout and the ability to maintain a healthy lifestyle among cardiology trainees in the United Kingdom (UK).

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Charles C. Wykoff, MD, PhD: Phase 1b/2a Results on Restoret for DME, nAMD

HCPLive

At AAO 2024, Wykoff discussed first-time extended results from AMARONE showing Restoret’s effectiveness in improving outcomes for patients with DME and nAMD.

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Management strategies and outcomes in pregnancy-related acute aortic dissection: a multicentre cohort study in China

Heart BMJ

Background Acute aortic dissection (AD) in pregnancy poses a lethal risk to both mother and fetus. However, well-established therapeutic guidelines are lacking. This study aimed to investigate clinical features, outcomes and optimal management strategies for pregnancy-related AD. Methods We conducted a retrospective multicentre cohort study including 67 women with acute AD during pregnancy or within 12 weeks postpartum from three major cardiovascular centres in China between 2003 and 2021.

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EARLY TAVR and EVOLVED: Early Intervention in Patients With Asymptomatic AS?

American College of Cardiology

Two separate late-breaking clinical trials – EARLY TAVR and EVOLVED – presented at TCT 2024 explore whether early aortic valve intervention improves outcomes in patients with asymptomatic aortic stenosis (AS).

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Management of bicuspid aortic valve disease in the transcatheter aortic valve implantation era

Heart BMJ

In an era of rapidly expanding use of transcatheter aortic valve implantation (TAVI), the management of patients with bicuspid aortic valve (BAV) disease is far less well established than in those with trileaflet anatomy. Results of isolated surgical aortic valve replacement are excellent in suitable patients, and surgery also allows treatment of concomitant pathology of the aortic root and ascending aorta that is frequently encountered in this cohort.

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Hormone Replacement Therapy Linked to Greater IBS, Gastric Motility Disorder Risk

HCPLive

Jacqueline Khalil, DO, reviews findings from 2 studies about the association between hormone replacement therapy with IBS and gastric motility disorders.

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Percutaneous revascularisation in chronic coronary syndromes: when real-world data unveil the other side of the coin

Heart BMJ

The optimal treatment of chronic coronary syndromes (CCS) represents to date a matter of debate as revascularisation has not shown a real advantage over optimal medical therapy (OMT) alone on long-term overall survival, and has recently been reaffirmed in the latest guidelines as a useful strategy only in case of an ineffective response to OMT. 1 Indeed, if the recently published ORBITA-2 trial demonstrated the benefit of revascularisation in relieving angina symptoms, 2 many other trials aiming

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Brian Lacy, MD, PhD: Profiling Gastric Activity Variations with Multiday Testing

HCPLive

Lacy explains the potential value of an ambulatory wireless patch test for identifying unique gastric activity patterns and individualizing patient care.

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ACC CardiaCast: Pulse Check: What’s New in Lipid Management for the Pharmacist CV Team Professional?

American College of Cardiology

In this episode, Andrea Price, MS, AACC hosts Tomasz Jurga, PharmD, BCPS, BCACP, BCCP, HF-Cert, AACC; Lydia Tran, PharmD, BCPS and Bruce Warden, PharmD, BCPS, FNLA, FASPC to discuss the role of the pharmacists of the care team for lipid management.

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Christine N. Kay, MD: TEASE Trials Show Promise of Gildeuretinol for Stargardt

HCPLive

At AAO 2024, Kay presented an overview of gildeuretinol, an oral vitamin A derivative offering hope for patients with Stargardt disease.

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Effectiveness and Safety of Early Administration of Heparin at First Medical Contact for STEMI Patients Undergoing Primary Percutaneous Coronary Intervention

American College of Cardiology

The goal of the HELP-PCI trial was to determine the efficacy and safety of administering unfractionated heparin at first medical contact versus during cardiac catheterization only in patients with ST-segment elevation myocardial infarction (STEMI).

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Ronnie Fass, MD: On-Demand Vonoprazan for Non-Erosive GERD “Within Our Reach”

HCPLive

Fass reviews findings from a post hoc analysis of a phase 2 trial suggesting the value of vonoprazan as an on-demand NERD treatment.

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Early Valve Replacement Guided by Biomarkers of Left Ventricular Decompensation in Asymptomatic Patients With Severe Aortic Stenosis

American College of Cardiology

The goal of the EVOLVED trial was to assess the safety and efficacy of early aortic valve replacement compared with conservative management among patients with asymptomatic severe aortic stenosis, normal ejection fraction (EF), and presence of myocardial fibrosis on cardiac magnetic resonance imaging (CMR).